Small-molecule WNK inhibition regulates cardiovascular and renal function von Yamada, Ken, Park, Hyi-Man, Rigel, Dean F, DiPetrillo, Keith, Whalen, Erin J, Anisowicz, Anthony, Beil, Michael, Berstler, James, Brocklehurst, Cara Emily, Burdick, Debra A, Caplan, Shari L, Capparelli, Michael P, Chen, Guanjing, Chen, Wei, Dale, Bethany, Deng, Lin, Fu, Fumin, Hamamatsu, Norio, Harasaki, Kouki, Herr, Tracey, Hoffmann, Peter, Hu, Qi-Ying, Huang, Waan-Jeng, Idamakanti, Neeraja, Imase, Hidetomo, Iwaki, Yuki, Jain, Monish, Jeyaseelan, Jey, Kato, Mitsunori, Kaushik, Virendar K, Kohls, Darcy, Kunjathoor, Vidya, LaSala, Daniel, Lee, Jongchan, Liu, Jing, Luo, Yang, Ma, Fupeng, Mo, Ruowei, Mowbray, Sarah, Mogi, Muneto, Ossola, Flavio, Pandey, Pramod, Patel, Sejal J, Raghavan, Swetha, Salem, Bahaa, Shanado, Yuka H, Trakshel, Gary M, Turner, Gordon, Wakai, Hiromichi, Wang, Chunhua, Weldon, Stephen, Wielicki, Jennifer B, Xie, Xiaoling, Xu, Lingfei, Yagi, Yukiko I, Yasoshima, Kayo, Yin, Jianning, Yowe, David, Zhang, Ji-Hu, Zheng, Gang, Monovich, Lauren

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Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism von Gulati, Sahil, Jastrzebska, Beata, Banerjee, Surajit, Placeres, Ángel L., Miszta, Przemyslaw, Gao, Songqi, Gunderson, Karl, Tochtrop, Gregory P., Filipek, Sławomir, Katayama, Kota, Kiser, Philip D., Mogi, Muneto, Stewart, Phoebe L., Palczewski, Krzysztof

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Discovery and Characterization of Allosteric WNK Kinase Inhibitors von Yamada, Ken, Zhang, Ji-Hu, Xie, Xiaoling, Reinhardt, Juergen, Xie, Amy Qiongshu, LaSala, Daniel, Kohls, Darcy, Yowe, David, Burdick, Debra, Yoshisue, Hajime, Wakai, Hiromichi, Schmidt, Isabel, Gunawan, Jason, Yasoshima, Kayo, Yue, Q. Kimberley, Kato, Mitsunori, Mogi, Muneto, Idamakanti, Neeraja, Kreder, Natasha, Drueckes, Peter, Pandey, Pramod, Kawanami, Toshio, Huang, Waanjeng, Yagi, Yukiko I, Deng, Zhan, Park, Hyi-Man

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Application of Imaging Mass Spectrometry to Assess Ocular Drug Transit von Grove, Kerri J., Kansara, Viral, Prentiss, Melissa, Long, Debby, Mogi, Muneto, Kim, Sean, Rudewicz, Patrick J.

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Lack of involvement of CEP adducts in TLR activation and in angiogenesis von Gounarides, John, Cobb, Jennifer S, Zhou, Jing, Cook, Frank, Yang, Xuemei, Yin, Hong, Meredith, Erik, Rao, Chang, Huang, Qian, Xu, YongYao, Anderson, Karen, De Erkenez, Andrea, Liao, Sha-Mei, Crowley, Maura, Buchanan, Natasha, Poor, Stephen, Qiu, Yubin, Fassbender, Elizabeth, Shen, Siyuan, Woolfenden, Amber, Jensen, Amy, Cepeda, Rosemarie, Etemad-Gilbertson, Bijan, Giza, Shelby, Mogi, Muneto, Jaffee, Bruce, Azarian, Sassan

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Efficient Route to 4a-Methyltetrahydrofluorenes:  A Total Synthesis of (±)-Dichroanal B via Intramolecular Heck Reaction von Planas, Loïc, Mogi, Muneto, Takita, Hirofumi, Kajimoto, Tetsuya, Node, Manabu

