PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance von Verma, Vivek, Shrimali, Rajeev K, Ahmad, Shamim, Dai, Winjie, Wang, Hua, Lu, Sumin, Nandre, Rahul, Gaur, Pankaj, Lopez, Jose, Sade-Feldman, Moshe, Yizhak, Keren, Bjorgaard, Stacey L., Flaherty, Keith T., Wargo, Jennifer A., Boland, Genevieve M., Sullivan, Ryan J., Getz, Gad, Hammond, Scott A., Tan, Ming, Qi, Jingjing, Wong, Phillip, Merghoub, Taha, Wolchok, Jedd, Hacohen, Nir, Janik, John E., Mkrtichyan, Mikayel, Gupta, Seema, Khleif, Samir N.

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MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects von Verma, Vivek, Jafarzadeh, Nazli, Boi, Shannon, Kundu, Subhadip, Jiang, Zhinuo, Fan, Yiping, Lopez, Jose, Nandre, Rahul, Zeng, Peng, Alolaqi, Fatmah, Ahmad, Shamim, Gaur, Pankaj, Barry, Simon T., Valge-Archer, Viia E., Smith, Paul D., Banchereau, Jacques, Mkrtichyan, Mikayel, Youngblood, Benjamin, Rodriguez, Paulo C., Gupta, Seema, Khleif, Samir N.

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Differential PI3Kδ Signaling in CD4 + T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy von Ahmad, Shamim, Abu-Eid, Rasha, Shrimali, Rajeev, Webb, Mason, Verma, Vivek, Doroodchi, Atbin, Berrong, Zuzana, Samara, Raed, Rodriguez, Paulo C, Mkrtichyan, Mikayel, Khleif, Samir N

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Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition von Abu Eid, Rasha, Ahmad, Shamim, Lin, Yuan, Webb, Mason, Berrong, Zuzana, Shrimali, Rajeev, Kumai, Takumi, Ananth, Sudha, Rodriguez, Paulo C, Celis, Esteban, Janik, John, Mkrtichyan, Mikayel, Khleif, Samir N

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Old-School Chemotherapy in Immunotherapeutic Combination in Cancer, A Low-cost Drug Repurposed von Abu Eid, Rasha, Razavi, Ghazaleh Shoja E, Mkrtichyan, Mikayel, Janik, John, Khleif, Samir N

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Author Correction: PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance von Verma, Vivek, Shrimali, Rajeev K, Ahmad, Shamim, Dai, Winjie, Wang, Hua, Lu, Sumin, Nandre, Rahul, Gaur, Pankaj, Lopez, Jose, Sade-Feldman, Moshe, Yizhak, Keren, Bjorgaard, Stacey L., Flaherty, Keith T., Wargo, Jennifer A., Boland, Genevieve M., Sullivan, Ryan J., Getz, Gad, Hammond, Scott A., Tan, Ming, Qi, Jingjing, Wong, Phillip, Merghoub, Taha, Wolchok, Jedd, Hacohen, Nir, Janik, John E., Mkrtichyan, Mikayel, Gupta, Seema, Khleif, Samir N.

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Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy von Movsesyan, Nina, Ghochikyan, Anahit, Mkrtichyan, Mikayel, Petrushina, Irina, Davtyan, Hayk, Olkhanud, Purevdorj B, Head, Elizabeth, Biragyn, Arya, Cribbs, David H, Agadjanyan, Michael G

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SANTAVACTM: Summary of Research and Development von Lokhov, Petr G., Mkrtichyan, Mikayel, Mamikonyan, Grigor, Balashova, Elena E.

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Agonist anti-GITR antibody significantly enhances the therapeutic efficacy of Listeria monocytogenes-based immunotherapy von Shrimali, Rajeev, Ahmad, Shamim, Berrong, Zuzana, Okoev, Grigori, Matevosyan, Adelaida, Razavi, Ghazaleh Shoja E, Petit, Robert, Gupta, Seema, Mkrtichyan, Mikayel, Khleif, Samir N

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Mannan-Abeta28 conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice von Petrushina, Irina, Ghochikyan, Anahit, Mkrtichyan, Mikayel, Mamikonyan, Grigor, Movsesyan, Nina, Ajdari, Rodmehr, Vasilevko, Vitaly, Karapetyan, Adrine, Lees, Andrew, Agadjanyan, Michael G, Cribbs, David H

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Antitumor efficacy of DNA vaccination to the epigenetically acting tumor promoting transcription factor BORIS and CD80 molecular adjuvant von Loukinov, Dmitri, Ghochikyan, Anahit, Mkrtichyan, Mikayel, Ichim, Thomas E., Lobanenkov, Victor V., Cribbs, David H., Agadjanyan, Michael G.

