Ten things you should know about protein kinases: IUPHAR Review 14 von Fabbro, Doriano, Cowan‐Jacob, Sandra W, Moebitz, Henrik

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The ABC of protein kinase conformations von Möbitz, Henrik

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Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties von Gao, Yijun, Chang, Matthew T, McKay, Daniel, Na, Na, Zhou, Bing, Yaeger, Rona, Torres, Neilawattie M, Muniz, Keven, Drosten, Matthias, Barbacid, Mariano, Caponigro, Giordano, Stuart, Darrin, Moebitz, Henrik, Solit, David B, Abdel-Wahab, Omar, Taylor, Barry S, Yao, Zhan, Rosen, Neal

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Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Pe... von Rueeger, Heinrich, Lueoend, Rainer, Rogel, Olivier, Rondeau, Jean-Michel, Möbitz, Henrik, Machauer, Rainer, Jacobson, Laura, Staufenbiel, Matthias, Desrayaud, Sandrine, Neumann, Ulf

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Type II Inhibitors Targeting CDK2 von Alexander, Leila T, Möbitz, Henrik, Drueckes, Peter, Savitsky, Pavel, Fedorov, Oleg, Elkins, Jonathan M, Deane, Charlotte M, Cowan-Jacob, Sandra W, Knapp, Stefan

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Paradoxical Increase of Permeability and Lipophilicity with the Increasing Topological Polar Surface Area within a Series of PRMT5 Inhibitors von Argikar, Upendra, Blatter, Markus, Bednarczyk, Dallas, Chen, Zhuoliang, Cho, Young Shin, Doré, Michaël, Dumouchel, Jennifer L., Ho, Samuel, Hoegenauer, Klemens, Kawanami, Toshio, Mathieu, Simon, Meredith, Erik, Möbitz, Henrik, Murphy, Stephen K., Parthasarathy, Saravanan, Soldermann, Carole Pissot, Santos, Jobette, Silver, Serena, Skolnik, Suzanne, Stojanovic, Aleksandar

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The Discovery of SWI/SNF Chromatin Remodeling Activity as a Novel and Targetable Dependency in Uveal Melanoma von Rago, Florencia, Elliott, GiNell, Li, Ailing, Sprouffske, Kathleen, Kerr, Grainne, Desplat, Aurore, Abramowski, Dorothee, Chen, Julie T., Farsidjani, Ali, Xiang, Kay X., Bushold, Geoffrey, Feng, Yun, Shirley, Matthew D., Bric, Anka, Vattay, Anthony, Moebitz, Henrik, Nakajima, Katsumasa, Adair, Christopher D., Mathieu, Simon, Ntaganda, Rukundo, Smith, Troy, Papillon, Julien P. N., Kauffmann, Audrey, Ruddy, David A., Bhang, Hyo-eun C., Castelletti, Deborah, Jagani, Zainab

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Ten things you should know about protein kinases: IUPHAR R eview 14 von Fabbro, Doriano, Cowan‐Jacob, Sandra W, Moebitz, Henrik

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New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse von Stauffer, Frédéric, Weiss, Andreas, Scheufler, Clemens, Möbitz, Henrik, Ragot, Christian, Beyer, Kim S, Calkins, Keith, Guthy, Daniel, Kiffe, Michael, Van Eerdenbrugh, Bernard, Tiedt, Ralph, Gaul, Christoph

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The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold von Gutmann, Sascha, Hinniger, Alexandra, Fendrich, Gabriele, Drückes, Peter, Antz, Sylvie, Mattes, Henri, Möbitz, Henrik, Ofner, Silvio, Schmiedeberg, Niko, Stojanovic, Aleksandar, Rieffel, Sebastien, Strauss, André, Troxler, Thomas, Glatthar, Ralf, Sparrer, Helmut

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Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor von Karpov, Alexei S, Amiri, Payman, Bellamacina, Cornelia, Bellance, Marie-Helene, Breitenstein, Werner, Daniel, Dylan, Denay, Regis, Fabbro, Doriano, Fernandez, Cesar, Galuba, Inga, Guerro-Lagasse, Stephanie, Gutmann, Sascha, Hinh, Linda, Jahnke, Wolfgang, Klopp, Julia, Lai, Albert, Lindvall, Mika K, Ma, Sylvia, Möbitz, Henrik, Pecchi, Sabina, Rummel, Gabriele, Shoemaker, Kevin, Trappe, Joerg, Voliva, Charles, Cowan-Jacob, Sandra W, Marzinzik, Andreas L

