Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure von Follmann, Markus, Ackerstaff, Jens, Redlich, Gorden, Wunder, Frank, Lang, Dieter, Kern, Armin, Fey, Peter, Griebenow, Nils, Kroh, Walter, Becker-Pelster, Eva-Maria, Kretschmer, Axel, Geiss, Volker, Li, Volkhart, Straub, Alexander, Mittendorf, Joachim, Jautelat, Rolf, Schirok, Hartmut, Schlemmer, Karl-Heinz, Lustig, Klemens, Gerisch, Michael, Knorr, Andreas, Tinel, Hanna, Mondritzki, Thomas, Trübel, Hubert, Sandner, Peter, Stasch, Johannes-Peter

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Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases von Bärfacker, Lars, Kuhl, Alexander, Hillisch, Alexander, Grosser, Rolf, Figueroa-Pérez, Santiago, Heckroth, Heike, Nitsche, Adam, Ergüden, Jens-Kerim, Gielen-Haertwig, Heike, Schlemmer, Karl-Heinz, Mittendorf, Joachim, Paulsen, Holger, Platzek, Johannes, Kolkhof, Peter

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BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α 2B Antagonist von Meibom, Daniel, Meyer, Jutta, von Buehler, Clemens-Jeremias, Collins, Karl D, Maassen, Stefanie, Gericke, Kersten Matthias, Hüser, Jörg, Mittendorf, Joachim, Ortega Hernandez, Nuria, Schamberger, Jens, Stampfuss, Jan, Straub, Alexander, Torge, Afra, Witowski, Norbert, Wunder, Frank

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Discovery and Preclinical Characterization of Fulacimstat (BAY 1142524), a Potent and Selective Chymase Inhibitor As a New Profibrinolytic Approach for Safe Thrombus Resolution von Fürstner, Chantal, Ackerstaff, Jens, Meier, Heinrich, Straub, Alexander, Mittendorf, Joachim, Schamberger, Jens, Schäfer, Martina, Börngen, Kirsten, Jörißen, Hannah, Zubov, Dmitry, Zimmermann, Katja, Tersteegen, Adrian, Geiss, Volker, Hartmann, Elke, Albrecht-Küpper, Barbara, D'Orléans-Juste, Pedro, Lapointe, Catherine, Vincent, Laurence, Heitmeier, Stefan, Tinel, Hanna

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Discovery of BAY 2413555, First Selective Positive Allosteric Modulator of the M2 Receptor to Restore Cardiac Autonomic Balance von Vakalopoulos, Alexandros, Basting, Daniel, Brechmann, Markus, Teller, Henrik, Boultadakis Arapinis, Melissa, Straub, Alexander, Mittendorf, Joachim, Meininghaus, Mark, Müller, Thomas, Nowak-Reppel, Katrin, Schäfer, Martina, Wittwer, Matthias, Kullmann, Maximilian, Terjung, Carsten, Lang, Dieter, Poethko, Thorsten, Marquardt, Tobias, Freudenberger, Till, Mondritzki, Thomas, Hüser, Jörg, Heckmann, Michael, Tinel, Hanna

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BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor von Meibom, Daniel, Wasnaire, Pierre, Beyer, Kristin, Broehl, Andreas, Cancho-Grande, Yolanda, Elowe, Nadine, Henninger, Kerstin, Johannes, Sarah, Jungmann, Natalia, Krainz, Tanja, Lindner, Niels, Maassen, Stefanie, MacDonald, Bryan, Menshykau, Denis, Mittendorf, Joachim, Sanchez, Guzman, Schaefer, Martina, Stefan, Eric, Torge, Afra, Xing, Yi, Zubov, Dmitry

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New Generation of sGC Stimulators: Discovery of Imidazo[1,2‑a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Re... von Vakalopoulos, Alexandros, Wunder, Frank, Hartung, Ingo V., Redlich, Gorden, Jautelat, Rolf, Buchgraber, Philipp, Hassfeld, Jorma, Gromov, Alexey V., Lindner, Niels, Bierer, Donald, Gries, Jörg, Kroh, Walter, Paulsen, Holger, Mittendorf, Joachim, Lang, Dieter, Becker-Pelster, Eva, Brockschnieder, Damian, Geiss, Volker, Li, Volkhart, Straub, Alexander, Knorr, Andreas, Mondritzki, Thomas, Trübel, Hubert, Raschke, Marian, Schaefer, Martina, Thomas, Dirk, Sandner, Peter, Stasch, Johannes-Peter, Follmann, Markus

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Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases von vonNussbaum, Franz, Li, Volkhart M-J, Allerheiligen, Swen, Anlauf, Sonja, Barfacker, Lars, Bechem, Martin, Delbeck, Martina, Fitzgerald, Mary F, Gerisch, Michael, Gielen-Haertwig, Heike, Haning, Helmut, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Meibom, Daniel, Mittendorf, Joachim, Rosentreter, Ulrich, Schafer, Martina, Schafer, Stefan, Schamberger, Jens, Telan, Leila A, Tersteegen, Adrian

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Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hyp... von von Nussbaum, Franz, Li, Volkhart M., Meibom, Daniel, Anlauf, Sonja, Bechem, Martin, Delbeck, Martina, Gerisch, Michael, Harrenga, Axel, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Mittendorf, Joachim, Schäfer, Martina, Schäfer, Stefan, Schamberger, Jens

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Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial AdenosineA1 Receptor Agonist for the Chronic Treatment of Heart Diseases von Meibom, Daniel, Albrecht-Kupper, Barbara, Diedrichs, Nicole, Hubsch, Walter, Kast, Raimund, Kramer, Thomas, Krenz, Ursula, Lerchen, Hans-Georg, Mittendorf, Joachim, Nell, Peter G, Sussmeier, Frank, Vakalopoulos, Alexandros, Zimmermann, Katja

