Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy von Bordi, Matteo, Berg, Martin J., Mohan, Panaiyur S., Peterhoff, Corrinne M., Alldred, Melissa J., Che, Shaoli, Ginsberg, Stephen D., Nixon, Ralph A.

Volltext

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations von Lee, Ju-Hyun, Yu, W. Haung, Kumar, Asok, Lee, Sooyeon, Mohan, Panaiyur S., Peterhoff, Corrinne M., Wolfe, Devin M., Martinez-Vicente, Marta, Massey, Ashish C., Sovak, Guy, Uchiyama, Yasuo, Westaway, David, Cuervo, Ana Maria, Nixon, Ralph A.

Volltext

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits von YANG, Dun-Sheng, STAVRIDES, Philip, PAWLIK, Monika, PETERHOFF, Corrinne M, YANG, Austin J, WILSON, Donald A, GEORGE-HYSLOP, Peter St, WESTAWAY, David, MATHEWS, Paul M, LEVY, Efrat, CUERVO, Ana M, NIXON, Ralph A, MOHAN, Panaiyur S, KAUSHIK, Susmita, KUMAR, Asok, OHNO, Masuo, SCHMIDT, Stephen D, WESSON, Daniel, BANDYOPADHYAY, Urmi, YING JIANG

Volltext

G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain von Subbanna, Shivakumar, Shivakumar, Madhu, Umapathy, Nagavedi S, Saito, Mariko, Mohan, Panaiyur S, Kumar, Asok, Nixon, Ralph A, Verin, Alexander D, Psychoyos, Delphine, Basavarajappa, Balapal S

Volltext

Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome von Kaur, Gurjinder, Gauthier, Sebastien A., Perez-Gonzalez, Rocio, Pawlik, Monika, Singh, Amol Bikram, Cosby, Benjamin, Mohan, Panaiyur S., Smiley, John F., Levy, Efrat

Volltext

The myosin Va head domain binds to the neurofilament-L rod and modulates endoplasmic reticulum (ER) content and distribution within axons von Rao, Mala V, Mohan, Panaiyur S, Kumar, Asok, Yuan, Aidong, Montagna, Lee, Campbell, Jabbar, Veeranna, Espreafico, Enilza M, Julien, Jean P, Nixon, Ralph A

Volltext

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis von Yang, Dun-Sheng, Stavrides, Philip, Mohan, Panaiyur S., Kaushik, Susmita, Kumar, Asok, Ohno, Masuo, Schmidt, Stephen D., Wesson, Daniel W., Bandyopadhyay, Urmi, Jiang, Ying, Pawlik, Monika, Peterhoff, Corrinne M., Yang, Austin J., Wilson, Donald A., St. George-Hyslop, Peter, Westaway, David, Mathews, Paul M., Levy, Efrat, Cuervo, Ana Maria, Nixon, Ralph A.

Volltext

Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST Overexpression von Rao, Mala V, Mohan, Panaiyur S, Peterhoff, Corrinne M, Yang, Dun-Sheng, Schmidt, Stephen D, Stavrides, Philip H, Campbell, Jabbar, Chen, Yuanxin, Jiang, Ying, Paskevich, Peter A, Cataldo, Anne M, Haroutunian, Vahram, Nixon, Ralph A

Volltext

Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99) von Jiang, Ying, Sato, Yutaka, Im, Eunju, Berg, Martin, Bordi, Matteo, Darji, Sandipkumar, Kumar, Asok, Mohan, Panaiyur S, Bandyopadhyay, Urmi, Diaz, Antonio, Cuervo, Ana Maria, Nixon, Ralph A

Volltext

β2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of ClC-7 von Lee, Ju-Hyun, Wolfe, Devin M., Darji, Sandipkumar, McBrayer, Mary Kate, Colacurcio, Daniel J., Kumar, Asok, Stavrides, Philip, Mohan, Panaiyur S., Nixon, Ralph A.

