Target and tissue selectivity of PROTAC degraders von Guenette, Robert G, Yang, Seung Wook, Min, Jaeki, Pei, Baikang, Potts, Patrick Ryan

Volltext

CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss von Teitz, Tal, Fang, Jie, Goktug, Asli N, Bonga, Justine D, Diao, Shiyong, Hazlitt, Robert A, Iconaru, Luigi, Morfouace, Marie, Currier, Duane, Zhou, Yinmei, Umans, Robyn A, Taylor, Michael R, Cheng, Cheng, Min, Jaeki, Freeman, Burgess, Peng, Junmin, Roussel, Martine F, Kriwacki, Richard, Guy, R Kiplin, Chen, Taosheng, Zuo, Jian

Volltext

Phenyl‐Glutarimides: Alternative Cereblon Binders for the Design of PROTACs von Min, Jaeki, Mayasundari, Anand, Keramatnia, Fatemeh, Jonchere, Barbara, Yang, Seung Wook, Jarusiewicz, Jamie, Actis, Marisa, Das, Sourav, Young, Brandon, Slavish, Jake, Yang, Lei, Li, Yong, Fu, Xiang, Garrett, Shalandus H., Yun, Mi‐Kyung, Li, Zhenmei, Nithianantham, Stanley, Chai, Sergio, Chen, Taosheng, Shelat, Anang, Lee, Richard E., Nishiguchi, Gisele, White, Stephen W., Roussel, Martine F., Potts, Patrick Ryan, Fischer, Marcus, Rankovic, Zoran

Volltext

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases von Yang, Seung Wook, Huang, Xin, Lin, Wenwei, Min, Jaeki, Miller, Darcie J., Mayasundari, Anand, Rodrigues, Patrick, Griffith, Elizabeth C., Gee, Clifford T., Li, Lei, Li, Wei, Lee, Richard E., Rankovic, Zoran, Chen, Taosheng, Potts, Patrick Ryan

Volltext

Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia von Chang, Yunchao, Min, Jaeki, Jarusiewicz, Jamie A., Actis, Marisa, Yu-Chen Bradford, Shanshan, Mayasundari, Anand, Yang, Lei, Chepyala, Divyabharathi, Alcock, Lisa J., Roberts, Kathryn G., Nithianantham, Stanley, Maxwell, Dylan, Rowland, Lauren, Larsen, Randolph, Seth, Aman, Goto, Hiroaki, Imamura, Toshihiko, Akahane, Koshi, Hansen, Baranda S., Pruett-Miller, Shondra M., Paietta, Elisabeth M., Litzow, Mark R., Qu, Chunxu, Yang, Jun J., Fischer, Marcus, Rankovic, Zoran, Mullighan, Charles G.

Volltext

Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia von Churchman, Michelle L., Low, Jonathan, Qu, Chunxu, Paietta, Elisabeth M., Kasper, Lawryn H., Chang, Yunchao, Payne-Turner, Debbie, Althoff, Mark J., Song, Guangchun, Chen, Shann-Ching, Ma, Jing, Rusch, Michael, McGoldrick, Dan, Edmonson, Michael, Gupta, Pankaj, Wang, Yong-Dong, Caufield, William, Freeman, Burgess, Li, Lie, Panetta, John C., Baker, Sharyn, Yang, Yung-Li, Roberts, Kathryn G., McCastlain, Kelly, Iacobucci, Ilaria, Peters, Jennifer L., Centonze, Victoria E., Notta, Faiyaz, Dobson, Stephanie M., Zandi, Sasan, Dick, John E., Janke, Laura, Peng, Junmin, Kodali, Kiran, Pagala, Vishwajeeth, Min, Jaeki, Mayasundari, Anand, Williams, Richard T., Willman, Cheryl L., Rowe, Jacob, Luger, Selina, Dickins, Ross A., Guy, R. Kiplin, Chen, Taosheng, Mullighan, Charles G.

Volltext

Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F von Cencic, Regina, Hall, David R., Robert, Francis, Du, Yuhong, Min, Jaeki, Li, Lian, Qui, Min, Lewis, Iestyn, Kurtkaya, Serdar, Dingledine, Ray, Fu, Haian, Kozakov, Dima, Vajda, Sandor, Pelletier, Jerry, Housman, David E.

Volltext

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells von Paugh, Steven W, Bonten, Erik J, Savic, Daniel, Ramsey, Laura B, Thierfelder, William E, Gurung, Prajwal, Malireddi, R K Subbarao, Actis, Marcelo, Mayasundari, Anand, Min, Jaeki, Coss, David R, Laudermilk, Lucas T, Panetta, John C, McCorkle, J Robert, Fan, Yiping, Crews, Kristine R, Stocco, Gabriele, Wilkinson, Mark R, Ferreira, Antonio M, Cheng, Cheng, Yang, Wenjian, Karol, Seth E, Fernandez, Christian A, Diouf, Barthelemy, Smith, Colton, Hicks, J Kevin, Zanut, Alessandra, Giordanengo, Audrey, Crona, Daniel, Bianchi, Joy J, Holmfeldt, Linda, Mullighan, Charles G, den Boer, Monique L, Pieters, Rob, Jeha, Sima, Dunwell, Thomas L, Latif, Farida, Bhojwani, Deepa, Carroll, William L, Pui, Ching-Hon, Myers, Richard M, Guy, R Kiplin, Kanneganti, Thirumala-Devi, Relling, Mary V, Evans, William E

