In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu 2/3 receptor antagonist von Witkin, Jeffrey M, Ornstein, Paul L, Mitch, Charles H, Li, Renhua, Smith, Stephon C, Heinz, Beverly A, Wang, Xu-Shan, Xiang, Chuanxi, Carter, Joan H, Anderson, Wesley H, Li, Xia, Broad, Lisa M, Pasqui, Francesca, Fitzjohn, Stephen M, Sanger, Helen E, Smith, Jodi L, Catlow, John, Swanson, Steven, Monn, James A

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LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders von Rorick-Kehn, Linda M., Witkin, Jeffrey M., Statnick, Michael A., Eberle, Elizabeth L., McKinzie, Jamie H., Kahl, Steven D., Forster, Beth M., Wong, Conrad J., Li, Xia, Crile, Robert S., Shaw, David B., Sahr, Allison E., Adams, Benjamin L., Quimby, Steven J., Diaz, Nuria, Jimenez, Alma, Pedregal, Concepcion, Mitch, Charles H., Knopp, Kelly L., Anderson, Wesley H., Cramer, Jeffrey W., McKinzie, David L.

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Duration of action of a broad range of selective κ-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation von Melief, Erica J, Miyatake, Mayumi, Carroll, F Ivy, Béguin, Cécile, Carlezon, Jr, William A, Cohen, Bruce M, Grimwood, Sarah, Mitch, Charles H, Rorick-Kehn, Linda, Chavkin, Charles

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Discovery of Aminobenzyloxyarylamides as κ Opioid Receptor Selective Antagonists: Application to Preclinical Development of a κ Opioid Receptor Antagonist Receptor Occupancy Tracer... von Mitch, Charles H, Quimby, Steven J, Diaz, Nuria, Pedregal, Concepcion, de la Torre, Marta G, Jimenez, Alma, Shi, Qing, Canada, Emily J, Kahl, Steven D, Statnick, Michael A, McKinzie, David L, Benesh, Dana R, Rash, Karen S, Barth, Vanessa N

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Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats von Shannon, Harlan E., Eberle, Elizabeth L., Mitch, Charles H., McKinzie, David L., Statnick, Michael A.

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In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2/3 receptor antagonist von Witkin, Jeffrey M., Ornstein, Paul L., Mitch, Charles H., Li, Renhua, Smith, Stephon C., Heinz, Beverly A., Wang, Xu-Shan, Xiang, Chuanxi, Carter, Joan H., Anderson, Wesley H., Li, Xia, Broad, Lisa M., Pasqui, Francesca, Fitzjohn, Stephen M., Sanger, Helen E., Smith, Jodi L., Catlow, John, Swanson, Steven, Monn, James A.

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Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabo... von Chappell, Mark D, Li, Renhua, Smith, Stephon C, Dressman, Bruce A, Tromiczak, Eric G, Tripp, Allie E, Blanco, Maria-Jesus, Vetman, Tatiana, Quimby, Steven J, Matt, James, Britton, Thomas C, Fivush, Adam M, Schkeryantz, Jeffrey M, Mayhugh, Daniel, Erickson, Jon A, Bures, Mark G, Jaramillo, Carlos, Carpintero, Mercedes, Diego, José Eugenio de, Barberis, Mario, Garcia-Cerrada, Susana, Soriano, José F, Antonysamy, Stephen, Atwell, Shane, MacEwan, Iain, Condon, Bradley, Sougias, Christine, Wang, Jing, Zhang, Aiping, Conners, Kris, Groshong, Chris, Wasserman, Stephen R, Koss, John W, Witkin, Jeffrey M, Li, Xia, Overshiner, Carl, Wafford, Keith A, Seidel, Wesley, Wang, Xu-Shan, Heinz, Beverly A, Swanson, Steven, Catlow, John T, Bedwell, David W, Monn, James A, Mitch, Charles H, Ornstein, Paul L

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Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human von Rorick-Kehn, Linda M, Witcher, Jennifer W, Lowe, Stephen L, Gonzales, Celedon R, Weller, Mary Ann, Bell, Robert L, Hart, John C, Need, Anne B, McKinzie, Jamie H, Statnick, Michael A, Suico, Jeffrey G, McKinzie, David L, Tauscher-Wisniewski, Sitra, Mitch, Charles H, Stoltz, Randall R, Wong, Conrad J

