Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates von Foster, Donald J., Brown, Christopher R., Shaikh, Sarfraz, Trapp, Casey, Schlegel, Mark K., Qian, Kun, Sehgal, Alfica, Rajeev, Kallanthottathil G., Jadhav, Vasant, Manoharan, Muthiah, Kuchimanchi, Satya, Maier, Martin A., Milstein, Stuart

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Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation von Kim, Chai-Wan, Addy, Carol, Kusunoki, Jun, Anderson, Norma N., Deja, Stanislaw, Fu, Xiaorong, Burgess, Shawn C., Li, Cai, Ruddy, Marcie, Chakravarthy, Manu, Previs, Steve, Milstein, Stuart, Fitzgerald, Kevin, Kelley, David E., Horton, Jay D.

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Multivalent N‑Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing von Nair, Jayaprakash K., Willoughby, Jennifer L. S., Chan, Amy, Charisse, Klaus, Alam, Md. Rowshon, Wang, Qianfan, Hoekstra, Menno, Kandasamy, Pachamuthu, Kel’in, Alexander V., Milstein, Stuart, Taneja, Nate, O’Shea, Jonathan, Shaikh, Sarfraz, Zhang, Ligang, van der Sluis, Ronald J., Jung, Michael E., Akinc, Akin, Hutabarat, Renta, Kuchimanchi, Satya, Fitzgerald, Kevin, Zimmermann, Tracy, van Berkel, Theo J. C., Maier, Martin A., Rajeev, Kallanthottathil G., Manoharan, Muthiah

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Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice von Michler, Thomas, Kosinska, Anna D., Festag, Julia, Bunse, Till, Su, Jinpeng, Ringelhan, Marc, Imhof, Hortenzia, Grimm, Dirk, Steiger, Katja, Mogler, Carolin, Heikenwalder, Mathias, Michel, Marie-Louise, Guzman, Carlos A., Milstein, Stuart, Sepp-Lorenzino, Laura, Knolle, Percy, Protzer, Ulrike

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Therapeutic siRNA silencing in inflammatory monocytes in mice von Weissleder, Ralph, Nahrendorf, Matthias, Leuschner, Florian, Dutta, Partha, Gorbatov, Rostic, Novobrantseva, Tatiana I, Donahoe, Jessica S, Courties, Gabriel, Lee, Kang Mi, Kim, James I, Markmann, James F, Marinelli, Brett, Panizzi, Peter, Lee, Won Woo, Iwamoto, Yoshiko, Milstein, Stuart, Epstein-Barash, Hila, Cantley, William, Wong, Jamie, Cortez-Retamozo, Virna, Newton, Andita, Love, Kevin, Libby, Peter, Pittet, Mikael J, Swirski, Filip K, Koteliansky, Victor, Langer, Robert, Anderson, Daniel G

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An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia von Sehgal, Alfica, Barros, Scott, Ivanciu, Lacramioara, Cooley, Brian, Qin, June, Racie, Tim, Hettinger, Julia, Carioto, Mary, Jiang, Yongfeng, Brodsky, Josh, Prabhala, Harsha, Zhang, Xuemei, Attarwala, Husain, Hutabarat, Renta, Foster, Don, Milstein, Stuart, Charisse, Klaus, Kuchimanchi, Satya, Maier, Martin A, Nechev, Lubo, Kandasamy, Pachamuthu, Kel'in, Alexander V, Nair, Jayaprakash K, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Meyers, Rachel, Sorensen, Benny, Simon, Amy R, Dargaud, Yesim, Negrier, Claude, Camire, Rodney M, Akinc, Akin

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Hepatocyte-Specific Delivery of siRNAs Conjugated to Novel Non-nucleosidic Trivalent N-Acetylgalactosamine Elicits Robust Gene Silencing in Vivo von Rajeev, Kallanthottathil G., Nair, Jayaprakash K., Jayaraman, Muthusamy, Charisse, Klaus, Taneja, Nate, O'Shea, Jonathan, Willoughby, Jennifer L. S., Yucius, Kristina, Nguyen, Tuyen, Shulga-Morskaya, Svetlana, Milstein, Stuart, Liebow, Abigail, Querbes, William, Borodovsky, Anna, Fitzgerald, Kevin, Maier, Martin A., Manoharan, Muthiah

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siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes von Matsuda, Shigeo, Keiser, Kristofer, Nair, Jayaprakash K, Charisse, Klaus, Manoharan, Rajar M, Kretschmer, Philip, Peng, Chang G, V. Kel’in, Alexander, Kandasamy, Pachamuthu, Willoughby, Jennifer L.S, Liebow, Abigail, Querbes, William, Yucius, Kristina, Nguyen, Tuyen, Milstein, Stuart, Maier, Martin A, Rajeev, Kallanthottathil G, Manoharan, Muthiah

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Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation von Kim, Chai-Wan, Addy, Carol, Kusunoki, Jun, Anderson, Norma N., Deja, Stanislaw, Fu, Xiaorong, Burgess, Shawn C., Li, Cai, Ruddy, Marcie, Chakravarthy, Manu, Previs, Steve, Milstein, Stuart, Fitzgerald, Kevin, Kelley, David E., Horton, Jay D.