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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases von Schubart, Anna, Anderson, Karen, Mainolfi, Nello, Sellner, Holger, Ehara, Takeru, Adams, Christopher M., Sweeney, Aengus Mac, Liao, Sha-Mei, Crowley, Maura, Littlewood-Evans, Amanda, Sarret, Sophie, Wieczorek, Grazyna, Perrot, Ludovic, Dubost, Valérie, Flandre, Thierry, Zhang, Yuzhou, Smith, Richard J. H., Risitano, Antonio M., Karki, Rajeshri G., Zhang, Chun, Valeur, Eric, Sirockin, Finton, Gerhartz, Bernd, Erbel, Paulus, Hughes, Nicola, Smith, Thomas M., Cumin, Frederic, Argikar, Upendra A., Haraldsson, Börje, Mogi, Muneto, Sedrani, Richard, Wiesmann, Christian, Jaffee, Bruce, Maibaum, Jürgen, Flohr, Stefanie, Harrison, Richard, Eder, Jörg

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Pharmacology of novel intraocular pressure-lowering targets that enhance conventional outflow facility: Pitfalls, promises and what lies ahead? von Prasanna, Ganesh, Li, Byron, Mogi, Muneto, Rice, Dennis S.

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Structure of neprilysin in complex with the active metabolite of sacubitril von Schiering, Nikolaus, D’Arcy, Allan, Villard, Frederic, Ramage, Paul, Logel, Claude, Cumin, Frederic, Ksander, Gary M., Wiesmann, Christian, Karki, Rajeshri G., Mogi, Muneto

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Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration von Crowley, Maura A, Garland, Donita L, Sellner, Holger, Banks, Angela, Fan, Lin, Rejtar, Tomas, Buchanan, Natasha, Delgado, Omar, Xu, Yong Yao, Jose, Sandra, Adams, Christopher M, Mogi, Muneto, Wang, Karen, Bigelow, Chad E, Poor, Stephen, Anderson, Karen, Jaffee, Bruce D, Prasanna, Ganesh, Grosskreutz, Cynthia, Fernandez-Godino, Rosario, Pierce, Eric A, Dryja, Thaddeus P, Liao, Sha-Mei

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Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Tr... von Mainolfi, Nello, Ehara, Takeru, Karki, Rajeshri G., Anderson, Karen, Mac Sweeney, Aengus, Liao, Sha-Mei, Argikar, Upendra A., Jendza, Keith, Zhang, Chun, Powers, James, Klosowski, Daniel W., Crowley, Maura, Kawanami, Toshio, Ding, Jian, April, Myriam, Forster, Cornelia, Serrano-Wu, Michael, Capparelli, Michael, Ramqaj, Rrezarta, Solovay, Catherine, Cumin, Frederic, Smith, Thomas M., Ferrara, Luciana, Lee, Wendy, Long, Debby, Prentiss, Melissa, De Erkenez, Andrea, Yang, Louis, Liu, Fang, Sellner, Holger, Sirockin, Finton, Valeur, Eric, Erbel, Paulus, Ostermeier, Daniela, Ramage, Paul, Gerhartz, Bernd, Schubart, Anna, Flohr, Stefanie, Gradoux, Nathalie, Feifel, Roland, Vogg, Barbara, Wiesmann, Christian, Maibaum, Juergen, Eder, Joerg, Sedrani, Richard, Harrison, Richard A., Mogi, Muneto, Jaffee, Bruce D., Adams, Christopher M.

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Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue von Alexander, Nathan S., Katayama, Kota, Sun, Wenyu, Salom, David, Gulati, Sahil, Zhang, Jianye, Mogi, Muneto, Palczewski, Krzysztof, Jastrzebska, Beata

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A Novel Selective Soluble Guanylate Cyclase Activator, MGV354, Lowers Intraocular Pressure in Preclinical Models, Following Topical Ocular Dosing von Prasanna, Ganesh, Ferrara, Luciana, Adams, Christopher, Ehara, Takeru, Li, Byron, Yang, Louis, Xiang, Chuanxi, Ng, Christopher Thow Hing, Kim, Sean, Towler, Christopher, Topley, Todd, McAllister, Cale, Ghosh, Malay, Newton, Ronald, Stacy, Rebecca, Rice, Dennis S, Mogi, Muneto