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Single variable domains from the T cell receptor β chain function as mono- and bifunctional CARs and TCRs von Oh, Julyun, Warshaviak, Dora Toledo, Mkrtichyan, Mikayel, Munguia, Melanie Lisette, Lin, Abby, Chai, Falene, Pigott, Craig, Kang, Jaspal, Gallo, Michael, Kamb, Alexander

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Concurrent PD-1 Blockade Negates the Effects of OX40 Agonist Antibody in Combination Immunotherapy through Inducing T-cell Apoptosis von Shrimali, Rajeev K, Ahmad, Shamim, Verma, Vivek, Zeng, Peng, Ananth, Sudha, Gaur, Pankaj, Gittelman, Rachel M, Yusko, Erik, Sanders, Catherine, Robins, Harlan, Hammond, Scott A, Janik, John E, Mkrtichyan, Mikayel, Gupta, Seema, Khleif, Samir N

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Mutant KRAS Conversion of Conventional T Cells into Regulatory T Cells von Zdanov, Stephanie, Mandapathil, Magis, Abu Eid, Rasha, Adamson-Fadeyi, Saudat, Wilson, Willie, Qian, Jiahua, Carnie, Andrea, Tarasova, Nadya, Mkrtichyan, Mikayel, Berzofsky, Jay A, Whiteside, Theresa L, Khleif, Samir N

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Anti‐PD‐1 synergizes with cyclophosphamide to induce potent anti‐tumor vaccine effects through novel mechanisms von Mkrtichyan, Mikayel, Najjar, Yana G., Raulfs, Estella C., Abdalla, Maher Y., Samara, Raed, Rotem‐Yehudar, Rinat, Cook, Larry, Khleif, Samir N.

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A Therapeutic Vaccine Targeting Rat BORIS (CTCFL) for the Treatment of Rat Breast Cancer Tumors von Loukinov, Dmitri, Anderson, Amanda Laust, Mkrtichyan, Mikayel, Ghochikyan, Anahit, Rivero-Hinojosa, Samuel, Tucker, Jo, Lobanenkov, Victor, Agadjanyan, Michael G, Nelson, Edward L

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Selective inhibition of regulatory T cells by targeting the PI3K-Akt pathway von Abu-Eid, Rasha, Samara, Raed N, Ozbun, Laurent, Abdalla, Maher Y, Berzofsky, Jay A, Friedman, Kevin M, Mkrtichyan, Mikayel, Khleif, Samir N

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IDO Vaccine Ablates Immune-Suppressive Myeloid Populations and Enhances Antitumor Effects Independent of Tumor Cell IDO Status von Nandre, Rahul, Verma, Vivek, Gaur, Pankaj, Patil, Veerupaxagouda, Yang, Xingdong, Ramlaoui, Zainab, Shobaki, Nour, Andersen, Mads Hald, Pedersen, Ayako Wakatsuki, Zocca, Mai-Britt, Mkrtichyan, Mikayel, Gupta, Seema, Khleif, Samir N

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Abstract 4717: MAP kinase inhibition induces metabolic reprogramming in T-cells leading to induction of stem cell memory CD8 cells that enhance potency of adoptive cell therapy and... von Verma, Vivek, Ahmad, Shamim, Zeng, Peng, Mkrtichyan, Mikayel, Barry, Simon T., Smith, Paul D., Rodriguez, Paulo C., Janik, John E., Gupta, Seema, Khleif, Samir N.

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SANTAVAC TM : Summary of Research and Development von Lokhov, Petr G, Mkrtichyan, Mikayel, Mamikonyan, Grigor, Balashova, Elena E

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