RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL von Lawlor, Kate E., Khan, Nufail, Mildenhall, Alison, Gerlic, Motti, Croker, Ben A., D’Cruz, Akshay A., Hall, Cathrine, Kaur Spall, Sukhdeep, Anderton, Holly, Masters, Seth L., Rashidi, Maryam, Wicks, Ian P., Alexander, Warren S., Mitsuuchi, Yasuhiro, Benetatos, Christopher A., Condon, Stephen M., Wong, W. Wei-Lynn, Silke, John, Vaux, David L., Vince, James E.

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Protein Kinase C Promotes Apoptosis in LNCaP Prostate Cancer Cells through Activation of p38 MAPK and Inhibition of the Akt Survival Pathway von Tanaka, Yuichi, Gavrielides, M.Veronica, Mitsuuchi, Yasuhiro, Fujii, Teruhiko, Kazanietz, Marcelo G.

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Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways von Xiao, Guang-Hui, Jeffers, Michael, Bellacosa, Alfonso, Mitsuuchi, Yasuhiro, Vande Woude, George F., Testa, Joseph R.

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Anti-Apoptotic Signaling by Hepatocyte Growth Factor/Met via the Phosphatidylinositol 3-Kinase/Akt and Mitogen-Activated Protein Kinase Pathways von Xiao, Guang-Hui, Jeffers, Michael, Bellacosa, Alfonso, Mitsuuchi, Yasuhiro, George F. Vande Woude, Testa, Joseph R.

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Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype von Apostolou, Sinoula, Klein, Julian O, Mitsuuchi, Yasuhiro, Shetler, Justin N, Poulikakos, Poulikos I, Jhanwar, Suresh C, Kruger, Warren D, Testa, Joseph R

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Cell Cycle Withdrawal Promotes Myogenic Induction of Akt, a Positive Modulator of Myocyte Survival von Fujio, Yasushi, Guo, Kun, Mano, Toshiaki, Mitsuuchi, Yasuhiro, Testa, Joseph R., Walsh, Kenneth

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Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2 von MITSUUCHI, Y, JOHNSON, S. W, SONODA, G, TANNO, S, GOLEMIS, E. A, TESTA, J. R

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Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin von ALTOMARE, D. A, LYONS, G. E, MITSUUCHI, Y, CHENG, J. Q, TESTA, J. R

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Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies von Condon, Stephen M, Mitsuuchi, Yasuhiro, Deng, Yijun, LaPorte, Matthew G, Rippin, Susan R, Haimowitz, Thomas, Alexander, Matthew D, Kumar, Pavan Tirunahari, Hendi, Mukta S, Lee, Yu-Hua, Benetatos, Christopher A, Yu, Guangyao, Kapoor, Gurpreet Singh, Neiman, Eric, Seipel, Martin E, Burns, Jennifer M, Graham, Martin A, McKinlay, Mark A, Li, Xiaochun, Wang, Jiawei, Shi, Yigong, Feltham, Rebecca, Bettjeman, Bodhi, Cumming, Mathew H, Vince, James E, Khan, Nufail, Silke, John, Day, Catherine L, Chunduru, Srinivas K

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The Novel SMAC Mimetic Birinapant Exhibits Potent Activity against Human Melanoma Cells von KREPLER, Clemens, CHUNDURU, Srinivas K, NATHANSON, Katherine L, AMARAVADI, Ravi K, PEHAMBERGER, Hubert, MCKINLAY, Mark, HERLYN, Meenhard, HALLORAN, Molly B, XU HE, MIN XIAO, VULTUR, Adina, VILLANUEVA, Jessie, MITSUUCHI, Yasuhiro, NEIMAN, Eric M, BENETATOS, Christopher

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Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions von Balsara, Binaifer R., Pei, Jianming, Mitsuuchi, Yasuhiro, Page, Robert, Klein-Szanto, Andres, Wang, Hao, Unger, Michael, Testa, Joseph R.

