Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis von Cai, Zhigang, Kotzin, Jonathan J., Ramdas, Baskar, Chen, Sisi, Nelanuthala, Sai, Palam, Lakshmi Reddy, Pandey, Ruchi, Mali, Raghuveer Singh, Liu, Yan, Kelley, Mark R., Sandusky, George, Mohseni, Morvarid, Williams, Adam, Henao-Mejia, Jorge, Kapur, Reuben

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Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition von LaRochelle, Jonathan R., Fodor, Michelle, Vemulapalli, Vidyasiri, Mohseni, Morvarid, Wang, Ping, Stams, Travis, LaMarche, Matthew J., Chopra, Rajiv, Acker, Michael G., Blacklow, Stephen C.

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Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer von LaMarche, Matthew J, Acker, Michael, Argintaru, Andreea, Bauer, Daniel, Boisclair, Julie, Chan, Homan, Chen, Christine Hiu-Tung, Chen, Ying-Nan, Chen, Zhouliang, Deng, Zhan, Dore, Michael, Dunstan, David, Fan, Jianmei, Fekkes, Peter, Firestone, Brant, Fodor, Michelle, Garcia-Fortanet, Jorge, Fortin, Pascal D, Fridrich, Cary, Giraldes, John, Glick, Meir, Grunenfelder, Denise, Hao, Huia-Xiang, Hentemann, Martin, Ho, Samuel, Jouk, Andriana, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Keen, Nick, Koenig, Robert, LaBonte, Laura R, Larrow, Jay, Liu, Gang, Liu, Shumei, Majumdar, Dyuti, Mathieu, Simon, Meyer, Matthew J, Mohseni, Morvarid, Ntaganda, Rukundo, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Reilly, John, Sarver, Patrick, Sellers, William R, Sendzik, Martin, Shultz, Michael D, Slisz, Joanna, Slocum, Kelly, Smith, Troy, Spence, Stanley, Stams, Travis, Straub, Christopher, Tamez, Victoriano, Toure, Bakary-Barry, Towler, Christopher, Wang, Ping, Wang, Hongyun, Williams, Sarah L, Yang, Fan, Yu, Bing, Zhang, Ji-Hu, Zhu, Suzanne

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SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms von Wang, Ye, Mohseni, Morvarid, Grauel, Angelo, Diez, Javier Estrada, Guan, Wei, Liang, Simon, Choi, Jiyoung Elizabeth, Pu, Minying, Chen, Dongshu, Laszewski, Tyler, Schwartz, Stephanie, Gu, Jane, Mansur, Leandra, Burks, Tyler, Brodeur, Lauren, Velazquez, Roberto, Kovats, Steve, Pant, Bhavesh, Buruzula, Giri, Deng, Emily, Chen, Julie T., Sari-Sarraf, Farid, Dornelas, Christina, Varadarajan, Malini, Yu, Haiyan, Liu, Chen, Lim, Joanne, Hao, Huai-Xiang, Jiang, Xiaomo, Malamas, Anthony, LaMarche, Matthew J., Geyer, Felipe Correa, McLaughlin, Margaret, Costa, Carlotta, Wagner, Joel, Ruddy, David, Jayaraman, Pushpa, Kirkpatrick, Nathaniel D., Zhang, Pu, Iartchouk, Oleg, Aardalen, Kimberly, Cremasco, Viviana, Dranoff, Glenn, Engelman, Jeffrey A., Silver, Serena, Wang, Hongyun, Hastings, William D., Goldoni, Silvia

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Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling von Vemulapalli, Vidyasiri, Chylek, Lily A., Erickson, Alison, Pfeiffer, Anamarija, Gabriel, Khal-Hentz, LaRochelle, Jonathan, Subramanian, Kartik, Cao, Ruili, Stegmaier, Kimberley, Mohseni, Morvarid, LaMarche, Matthew J., Acker, Michael G., Sorger, Peter K., Gygi, Steven P., Blacklow, Stephen C.

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Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody–Drug Conjugates von Karpov, Alexei S, Abrams, Tinya, Clark, Suzanna, Raikar, Ankita, D’Alessio, Joseph A, Dillon, Michael P, Gesner, Thomas G, Jones, Darryl, Lacaud, Marion, Mallet, William, Martyniuk, Piotr, Meredith, Erik, Mohseni, Morvarid, Nieto-Oberhuber, Cristina M, Palacios, Daniel, Perruccio, Francesca, Piizzi, Grazia, Zurini, Mauro, Bialucha, Carl Uli

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The Headpiece Domain of Dematin Regulates Cell Shape, Motility, and Wound Healing by Modulating RhoA Activation von Mohseni, Morvarid, Chishti, Athar H.

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Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer von Mori, Masaki, Triboulet, Robinson, Mohseni, Morvarid, Schlegelmilch, Karin, Shrestha, Kriti, Camargo, Fernando D., Gregory, Richard I.

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Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis von Lau, Allison N, Curtis, Stephen J, Fillmore, Christine M, Rowbotham, Samuel P, Mohseni, Morvarid, Wagner, Darcy E, Beede, Alexander M, Montoro, Daniel T, Sinkevicius, Kerstin W, Walton, Zandra E, Barrios, Juliana, Weiss, Daniel J, Camargo, Fernando D, Wong, Kwok-Kin, Kim, Carla F

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A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway von Mohseni, Morvarid, Sun, Jianlong, Lau, Allison, Curtis, Stephen, Goldsmith, Jeffrey, Fox, Victor L., Wei, Chongjuan, Frazier, Marsha, Samson, Owen, Wong, Kwok-Kin, Kim, Carla, Camargo, Fernando D.

