A computational approach to distinguish somatic vs. germline origin of genomic alterations from deep sequencing of cancer specimens without a matched normal von Sun, James X, He, Yuting, Sanford, Eric, Montesion, Meagan, Frampton, Garrett M, Vignot, Stéphane, Soria, Jean-Charles, Ross, Jeffrey S, Miller, Vincent A, Stephens, Phil J, Lipson, Doron, Yelensky, Roman

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Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study von Sicklick, Jason K., Kato, Shumei, Okamura, Ryosuke, Schwaederle, Maria, Hahn, Michael E., Williams, Casey B., De, Pradip, Krie, Amy, Piccioni, David E., Miller, Vincent A., Ross, Jeffrey S., Benson, Adam, Webster, Jennifer, Stephens, Philip J., Lee, J. Jack, Fanta, Paul T., Lippman, Scott M., Leyland-Jones, Brian, Kurzrock, Razelle

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Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden von Chalmers, Zachary R, Connelly, Caitlin F, Fabrizio, David, Gay, Laurie, Ali, Siraj M, Ennis, Riley, Schrock, Alexa, Campbell, Brittany, Shlien, Adam, Chmielecki, Juliann, Huang, Franklin, He, Yuting, Sun, James, Tabori, Uri, Kennedy, Mark, Lieber, Daniel S, Roels, Steven, White, Jared, Otto, Geoffrey A, Ross, Jeffrey S, Garraway, Levi, Miller, Vincent A, Stephens, Phillip J, Frampton, Garrett M

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New Strategies in Overcoming Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Cancer von OXNARD, Geoffrey R, ARCILA, Maria E, CHMIELECKI, Juliann, LADANYI, Marc, MILLER, Vincent A, PAO, William

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Clinical Characteristics of Patients With Lung Adenocarcinomas Harboring BRAF Mutations von PAIK, Paul K, ARCILA, Maria E, FARA, Michael, SIMA, Camelia S, MILLER, Vincent A, KRIS, Mark G, LADANYI, Marc, RIELY, Gregory J

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Epidermal Growth Factor Receptor Mutations, Small-Molecule Kinase Inhibitors, and Non–Small-Cell Lung Cancer: Current Knowledge and Future Directions von PAO, William, MILLER, Vincent A

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The distribution of BRAF gene fusions in solid tumors and response to targeted therapy von Ross, Jeffrey S., Wang, Kai, Chmielecki, Juliann, Gay, Laurie, Johnson, Adrienne, Chudnovsky, Jacob, Yelensky, Roman, Lipson, Doron, Ali, Siraj M, Elvin, Julia A., Vergilio, Jo‐Anne, Roels, Steven, Miller, Vincent A, Nakamura, Brooke N., Gray, Adam, Wong, Michael K, Stephens, Philip J

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On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation von Brown, Benjamin P, Zhang, Yun-Kai, Westover, David, Yan, Yingjun, Qiao, Huan, Huang, Vincent, Du, Zhenfang, Smith, Jarrod A, Ross, Jeffrey S, Miller, Vincent A, Ali, Siraj, Bazhenova, Lyudmila, Schrock, Alexa B, Meiler, Jens, Lovly, Christine M

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Enrichment of Targetable Mutations in the Relapsed Neuroblastoma Genome von Padovan-Merhar, Olivia M, Raman, Pichai, Ostrovnaya, Irina, Kalletla, Karthik, Rubnitz, Kaitlyn R, Sanford, Eric M, Ali, Siraj M, Miller, Vincent A, Mossé, Yael P, Granger, Meaghan P, Weiss, Brian, Maris, John M, Modak, Shakeel

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Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3 von Ross, Jeffrey S., Fakih, Marwan, Ali, Siraj M., Elvin, Julia A., Schrock, Alexa B., Suh, James, Vergilio, Jo‐Anne, Ramkissoon, Shakti, Severson, Eric, Daniel, Sugganth, Fabrizio, David, Frampton, Garrett, Sun, James, Miller, Vincent A., Stephens, Philip J., Gay, Laurie M.

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Impact of EML4-ALK Variant on Resistance Mechanisms and Clinical Outcomes in ALK-Positive Lung Cancer von Lin, Jessica J, Zhu, Viola W, Yoda, Satoshi, Yeap, Beow Y, Schrock, Alexa B, Dagogo-Jack, Ibiayi, Jessop, Nicholas A, Jiang, Ginger Y, Le, Long P, Gowen, Kyle, Stephens, Philip J, Ross, Jeffrey S, Ali, Siraj M, Miller, Vincent A, Johnson, Melissa L, Lovly, Christine M, Hata, Aaron N, Gainor, Justin F, Iafrate, Anthony J, Shaw, Alice T, Ou, Sai-Hong Ignatius

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Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions von Lovly, Christine M, Gupta, Abha, Lipson, Doron, Otto, Geoff, Brennan, Tina, Chung, Catherine T, Borinstein, Scott C, Ross, Jeffrey S, Stephens, Philip J, Miller, Vincent A, Coffin, Cheryl M

