Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]be... von Penning, Thomas D, Talley, John J, Bertenshaw, Stephen R, Carter, Jeffery S, Collins, Paul W, Docter, Stephen, Graneto, Matthew J, Lee, Len F, Malecha, James W, Miyashiro, Julie M, Rogers, Roland S, Rogier, D. J, Yu, Stella S, Anderson, Gary D, Burton, Earl G, Cogburn, J. Nita, Gregory, Susan A, Koboldt, Carol M, Perkins, William E, Seibert, Karen, Veenhuizen, Amy W, Zhang, Yan Y, Isakson, Peter C

Volltext

Aminopyrimidinone Cdc7 Kinase Inhibitors von Woods, Keith W., Lai, Chunqiu, Miyashiro, Julie M., Tong, Yunsong, Florjancic, Alan S., Han, Edward K., Soni, Niru, Shi, Yan, Lasko, Loren, Leverson, Joel D., Johnson, Eric F., Shoemaker, Alexander R., Penning, Thomas D.

Volltext

Structure−Activity Relationship Studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a Potent Inhibitor of Leukotriene A4 (LTA4) Hydrolase von Penning, Thomas D, Chandrakumar, Nizal S, Chen, Barbara B, Chen, Helen Y, Desai, Bipin N, Djuric, Stevan W, Docter, Stephen H, Gasiecki, Alan F, Haack, Richard A, Miyashiro, Julie M, Russell, Mark A, Yu, Stella S, Corley, David G, Durley, Richard C, Kilpatrick, Brian F, Parnas, Barry L, Askonas, Leslie J, Gierse, James K, Harding, Elizabeth I, Highkin, Maureen K, Kachur, James F, Kim, Suzanne H, Krivi, Gwen G, Villani-Price, Doreen, Pyla, E. Yvonne, Smith, Walter G, Ghoreishi-Haack, Nayereh S

Volltext

1,2-Diarylpyrroles as Potent and Selective Inhibitors of Cyclooxygenase-2 von Khanna, Ish K, Weier, Richard M, Yu, Yi, Collins, Paul W, Miyashiro, Julie M, Koboldt, Carol M, Veenhuizen, Amy W, Currie, Jerry L, Seibert, Karen, Isakson, Peter C

Volltext

Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase von PENNING, Thomas D, CHANDRAKUMAR, Nizal S, HARDING, Elizabeth I, HIGHKIN, Maureen K, KACHUR, James F, KIM, Suzanne H, VILLANI-PRICE, Doreen, PYLA, E. Yvonne, GHOREISHI-HAACK, Nayereh S, SMITH, Walter G, DESAI, Bipin N, DJURIC, Stevan W, GASIECKI, Alan F, MALECHA, James W, MIYASHIRO, Julie M, RUSSELL, Mark A, ASKONAS, Leslie J, GIERSE, James K

Volltext

Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A4 hydrolase von PENNING, Thomas D, CHANDRAKUMAR, Nizal S, HARDING, Elizabeth I, HIGHKIN, Maureen K, KACHUR, James F, KIM, Suzanne H, VILLANI-PRICE, Doreen, PYLA, E. Yvonne, GHOREISHI-HAACK, Nayereh S, SMITH, Walter G, DESAI, Bipin N, DJURIC, Stevan W, GASIECKI, Alan F, LIANG, Chi-Dean, MIYASHIRO, Julie M, RUSSELL, Mark A, ASKONAS, Leslie J, GIERSE, James K

Volltext

A practical enantioselective synthesis of 12-hydroxyeicosatetraenoic acids von Djurić, Stevan W, Miyashiro, Julie M, Penning, Thomas D

Volltext

Synthesis of Potent Leukotriene A4 Hydrolase Inhibitors. Identification of 3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid von Penning, Thomas D, Russell, Mark A, Chen, Barbara B, Chen, Helen Y, Liang, Chi-Dean, Mahoney, Matthew W, Malecha, James W, Miyashiro, Julie M, Yu, Stella S, Askonas, Leslie J, Gierse, James K, Harding, Elizabeth I, Highkin, Maureen K, Kachur, James F, Kim, Suzanne H, Villani-Price, Doreen, Pyla, E. Yvonne, Ghoreishi-Haack, Nayereh S, Smith, Walter G

Volltext

Second Generation Leukotriene B4 Receptor Antagonists Related to SC-41930: Heterocyclic Replacement of the Methyl Ketone Pharmacophore von Penning, Thomas D, Djuric', Stevan W, Miyashiro, Julie M, Yu, Stella, Snyder, James P, Spangler, Dale, Anglin, Charles P, Fretland, Donald J, Kachur, James F

