Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism von Prusiner, Stanley B., Woerman, Amanda L., Mordes, Daniel A., Watts, Joel C., Rampersaud, Ryan, Berry, David B., Patel, Smita, Oehler, Abby, Lowe, Jennifer K., Kravitz, Stephanie N., Geschwind, Daniel H., Glidden, David V., Halliday, Glenda M., Middleton, Lefkos T., Gentleman, Steve M., Grinberg, Lea T., Giles, Kurt

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Why has therapy development for dementia failed in the last two decades? von Gauthier, Serge, Albert, Marilyn, Fox, Nick, Goedert, Michel, Kivipelto, Miia, Mestre-Ferrandiz, Jorge, Middleton, Lefkos T

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Diabetes mellitus, prediabetes and the risk of Parkinson’s disease: a systematic review and meta-analysis of 15 cohort studies with 29.9 million participants and 86,345 cases von Aune, Dagfinn, Schlesinger, Sabrina, Mahamat-Saleh, Yahya, Zheng, Bang, Udeh-Momoh, Chinedu T., Middleton, Lefkos T.

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Propagation of prions causing synucleinopathies in cultured cells von Woerman, Amanda L., Stöhr, Jan, Aoyagi, Atsushi, Rampersaud, Ryan, Krejciova, Zuzana, Watts, Joel C., Ohyama, Takao, Patel, Smita, Widjaja, Kartika, Oehler, Abby, Sanders, David W., Diamond, Marc I., Seeley, William W., Middleton, Lefkos T., Gentleman, Steve M., Mordes, Daniel A., Südhof, Thomas C., Giles, Kurt, Prusiner, Stanley B.

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Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCAA53T) mouse lines von Woerman, Amanda L., Oehler, Abby, Kazmi, Sabeen A., Lee, Jisoo, Halliday, Glenda M., Middleton, Lefkos T., Gentleman, Steve M., Mordes, Daniel A., Spina, Salvatore, Grinberg, Lea T., Olson, Steven H., Prusiner, Stanley B.

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The impacts of social restrictions during the COVID-19 pandemic on the physical activity levels of over 50-year olds: The CHARIOT COVID-19 Rapid Response (CCRR) cohort study von Green, Conall, Beaney, Thomas, Salman, David, Robb, Catherine, de Jager Loots, Celeste A, Giannakopoulou, Parthenia, Udeh-Momoh, Chi, Ahmadi-Abhari, Sara, Majeed, Azeem, Middleton, Lefkos T, McGregor, Alison H

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A genome-wide investigation of SNPs and CNVs in schizophrenia von Need, Anna C, Ge, Dongliang, Weale, Michael E, Maia, Jessica, Feng, Sheng, Heinzen, Erin L, Shianna, Kevin V, Yoon, Woohyun, Kasperaviciūte, Dalia, Gennarelli, Massimo, Strittmatter, Warren J, Bonvicini, Cristian, Rossi, Giuseppe, Jayathilake, Karu, Cola, Philip A, McEvoy, Joseph P, Keefe, Richard S E, Fisher, Elizabeth M C, St Jean, Pamela L, Giegling, Ina, Hartmann, Annette M, Möller, Hans-Jürgen, Ruppert, Andreas, Fraser, Gillian, Crombie, Caroline, Middleton, Lefkos T, St Clair, David, Roses, Allen D, Muglia, Pierandrea, Francks, Clyde, Rujescu, Dan, Meltzer, Herbert Y, Goldstein, David B

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Impact of social restrictions during the COVID-19 pandemic on the physical activity levels of adults aged 50–92 years: a baseline survey of the CHARIOT COVID-19 Rapid Response pros... von Salman, David, Beaney, Thomas, E Robb, Catherine, de Jager Loots, Celeste A, Giannakopoulou, Parthenia, Udeh-Momoh, Chinedu T, Ahmadi-Abhari, Sara, Majeed, Azeem, Middleton, Lefkos T, McGregor, Alison H

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Novel PET Biomarkers to Disentangle Molecular Pathways across Age-Related Neurodegenerative Diseases von Wilson, Heather, Politis, Marios, Rabiner, Eugenii A, Middleton, Lefkos T

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Development of the CHARIOT Research Register for the Prevention of Alzheimer's Dementia and Other Late Onset Neurodegenerative Diseases von Larsen, Mark E, Curry, Lisa, Mastellos, Nikolaos, Robb, Catherine, Car, Josip, Middleton, Lefkos T