Volltext

Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons von Lie, Pearl P.Y., Yang, Dun-Sheng, Stavrides, Philip, Goulbourne, Chris N., Zheng, Ping, Mohan, Panaiyur S., Cataldo, Anne M., Nixon, Ralph A.

Volltext

Myosin Va Binding to Neurofilaments Is Essential for Correct Myosin Va Distribution and Transport and Neurofilament Density von Rao, Mala V., Engle, Linda J., Mohan, Panaiyur S., Yuan, Aidong, Qiu, Dike, Cataldo, Anne, Hassinger, Linda, Jacobsen, Stephen, Virginia M-Y. Lee, Andreadis, Athena, Julien, Jean-Pierre, Bridgman, Paul C., Nixon, Ralph A.

Volltext

Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice von Yang, Dun-Sheng, Stavrides, Philip, Kumar, Asok, Jiang, Ying, Mohan, Panaiyur S, Ohno, Masuo, Dobrenis, Kostantin, Davidson, Cristin D, Saito, Mitsuo, Pawlik, Monika, Huo, Chunfeng, Walkley, Steven U, Nixon, Ralph A

Volltext

Macroautophagy: A Novel β-Amyloid Peptide-Generating Pathway Activated in Alzheimer's Disease von Yu, W. Haung, Cuervo, Ana Maria, Kumar, Asok, Peterhoff, Corrinne M., Schmidt, Stephen D., Lee, Ju-Hyun, Mohan, Panaiyur S., Mercken, Marc, Farmery, Mark R., Tjernberg, Lars O., Jiang, Ying, Duff, Karen, Uchiyama, Yasuo, Näslund, Jan, Mathews, Paul M., Cataldo, Anne M., Nixon, Ralph A.

Volltext

beta 2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of CIC-7 von Lee, Ju-Hyun, Wolfe, Devin M., Darji, Sandipkumar, McBrayer, Mary Kate, Colacurcio, Daniel J., Kumar, Asok, Stavrides, Philip, Mohan, Panaiyur S., Nixon, Ralph A.

Volltext

Presenilin 1 (PS1) is required for lysosome acidification: FAD mutations of PS1 cause loss of protein turnover by autophagy von Lee, Ju-Hyun, Yu, W. Haung, Kumar, Asok, Lee, Sooyeon, Mohan, Panaiyur S, Peterhoff, Corrinne M, Martinez-Vicente, Marta, Massey, Ashish C, Sovak, Guy, Uchiyama, Yasuo, Westaway, David, Sisodia, Sangram S, Cuervo, Ana Maria, Nixon, Ralph A

Volltext

Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo von Yuan, A, Sershen, H, Veeranna, Basavarajappa, B S, Kumar, A, Hashim, A, Berg, M, Lee, J-H, Sato, Y, Rao, M V, Mohan, P S, Dyakin, V, Julien, J-P, Lee, V M-Y, Nixon, R A

Volltext

Sulfoglucuronyl Glycolipids Bind Laminin von Mohan, Panaiyur S., Chou, Denise K. H., Jungalwala, Firoze B.

Volltext

The Myosin Va Head Domain Binds to the Neurofilament-L Rod and Modulates Endoplasmic Reticulum von Rao, Mala V, Mohan, Panaiyur S, Kumar, Asok, Yuan, Aidong, Montagna, Lee, Campbell, Jabbar, Veeranna, Espreafico, Enilza M, Julien, Jean P, Nixon, Ralph A

Volltext

P2‐271: Presenilin 1 (PS1) is required for lysosome acidification: FAD mutations of PS1 cause loss of protein turnover by autophagy von Lee, Ju-Hyun, Yu, W. Haung, Kumar, Asok, Lee, Sooyeon, Mohan, Panaiyur S., Peterhoff, Corrinne M., Martinez-Vicente, Marta, Massey, Ashish C., Sovak, Guy, Uchiyama, Yasuo, Westaway, David, Sisodia, Sangram S., Cuervo, Ana Maria, Nixon, Ralph A.

Volltext