Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting von Suhre, Karsten, Meisinger, Christa, Döring, Angela, Altmaier, Elisabeth, Belcredi, Petra, Gieger, Christian, Chang, David, Milburn, Michael V, Gall, Walter E, Weinberger, Klaus M, Mewes, Hans-Werner, Hrabé de Angelis, Martin, Wichmann, H-Erich, Kronenberg, Florian, Adamski, Jerzy, Illig, Thomas

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alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population von Gall, Walter E, Beebe, Kirk, Lawton, Kay A, Adam, Klaus-Peter, Mitchell, Matthew W, Nakhle, Pamela J, Ryals, John A, Milburn, Michael V, Nannipieri, Monica, Camastra, Stefania, Natali, Andrea, Ferrannini, Ele

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Plasma metabolomic profiles enhance precision medicine for volunteers of normal health von Guo, Lining, Milburn, Michael V., Ryals, John A., Lonergan, Shaun C., Mitchell, Matthew W., Wulff, Jacob E., Alexander, Danny C., Evans, Anne M., Bridgewater, Brandi, Miller, Luke, Gonzalez-Garay, Manuel L., Caskey, C. Thomas

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Bladder cancer biomarker discovery using global metabolomic profiling of urine von Wittmann, Bryan M, Stirdivant, Steven M, Mitchell, Matthew W, Wulff, Jacob E, McDunn, Jonathan E, Li, Zhen, Dennis-Barrie, Aphrihl, Neri, Bruce P, Milburn, Michael V, Lotan, Yair, Wolfert, Robert L

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Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information von Krumsiek, Jan, Suhre, Karsten, Evans, Anne M, Mitchell, Matthew W, Mohney, Robert P, Milburn, Michael V, Wägele, Brigitte, Römisch-Margl, Werner, Illig, Thomas, Adamski, Jerzy, Gieger, Christian, Theis, Fabian J, Kastenmüller, Gabi

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Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression von Zhang, Yujin, Berka, Vladimir, Song, Anren, Sun, Kaiqi, Wang, Wei, Zhang, Weiru, Ning, Chen, Li, Chonghua, Zhang, Qibo, Bogdanov, Mikhail, Alexander, Danny C, Milburn, Michael V, Ahmed, Mostafa H, Lin, Han, Idowu, Modupe, Zhang, Jun, Kato, Gregory J, Abdulmalik, Osheiza Y, Zhang, Wenzheng, Dowhan, William, Kellems, Rodney E, Zhang, Pumin, Jin, Jianping, Safo, Martin, Tsai, Ah-Lim, Juneja, Harinder S, Xia, Yang

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Detrimental effects of adenosine signaling in sickle cell disease von Xia, Yang, Zhang, Yujin, Dai, Yingbo, Wen, Jiaming, Zhang, Weiru, Grenz, Almut, Sun, Hong, Tao, Lijian, Lu, Guangxiu, Alexander, Danny C, Milburn, Michael V, Carter-Dawson, Louvenia, Lewis, Dorothy E, Zhang, Wenzheng, Eltzschig, Holger K, Kellems, Rodney E, Blackburn, Michael R, Juneja, Harinder S

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Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats von Yamazaki, Makoto, Miyake, Manami, Sato, Hiroko, Masutomi, Naoya, Tsutsui, Naohisa, Adam, Klaus-Peter, Alexander, Danny C., Lawton, Kay A., Milburn, Michael V., Ryals, John A., Wulff, Jacob E., Guo, Lining

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Untargeted Metabolomic Profiling as an Evaluative Tool of Fenofibrate-Induced Toxicology in Fischer 344 Male Rats von Ohta, Tetsuya, Masutomi, Naoya, Tsutsui, Naohisa, Sakairi, Tetsuya, Mitchell, Matthew, Milburn, Michael V., Ryals, John A., Beebe, Kirk D., Guo, Lining

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Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline von Sha, Wei, da Costa, Kerry-Ann, Fischer, Leslie M, Milburn, Michael V, Lawton, Kay A, Berger, Alvin, Jia, Wei, Zeisel, Steven H

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A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design von Zhang, Kam Y J, Card, Graeme L, Blasdel, Landy, England, Bruce P, Zhang, Chao, Suzuki, Yoshihisa, Gillette, Sam, Fong, Daniel, Ibrahim, Prabha N, Artis, Dean R, Bollag, Gideon, Milburn, Michael V, Kim, Sung-Hou, Schlessinger, Joseph

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Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent von Artis, Dean R, Lin, Jack J, Zhang, Chao, Wang, Weiru, Mehra, Upasana, Perreault, Mylene, Erbe, David, Krupka, Heike I, England, Bruce P, Arnold, James, Plotnikov, Alexander N, Marimuthu, Adhirai, Nguyen, Hoa, Will, Sarah, Signaevsky, Maxime, Kral, John, Cantwell, John, Settachatgull, Calvin, Yan, Douglas S, Fong, Daniel, Oh, Angela, Shi, Shenghua, Womack, Patrick, Powell, Benjamin, Habets, Gaston, West, Brian L, Zhang, Kam Y.J, Milburn, Michael V, Vlasuk, George P, Hirth, K. Peter, Nolop, Keith, Bollag, Gideon, Ibrahim, Prabha N, Tobin, James F

