The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K von Gauthier, Jacques Yves, Chauret, Nathalie, Cromlish, Wanda, Desmarais, Sylvie, Duong, Le T., Falgueyret, Jean-Pierre, Kimmel, Donald B., Lamontagne, Sonia, Léger, Serge, LeRiche, Tammy, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Nicoll-Griffith, Deborah A., Oballa, Renata M., Palmer, James T., Percival, M. David, Riendeau, Denis, Robichaud, Joel, Rodan, Gideon A., Rodan, Sevgi B., Seto, Carmai, Thérien, Michel, Truong, Vouy-Linh, Venuti, Michael C., Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Black, W. Cameron

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identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y von Gauthier, Jacques Yves, Belley, Michel, Deschênes, Denis, Fournier, Jean-François, Gagné, Sébastien, Gareau, Yves, Hamel, Martine, Hénault, Martin, Hyjazie, Huda, Kargman, Stacia, Lavallée, Geneviève, Levesque, Jean-François, Li, Lianhai, Mamane, Yaël, Mancini, Joseph, Morin, Nicolas, Mulrooney, Erin, Robichaud, Joël, Thérien, Michel, Tranmer, Geoffrey, Wang, Zhaoyin, Wu, Jin, Black, W. Cameron

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Identification of a Nonbasic, Nitrile-Containing Cathepsin K Inhibitor (MK-1256) that is Efficacious in a Monkey Model of Osteoporosis von Robichaud, Jöel, Black, W. Cameron, Thérien, Michel, Paquet, Julie, Oballa, Renata M, Bayly, Christopher I, McKay, Daniel J, Wang, Qingping, Isabel, Elise, Léger, Serge, Mellon, Christophe, Kimmel, Donald B, Wesolowski, Gregg, Percival, M. David, Massé, Fréderic, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Crane, Sheldon N

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Conformation-assisted Inhibition of Protein-tyrosine Phosphatase-1B Elicits Inhibitor Selectivity over T-cell Protein-tyrosine Phosphatase von Asante-Appiah, Ernest, Patel, Sangita, Desponts, Caroline, Taylor, Jillian M., Lau, Cheuk, Dufresne, Claude, Therien, Michel, Friesen, Rick, Becker, Joseph W., Leblanc, Yves, Kennedy, Brian P., Scapin, Giovanna

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Difluoroethylamines as an amide isostere in inhibitors of cathepsin K von Isabel, Elise, Mellon, Christophe, Boyd, Michael J., Chauret, Nathalie, Deschênes, Denis, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Khougaz, Karine, Lau, Cheuk K., Léger, Serge, Levorse, Dorothy A., Li, Chun Sing, Massé, Frédéric, David Percival, M., Roy, Bruno, Scheigetz, John, Thérien, Michel, Truong, Vouy Linh, Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Cameron Black, W.

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The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor von Isabel, Elise, Bateman, Kevin P., Chauret, Nathalie, Cromlish, Wanda, Desmarais, Sylvie, Duong, Le T., Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Lamontagne, Sonia, Lau, Cheuk K., Léger, Serge, LeRiche, Tammy, Lévesque, Jean-François, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Mellon, Christophe, Nicoll-Griffith, Deborah A., Oballa, Renata M., Percival, M. David, Riendeau, Denis, Robichaud, Joël, Rodan, Gideon A., Rodan, Sevgi B., Seto, Carmai, Thérien, Michel, Truong, Vouy Linh, Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Black, W. Cameron

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Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein von Macdonald, Dwight, Brideau, Christine, Chan, Chi Chung, Falgueyret, Jean-Pierre, Frenette, Richard, Guay, Jocelyne, Hutchinson, John H., Perrier, Hélène, Prasit, Peptiboon, Riendeau, Denis, Tagari, Philip, Thérien, Michel, Young, Robert N., Girard, Yves

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The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14 von YVES GAUTHIER, Jacques, BELLEY, Michel, LAVALLEE, Geneviève, LEVESQUE, Jean-François, LIANHAI LI, MAMANE, Yael, MANCINI, Joseph, MORIN, Nicolas, MULROONEY, Erin, ROBICHAUD, Joel, THERIEN, Michel, TRANMER, Geoffrey, DESCHENES, Denis, ZHAOYIN WANG, JIN WU, BLACK, W. Cameron, FOURNIER, Jean-François, GAGNE, Sébastien, GAREAU, Yves, HAMEL, Martine, HENAULT, Martin, HYJAZIE, Huda, KARGMAN, Stacia

