A comprehensive review of lysine-specific demethylase 1 and its roles in cancer von Hosseini, Amir, Minucci, Saverio

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Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure von Ablain, Julien, Rice, Kim, Soilihi, Hassane, de Reynies, Aurélien, Minucci, Saverio, de Thé, Hugues

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Sex-Based Dimorphism of Anticancer Immune Response and Molecular Mechanisms of Immune Evasion von Conforti, Fabio, Pala, Laura, Pagan, Eleonora, Bagnardi, Vincenzo, De Pas, Tommaso, Queirolo, Paola, Pennacchioli, Elisabetta, Catania, Chiara, Cocorocchio, Emilia, Ferrucci, Pier Francesco, Saponara, Maristella, Orsolini, Gianmarco, Zagami, Paola, Nicolo, Eleonora, De Marinis, Filippo, Tortora, Giampaolo, Bria, Emilio, Minucci, Saverio, Joffe, Hadine, Veronesi, Paolo, Wargo, Jennifer, Rosenthal, Rachel, Swanton, Charles, Mantovani, Alberto, Gelber, Richard D., Viale, Giuseppe, Goldhirsch, Aron, Giaccone, Giuseppe

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Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML von Nicosia, Luciano, Boffo, Francesca Ludovica, Ceccacci, Elena, Conforti, Fabio, Pallavicini, Isabella, Bedin, Fabio, Ravasio, Roberto, Massignani, Enrico, Somervaille, Tim C. P., Minucci, Saverio, Bonaldi, Tiziana

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Co-targeting leukemia-initiating cells and leukemia bulk leads to disease eradication von Moretti, Simona, Abdel-Aziz, Amal Kamal, Ceccacci, Elena, Pallavicini, Isabella, Santoro, Fabio, de Thé, Hugues, Minucci, Saverio

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Self-renewal of tumor cells: epigenetic determinants of the cancer stem cell phenotype von Ravasio, Roberto, Ceccacci, Elena, Minucci, Saverio

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells von Bracken, Adrian P, Kleine-Kohlbrecher, Daniela, Dietrich, Nikolaj, Pasini, Diego, Gargiulo, Gaetano, Beekman, Chantal, Theilgaard-Mönch, Kim, Minucci, Saverio, Porse, Bo T, Marine, Jean-Christophe, Hansen, Klaus H, Helin, Kristian

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Chromatin immunoprecipitation and high-throughput sequencing from paraffin-embedded pathology tissue von Fanelli, Mirco, Amatori, Stefano, Barozzi, Iros, Minucci, Saverio

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HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles von Saccone, Valentina, Consalvi, Silvia, Giordani, Lorenzo, Mozzetta, Chiara, Barozzi, Iros, Sandoná, Martina, Ryan, Tammy, Rojas-Muñoz, Agustin, Madaro, Luca, Fasanaro, Pasquale, Borsellino, Giovanna, De Bardi, Marco, Frigè, Gianmaria, Termanini, Alberto, Sun, Xin, Rossant, Janet, Bruneau, Benoit G, Mercola, Mark, Minucci, Saverio, Puri, Pier Lorenzo

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Thieno[3,2‑b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure–Activity Relationship... von Vianello, Paola, Sartori, Luca, Amigoni, Federica, Cappa, Anna, Fagá, Giovanni, Fattori, Raimondo, Legnaghi, Elena, Ciossani, Giuseppe, Mattevi, Andrea, Meroni, Giuseppe, Moretti, Loris, Cecatiello, Valentina, Pasqualato, Sebastiano, Romussi, Alessia, Thaler, Florian, Trifiró, Paolo, Villa, Manuela, Botrugno, Oronza A, Dessanti, Paola, Minucci, Saverio, Vultaggio, Stefania, Zagarrí, Elisa, Varasi, Mario, Mercurio, Ciro

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Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner von Elgendy, Mohamed, Ciro, Marco, Abdel-Aziz, Amal Kamal, Belmonte, Giuseppe, Zuffo, Roberto Dal, Mercurio, Ciro, Miracco, Clelia, Lanfrancone, Luisa, Foiani, Marco, Minucci, Saverio