Volltext

Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation von Hammill, Jared T, Bhasin, Deepak, Scott, Daniel C, Min, Jaeki, Chen, Yizhe, Lu, Yan, Yang, Lei, Kim, Ho Shin, Connelly, Michele C, Hammill, Courtney, Holbrook, Gloria, Jeffries, Cynthia, Singh, Bhuvanesh, Schulman, Brenda A, Guy, R. Kiplin

Volltext

Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase von Scott, Daniel C, Hammill, Jared T, Min, Jaeki, Rhee, David Y, Connelly, Michele, Sviderskiy, Vladislav O, Bhasin, Deepak, Chen, Yizhe, Ong, Su-Sien, Chai, Sergio C, Goktug, Asli N, Huang, Guochang, Monda, Julie K, Low, Jonathan, Kim, Ho Shin, Paulo, Joao A, Cannon, Joe R, Shelat, Anang A, Chen, Taosheng, Kelsall, Ian R, Alpi, Arno F, Pagala, Vishwajeeth, Wang, Xusheng, Peng, Junmin, Singh, Bhuvanesh, Harper, J Wade, Schulman, Brenda A, Guy, R Kip

Volltext

Blocking eIF4E-eIF4G Interaction as a Strategy To Impair Coronavirus Replication von CENCIC, Regina, DESFORGES, Marc, PELLETIER, Jerry, HALL, David R, KOZAKOV, Dima, YUHONG DU, MIN, Jaeki, DINGLEDINE, Raymond, HAIAN FU, VAJDA, Sandor, TALBOT, Pierre J

Volltext

Monitoring Ligand-Induced Protein Ordering in Drug Discovery von Grace, Christy R., Ban, David, Min, Jaeki, Mayasundari, Anand, Min, Lie, Finch, Kristin E., Griffiths, Lyra, Bharatham, Nagakumar, Bashford, Donald, Kiplin Guy, R., Dyer, Michael A., Kriwacki, Richard W.

Volltext

Comparison of the Enzymatic and Functional Properties of Three Cytosolic Carboxypeptidase Family Members von Wu, Hui-Yuan, Rong, Yongqi, Correia, Kristen, Min, Jaeki, Morgan, James I.

Volltext

Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single-Enantiomer cis-Imidazolines for Protein–P... von Vara, Brandon A, Mayasundari, Anand, Tellis, John C, Danneman, Michael W, Arredondo, Vanessa, Davis, Tyler A, Min, Jaeki, Finch, Kristin, Guy, R. Kiplin, Johnston, Jeffrey N

Volltext

Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins von Ippagunta, Sirish K, Pollock, Julie A, Sharma, Naina, Lin, Wenwei, Chen, Taosheng, Tawaratsumida, Kazuki, High, Anthony A, Min, Jaeki, Chen, Yizhe, Guy, R Kiplin, Redecke, Vanessa, Katzenellenbogen, John A, Häcker, Hans

Volltext

Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening von Ortiz, Diana, Guiguemde, W Armand, Hammill, Jared T, Carrillo, Angela K, Chen, Yizhe, Connelly, Michele, Stalheim, Kayla, Elya, Carolyn, Johnson, Alex, Min, Jaeki, Shelat, Anang, Smithson, David C, Yang, Lei, Zhu, Fangyi, Guy, R Kiplin, Landfear, Scott M

Volltext

Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds von Ortiz, Diana, Guiguemde, W Armand, Johnson, Alex, Elya, Carolyn, Anderson, Johanna, Clark, Julie, Connelly, Michele, Yang, Lei, Min, Jaeki, Sato, Yuko, Guy, R Kiplin, Landfear, Scott M

Volltext

On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53 von Bista, Michal, Smithson, David, Pecak, Aleksandra, Salinas, Gabriella, Pustelny, Katarzyna, Min, Jaeki, Pirog, Artur, Finch, Kristin, Zdzalik, Michal, Waddell, Brett, Wladyka, Benedykt, Kedracka-Krok, Sylwia, Dyer, Michael A, Dubin, Grzegorz, Guy, R Kiplin

Volltext

Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen von Tanaka, Takeshi Q, Guiguemde, W Armand, Barnett, David S, Maron, Maxim I, Min, Jaeki, Connelly, Michele C, Suryadevara, Praveen Kumar, Guy, R Kiplin, Williamson, Kim C

Volltext

Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction von Pettersson, Mariell, Quant, Maria, Min, Jaeki, Iconaru, Luigi, Kriwacki, Richard W, Waddell, M Brett, Guy, R Kiplin, Luthman, Kristina, Grøtli, Morten

Volltext