Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures von Franciosa, Giulia, Smits, Jos G. A., Minuzzo, Sonia, Martinez-Val, Ana, Indraccolo, Stefano, Olsen, Jesper V.

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SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia von García-Cañaveras, Juan C., Lancho, Olga, Ducker, Gregory S., Ghergurovich, Jonathan M., Xu, Xincheng, da Silva-Diz, Victoria, Minuzzo, Sonia, Indraccolo, Stefano, Kim, Hahn, Herranz, Daniel, Rabinowitz, Joshua D.

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mTOR inhibition downregulates glucose-6-phosphate dehydrogenase and induces ROS-dependent death in T-cell acute lymphoblastic leukemia cells von Silic-Benussi, Micol, Sharova, Evgenyia, Ciccarese, Francesco, Cavallari, Ilaria, Raimondi, Vittoria, Urso, Loredana, Corradin, Alberto, Kotler, Harel, Scattolin, Gloria, Buldini, Barbara, Francescato, Samuela, Basso, Giuseppe, Minuzzo, Sonia A., Indraccolo, Stefano, D'Agostino, Donna M., Ciminale, Vincenzo

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Dissecting molecular mechanisms of resistance to NOTCH1-targeted therapy in T-cell acute lymphoblastic leukemia xenografts von Agnusdei, Valentina, Minuzzo, Sonia, Pinazza, Marica, Gasparini, Alessandra, Pezzè, Laura, Amaro, Adriana Agnese, Pasqualini, Lorenza, Bianco, Paola Del, Tognon, Martina, Frasson, Chiara, Palumbo, Pietro, Ciribilli, Yari, Pfeffer, Ulrich, Carella, Massimo, Amadori, Alberto, Indraccolo, Stefano

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Repurposing Verapamil to Enhance Killing of T-ALL Cells by the mTOR Inhibitor Everolimus von Silic-Benussi, Micol, Sharova, Evgeniya, Corradin, Alberto, Urso, Loredana, Raimondi, Vittoria, Cavallari, Ilaria, Buldini, Barbara, Francescato, Samuela, Minuzzo, Sonia A, D'Agostino, Donna M, Ciminale, Vincenzo

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Anti-VEGF therapy selects for clones resistant to glucose starvation in ovarian cancer xenografts von Boso, Daniele, Tognon, Martina, Curtarello, Matteo, Minuzzo, Sonia, Piga, Ilaria, Brillo, Valentina, Lazzarini, Elisabetta, Carlet, Jessica, Marra, Ludovica, Trento, Chiara, Rasola, Andrea, Masgras, Ionica, Caporali, Leonardo, Del Ben, Fabio, Brisotto, Giulia, Turetta, Matteo, Pastorelli, Roberta, Brunelli, Laura, Navaglia, Filippo, Esposito, Giovanni, Grassi, Angela, Indraccolo, Stefano

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WT1 loss attenuates the TP53-induced DNA damage response in T-cell acute lymphoblastic leukemia von Bordin, Fulvio, Piovan, Erich, Masiero, Elena, Ambesi-Impiombato, Alberto, Minuzzo, Sonia, Bertorelle, Roberta, Sacchetto, Valeria, Pilotto, Giorgia, Basso, Giuseppe, Zanovello, Paola, Amadori, Alberto, Tosello, Valeria

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miR-22-3p Negatively Affects Tumor Progression in T-Cell Acute Lymphoblastic Leukemia von Saccomani, Valentina, Grassi, Angela, Piovan, Erich, Bongiovanni, Deborah, Di Martino, Ludovica, Minuzzo, Sonia, Tosello, Valeria, Zanovello, Paola

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Targeting NOTCH1 in combination with antimetabolite drugs prolongs life span in relapsed pediatric and adult T-acute lymphoblastic leukemia xenografts von Minuzzo, Sonia, Agnusdei, Valentina, Pinazza, Marica, Amaro, Adriana A, Sacchetto, Valeria, Pfeffer, Ulrich, Bertorelle, Roberta, Spinelli, Orietta, Serafin, Valentina, Indraccolo, Stefano

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Identification of Genes Selectively Regulated by IFNs in Endothelial Cells von Indraccolo, Stefano, Pfeffer, Ulrich, Minuzzo, Sonia, Esposito, Giovanni, Roni, Valeria, Mandruzzato, Susanna, Ferrari, Nicoletta, Anfosso, Luca, Dell'Eva, Raffaella, Noonan, Douglas M, Chieco-Bianchi, Luigi, Albini, Adriana, Amadori, Alberto