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LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness von Pallavicini, Isabella, Frasconi, Teresa Maria, Catozzi, Carlotta, Ceccacci, Elena, Tiberti, Silvia, Haas, Dorothee, Samson, Jule, Heuser-Loy, Christoph, Nava Lauson, Carina B., Mangione, Marta, Preto, Elisa, Bigogno, Alberto, Sala, Eleonora, Iannacone, Matteo, Mercurio, Ciro, Gattinoni, Luca, Caruana, Ignazio, Kuka, Mirela, Nezi, Luigi, Minucci, Saverio, Manzo, Teresa

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SILAC-based proteomic analysis to dissect the “histone modification signature” of human breast cancer cells von Cuomo, Alessandro, Moretti, Simona, Minucci, Saverio, Bonaldi, Tiziana

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Caloric restriction leads to druggable LSD1-dependent cancer stem cells expansion von Pallavi, Rani, Gatti, Elena, Durfort, Tiphanie, Stendardo, Massimo, Ravasio, Roberto, Leonardi, Tommaso, Falvo, Paolo, Duso, Bruno Achutti, Punzi, Simona, Xieraili, Aobuli, Polazzi, Andrea, Verrelli, Doriana, Trastulli, Deborah, Ronzoni, Simona, Frascolla, Simone, Perticari, Giulia, Elgendy, Mohamed, Varasi, Mario, Colombo, Emanuela, Giorgio, Marco, Lanfrancone, Luisa, Minucci, Saverio, Mazzarella, Luca, Pelicci, Pier Giuseppe

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Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition von Cazzoli, Riccardo, Romeo, Francesco, Pallavicini, Isabella, Peri, Sebastiano, Romanenghi, Mauro, Pérez-Valencia, Juan Alberto, Hagag, Eman, Ferrucci, Filippo, Elgendy, Mohamed, Vittorio, Orazio, Pece, Salvatore, Foiani, Marco, Westermarck, Jukka, Minucci, Saverio

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Thieno[3,2‑b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration von Sartori, Luca, Mercurio, Ciro, Amigoni, Federica, Cappa, Anna, Fagá, Giovanni, Fattori, Raimondo, Legnaghi, Elena, Ciossani, Giuseppe, Mattevi, Andrea, Meroni, Giuseppe, Moretti, Loris, Cecatiello, Valentina, Pasqualato, Sebastiano, Romussi, Alessia, Thaler, Florian, Trifiró, Paolo, Villa, Manuela, Vultaggio, Stefania, Botrugno, Oronza A, Dessanti, Paola, Minucci, Saverio, Zagarrí, Elisa, Carettoni, Daniele, Iuzzolino, Lucia, Varasi, Mario, Vianello, Paola

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Dual modulation of MCL-1 and mTOR determines the response to sunitinib von Elgendy, Mohamed, Abdel-Aziz, Amal Kamal, Renne, Salvatore Lorenzo, Bornaghi, Viviana, Procopio, Giuseppe, Colecchia, Maurizio, Kanesvaran, Ravindran, Toh, Chee Keong, Bossi, Daniela, Pallavicini, Isabella, Perez-Gracia, Jose Luis, Lozano, Maria Dolores, Giandomenico, Valeria, Mercurio, Ciro, Lanfrancone, Luisa, Fazio, Nicola, Nole, Franco, Teh, Bin Tean, Renne, Giuseppe, Minucci, Saverio

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Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway von Minucci, Saverio, Pelicci, Pier Giuseppe, Insinga, Alessandra, Monestiroli, Silvia, Ronzoni, Simona, Gelmetti, Vania, Marchesi, Francesco, Viale, Andrea, Altucci, Lucia, Nervi, Clara

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Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation von Ravasio, Roberto, Ceccacci, Elena, Nicosia, Luciano, Hosseini, Amir, Rossi, Pier Luigi, Barozzi, Iros, Fornasari, Lorenzo, Dal Zuffo, Roberto, Valente, Sergio, Fioravanti, Rossella, Mercurio, Ciro, Varasi, Mario, Mattevi, Andrea, Mai, Antonello, Pavesi, Giulio, Bonaldi, Tiziana, Minucci, Saverio

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Role of the Polycomb Repressive Complex 2 in Acute Promyelocytic Leukemia von Villa, Raffaella, Pasini, Diego, Gutierrez, Arantxa, Morey, Lluis, Occhionorelli, Manuela, Viré, Emmanuelle, Nomdedeu, Josep F., Jenuwein, Thomas, Pelicci, Pier Giuseppe, Minucci, Saverio, Fuks, Francois, Helin, Kristian, Di Croce, Luciano

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