Volltext

AZETIDINYL BENZOXAZOLE COMPOUNDS AND THEIR USE AS MER AND AXL INHIBITORS von DAI, Yujia, JI, Zhiqin, MIYASHIRO, Julie M, FREY, Robin R, PENNING, Thomas D

Volltext bestellen

Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid von Penning, Thomas D, Russell, Mark A, Chen, Barbara B, Chen, Helen Y, Liang, Chi-Dean, Mahoney, Matthew W, Malecha, James W, Miyashiro, Julie M, Yu, Stella S, Askonas, Leslie J, Gierse, James K, Harding, Elizabeth I, Highkin, Maureen K, Kachur, James F, Kim, Suzanne H, Villani-Price, Doreen, Pyla, E Yvonne, Ghoreishi-Haack, Nayereh S, Smith, Walter G

Volltext

AZETIDINYL BENZOXAZOLE COMPOUNDS AND THEIR USE AS MER AND AXL INHIBITORS von DAI, Yujia, JI, Zhiqin, MIYASHIRO, Julie M, FREY, Robin R, PENNING, Thomas D

Volltext bestellen

Discovery of Diphenylmethanepropionic and Dihydrostilbeneacetic Acids as Antagonists of the Integrin αvβ3 von Nagarajan, Srinivasan R., Meyer, Jane M., Miyashiro, Julie M., Engleman, V. Wayne, Freeman, Sandra K., Griggs, David W., Klover, Jon A., Nickols, G. Alan

Volltext

Discovery of Diphenylmethanepropionic and Dihydrostilbeneacetic Acids as Antagonists of the Integrin α v β 3 von Nagarajan, Srinivasan R., Meyer, Jane M., Miyashiro, Julie M., Engleman, V. Wayne, Freeman, Sandra K., Griggs, David W., Klover, Jon A., Nickols, G. Alan

Volltext

Research Letter: Discovery of Diphenylmethanepropionic and Dihydrostilbeneacetic Acids as Antagonists of the Integrin alpha sub(v) beta sub(3) von Nagarajan, Srinivasan R, Meyer, Jane M, Miyashiro, Julie M, Engleman, VWayne, Freeman, Sandra K, Griggs, David W, Klover, Jon A, Nickols, GAlan

Volltext

Discovery of diphenylmethanepropionic and dihydrostilbeneacetic acids as antagonists of the integrin alphavbeta3 von Nagarajan, Srinivasan R, Meyer, Jane M, Miyashiro, Julie M, Engleman, V Wayne, Freeman, Sandra K, Griggs, David W, Klover, Jon A, Nickols, G Alan

Volltext

FUSED BICYCLIC COMPOUNDS AND THEIR USE AS MER AND AXL INHIBITORS von DAI, Yujia, JI, Zhiqin, CLARK, Richard F, BRADY, Patrick B, YU, Yiyun, ZHU, Guidong, GONG, Jane, RISI, Roberto M, MIYASHIRO, Julie M, FREY, Robin R, PENNING, Thomas D

Volltext bestellen

FUSED BICYCLIC COMPOUNDS AND THEIR USE AS MER AND AXL INHIBITORS von DAI, Yujia, JI, Zhiqin, CLARK, Richard F, BRADY, Patrick B, YU, Yiyun, ZHU, Guidong, GONG, Jane, RISI, Roberto M, MIYASHIRO, Julie M, FREY, Robin R, PENNING, Thomas D

Volltext bestellen

Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase von Penning, Thomas D, Chandrakumar, Nizal S, Desai, Bipin N, Djuric, Stevan W, Gasiecki, Alan F, Liang, Chi-Dean, Miyashiro, Julie M, Russell, Mark A, Askonas, Leslie J, Gierse, James K, Harding, Elizabeth I, Highkin, Maureen K, Kachur, James F, Kim, Suzanne H, Villani-Price, Doreen, Pyla, E Yvonne, Ghoreishi-Haack, Nayereh S, Smith, Walter G

Volltext

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents von Kurumbail, Ravi G, Stevens, Anna M, Gierse, James K, McDonald, Joseph J, Stegeman, Roderick A, Pak, Jina Y, Gildehaus, Daniel, Miyashiro, Julie M, Penning, Thomas D, Seibert, Karen, Isakson, Peter C, Stallings, William C

Volltext