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The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy von Knepper, Todd C, Montesion, Meagan, Russell, Jeffery S, Sokol, Ethan S, Frampton, Garrett M, Miller, Vincent A, Albacker, Lee A, McLeod, Howard L, Eroglu, Zeynep, Khushalani, Nikhil I, Sondak, Vernon K, Messina, Jane L, Schell, Michael J, DeCaprio, James A, Tsai, Kenneth Y, Brohl, Andrew S

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Diverse EGFR Exon 20 Insertions and Co-Occurring Molecular Alterations Identified by Comprehensive Genomic Profiling of NSCLC von Riess, Jonathan W., Gandara, David R., Frampton, Garrett M., Madison, Russell, Peled, Nir, Bufill, Jose A., Dy, Grace K., Ou, Sai-Hong Ignatius, Stephens, Philip J., McPherson, John D., Lara, Primo N., Burich, Rebekah A., Ross, Jeffrey S., Miller, Vincent A., Ali, Siraj M., Mack, Philip C., Schrock, Alexa B.

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A Novel Next-Generation Sequencing Approach to Detecting Microsatellite Instability and Pan-Tumor Characterization of 1000 Microsatellite Instability–High Cases in 67,000 Patient S... von Trabucco, Sally E., Gowen, Kyle, Maund, Sophia L., Sanford, Eric, Fabrizio, David A., Hall, Michael J., Yakirevich, Evgeny, Gregg, Jeffrey P., Stephens, Phil J., Frampton, Garrett M., Hegde, Priti S., Miller, Vincent A., Ross, Jeffrey S., Hartmaier, Ryan J., Huang, Shih-Min A., Sun, James X.

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Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma von Ho, Allen S, Ochoa, Angelica, Jayakumaran, Gowtham, Zehir, Ahmet, Valero Mayor, Cristina, Tepe, Justin, Makarov, Vladimir, Dalin, Martin G, He, Jie, Bailey, Mark, Montesion, Meagan, Ross, Jeffrey S, Miller, Vincent A, Chan, Lindsay, Ganly, Ian, Dogan, Snjezana, Katabi, Nora, Tsipouras, Petros, Ha, Patrick, Agrawal, Nishant, Solit, David B, Futreal, P Andrew, El Naggar, Adel K, Reis-Filho, Jorge S, Weigelt, Britta, Ho, Alan L, Schultz, Nikolaus, Chan, Timothy A, Morris, Luc Gt

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Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-... von Miller, Vincent A, Prof, Hirsh, Vera, MD, Cadranel, Jacques, Prof, Chen, Yuh-Min, MD, Park, Keunchil, Prof, Kim, Sang-We, Prof, Zhou, Caicun, Prof, Su, Wu-Chou, Prof, Wang, Mengzhao, Prof, Sun, Yan, Prof, Heo, Dae Seog, Prof, Crino, Lucio, Prof, Tan, Eng-Huat, MD, Chao, Tsu-Yi, Prof, Shahidi, Mehdi, MD, Cong, Xiuyu Julie, PhD, Lorence, Robert M, MD, Yang, James Chih-Hsin, Prof

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Clinical Definition of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non–Small-Cell Lung Cancer von JACKMAN, David, PAO, William, RIELY, Gregory J, ENGELMAN, Jeffrey A, KRIS, Mark G, JÄNNE, Pasi A, LYNCH, Thomas, JOHNSON, Bruce E, MILLER, Vincent A

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Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors von Frampton, Garrett M, Ali, Siraj M, Rosenzweig, Mark, Chmielecki, Juliann, Lu, Xinyuan, Bauer, Todd M, Akimov, Mikhail, Bufill, Jose A, Lee, Carrie, Jentz, David, Hoover, Rick, Ou, Sai-Hong Ignatius, Salgia, Ravi, Brennan, Tim, Chalmers, Zachary R, Jaeger, Savina, Huang, Alan, Elvin, Julia A, Erlich, Rachel, Fichtenholtz, Alex, Gowen, Kyle A, Greenbowe, Joel, Johnson, Adrienne, Khaira, Depinder, McMahon, Caitlin, Sanford, Eric M, Roels, Steven, White, Jared, Greshock, Joel, Schlegel, Robert, Lipson, Doron, Yelensky, Roman, Morosini, Deborah, Ross, Jeffrey S, Collisson, Eric, Peters, Malte, Stephens, Philip J, Miller, Vincent A

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Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease von Yaeger, Rona, Shah, Manish A, Miller, Vincent A, Kelsen, Judith R, Wang, Kai, Heins, Zachary J, Ross, Jeffrey S, He, Yuting, Sanford, Eric, Yantiss, Rhonda K, Balasubramanian, Sohail, Stephens, Philip J, Schultz, Nikolaus, Oren, Moshe, Tang, Laura, Kelsen, David

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