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A small-molecule inhibitor of C5 complement protein von Jendza, Keith, Kato, Mitsunori, Salcius, Michael, Srinivas, Honnappa, De Erkenez, Andrea, Nguyen, Anh, McLaughlin, Doug, Be, Celine, Wiesmann, Christian, Murphy, Jason, Bolduc, Philippe, Mogi, Muneto, Duca, Jose, Namil, Abdel, Capparelli, Michael, Darsigny, Veronique, Meredith, Erik, Tichkule, Ritesh, Ferrara, Luciana, Heyder, Jessica, Liu, Fang, Horton, Patricia A., Romanowski, Michael J., Schirle, Markus, Mainolfi, Nello, Anderson, Karen, Michaud, Gregory A.

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A Randomized, Controlled Phase I/II Study to Evaluate the Safety and Efficacy of MGV354 for Ocular Hypertension or Glaucoma von Stacy, Rebecca, Huttner, Kenneth, Watts, Jen, Peace, James, Wirta, David, Walters, Tom, Sall, Kenneth, Seaman, John, Ni, Xiao, Prasanna, Ganesh, Mogi, Muneto, Adams, Christopher, Yan, Jing-He, Wald, Michael, He, Yunsheng, Newton, Ronald, Kolega, Randall, Grosskreutz, Cynthia

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Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway von Karki, Rajeshri G, Powers, James, Mainolfi, Nello, Anderson, Karen, Belanger, David B, Liu, Donglei, Ji, Nan, Jendza, Keith, Gelin, Christine F, Mac Sweeney, Aengus, Solovay, Catherine, Delgado, Omar, Crowley, Maura, Liao, Sha-Mei, Argikar, Upendra A, Flohr, Stefanie, La Bonte, Laura R, Lorthiois, Edwige L, Vulpetti, Anna, Brown, Ann, Long, Debby, Prentiss, Melissa, Gradoux, Nathalie, de Erkenez, Andrea, Cumin, Frederic, Adams, Christopher, Jaffee, Bruce, Mogi, Muneto

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Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma von Yamada, Ken, Brousseau, Margaret, Honma, Wataru, Iimura, Akiko, Imase, Hidetomo, Iwaki, Yuki, Kawanami, Toshio, LaSala, Daniel, Liang, Guiqing, Mitani, Hironobu, Nonomura, Kazuhiko, Ohmori, Osamu, Pan, Meihui, Rigel, Dean F, Umemura, Ichiro, Yasoshima, Kayo, Zhu, Guoming, Mogi, Muneto

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Ocular Pharmacology and Toxicology of TRPV1 Antagonist SAF312 (Libvatrep) von Mogi, Muneto, Mendonza, Anisha E., Chastain, James, Demirs, John T., Medley, Quintus G., Zhang, Qin, Papillon, Julien P. N., Yang, Junzheng, Gao, Yan, Xu, YongYao, Stasi, Kalliopi

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The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a... von Ehara, Takeru, Adams, Christopher M, Bevan, Doug, Ji, Nan, Meredith, Erik L, Belanger, David B, Powers, James, Kato, Mitsunori, Solovay, Catherine, Liu, Donglei, Capparelli, Michael, Bolduc, Philippe, Grob, Jonathan E, Daniels, Matthew H, Ferrara, Luciana, Yang, Louis, Li, Byron, Towler, Christopher S, Stacy, Rebecca C, Prasanna, Ganesh, Mogi, Muneto

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Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors von Kawanami, Toshio, Karki, Rajeshri G, Cody, Emma, Liu, Qian, Liang, Guiqing, Ksander, Gary M, Rigel, Dean F, Schiering, Nikolaus, Gong, Yongjin, Coppola, Gary M, Iwaki, Yuki, Sun, Robert, Neubert, Alan, Fan, Li, Ingles, Sara, D’Arcy, Allan, Villard, Frederic, Ramage, Paul, Jeng, Arco Y, Leung-Chu, Jennifer, Liu, Jing, Beil, Michael, Fu, Fumin, Chen, Wei, Cumin, Frederic, Wiesmann, Christian, Mogi, Muneto

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