A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer von Ott, Patrick A., Hu-Lieskovan, Siwen, Chmielowski, Bartosz, Govindan, Ramaswamy, Naing, Aung, Bhardwaj, Nina, Margolin, Kim, Awad, Mark M., Hellmann, Matthew D., Lin, Jessica J., Friedlander, Terence, Bushway, Meghan E., Balogh, Kristen N., Sciuto, Tracey E., Kohler, Victoria, Turnbull, Samantha J., Besada, Rana, Curran, Riley R., Trapp, Benjamin, Scherer, Julian, Poran, Asaf, Harjanto, Dewi, Barthelme, Dominik, Ting, Ying Sonia, Dong, Jesse Z., Ware, Yvonne, Huang, Yuting, Huang, Zhengping, Wanamaker, Amy, Cleary, Lisa D., Moles, Melissa A., Manson, Kelledy, Greshock, Joel, Khondker, Zakaria S., Fritsch, Ed, Rooney, Michael S., DeMario, Mark, Gaynor, Richard B., Srinivasan, Lakshmi

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Personalized neoantigen vaccine NEO-PV-01 with chemotherapy and anti-PD-1 as first-line treatment for non-squamous non-small cell lung cancer von Awad, Mark M., Govindan, Ramaswamy, Balogh, Kristen N., Spigel, David R., Garon, Edward B., Bushway, Meghan E., Poran, Asaf, Sheen, Joong Hyuk, Kohler, Victoria, Esaulova, Ekaterina, Srouji, John, Ramesh, Suchitra, Vyasamneni, Rohit, Karki, Binisha, Sciuto, Tracey E., Sethi, Himanshu, Dong, Jesse Z., Moles, Melissa A., Manson, Kelledy, Rooney, Michael S., Khondker, Zakaria S., DeMario, Mark, Gaynor, Richard B., Srinivasan, Lakshmi

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A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors von RODON, Jordi, TAWBI, Hussein A, LIN YANG, GRANVIL, Camille, EUNJU HURH, ROSE, Kristine L, AMAKYE, Dereck D, DUMMER, Reinhard, MITA, Alain C, THOMAS, Anne L, STOLLER, Ronald G, TURTSCHI, Christian P, BASELGA, Jose, SARANTOPOULOS, John, MAHALINGAM, Devalingam, YAPING SHOU, MOLES, Melissa A

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Abstract 73: A personal neoantigen vaccine NEO-PV-01 in combination with chemotherapy and pembrolizumab induces broad de novo immune responses in first-line non-squamous NSCLC: Ass... von Awad, Mark M., Govindan, Ramaswamy, Spigel, David R., Garon, Edward B., Kohler, Victoria, Vyasamneni, Rohit, Ramesh, Suchitra, Sciuto, Tracey E., Moles, Melissa A., Tepper, Jennifer, Wanamaker, Amy, Khondkar, Zakaria S., Srouji, John, Dong, Jesse Z., Balogh, Kristen N., Poran, Asaf, Bushway, Meghan E., DeMario, Mark, Gaynor, Richard B., Srinivasan, Lakshmi

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Abstract 5006: Comprehensive gene expression analysis of the tumor microenvironment in patients with advanced cancer treated with a personalized neoantigen vaccine, NEO-PV-01, in c... von Bushway, Meghan E., Ting, Ying Sonia, Besada, Rana H., Sciuto, Tracey E., Prabhakara, Jasmina, Scherer, Julian, Balogh, Kristen N., Lamb, April, Kaplan, Jennifer A., Cleary, Lisa D., Moles, Melissa A., Church, Sarah E., Ren, Yuqi, Ren, Xing, Gaynor, Richard B., Goldstein, Matthew J., Brail, Les H., Greshock, Joel, Srinivasan, Lakshmi

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Abstract 942: The personalized vaccine, NEO-PV-01 with anti-PD1, induces neoantigen-specific de novo immune responses in patients with advanced metastatic melanoma: Association wit... von Hu-Lieskovan, Siwen, Ott, Patrick A., Naing, Aung, Besada, Rana H., Gates, Samantha J., Kohler, Victoria R., Curran, Riley R., Bushway, Meghan E., Scherer, Julian, Balogh, Kristen N., Sciuto, Tracey E., Ting, Ying S., Rooney, Michael S., Harjanto, Dewi, Huang, Zhengping, Huang, Yuting, Ware, Yvonne, Lamb, April, Cleary, Lisa D., Moles, Melissa A., Gaynor, Richard B., Goldstein, Matthew J., Brail, Les H., Greshock, Joel, Srinivasan, Lakshmi