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Na + modulation, inverse agonism, and anorectic potency of 4-phenylpiperidine opioid antagonists von Emmerson, Paul J, McKinzie, Jamie H, Surface, Peggy L, Suter, Todd M, Mitch, Charles H, Statnick, Michael A

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Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression von Dressman, Bruce A., Tromiczak, Eric G., Chappell, Mark D., Tripp, Allie E., Quimby, Steven J., Vetman, Tatiana, Fivush, Adam M., Matt, James, Jaramillo, Carlos, Li, Renhua, Khilevich, Albert, Blanco, Maria-Jesus, Smith, Stephon C., Carpintero, Mercedes, de Diego, José Eugenio, Barberis, Mario, García-Cerrada, Susana, Soriano, José F., Schkeryantz, Jeffrey M., Witkin, Jeffrey M., Wafford, Keith A., Seidel, Wesley, Britton, Thomas, Overshiner, Carl D., Li, Xia, Wang, Xu-Shan, Heinz, Beverly A., Catlow, John T., Swanson, Steven, Bedwell, David, Ornstein, Paul L., Mitch, Charles H.

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Activation of mesolimbic dopamine neurons during novel and daily limited access to palatable food is blocked by the opioid antagonist LY255582 von Sahr, Allison E, Sindelar, Dana K, Alexander-Chacko, Jesline T, Eastwood, Brian J, Mitch, Charles H, Statnick, Michael A

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In vivo rat brain opioid receptor binding of LY255582 assessed with a novel method using LC/MS/MS and the administration of three tracers simultaneously von Need, Anne B., McKinzie, Jamie H., Mitch, Charles H., Statnick, Michael A., Phebus, Lee A.

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Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines von Sauerberg, Per, Olesen, Preben H, Nielsen, Susanne, Treppendahl, Svend, Sheardown, Malcolm J, Honore, Tage, Mitch, Charles H, Ward, John S, Pike, Andrew J

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Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain von Wang, Changning, Eessalu, Thomas E, Barth, Vanessa N, Mitch, Charles H, Wagner, Florence F, Hong, Yijia, Neelamegam, Ramesh, Schroeder, Frederick A, Holson, Edward B, Haggarty, Stephen J, Hooker, Jacob M

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Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2 von Takeuchi, Kumiko, Holloway, William G., Mitch, Charles H., Quimby, Steven J., McKinzie, Jamie H., Suter, Todd M., Statnick, Michael A., Surface, Peggy L., Emmerson, Paul J., Thomas, Elizabeth M., Siegel, Miles G.

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Structure–activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1 von Takeuchi, Kumiko, Holloway, William G., McKinzie, Jamie H., Suter, Todd M., Statnick, Michael A., Surface, Peggy L., Emmerson, Paul J., Thomas, Elizabeth M., Siegel, Miles G., Matt, James E., Wolfe, Chad N., Mitch, Charles H.

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Na +-dependent high affinity binding of [ 3H]LY515300, a 3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid receptor inverse agonist von Statnick, Michael A., Suter, Todd M., Gackenheimer, Susan L., Emmerson, Paul J., Quimby, Steve J., Gehlert, Donald R., Wheeler, William J., Mitch, Charles H.

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Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5 R,6 R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane von Bymaster, Frank P, Shannon, Harlan E, Rasmussen, Kurt, Delapp, Neil W, Mitch, Charles H, Ward, John S, Calligaro, David O, Ludvigsen, Thomas S, Sheardown, Malcolm J, Olesen, Preben H, Swedberg, Michael D.B, Sauerberg, Per, Fink-Jensen, Anders

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1,2,5-Thiadiazole Analogues of Aceclidine as Potent m1 Muscarinic Agonists von Ward, John S, Merritt, Leander, Calligaro, David O, Bymaster, Franklin P, Shannon, Harlan E, Mitch, Charles H, Whitesitt, Celia, Brunsting, David, Sheardown, Malcolm J, Olesen, Preben H, Swedberg, Michael D. B, Jeppesen, Lone, Sauerberg, Per

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The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from chinese hamster ovary-m1 cells von Eckols, Kris, Bymaster, Frank P., Mitch, Charles H., Shannon, Harlan E., Ward, John S., DeLapp, Neil W.

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