A landmark in drug discovery based on complex natural product synthesis von Kawano, Satoshi, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Abe, Takanori, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, Kishi, Yoshito

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Development of an Efficient Manufacturing Process for E2212 toward Rapid Clinical Introduction von Isomura, Minetaka, Nakamura, Taiju, Kamada, Atsushi, Sasaki, Takeo, Uemura, Toshiyuki, Hoshino, Yorihisa, Matsuda, Masaaki, Hu, Yongbo, Hasegawa, Daiju, Inanaga, Kazato, Sato, Nobuaki, Yoshizawa, Kazuhiro, Moniz, George A, Wilkie, Gordon D, Fang, Francis G, Nishikawa, Yoshihiro, Tagami, Katsuya

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Development of an Efficient Manufacturing Process for E2212 toward Rapid Clinical Introduction von Isomura, Minetaka, Nakamura, Taiju

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Two-Phase Synthesis of (−)-Taxuyunnanine D von Wilde, Nathan C, Isomura, Minetaka, Mendoza, Abraham, Baran, Phil S

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Ten-Gram-Scale Total Synthesis of the Anticancer Drug Candidate E7130 to Supply Clinical Trials von Kaburagi, Yosuke, Kira, Kazunobu, Yahata, Kenzo, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Azuma, Hiroshi, Iida, Daisuke, Ishida, Tasuku, Itano, Wataru, Matsuda, Masaaki, Matsukura, Masayuki, Murai, Norio, Nagao, Satoshi, Seki, Masashi, Yamamoto, Akihiko, Yamamoto, Yuji, Yoneda, Naoki, Watanabe, Yuzo, Kamada, Atsushi, Kayano, Akio, Tagami, Katsuya, Asano, Osamu, Owa, Takashi, Kishi, Yoshito

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What Does It Take to Develop Structurally Complex Molecules by Total Synthesis? Rapid Process Development and GMP Manufacturing of E7130 Drug Substance for First-in-Human Clinical... von Sasaki, Takeo, Yahata, Kenzo, Isomura, Minetaka, Ohashi, Isao, Fukuyama, Takashi, Miyashita, Yusuke, Watanabe, Yuzo, Murai, Norio, Matsuda, Masaaki, Kamada, Atsushi, Kaburagi, Yosuke, Kira, Kazunobu, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Matsumoto, Yasunobu, Azuma, Hiroshi, Iida, Daisuke, Ishida, Tasuku, Itano, Wataru, Nagao, Satoshi, Seki, Masashi, Yamamoto, Akihiko, Yamamoto, Yuji, Yoneda, Naoki, Matsukura, Masayuki, Asano, Osamu, Kayano, Akio, Tagami, Katsuya, Owa, Takashi, Kishi, Yoshito

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Singlet Oxygen for Organic Syntheses-Novel Approaches for Scale-up von Isomura, Minetaka

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Abstract 4183: Mechanism of action analysis of anti-CAF activity of E7130, a novel tumor-microenvironment ameliorator von Abe, Takanori, Kawano, Satoshi, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, Kishi, Yoshito

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Abstract 4179: E7130 derived from total synthesis of halichondrin as a novel tumor-microenvironment ameliorator von Kawano, Satoshi, Abe, Takanori, Ito, Ken, Yahata, Kenzo, Kira, Kazunobu, Akagi, Tsuyoshi, Asano, Makoto, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Kaburagi, Yosuke, Yokoi, Akira, Asano, Osamu, Owa, Takashi, Kishi, Yoshito

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Singlet Oxygen for Organic Syntheses: Novel Approaches for Scale-up von Isomura, Minetaka

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迅速な臨床導入に向けたE2212原薬の効率的製法の開発 von 磯村, 峰孝, 中村, 太樹

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ChemInform Abstract: Two-Phase Synthesis of (-)-Taxuyunnanine D von Wilde, Nathan C., Isomura, Minetaka, Mendoza, Abraham, Baran, Phil S.

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METHOD OF PRODUCING PYRAZINO[2,1-C][1,2,4]TRIAZINE COMPOUND von ISOMURA Minetaka, KOSAKA Yuki, ODAGAMI Takenao, NAGAI Mitsuo, KOUJI Hiroyuki

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METHOD OF PRODUCING PYRAZINO[2,1-C][1,2,4]TRIAZINE COMPOUND von NAGAI MITSUO, ODAGAMI TAKENAO, ISOMURA MINETAKA, KOUJI HIROYUKI, KOSAKA YUKI

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METHOD OF PRODUCING PYRAZINO[2,1-C][1,2,4]TRIAZINE COMPOUND von NAGAI MITSUO, ODAGAMI TAKENAO, ISOMURA MINETAKA, KOUJI HIROYUKI, KOSAKA YUKI

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Method of producing pyrazino[2,1-c][1,2,4]triazine compound von NAGAI MITSUO, ODAGAMI TAKENAO, ISOMURA MINETAKA, KOUJI HIROYUKI, KOSAKA YUKI

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METHOD OF PRODUCING PYRAZINO[2,1-C][1,2,4]TRIAZINE COMPOUND von KOSAKA, YUKI, NAGAI, MITSUO, ISOMURA, MINETAKA, ODAGAMI, TAKENAO, KOUJI, HIROYUKI

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METHOD FOR PRODUCING TETRAHYDROTRIAZOLOPYRIDINE DERIVATIVE von HOSHINO TAKEHISA, ISOMURA MINETAKA, KAMIMURA TOSHIYUKI

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Gram-Scale Synthesis of a Halichondrin-Class Anticancer Drug Candidate E7130 von Kaburagi, Yosuke, Kira, Kazunobu, Yahata, Kenzo, Iso, Kentaro, Sato, Yuki, Matsuura, Fumiyoshi, Ohashi, Isao, Matsumoto, Yasunobu, Isomura, Minetaka, Sasaki, Takeo, Fukuyama, Takashi, Miyashita, Yusuke, Azuma, Hiroshi, Iida, Daisuke, Ishida, Tasuku, Itano, Wataru, Matsuda, Masaaki, Matsukura, Masayuki, Murai, Norio, Nagao, Satoshi, Seki, Masashi, Yamamoto, Akihiko, Yamamoto, Yuji, Yoneda, Naoki, Watanabe, Yuzo, Asano, Osamu, Owa, Takashi, Kishi, Yoshito

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ハリコンドリン全合成由来の新規抗がん剤候補化合物E7130のグラムスケール合成 von 鏑木, 洋介, 吉良, 和信, 八幡, 健三, 磯, 健太郎, 佐藤, 勇気, 松浦, 史義, 大橋, 功, 松本, 泰信, 磯村, 峰孝, 佐々木, 健雄, 福山, 尚, 宮下, 祐輔, 東, 宏, 飯田, 大介, 石田, 祐, 板野, 航, 松田, 将明, 松倉, 正幸, 村井, 則夫, 永尾, 聰, 関, 雅史, 山本, 暁彦, 山本, 祐二, 米田, 直樹, 渡部, 雄造, 浅野, 修, 大和, 隆志, 岸, 義人

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