Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status von Roering, Pia, Siddiqui, Arafat, Heuser, Vanina D., Potdar, Swapnil, Mikkonen, Piia, Oikkonen, Jaana, Li, Yilin, Pikkusaari, Sanna, Wennerberg, Krister, Hynninen, Johanna, Grenman, Seija, Huhtinen, Kaisa, Auranen, Annika, Carpén, Olli, Kaipio, Katja

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FHOD1, a formin upregulated in epithelial-mesenchymal transition, participates in cancer cell migration and invasion von Gardberg, Maria, Kaipio, Katja, Lehtinen, Laura, Mikkonen, Piia, Heuser, Vanina D, Talvinen, Kati, Iljin, Kristiina, Kampf, Caroline, Uhlen, Mathias, Grénman, Reidar, Koivisto, Mari, Carpén, Olli

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Protocol for 3D drug sensitivity and resistance testing of patient-derived cancer cells in 384-well plates von Feodoroff, Michaela, Mikkonen, Piia, Arjama, Mariliina, Murumägi, Astrid, Kallioniemi, Olli, Potdar, Swapnil, Turunen, Laura, Pietiäinen, Vilja

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Comparison of two supporting matrices for patient-derived cancer cells in 3D drug sensitivity and resistance testing assay (3D-DSRT) von Feodoroff, Michaela, Mikkonen, Piia, Turunen, Laura, Hassinen, Antti, Paasonen, Lauri, Paavolainen, Lassi, Potdar, Swapnil, Murumägi, Astrid, Kallioniemi, Olli, Pietiäinen, Vilja

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Distinct molecular profiles and shared drug vulnerabilities in pancreatic metastases of renal cell carcinoma von Roos-Mattila, Matilda, Kallio, Pauliina, Luck, Tamara J., Polso, Minttu, Kumari, Romika, Mikkonen, Piia, Välimäki, Katja, Malmstedt, Minna, Ellonen, Pekka, Pellinen, Teijo, Heckman, Caroline A., Mustonen, Harri, Puolakkainen, Pauli A., Alitalo, Kari, Kallioniemi, Olli, Mirtti, Tuomas, Rannikko, Antti S., Pietiäinen, Vilja M., Seppänen, Hanna E.

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ALDH1A1‐related stemness in high‐grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR‐PI3K/aurora kinase inhibitors von Kaipio, Katja, Chen, Ping, Roering, Pia, Huhtinen, Kaisa, Mikkonen, Piia, Östling, Päivi, Lehtinen, Laura, Mansuri, Naziha, Korpela, Taina, Potdar, Swapnil, Hynninen, Johanna, Auranen, Annika, Grénman, Seija, Wennerberg, Krister, Hautaniemi, Sampsa, Carpén, Olli

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Avidin-Conjugated Nanofibrillar Cellulose Hydrogel Functionalized with Biotinylated Fibronectin and Vitronectin Promotes 3D Culture of Fibroblasts von Leppiniemi, Jenni, Mutahir, Zeeshan, Dulebo, Alexander, Mikkonen, Piia, Nuopponen, Markus, Turkki, Paula, Hytönen, Vesa P

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Accurate Morphology Preserving Segmentation of Overlapping Cells based on Active Contours von Molnar, Csaba, Jermyn, Ian H., Kato, Zoltan, Rahkama, Vesa, Östling, Päivi, Mikkonen, Piia, Pietiäinen, Vilja, Horvath, Peter

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Abstract 5302: Phenotypic heterogeneity of patient-derived tumor cells visualized by unsupervised analysis in cell-based personalized drug testing von Turkki, Riku, Paavolainen, Lassi, Mikkonen, Piia, Östling, Päivi, Horvath, Peter, Pietiäinen, Vilja, Kallioniemi, Olli

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Abstract A57: Drug sensitivity and resistance testing (DSRT) of clinically important compounds on primary ovarian cancer cell lines von Roering, Pia, Mikkonen, Piia, Potdar, Swapnil, Wennerberg, Krister, Hynninen, Johanna, Grénman, Seija, Auranen, Annika, Carpén, Olli, Kaipio, Katja

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Abstract 5029: Precision cancer medicine based on 3D drug profiling of patient-derived cancer cell spheroid models von Mikkonen, Piia, Turunen, Laura, Paasonen, Lauri, Potdar, Swapnil, Paavolainen, Lassi, Murumägi, Astrid, Kallioniemi, Olli, Pietiäinen, Vilja M.