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Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-... von Rueeger, Heinrich, Lueoend, Rainer, Machauer, Rainer, Veenstra, Siem Jacob, Jacobson, Laura Helen, Staufenbiel, Matthias, Desrayaud, Sandrine, Rondeau, Jean-Michel, Möbitz, Henrik, Neumann, Ulf

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Structural biology contributions to tyrosine kinase drug discovery von Cowan-Jacob, Sandra W, Möbitz, Henrik, Fabbro, Doriano

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Perspective on computational and structural aspects of kinase discovery from IPK2014 von Martin, Eric, Knapp, Stefan, Engh, Richard A., Moebitz, Henrik, Varin, Thibault, Roux, Benoit, Meiler, Jens, Berdini, Valerio, Baumann, Alexander, Vieth, Michal

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Abstract B143: HRO761, a first-in-class, clinical stage WRN inhibitor with potent preclinical anti-tumor activity in MSIhigh models von Ferretti, Stephane, Jaco, Isabel, Decker, Andrea, Hemmerlin, Christelle, Scheufler, Clemens, Quadt, Cornelia, Sterker, Dario, Gavioli, Elena, Nunez, Eloisa Jimenez, Dammassa, Ernesta, Schaeffer, Fanny, Albrecht, Genevieve, Clementi, Giorgia, Martus, Hansjoerg, Hamon, Jacques, Hinrichs, Juergen, Laborde, Laurent, Dourdoigne, Marion, Moschetta, Michele, Stump, Ramona, Andraos-Rey, Rita, Welly, Sarah, Barbe, Stephanie, Romanet, Vincent, Reschke, Markus, Kanter, Ruben De, Jensen, Michael, Moebitz, Henrik, Cros, Marta Cortes

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Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors von Rueeger, Heinrich, Rondeau, Jean-Michel, McCarthy, Clive, Möbitz, Henrik, Tintelnot-Blomley, Marina, Neumann, Ulf, Desrayaud, Sandrine

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Abstract PR007: Discovery of HRO761, a novel, first-in-class clinical stage WRN inhibitor with potent and selective anti-tumor activity in cancers with microsatellite instability von Cortes-Cros, Marta, Moebitz, Henrik, Barbe, Stephanie, Blank, Jutta, Bordas, Vincent, Clementi, Giorgia, Dammassa, Ernesta, Decker, Andrea, Nanni, Noemi Di, de Kanter, Ruben, Dourdoigne, Marion, Gavioli, Elena, Ferretti, Stephane, Hattenberger, Marc, Hemmerlin, Christelle, Hamon, Jacques, Hinrichs, Juergen, Jaco, Isabel, Jankovic, Dragana, Nunez, Eloisa Jimenez, Li, Yifang, Martus, Hans-Joerg, Moschetta, Michele, Quadt, Cornelia, Reschke, Markus, Romanet, Vincent, Scheufler, Clemens, Schoepfer, Joseph, Strang, Ross, Therier, Maxime, Voshol, Hans, Wartmann, Markus, Welly, Sarah, Pham, Monica, Laborde, Laurent

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Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy von Velcicky, Juraj, Feifel, Roland, Hawtin, Stuart, Heng, Richard, Huppertz, Christine, Koch, Guido, Kroemer, Markus, Moebitz, Henrik, Revesz, Laszlo, Scheufler, Clemens, Schlapbach, Achim

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The Substrate-Activity-Screening methodology applied to receptor tyrosine kinases: A proof-of-concept study von Chapelat, Julien, Berst, Frédéric, Marzinzik, Andreas L., Moebitz, Henrik, Drueckes, Peter, Trappe, Joerg, Fabbro, Doriano, Seebach, Dieter

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Pyrrolo-pyrimidones : A novel class of MK2 inhibitors with potent cellular activity von SCHLAPBACH, Achim, FEIFEL, Roland, HUPPERTZ, Christine, HAWTIN, Stuart, HENG, Richard, KOCH, Guido, MOEBITZ, Henrik, REVESZ, Laszlo, SCHEUFLER, Clemens, VELCICKY, Juraj, WAELCHLI, Rudolf

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