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Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors von Xu, H.Eric, Lambert, Millard H, Montana, Valerie G, Parks, Derek J, Blanchard, Steven G, Brown, Peter J, Sternbach, Daniel D, Lehmann, Jürgen M, Wisely, G.Bruce, Willson, Timothy M, Kliewer, Steven A, Milburn, Michael V

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Distinct Predictive Immunogenomic Profiles of Response to Immune Checkpoint Inhibitors and IL2: A Real-world Evidence Study of Patients with Advanced Renal Cancer von Eisner, Joel R, Beebe, Kirk D, Mayhew, Gregory M, Shibata, Yoichiro, Guo, Yuelong, Farhangfar, Carol, Farhangfar, Farhang, Uronis, Joshua M, Mooney, Jill, Milburn, Michael V, Foureau, David, White, Richard L, Amin, Asim, Milla, Marcos E

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An atlas of genetic influences on human blood metabolites von Shin, So-Youn, Fauman, Eric B, Petersen, Ann-Kristin, Krumsiek, Jan, Santos, Rita, Huang, Jie, Arnold, Matthias, Erte, Idil, Forgetta, Vincenzo, Yang, Tsun-Po, Walter, Klaudia, Menni, Cristina, Chen, Lu, Vasquez, Louella, Valdes, Ana M, Hyde, Craig L, Wang, Vicky, Ziemek, Daniel, Roberts, Phoebe, Xi, Li, Grundberg, Elin, Waldenberger, Melanie, Richards, J Brent, Mohney, Robert P, Milburn, Michael V, John, Sally L, Trimmer, Jeff, Theis, Fabian J, Overington, John P, Suhre, Karsten, Brosnan, M Julia, Gieger, Christian, Kastenmüller, Gabi, Spector, Tim D, Soranzo, Nicole

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The Crystal Structures of Human Steroidogenic Factor-1 and Liver Receptor Homologue-1 von Wang, Weiru, Zhang, Chao, Marimuthu, Adhirai, Krupka, Heike I., Tabrizizad, Maryam, Shelloe, Rafe, Mehra, Upasana, Eng, Kevin, Nguyen, Hoa, Settachatgul, Calvin, Powell, Ben, Milburn, Michael V., West, Brian L., Dixon, Jack E.

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Early Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance von FERRANNINI, Ele, NATALI, Andrea, LYSSENKO, Valeriya, GROOP, Leif, GALL, Walter E, CAMASTRA, Stefania, NANNIPIERI, Monica, MARI, Andrea, ADAM, Klaus-Peter, MILBURN, Michael V, KASTENMÜLLER, Gabi, ADAMSKI, Jerzy, TUOMI, Tiinamaija

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Ethylene Glycol Monomethyl Ether–Induced Toxicity Is Mediated through the Inhibition of Flavoprotein Dehydrogenase Enzyme Family von Takei, Makoto, Ando, Yosuke, Saitoh, Wataru, Tanimoto, Tomoe, Kiyosawa, Naoki, Manabe, Sunao, Sanbuissho, Atsushi, Okazaki, Osamu, Iwabuchi, Haruo, Yamoto, Takashi, Adam, Klaus-Peter, Weiel, James E., Ryals, John A., Milburn, Michael V., Guo, Lining

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Human metabolic individuality in biomedical and pharmaceutical research von Suhre, Karsten, Shin, So-Youn, Petersen, Ann-Kristin, Mohney, Robert P., Meredith, David, Wägele, Brigitte, Altmaier, Elisabeth, Deloukas, Panos, Erdmann, Jeanette, Grundberg, Elin, Hammond, Christopher J., de Angelis, Martin Hrabé, Kastenmüller, Gabi, Köttgen, Anna, Kronenberg, Florian, Mangino, Massimo, Meisinger, Christa, Meitinger, Thomas, Mewes, Hans-Werner, Milburn, Michael V., Prehn, Cornelia, Raffler, Johannes, Ried, Janina S., Römisch-Margl, Werner, Samani, Nilesh J., Small, Kerrin S., -Erich Wichmann, H., Zhai, Guangju, Illig, Thomas, Spector, Tim D., Adamski, Jerzy, Soranzo, Nicole, Gieger, Christian

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Untargeted metabolomic analysis for the clinical screening of inborn errors of metabolism von Miller, Marcus J., Kennedy, Adam D., Eckhart, Andrea D., Burrage, Lindsay C., Wulff, Jacob E., Miller, Luke A.D., Milburn, Michael V., Ryals, John A., Beaudet, Arthur L., Sun, Qin, Sutton, V. Reid, Elsea, Sarah H.

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