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LRRK2 Gly2019Ser penetrance in Arab–Berber patients from Tunisia: a case-control genetic study von Hulihan, Mary M, MPH, Ishihara-Paul, Lianna, PhD, Kachergus, Jennifer, BSc, Warren, Liling, PhD, Amouri, Rim, PhD, Elango, Ramu, PhD, Prinjha, Rab K, PhD, Upmanyu, Ruchi, MSc, Kefi, Mounir, MD, Zouari, Mourad, MD, Sassi, Samia Ben, MD, Yahmed, Samia Ben, MD, El Euch-Fayeche, Ghada, MD, Matthews, Paul M, PhD, Middleton, Lefkos T, MD, Gibson, Rachel A, PhD, Hentati, Fayçal, MD, Farrer, Matthew J, PhD

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Practice Effect of Repeated Cognitive Tests Among Older Adults: Associations With Brain Amyloid Pathology and Other Influencing Factors von Zheng, Bang, Udeh-Momoh, Chinedu, Watermeyer, Tamlyn, de Jager Loots, Celeste A., Ford, Jamie K., Robb, Catherine E., Giannakopoulou, Parthenia, Ahmadi-Abhari, Sara, Baker, Susan, Novak, Gerald P., Price, Geraint, Middleton, Lefkos T.

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Glycyl tRNA Synthetase Mutations in Charcot-Marie-Tooth Disease Type 2D and Distal Spinal Muscular Atrophy Type V von Antonellis, Anthony, Ellsworth, Rachel E., Sambuughin, Nyamkhishig, Puls, Imke, Abel, Annette, Lee-Lin, Shih-Queen, Jordanova, Albena, Kremensky, Ivo, Christodoulou, Kyproula, Middleton, Lefkos T., Sivakumar, Kumaraswamy, Ionasescu, Victor, Funalot, Benoit, Vance, Jeffery M., Goldfarb, Lev G., Fischbeck, Kenneth H., Green, Eric D.

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Systematic evaluation of the associations between environmental risk factors and dementia: An umbrella review of systematic reviews and meta-analyses von Bellou, Vanesa, Belbasis, Lazaros, Tzoulaki, Ioanna, Middleton, Lefkos T, Ioannidis, John P.A, Evangelou, Evangelos

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Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease von van der Walt, Joelle M., Nicodemus, Kristin K., Martin, Eden R., Scott, William K., Nance, Martha A., Watts, Ray L., Hubble, Jean P., Haines, Jonathan L., Koller, William C., Lyons, Kelly, Pahwa, Rajesh, Stern, Matthew B., Colcher, Amy, Hiner, Bradley C., Jankovic, Joseph, Ondo, William G., Allen Jr, Fred H., Goetz, Christopher G., Small, Gary W., Mastaglia, Frank, Stajich, Jeffrey M., McLaurin, Adam C., Middleton, Lefkos T., Scott, Burton L., Schmechel, Donald E., Pericak-Vance, Margaret A., Vance, Jeffery M.

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Transition from physical to virtual visit format for a longitudinal brain aging study, in response to the Covid‐19 pandemic. Operationalizing adaptive methods and challenges von Udeh‐Momoh, Chinedu Theresa, Jager‐Loots, Celeste A., Price, Geraint, Middleton, Lefkos T.

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Health, Lifestyle, and Psycho-Social Determinants of Poor Sleep Quality During the Early Phase of the COVID-19 Pandemic: A Focus on UK Older Adults Deemed Clinically Extremely Vuln... von Udeh-Momoh, Chinedu T, Watermeyer, Tamlyn, Sindi, Shireen, Giannakopoulou, Parthenia, Robb, Catherine E, Ahmadi-Abhari, Sara, Zheng, Bang, Waheed, Amina, McKeand, James, Salman, David, Beaney, Thomas, de Jager Loots, Celeste A, Price, Geraint, Atchison, Christina, Car, Josip, Majeed, Azeem, McGregor, Alison H, Kivipelto, Miia, Ward, Helen, Middleton, Lefkos T

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α-Synuclein: Multiple System Atrophy Prions von Woerman, Amanda L, Watts, Joel C, Aoyagi, Atsushi, Giles, Kurt, Middleton, Lefkos T, Prusiner, Stanley B

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Mitochondrial Complex 1, Sigma 1, and Synaptic Vesicle 2A in Early Drug‐Naive Parkinson's Disease von Wilson, Heather, Pagano, Gennaro, Natale, Edoardo Rosario, Mansur, Ayla, Caminiti, Silvia Paola, Polychronis, Sotirios, Middleton, Lefkos T., Price, Geraint, Schmidt, Karl F., Gunn, Roger N., Rabiner, Eugenii A., Politis, Marios

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MSA prions exhibit remarkable stability and resistance to inactivation von Woerman, Amanda L., Kazmi, Sabeen A., Patel, Smita, Freyman, Yevgeniy, Oehler, Abby, Aoyagi, Atsushi, Mordes, Daniel A., Halliday, Glenda M., Middleton, Lefkos T., Gentleman, Steve M., Olson, Steven H., Prusiner, Stanley B.

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