Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease von Milnerwood, Austen J, Raymond, Lynn A

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Insights from late-onset familial parkinsonism on the pathogenesis of idiopathic Parkinson's disease von Volta, Mattia, PhD, Milnerwood, Austen J, PhD, Farrer, Matthew J, Prof

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A Critical LRRK at the Synapse? The Neurobiological Function and Pathophysiological Dysfunction of LRRK2 von Kuhlmann, Naila, Milnerwood, Austen J.

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Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice von Milnerwood, Austen J., Gladding, Clare M., Pouladi, Mahmoud A., Kaufman, Alexandra M., Hines, Rochelle M., Boyd, Jamie D., Ko, Rebecca W.Y., Vasuta, Oana C., Graham, Rona K., Hayden, Michael R., Murphy, Timothy H., Raymond, Lynn A.

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Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition von Kadgien, Chelsie A, Kamesh, Anusha, Milnerwood, Austen J

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Maternal gastrointestinal nematode infection alters hippocampal neuroimmunity, promotes synaptic plasticity, and improves resistance to direct infection in offspring von Noel, Sophia C., Madranges, Jeanne F., Gothié, Jean-David M., Ewald, Jessica, Milnerwood, Austen J., Kennedy, Timothy E., Scott, Marilyn E.

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Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load von Milnerwood, Austen J., Raymond, Lynn A.

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The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation von Shimell, Jordan J., Shah, Bhavin S., Cain, Stuart M., Thouta, Samrat, Kuhlmann, Naila, Tatarnikov, Igor, Jovellar, D. Blair, Brigidi, G. Stefano, Kass, Jennifer, Milnerwood, Austen J., Snutch, Terrance P., Bamji, Shernaz X.

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Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice von Volta, Mattia, Beccano-Kelly, Dayne A, Paschall, Sarah A, Cataldi, Stefano, MacIsaac, Sarah E, Kuhlmann, Naila, Kadgien, Chelsie A, Tatarnikov, Igor, Fox, Jesse, Khinda, Jaskaran, Mitchell, Emma, Bergeron, Sabrina, Melrose, Heather, Farrer, Matthew J, Milnerwood, Austen J

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DNAJC13 p.Asn855Ser, implicated in familial parkinsonism, alters membrane dynamics of sorting nexin 1 von Follett, Jordan, Fox, Jesse D., Gustavsson, Emil K., Kadgien, Chelsie, Munsie, Lise N., Cao, Li Ping, Tatarnikov, Igor, Milnerwood, Austen J., Farrer, Matthew J.

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Chronic and Acute Manipulation of Cortical Glutamate Transmission Induces Structural and Synaptic Changes in Co-cultured Striatal Neurons von Kuhlmann, Naila, Wagner Valladolid, Miriam, Quesada-Ramírez, Lucía, Farrer, Matthew J, Milnerwood, Austen J

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Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice von Beccano-Kelly, Dayne A, Kuhlmann, Naila, Tatarnikov, Igor, Volta, Mattia, Munsie, Lise N, Chou, Patrick, Cao, Li-Ping, Han, Heather, Tapia, Lucia, Farrer, Matthew J, Milnerwood, Austen J

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Memory and synaptic deficits in Hip14/DHHC17 Knockout mice von Milnerwood, Austen J., Parsons, Matthew P., Young, Fiona B., Singaraja, Roshni R., Franciosi, Sonia, Volta, Mattia, Bergeron, Sabrina, Hayden, Michael R., Raymond, Lynn A.

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P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease von Fan, Jing, Gladding, Clare M, Wang, Liang, Zhang, Lily Y.J, Kaufman, Alexandra M, Milnerwood, Austen J, Raymond, Lynn A

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Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice von Milnerwood, Austen J, Kaufman, Alexandra M, Sepers, Marja D, Gladding, Clare M, Zhang, Lily, Wang, Liang, Fan, Jing, Coquinco, Ainsley, Qiao, Joy Yi, Lee, Hwan, Wang, Yu Tian, Cynader, Max, Raymond, Lynn A

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Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous Lrrk2 mutations and ameliorated by Lrrk2 genetic knock-out von MacIsaac, Sarah, Quevedo Melo, Thaiany, Zhang, Yuting, Volta, Mattia, Farrer, Matthew J, Milnerwood, Austen J

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Dendritic Polyglycerol Amine: An Enhanced Substrate to Support Long-Term Neural Cell Culture von Clément, Jean-Pierre, Al-Alwan, Laila, Glasgow, Stephen D., Stolow, Avya, Ding, Yi, Quevedo Melo, Thaiany, Khayachi, Anouar, Liu, Yumin, Hellmund, Markus, Haag, Rainer, Milnerwood, Austen J, Grütter, Peter, Kennedy, Timothy E.

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G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons von Volpicelli-Daley, Laura A, Abdelmotilib, Hisham, Liu, Zhiyong, Stoyka, Lindsay, Daher, João Paulo Lima, Milnerwood, Austen J, Unni, Vivek K, Hirst, Warren D, Yue, Zhenyu, Zhao, Hien T, Fraser, Kyle, Kennedy, Richard E, West, Andrew B

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Palmitoylation of δ-catenin by DHHC5 mediates activity-induced synapse plasticity von Brigidi, G Stefano, Sun, Yu, Beccano-Kelly, Dayne, Pitman, Kimberley, Mobasser, Mahsan, Borgland, Stephanie L, Milnerwood, Austen J, Bamji, Shernaz X

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Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons von Kaufman, Alexandra M, Milnerwood, Austen J, Sepers, Marja D, Coquinco, Ainsley, She, Kevin, Wang, Liang, Lee, Hwan, Craig, Ann Marie, Cynader, Max, Raymond, Lynn A

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