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A Phase 1, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Hedgehog Inhibitor Sonidegib (LDE225) in Patients With Advanced Solid Tumors von Rodon, Jordi, Tawbi, Hussein A, Thomas, Anne L, Stoller, Ronald, Turtschi, Christian P, Baselga, Jose, Sarantopoulos, John, Mahalingam, Devalingam, Shou, Yaping, Moles, Melissa A, Yang, Lin, Granvil, Camille, Hurh, Eunju, Rose, Kristine L, Amakye, Dereck D, Dummer, Reinhard, Mita, Alain C

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Assessment of blind predictions of the clinical significance of BRCA1 and BRCA2 variants von Cline, Melissa S., Babbi, Giulia, Bonache, Sandra, Cao, Yue, Casadio, Rita, Cruz, Xavier, Díez, Orland, Gutiérrez‐Enríquez, Sara, Katsonis, Panagiotis, Lai, Carmen, Lichtarge, Olivier, Martelli, Pier L., Mishne, Gilad, Moles‐Fernández, Alejandro, Montalban, Gemma, Mooney, Sean D., O'Conner, Robert, Ootes, Lars, Özkan, Selen, Padilla, Natalia, Pagel, Kymberleigh A., Pejaver, Vikas, Radivojac, Predrag, Riera, Casandra, Savojardo, Castrense, Shen, Yang, Sun, Yuanfei, Topper, Scott, Parsons, Michael T., Spurdle, Amanda B., Goldgar, David E.

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The Soothing Sea: A Virtual Coastal Walk Can Reduce Experienced and Recollected Pain von Tanja-Dijkstra, Karin, Pahl, Sabine, White, Mathew P., Auvray, Melissa, Stone, Robert J., Andrade, Jackie, May, Jon, Mills, Ian, Moles, David R.

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BRCA1 and BRCA2 5′ noncoding region variants identified in breast cancer patients alter promoter activity and protein binding von Burke, Leslie J., Sevcik, Jan, Gambino, Gaetana, Tudini, Emma, Mucaki, Eliseos J., Shirley, Ben C., Whiley, Phillip, Parsons, Michael T., Leeneer, Kim, Gutiérrez‐Enríquez, Sara, Santamariña, Marta, Caputo, Sandrine M., Santana dos Santos, Elizabeth, Soukupova, Jana, Janatova, Marketa, Zemankova, Petra, Lhotova, Klara, Stolarova, Lenka, Borecka, Mariana, Moles‐Fernández, Alejandro, Manoukian, Siranoush, Bonanni, Bernardo, Edwards, Stacey L., Blok, Marinus J., Overeem Hansen, Thomas, Rossing, Maria, Diez, Orland, Vega, Ana, Claes, Kathleen B.M., Goldgar, David E., Rouleau, Etienne, Radice, Paolo, Peterlongo, Paolo, Rogan, Peter K., Caligo, Maria, Spurdle, Amanda B., Brown, Melissa A.

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Medication errors related to computerized provider order entry systems in hospitals and how they change over time: A narrative review von Kinlay, Madaline, Zheng, Wu Yi, Burke, Rosemary, Juraskova, Ilona, Moles, Rebekah, Baysari, Melissa

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First international workshop of the ATM and cancer risk group (4-5 December 2019) von Lesueur, Fabienne, Easton, Douglas F., Renault, Anne-Laure, Tavtigian, Sean V., Bernstein, Jonine L., Kote-Jarai, Zsofia, Eeles, Rosalind A., Plaseska-Karanfia, Dijana, Feliubadaló, Lidia, Arun, Banu, Herold, Natalie, Versmold, Beatrix, Schmutzler, Rita Katharina, Nguyen-Dumont, Tú, Southey, Melissa C., Dorling, Leila, Dunning, Alison M., Ghiorzo, Paola, Dalmasso, Bruna Samia, Cavaciuti, Eve, Le Gal, Dorothée, Roberts, Nicholas J., Dominguez-Valentin, Mev, Rookus, Matti, Taylor, Alexander M. R., Goldstein, Alisa M., Goldgar, David E., Stoppa-Lyonnet, Dominique, Andrieu, Nadine

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An open-label, phase 1b study of NEO-PV-01 with pembrolizumab plus chemotherapy in patients with advanced or metastatic nonsquamous non-small cell lung cancer von Govindan, Ramaswamy, Awad, Mark M., Cleary, Lisa D, Moles, Melissa Ann, Gaynor, Richard, Goldstein, Matthew Jordan, Spigel, David R.