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Identification of Prognostic Groups in High-Grade Serous Ovarian Cancer Treated with Platinum-Taxane Chemotherapy von Chen, Ping, Huhtinen, Kaisa, Kaipio, Katja, Mikkonen, Piia, Aittomäki, Viljami, Lindell, Rony, Hynninen, Johanna, Auranen, Annika, Grénman, Seija, Lehtonen, Rainer, Carpén, Olli, Hautaniemi, Sampsa

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Abstract 2945: Clinical implementation of precision systems oncology in the treatment of ovarian cancer based on ex-vivo drug testing and molecular profiling von Murumägi, Astrid, Ungureanu, Daniela, Khan, Suleiman, Hirasawa, Akira, Arjama, Mariliina, Välimäki, Katja, Mikkonen, Piia, Niininen, Wilhelmiina, Kumar, Ashwini, Eldfors, Samuli, Pellinen, Teijo, Pietiäinen, Vilja, Mägi, Andrus, Koivisto-Korander, Riitta, Tapper, Johanna, Loukovaara, Mikko, Aittokallio, Tero, Bützow, Ralf, Kallioniemi, Olli

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Abstract B43: Xenograft mouse models for ovarian cancer von Lamminen, Tarja, Kaipio, Katja, Mikkonen, Piia, Roering, Pia, Carpén, Olli

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Abstract 3854: Precision medicine approach: analysis of renal cancer patient-derived cells with phenomics, genomics and drug sensitivity profiling von Pietiäinen, Vilja M., Mikkonen, Piia, Saeed, Khalid, Paavolainen, Lassi, Pellinen, Teijo, Potdar, Swapnil, Mpindi, John, Nisén, Harry, Rannikko, Antti, Mirtti, Tuomas, Horvath, Peter, Östling, Päivi, Kallioniemi, Olli

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A Facile, Transfection‐Free Approach to siRNA Delivery in In Vitro 3D Spheroid Models von Riching, Andrew S., Malloy, Allyson, Anderson, Emily M., Sheard, Jonathan, Mikkonen, Piia, Brabant Smith, Anja, Strezoska, Zaklina, Levenga, Josien

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Abstract A31: High-grade serous ovarian cancer subtyping identifies pathways for targeted therapy von Huhtinen, Kaisa, Chen, Ping, Kaipio, Katja, Mikkonen, Piia, Aittomäki, Viljami, Lindell, Rony, Hynninen, Johanna, Auranen, Annika, Grenman, Seija, Lehtonen, Rainer, Hautaniemi, Sampsa, Carpén, Olli

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Abstract B47: Novel integrative approach to identify therapy sensitive and insensitive ovarian cancer patients von Chen, Ping, Huhtinen, Kaisa, Kaipio, Katja, Mikkonen, Piia, Aittomaki, Viljami, Lindell, Rony, Hynninen, Johanna, Auranen, Annika, Grenman, Seija, Lehtonen, Rainer, Carpén, Olli, Hautaniemi, Sampsa

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Abstract 3899: Discovery and clinical implementation of individualized therapies in acute myeloid leukemia based on ex vivo drug sensitivity testing and multi-omics profiling von Malani, Disha, Kumar, Ashwini, Yadav, Bhagwan, Kontro, Mika, Potdar, Swapnil, Brück, Oscar, Kytölä, Sari, Saarela, Jani, Eldfors, Samuli, Ojamies, Poojitha, Riikka, Karjalainen, Majumder, Muntasir Mamun, Västrik, Imre, Ellonen, Pekka, Kankainen, Matti, Suvela, Minna, Knappila, Siv, Parson, Alun, Palva, Aino, Mattila, Pirkko, Kulesskiy1, Evgeny, Turunen, Laura, Laamanen, Karoliina, Lehtinen, Elina, Mikkonen, Piia, Nurmi, Maria, Timonen, Sanna, Murumägi, Astrid, Gjersten, Bjorn Tore, Mustjoki, Satu, Aittokallio, Tero, Wennerberg, Krister, Anders, Simon, Wolf, Maija, Heckman, Caroline, Porkka, Kimmo, Kallioniemi, Olli

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Multiparametric Homogeneous Method for Identification of Ligand Binding to G Protein-Coupled Receptors: Receptor-Ligand Binding and [Beta]-Arrestin Assay von Kopra, Kari, Kainulainen, Markus, Mikkonen, Piia, Rozwandowicz-Jansen, Anita, Hänninen, Pekka, Härmä, Harri

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