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Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification von Chan, Amy, Liebow, Abigail, Yasuda, Makiko, Gan, Lin, Racie, Tim, Maier, Martin, Kuchimanchi, Satya, Foster, Don, Milstein, Stuart, Charisse, Klaus, Sehgal, Alfica, Manoharan, Muthiah, Meyers, Rachel, Fitzgerald, Kevin, Simon, Amy, Desnick, Robert J, Querbes, William

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Edgetic perturbation models of human inherited disorders von Hill, David E, Klitgord, Niels, Yan, Han, Cusick, Michael E, Heuze, Fabien, Lin, Chenwei, Vidal, Marc, Venkatesan, Kavitha, Zhong, Quan, Mou, Danny, Simonis, Nicolas, Swearingen, Venus, Yildirim, Muhammed A, Szeto, David, Fan, Changyu, Li, Qian-Ru, Yu, Haiyuan, Dricot, Amélie, Brasseur, Robert, Hao, Tong, Charloteaux, Benoit, Dupuy, Denis, Milstein, Stuart, Tam, Stanley

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Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network von Hill, David E, Tavernier, Jan, Roth, Frederick P, Vidal, Marc, Simonis, Nicolas, Rual, Jean-François, Carvunis, Anne-Ruxandra, Tasan, Murat, Lemmens, Irma, Hirozane-Kishikawa, Tomoko, Hao, Tong, Sahalie, Julie M, Venkatesan, Kavitha, Gebreab, Fana, Cevik, Sebiha, Klitgord, Niels, Fan, Changyu, Braun, Pascal, Li, Ning, Ayivi-Guedehoussou, Nono, Dann, Elizabeth, Bertin, Nicolas, Szeto, David, Dricot, Amélie, Yildirim, Muhammed A, Lin, Chenwei, de Smet, Anne-Sophie, Kao, Huey-Ling, Simon, Christophe, Smolyar, Alex, Ahn, Jin Sook, Tewari, Muneesh, Boxem, Mike, Milstein, Stuart, Yu, Haiyuan, Dreze, Matija, Vandenhaute, Jean, Gunsalus, Kristin C, Cusick, Michael E

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hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes von Lamesch, Philippe, Li, Ning, Milstein, Stuart, Fan, Changyu, Hao, Tong, Szabo, Gabor, Hu, Zhenjun, Venkatesan, Kavitha, Bethel, Graeme, Martin, Paul, Rogers, Jane, Lawlor, Stephanie, McLaren, Stuart, Dricot, Amélie, Borick, Heather, Cusick, Michael E., Vandenhaute, Jean, Dunham, Ian, Hill, David E., Vidal, Marc

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Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice von Ai, Ding, Baez, Juan M, Jiang, Hongfeng, Conlon, Donna M, Hernandez-Ono, Antonio, Frank-Kamenetsky, Maria, Milstein, Stuart, Fitzgerald, Kevin, Murphy, Andrew J, Woo, Connie W, Strong, Alanna, Ginsberg, Henry N, Tabas, Ira, Rader, Daniel J, Tall, Alan R

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Differential regulation of germ line apoptosis and germ cell differentiation by CPEB family members in C. elegans von Singh, Kapil Dev, Zheng, Xue, Milstein, Stuart, Keller, Martin, Roschitzki, Bernd, Grossmann, Jonas, Hengartner, Michael O

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An antibiotic selection marker for nematode transgenesis von Dupuy, Denis, Giordano-Santini, Rosina, Milstein, Stuart, Svrzikapa, Nenad, Tu, Domena, Johnsen, Robert, Baillie, David, Vidal, Marc

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A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans von Gartner, A, Milstein, S, Ahmed, S, Hodgkin, J, Hengartner, M O

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Caenorhabditis elegans HUS-1 Is a DNA Damage Checkpoint Protein Required for Genome Stability and EGL-1-Mediated Apoptosis von Hofmann, E.Randal, Milstein, Stuart, Boulton, Simon J., Ye, Mianjia, Hofmann, Jen J., Stergiou, Lilli, Gartner, Anton, Vidal, Marc, Hengartner, Michael O.

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Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells von Novobrantseva, Tatiana I, Borodovsky, Anna, Wong, Jamie, Klebanov, Boris, Zafari, Mohammad, Yucius, Kristina, Querbes, William, Ge, Pei, Ruda, Vera M, Milstein, Stuart, Speciner, Lauren, Duncan, Rick, Barros, Scott, Basha, Genc, Cullis, Pieter, Akinc, Akin, Donahoe, Jessica S, Narayanannair Jayaprakash, K, Jayaraman, Muthusamy, Bogorad, Roman L, Love, Kevin, Whitehead, Katie, Levins, Chris, Manoharan, Muthiah, Swirski, Filip K, Weissleder, Ralph, Langer, Robert, Anderson, Daniel G, de Fougerolles, Antonin, Nahrendorf, Matthias, Koteliansky, Victor

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'Edgetic' perturbation of a C. elegans BCL2 ortholog von Vidal, Marc, Dreze, Matija, Charloteaux, Benoit, Milstein, Stuart, Vidalain, Pierre-Olivier, Yildirim, Muhammed A, Zhong, Quan, Svrzikapa, Nenad, Romero, Viviana, Laloux, Géraldine, Brasseur, Robert, Vandenhaute, Jean, Boxem, Mike, Cusick, Michael E, Hill, David E

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