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Structure-Permeability Relationship of Semi-Peptidic Macrocycles - Understanding and Optimizing Passive Permeability and Efflux Ratio von Le Roux, Antoine, Blaise, Emilie, Boudreault, Pierre-Luc, Comeau, Christian, Doucet, Annie, Giarrusso, Marilena, Collin, Marie-Pierre, Neubauer, Thomas, Koelling, Florian, Göller, Andreas H, Seep, Lea, Tshitenge, Dieudonné T, Wittwer, Matthias, Kullmann, Maximilian, Hillisch, Alexander, Mittendorf, Joachim, Marsault, Éric

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Design and Synthesis of Potent and Selective Azaindole-Based Rho Kinase (ROCK) Inhibitors von Schirok, Hartmut, Kast, Raimund, Figueroa-Pérez, Santiago, Bennabi, Samir, Gnoth, Mark J., Feurer, Achim, Heckroth, Heike, Thutewohl, Michael, Paulsen, Holger, Knorr, Andreas, Hütter, Joachim, Lobell, Mario, Münter, Klaus, Geiß, Volker, Ehmke, Heimo, Lang, Dieter, Radtke, Martin, Mittendorf, Joachim, Stasch, Johannes-Peter

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Cover Picture: Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary D... von vonNussbaum, Franz, Li, Volkhart M-J, Allerheiligen, Swen, Anlauf, Sonja, Barfacker, Lars, Bechem, Martin, Delbeck, Martina, Fitzgerald, Mary F, Gerisch, Michael, Gielen-Haertwig, Heike, Haning, Helmut, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Meibom, Daniel, Mittendorf, Joachim, Rosentreter, Ulrich, Schafer, Martina, Schafer, Stefan, Schamberger, Jens, Telan, Leila A, Tersteegen, Adrian

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Cover Picture: The Chemistry and Biology of Soluble Guanylate Cyclase Stimulators and Activators / Nicotinic Acetylcholine Receptor Agonists: A Milestone for Modern Crop Protection... von Follmann, Markus, Griebenow, Nils, Hahn, Michael G., Hartung, Ingo, Mais, Franz-Josef, Mittendorf, Joachim, Schäfer, Martina, Schirok, Hartmut, Stasch, Johannes-Peter, Stoll, Friederike, Straub, Alexander, Jeschke, Peter, Nauen, Ralf, Beck, Michael Edmund, Engels, Hans-Wilhelm, Pirkl, Hans-Georg, Albers, Reinhard, Albach, Rolf W., Krause, Jens, Hoffmann, Andreas, Casselmann, Holger, Dormish, Jeff

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Efficient Asymmetric Synthesis of β-Amino Acid BAY 10-8888/PLD-118, a Novel Antifungal for the Treatment of Yeast Infections von Mittendorf, Joachim, Benet-Buchholz, Jordi, Fey, Peter, Mohrs, Klaus-Helmut

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Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases von von Nussbaum, Franz, Li, Volkhart M.-J., Allerheiligen, Swen, Anlauf, Sonja, Bärfacker, Lars, Bechem, Martin, Delbeck, Martina, Fitzgerald, Mary F., Gerisch, Michael, Gielen-Haertwig, Heike, Haning, Helmut, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Meibom, Daniel, Mittendorf, Joachim, Rosentreter, Ulrich, Schäfer, Martina, Schäfer, Stefan, Schamberger, Jens, Telan, Leila A., Tersteegen, Adrian

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Cover Picture: Discovery of BAY 94-8862: A Nonsteroidal Antagonist of the Mineralocorticoid Receptor for the Treatment of Cardiorenal Diseases (ChemMedChem 8/2012) von Bärfacker, Lars, Kuhl, Alexander, Hillisch, Alexander, Grosser, Rolf, Figueroa-Pérez, Santiago, Heckroth, Heike, Nitsche, Adam, Ergüden, Jens-Kerim, Gielen-Haertwig, Heike, Schlemmer, Karl-Heinz, Mittendorf, Joachim, Paulsen, Holger, Platzek, Johannes, Kolkhof, Peter

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Substituted uracil derivatives as potent inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1) von Steinhagen, Henning, Gerisch, Michael, Mittendorf, Joachim, Schlemmer, Karl-Heinz, Albrecht, Barbara

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Cover Picture: Design and Synthesis of Potent and Selective Azaindole-Based Rho Kinase (ROCK) Inhibitors (ChemMedChem 12/2008) von Schirok, Hartmut, Kast, Raimund, Figueroa-Pérez, Santiago, Bennabi, Samir, Gnoth, Mark J., Feurer, Achim, Heckroth, Heike, Thutewohl, Michael, Paulsen, Holger, Knorr, Andreas, Hütter, Joachim, Lobell, Mario, Münter, Klaus, Geiß, Volker, Ehmke, Heimo, Lang, Dieter, Radtke, Martin, Mittendorf, Joachim, Stasch, Johannes-Peter

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Cover Picture: Discovery of Riociguat (BAY 63-2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension (ChemMedChem 5/2009) von Mittendorf, Joachim, Weigand, Stefan, Alonso-Alija, Cristina, Bischoff, Erwin, Feurer, Achim, Gerisch, Michael, Kern, Armin, Knorr, Andreas, Lang, Dieter, Muenter, Klaus, Radtke, Martin, Schirok, Hartmut, Schlemmer, Karl-Heinz, Stahl, Elke, Straub, Alexander, Wunder, Frank, Stasch, Johannes-Peter

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