Structural Basis for the Autoinhibition and STI-571 Inhibition of c-Kit Tyrosine Kinase von Mol, Clifford D, Dougan, Douglas R, Schneider, Thomas R, Skene, Robert J, Kraus, Michelle L, Scheibe, Daniel N, Snell, Gyorgy P, Zou, Hua, Sang, Bi-Ching, Wilson, Keith P

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DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination von Tainer, John A, Mol, Clifford D, Izumi, Tadahide, Mitra, Sankar

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Switching on kinases: oncogenic activation of BRAF and the PDGFR family von Dibb, Nick J, Dilworth, Stephen M, Mol, Clifford D

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Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation von Mol, Clifford D., Lim, Kheng B., Sridhar, Vandana, Zou, Hua, Chien, Ellen Y.T., Sang, Bi-Ching, Nowakowski, Jacek, Kassel, Daniel B., Cronin, Ciarán N., McRee, Duncan E.

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Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists von Wu, Beili, Chien, Ellen Y.T, Mol, Clifford D, Fenalti, Gustavo, Liu, Wei, Katritch, Vsevolod, Abagyan, Ruben, Brooun, Alexei, Wells, Peter, Bi, F. Christopher, Hamel, Damon J, Kuhn, Peter, Handel, Tracy M, Cherezov, Vadim, Stevens, Raymond C

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Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists von Asano, Moriteru, Hashimoto, Kentaro, Saito, Bunnai, Shiokawa, Zenyu, Sumi, Hiroyuki, Yabuki, Masato, Yoshimatsu, Mie, Aoyama, Kazunobu, Hamada, Teruki, Morishita, Nao, Dougan, Douglas R., Mol, Clifford D., Yoshida, Sei, Ishikawa, Tomoyasu

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A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA von Slupphaug, Geir, Mol, Clifford D, Kavli, Bodil, Arvai, Andrew S, Krokan, Hans E, Tainer, John A

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Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes von Tsutakawa, Susan E., Shin, David S., Mol, Clifford D., Izumi, Tadahide, Arvai, Andrew S., Mantha, Anil K., Szczesny, Bartosz, Ivanov, Ivaylo N., Hosfield, David J., Maiti, Buddhadev, Pique, Mike E., Frankel, Kenneth A., Hitomi, Kenichi, Cunningham, Richard P., Mitra, Sankar, Tainer, John A.

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Crystal structure and mutational analysis of human uracil-DNA glycosylase: Structural basis for specificity and catalysis von Mol, Clifford D, Arvai, Andrew S, Slupphaug, Geir, Kavli, Bodil, Alseth, Ingrun, Krokan, Hans E, Tainer, John A

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2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole Derivatives as Novel Inhibitors of Glycogen Synthase Kinase-3β with Good Brain Permeability von Saitoh, Morihisa, Kunitomo, Jun, Kimura, Eiji, Iwashita, Hiroki, Uno, Yumiko, Onishi, Tomohiro, Uchiyama, Noriko, Kawamoto, Tomohiro, Tanaka, Toshimasa, Mol, Clifford D, Dougan, Douglas R, Textor, Garret P, Snell, Gyorgy P, Takizawa, Masayuki, Itoh, Fumio, Kori, Masakuni

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Structure and function of the multifunctional DNA-repair enzyme exonuclease III von Mol, Clifford D, Kuo, Che-Fu, Thayer, Maria M, Cunningham, Richard P, Tainer, John A

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Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:l-Alanine Ligase (MurC) from Haemophilus influenzae von Mol, Clifford D, Brooun, Alexei, Dougan, Douglas R, Hilgers, Mark T, Tari, Leslie W, Wijnands, Robert A, Knuth, Mark W, McRee, Duncan E, Swanson, Ronald V

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Design, synthesis and structure–activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β von Saitoh, Morihisa, Kunitomo, Jun, Kimura, Eiji, Hayase, Yoji, Kobayashi, Hiromi, Uchiyama, Noriko, Kawamoto, Tomohiro, Tanaka, Toshimasa, Mol, Clifford D., Dougan, Douglas R., Textor, Garret S., Snell, Gyorgy P., Itoh, Fumio

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Structure and activity of a thermostable thymine-DNA glycosylase: evidence for base twisting to remove mismatched normal DNA bases von Mol, Clifford D, Arvai, Andrew S, Begley, Thomas J, Cunningham, Richard P, Tainer, John A

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Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors von Wallace, Michael B., Adams, Mark E., Kanouni, Toufike, Mol, Clifford D., Dougan, Douglas R., Feher, Victoria A., O’Connell, Shawn M., Shi, Lihong, Halkowycz, Petro, Dong, Qing

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Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA von Parikh, Sudip S., Mol, Clifford D., Slupphaug, Geir, Bharati, Sangeeta, Krokan, Hans E., Tainer, John A.

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A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: Design and synthesis of benzylpyrazol... von Rikimaru, Kentaro, Wakabayashi, Takeshi, Abe, Hidenori, Imoto, Hiroshi, Maekawa, Tsuyoshi, Ujikawa, Osamu, Murase, Katsuhito, Matsuo, Takanori, Matsumoto, Mitsuharu, Nomura, Chisako, Tsuge, Hiroko, Arimura, Naoto, Kawakami, Kazutoshi, Sakamoto, Junichi, Funami, Miyuki, Mol, Clifford D., Snell, Gyorgy P., Bragstad, Kenneth A., Sang, Bi-Ching, Dougan, Douglas R., Tanaka, Toshimasa, Katayama, Nozomi, Horiguchi, Yoshiaki, Momose, Yu

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MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily von Tainer, John A, Guan, Yue, Manuel, Raymond C, Arvai, Andrew S, Parikh, Sudip S, Mol, Clifford D, Miller, Jeffrey H, Lloyd, R. Stephen

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Structure of the DNA Repair and Replication Endonuclease and Exonuclease FEN-1: Coupling DNA and PCNA Binding to FEN-1 Activity von Hosfield, David J, Mol, Clifford D, Shen, Binghui, Tainer, John A

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Design, synthesis, and structure–activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors von Yamashita, Tohru, Kamata, Makoto, Endo, Satoshi, Yamamoto, Mitsuo, Kakegawa, Keiko, Watanabe, Hiroyuki, Miwa, Katsuhiko, Yamano, Toru, Funata, Masaaki, Sakamoto, Jyun-ichi, Tani, Akiyoshi, Mol, Clifford D., Zou, Hua, Dougan, Douglas R., Sang, BiChing, Snell, Gyorgy, Fukatsu, Kohji

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