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Abstract 2278: The SMAC-mimetic birinapant regulates autocrine TNF production by caspase-8:RIPK1 complex via p38MAPK pathway von Kapoor, Gurpreet Singh, Benetatos, Christopher A., Mitsuuchi, Yasuhiro, Neiman, Eric M., Yu, Guangyao, Mckinlay, Mark A., Burns, Jennifer, Silke, John, Condon, Stephen M., Chunduru, Srinivas K.

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Abstract 1806: Birinapant, a bivalent SMAC-mimetic, promotes efficient cellular IAP E3 ligase activity and formation of a pro-apoptotic RIPK1:caspase-8 complex while monovalent IAP... von Mitsuuchi, Yasuhiro, Benetatos, Christopher A., Haimowitz, Thomas, Deng, Yijun, Mufalli, Angeline C., Seipel, Martin E., Burns, Jennifer M., Kapoor, Gurpreet S., Begley, C. Glenn, Condon, Stephen M.

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AKT activation up-regulates insulin-like growth factor-I receptor expression and promotes invasiveness of human pancreatic cancer cells von Tanno, Satoshi, Testa, Joseph R., Kohgo, Yutaka

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Abstract 599: Potential biomarkers of Smac mimetic tumor sensitivity: inhibitor of apoptosis protein DNA copy number von Kapoor, Gurpreet S., Geier, Brian, Neiman, Eric M., Mitsuuchi, Yasuhiro, Benetatos, Christopher A., Condon, Stephen M., Chunduru, Srinivas, Begley, C. Glenn

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Abstract 5302: Characterization of tumor cell lines resistant to birinapant, a novel bivalent smac mimetic von Neiman, Eric M., Benetatos, Christopher A., Kapoor, Gurpreet S., Mitsuuchi, Yasuhiro, McKinlay, Mark A., Seipel, Martin E., Yu, Guangyao, Condon, Stephen M., Chunduru, Srinivas K.

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RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL von Lawlor, Kate E, Khan, Nufail, Mildenhall, Alison, Gerlic, Motti, Croker, Ben A, D’Cruz, Akshay A, Hall, Cathrine, Kaur Spall, Sukhdeep, Anderton, Holly, Masters, Seth L, Rashidi, Maryam, Wicks, Ian P, Alexander, Warren S, Mitsuuchi, Yasuhiro, Benetatos, Christopher A, Condon, Stephen M, Wong, W. Wei-Lynn, Silke, John, Vaux, David L, Vince, James E

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Abstract 3333: Birinapant, a novel bivalent Smac mimetic drug, is superior to monovalent Smac mimetics in inhibition of NF-kB by targeting TRAF2-bound cIAP1 and cIAP2 von Mitsuuchi, Yasuhiro, Condon, Stephen M., Neiman, Eric M., Benetatos, Christopher A., Seipel, Martin E., Kapoor, Gurpreet Singh, Mufalli, Angeline C., Yu, Guangyao, Maguire, Orla, Minderman, Hans, Mckinlay, Mark A., Graham, Martin, Weng, David, Chunduru, Srinivas

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Abstract 3336: The Smac Mimetic Birinapant Synergistically Induces Apoptosis in Combination with Type I Interferons and GM-CSF von Benetatos, Christopher A., Burns, Jennifer M., Borden, Ernest C., Lindner, Daniel, Mitsuuchi, Yasuhiro, Mckinlay, Mark A., Kapoor, Gurpreet Singh, Neiman, Eric M., Seipel, Martin E., Yu, Guangyao, Graham, Martin, Weng, David, Condon, Stephen M., Begley, C. Glenn, Chunduru, Srinivas

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Abstract A225: Dose scheduling and efficacy analysis of the SMAC mimetic TL32711 in primary melanoma tumor xenotransplant models von Burns, Jennifer M., Mitsuuchi, Yasuhiro, Chunduru, Srinivas K., Nieves, Francis E., Wick, Michael J., Tolcher, Anthony W., Papadopoulos, Kyriakos, Graham, Martin A., McKinlay, Mark A.

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