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Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation von Schlegelmilch, Karin, Mohseni, Morvarid, Kirak, Oktay, Pruszak, Jan, Rodriguez, J. Renato, Zhou, Dawang, Kreger, Bridget T., Vasioukhin, Valera, Avruch, Joseph, Brummelkamp, Thijn R., Camargo, Fernando D.

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Abstract LB-122: Combinations of SHP2 inhibitor to overcome RAS activation by receptor tyrosine kinases in response to ERK inhibition von Hao, Huaixiang, Liu, Chen, Wang, Hongyun, Lu, Hengyu, Delach, Scott, LaMarche, Matthew, Engelman, Jeffrey, Hammerman, Peter, Caponigro, Giordano, Moody, Susan, Mohseni, Morvarid

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Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2 von LaRochelle, Jonathan R., Fodor, Michelle, Ellegast, Jana M., Liu, Xiaoxi, Vemulapalli, Vidyasiri, Mohseni, Morvarid, Stams, Travis, Buhrlage, Sara J., Stegmaier, Kimberly, LaMarche, Matthew J., Acker, Michael G., Blacklow, Stephen C.

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PI3K inhibition circumvents resistance to SHP2 blockade in metastatic triple-negative breast cancer von Amante, Romain J., Jehanno, Charly, De Silva, Duvini, Coissieux, Marie-May, Ackerknecht, Markus, Romanet, Vincent, Sethi, Atul, Hamelin, Baptiste, Preca, Bogdan-Tiberius, Piscuoglio, Salvatore, Ng, Charlotte K. Y., Mohseni, Morvarid, Bentires-Alj, Mohamed

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Abstract 954: SHP2 inhibition overcomes RTK-mediated pathway reactivation in KRAS mutant tumors treated with MEK inhibitors von Lu, Hengyu, Liu, Chen, Velazquez, Roberto, Wang, Hongyun, Dunkl, Lukas M., Kazic-Legueux, Malika, Haberkorn, Anne, Billy, Eric, Manchado, Eusebio, Brachmann, Saskia M., Moody, Susan, Engelman, Jeffrey A., Hammerman, Peter S., Caponigro, Giordano, Mohseni, Morvarid, Hao, Huaixiang

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Downregulation of Morrbid in Tet2-Deficient Preleukemic Cells Overcomes Resistance to Inflammatory Stress and Mitigates Clonal Hematopoiesis von Cai, Zhigang, Kotzin, Jonathan, Ramdas, Baskar, Chen, Sisi, Nelanuthala, Sai, Palam, Lakshmi Reddy, Pandey, Ruchi, Mali, Raghuveer, Liu, Yan, Kelley, Mark R., Sandusky, George, Mohseni, Morvarid, Williams, Adam, Henao-Mejia, Jorge, Kapur, Reuben

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Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations von Ladd, Brendon, Mazzola, Anne Marie, Bihani, Teeru, Lai, Zhongwu, Bradford, James, Collins, Michael, Barry, Evan, Goeppert, Anne U, Weir, Hazel M, Hearne, Kelly, Renshaw, Jonathan G, Mohseni, Morvarid, Hurt, Elaine, Jalla, Sanjoo, Bao, Haifeng, Hollingsworth, Robert, Reimer, Corinne, Zinda, Michael, Fawell, Stephen, D'Cruz, Celina M

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Correction to 6‑Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors von Sarver, Patrick, Acker, Michael, Bagdanoff, Jeffrey T, Chen, Zhouliang, Chen, Ying-Nan, Chan, Homan, Firestone, Brant, Fodor, Michelle, Fortanet, Jorge, Hao, Huaixiang, Hentemann, Murphy, Jouk, Andriana, Kato, Mitsunori, Koenig, Robert, LaBonte, Laura R, Liu, Gang, Liu, Shumei, Liu, Chen, McNeill, Eric, Mohseni, Morvarid, Shultz, Michael D, Sendzik, Martin, Stams, Travis, Spence, Stan, Tamez, Victoriano, Tichkule, Ritesh, Towler, Christopher, Wang, Hongyun, Wang, Ping, Williams, Sarah L, Yu, Bing, LaMarche, Matthew J

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Erythrocyte Dematin Regulates Glucose Transport Via Akt Phosphorylation and 14-3-3zeta Association von Mohseni, Morvarid, Khan, Anwar, Chishti, Athar H.

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SHP2 inhibition restores sensitivity to ALK inhibitors in resistant ALK-rearranged non-small cell lung cancer von Dardaei, Leila, Wang, Hui Qin, Singh, Manrose, Fordjour, Paul, Shaw, Katherine X., Yoda, Satoshi, Kerr, Grainne, Yu, Kristine, Liang, Jinsheng, Cao, Yichen, Chen, Yan, Lawrence, Michael S., Langenbucher, Adam, Gainor, Justin F., Friboulet, Luc, Dagogo-Jack, Ibiayi, Myers, David T., Labrot, Emma, Ruddy, David, Parks, Melissa, Lee, Dana, DiCecca, Richard H., Moody, Susan, Hao, Huaixiang, Mohseni, Morvarid, LaMarche, Matthew, Williams, Juliet, Hoffmaster, Keith, Caponigro, Giordano, Shaw, Alice T., Hata, Aaron N., Benes, Cyril H., Li, Fang, Engelman, Jeffrey A.

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