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Electronic Medication Management Systems: Analysis of Enhancements to Reduce Errors and Improve Workflow von Kinlay, Madaline, Ho, Lai Mun Rebecca, Zheng, Wu Yi, Burke, Rosemary, Juraskova, Ilona, Moles, Rebekah, Baysari, Melissa

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Evaluation of the association of heterozygous germline variants in NTHL1 with breast cancer predisposition: an international multi-center study of 47,180 subjects von Li, Na, Zethoven, Magnus, McInerny, Simone, Devereux, Lisa, Huang, Yu-Kuan, Thio, Niko, Cheasley, Dane, Gutiérrez-Enríquez, Sara, Moles-Fernández, Alejandro, Diez, Orland, Nguyen-Dumont, Tu, Southey, Melissa C., Hopper, John L., Simard, Jacques, Dumont, Martine, Soucy, Penny, Meindl, Alfons, Schmutzler, Rita, Schmidt, Marjanka K., Adank, Muriel A., Andrulis, Irene L., Hahnen, Eric, Engel, Christoph, Lesueur, Fabienne, Girard, Elodie, Neuhausen, Susan L., Ziv, Elad, Allen, Jamie, Easton, Douglas F., Scott, Rodney J., Gorringe, Kylie L., James, Paul A., Campbell, Ian G.

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An open-label, phase Ib study of NEO-PV-01 + adjuvant with nivolumab in patients with melanoma, non-small cell lung carcinoma, or transitional cell carcinoma of the bladder von Naing, Aung, Hu-Lieskovan, Siwen, Govindan, Ramaswamy, Margolin, Kim Allyson, Moles, Melissa Ann, Gaynor, Richard, Goldstein, Matthew Jordan, Ott, Patrick Alexander

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Abstract CT125: A personal neoantigen vaccine, NEO-PV-01, with anti-PD1 induces broad de novo anti-tumor immunity in patients with metastatic melanoma, NSCLC, and bladder cancer von Ott, Patrick A., Govindan, Ramaswamy, Naing, Aung, Friedlander, Terence W., Margolin, Kim, Lin, Jessica J., Bhardwaj, Nina, Hellmann, Matthew D., Srinivasan, Lakshmi, Greshock, Joel, Moles, Melissa, Gaynor, Richard B., Goldstein, Matthew J., Hu-Lieskovan, Siwen

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364 A personal neoantigen vaccine NEO-PV-01 in combination with chemotherapy and pembrolizumab induces broad de novo immune responses in first line, non-squamous NSCLC von Awad, Mark, Spigel, David, Garon, Edward, Waqar, Saiama, Lisberg, Aaron, Moles, Melissa, Tepper, Jennifer, Lamb, April, Wanamaker, Amy, Khondker, Zakaria, Srouji, John, Dong, Jesse, Poran, Asaf, Balogh, Kristen, Bushway, Meghan, DeMario, Mark, Srinivasan, Lakshmi, Gaynor, Richard, Govindan, Ramaswamy

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Abstract LB-147: Comprehensive immune and molecular analysis of two metastatic melanoma patients treated with a personal neoantigen vaccine, NEO-PV-01, in combination with anti-PD1... von Naing, Aung, Ott, Patrick A., Gates, Samantha J., Martinez, Jose G., Curran, Riley R., Kohler, Victoria L., Bushway, Meghan E., Scherer, Julian, Barthelme, Dominik, Dong, Jesse Z., Lamb, April, Cleary, Lisa D., Moles, Melissa, Greshock, Joel, Gaynor, Richard B., Goldstein, Matthew J., Srinivasan, Lakshmi

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Can virtual nature improve patient experiences and memories of dental treatment? A study protocol for a randomized controlled trial von Tanja-Dijkstra, Karin, Pahl, Sabine, White, Mathew P, Andrade, Jackie, May, Jon, Stone, Robert J, Bruce, Malcolm, Mills, Ian, Auvray, Melissa, Gabe, Rhys, Moles, David R

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