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Interruption of Tumor Dormancy by a Transient Angiogenic Burst within the Tumor Microenvironment von Indraccolo, Stefano, Stievano, Laura, Minuzzo, Sonia, Tosello, Valeria, Esposito, Giovanni, Piovan, Erich, Zamarchi, Rita, Chieco-Bianchi, Luigi, Amadori, Alberto

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Ligand-driven activation of the Notch pathway in T-all and solid tumors: Why Not(ch)? von Indraccolo, Stefano, Minuzzo, Sonia, Masiero, Massimo, Amador, Alberto

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A Novel t(8;14)(q24;q11) Rearranged Human Cell Line as a Model for Mechanistic and Drug Discovery Studies of NOTCH1-Independent Human T-Cell Leukemia von Tosello, Valeria, Milani, Gloria, Martines, Annalisa, Macri, Nadia, Van Loocke, Wouder, Matthijssens, Filip, Buldini, Barbara, Minuzzo, Sonia, Bongiovanni, Deborah, Schumacher, Richard Fabian, Amadori, Alberto, Van Vlierberghe, Pieter, Piovan, Erich

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Glucocorticoid resistance is reverted by LCK inhibition in pediatric T-cell acute lymphoblastic leukemia von Serafin, Valentina, Capuzzo, Giorgia, Milani, Gloria, Minuzzo, Sonia Anna, Pinazza, Marica, Bortolozzi, Roberta, Bresolin, Silvia, Porcù, Elena, Frasson, Chiara, Indraccolo, Stefano, Basso, Giuseppe, Accordi, Benedetta

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Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL von Sergio, Ilaria, Varricchio, Claudia, Patel, Sandesh Kumar, Del Gaizo, Martina, Russo, Eleonora, Orlando, Andrea, Peruzzi, Giovanna, Ferrandino, Francesca, Tsaouli, Georgia, Coni, Sonia, Peluso, Daniele, Besharat, Zein Mersini, Campolo, Federica, Venneri, Mary Anna, Del Bufalo, Donatella, Lai, Silvia, Indraccolo, Stefano, Minuzzo, Sonia, La Starza, Roberta, Bernardini, Giovanni, Screpanti, Isabella, Campese, Antonio Francesco, Felli, Maria Pia

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Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells von Pinazza, Marica, Ghisi, Margherita, Minuzzo, Sonia, Agnusdei, Valentina, Fossati, Gianluca, Ciminale, Vincenzo, Pezzè, Laura, Ciribilli, Yari, Pilotto, Giorgia, Venturoli, Carolina, Amadori, Alberto, Indraccolo, Stefano

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The Transcription Factors NFATc1 and NFATc2 Control Glucocorticoid Resistance in Pediatric T-Cell Acute Lymphoblastic Leukemia von Veltri, Giulia, Peloso, Alberto, Cani, Alice, Mariotto, Elena, Borile, Giulia, Russo, Loris, Frasson, Chiara, Cescon, Matilde, Iorio, Egidio, Minuzzo, Sonia, Ntziachristos, Panagiotis, Biffi, Alessandra, Buldini, Barbara, Pigazzi, Martina, Indraccolo, Stefano, Bresolin, Silvia, Serafin, Valentina

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Correction: Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL von Sergio, Ilaria, Varricchio, Claudia, Patel, Sandesh Kumar, Del Gaizo, Martina, Russo, Eleonora, Orlando, Andrea, Peruzzi, Giovanna, Ferrandino, Francesca, Tsaouli, Georgia, Coni, Sonia, Peluso, Daniele, Besharat, Zein Mersini, Campolo, Federica, Venneri, Mary Anna, Del Bufalo, Donatella, Lai, Silvia, Indraccolo, Stefano, Minuzzo, Sonia, La Starza, Roberta, Bernardini, Giovanni, Screpanti, Isabella, Campese, Antonio Francesco, Felli, Maria Pia

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A novel and highly effective mitochondrial uncoupling drug in T-cell leukemia von da Silva-Diz, Victoria, Cao, Bin, Lancho, Olga, Chiles, Eric, Alasadi, Amer, Aleksandrova, Maya, Luo, Shirley, Singh, Amartya, Tao, Hanlin, Augeri, David, Minuzzo, Sonia, Indraccolo, Stefano, Khiabanian, Hossein, Su, Xiaoyang, Jin, Shengkan, Herranz, Daniel

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AKR1C enzymes sustain therapy resistance in paediatric T-ALL von Bortolozzi, Roberta, Bresolin, Silvia, Rampazzo, Elena, Paganin, Maddalena, Maule, Francesca, Mariotto, Elena, Boso, Daniele, Minuzzo, Sonia, Agnusdei, Valentina, Viola, Giampietro, te Kronnie, Geertruy, Cazzaniga, Giovanni, Basso, Giuseppe, Persano, Luca

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