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Identification of a potent and selective non-basic cathepsin K inhibitor von Li, Chun Sing, Deschenes, Denis, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Kimmel, Donald. B., Léger, Serge, Massé, Frédéric, McGrath, Mary E., McKay, Daniel J., Percival, M. David, Riendeau, Denis, Rodan, Sevgi B., Thérien, Michel, Truong, Vouy-Linh, Wesolowski, Gregg, Zamboni, Robert, Black, W. Cameron

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Regulation of cardiac nitric oxide signaling by nuclear β-adrenergic and endothelin receptors von Vaniotis, George, Glazkova, Irina, Merlen, Clémence, Smith, Carter, Villeneuve, Louis R, Chatenet, David, Therien, Michel, Fournier, Alain, Tadevosyan, Artavazd, Trieu, Phan, Nattel, Stanley, Hébert, Terence E, Allen, Bruce G

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Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y₁₄ receptor antagonists von Guay, Daniel, Beaulieu, Christian, Belley, Michel, Crane, Sheldon N, DeLuca, Jeancarlo, Gareau, Yves, Hamel, Martine, Henault, Martin, Hyjazie, Huda, Kargman, Stacia, Chan, Chi Chung, Xu, Lijing, Gordon, Robert, Li, Lianhai, Mamane, Yael, Morin, Nicolas, Mancini, Joseph, Thérien, Michel, Tranmer, Geoffrey, Truong, Vouy Linh, Wang, Zhaoyin, Black, W. Cameron

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Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme von THERIEN, Michel, SKOREY, Kathryn, ZAMBONI, Robert, CHUN SING LI, LAU, Cheuk K, LERICHE, Tammy, VOUY LINH TRUONG, WADDLETON, Deena, RAMACHANDRAN, Chidambaram

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Pyridazinones as selective cyclooxygenase-2 inhibitors von Li, Chun Sing, Brideau, Christine, Chan, Chi Chung, Savoie, Chantal, Claveau, David, Charleson, Stella, Gordon, Robert, Greig, Gillian, Gauthier, Jacques Yves, Lau, Cheuk K, Riendeau, Denis, Thérien, Michel, Wong, Elizabeth, Prasit, Petpiboon

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Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor von Han, Yongxin, Belley, Michel, Bayly, Christopher I., Colucci, John, Dufresne, Claude, Giroux, Andre, Lau, Cheuk K., Leblanc, Yves, McKay, Daniel, Therien, Michel, Wilson, Marie-Claire, Skorey, Kathryn, Chan, Chi-Chung, Scapin, Giovana, Kennedy, Brian P.

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The Structural Basis for the Selectivity of Benzotriazole Inhibitors of PTP1B von Scapin, Giovanna, Patel, Sangita B, Becker, Joseph W, Wang, Qingping, Desponts, Caroline, Waddleton, Deena, Skorey, Kathryn, Cromlish, Wanda, Bayly, Christopher, Therien, Michel, Gauthier, Jacques Yves, Li, Chun Sing, Lau, Cheuk K, Ramachandran, Chidambaram, Kennedy, Brian P, Asante-Appiah, Ernest

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Regiocontrolled opening of cyclic ethers using dimethylboron bromide von Guindon, Yvan, Therien, Michel, Girard, Yves, Yoakim, Christiane

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Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors von LOU, Cheuk K, BAYLY, Christopher I, QINGPING WANG, SKOREY, Kathryn, WADDLETON, Deena, PAYETTE, Paul, RAMACHANDRAN, Chidambaram, KENNEDY, Brian P, SCAPIN, Giovana, GAUTHIER, Jacques Yves, CHUN SING LI, THERIEN, Michel, ASANTE-APPIAH, Ernest, CROMLISH, Wanda, BOIE, Yves, FORGHANI, Farnaz, DESMARAIS, Sylvie

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Enzyme occupancy measurement of intracellular protein tyrosine phosphatase 1B using photoaffinity probes von Skorey, Kathryn, Waddleton, Deena, Therien, Michel, Leriche, Tammy

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3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility von Black, W.Cameron, Brideau, Christine, Chan, Chi-Chung, Charleson, Stella, Cromlish, Wanda, Gordon, Robert, Grimm, Erich L., Hughes, Gregory, Leger, Serge, Li, Chun-Sing, Riendeau, Denis, Thérien, Michel, Wang, Zhaoyin, Xu, Li-Jing, Prasit, Petpiboon

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The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y sub(14) von Gauthier, Jacques Yves, Belley, Michel, Deschenes, Denis, Fournier, Jean-Francois, Gagne, Sebastien, Gareau, Yves, Hamel, Martine, Henault, Martin, Hyjazie, Huda, Kargman, Stacia, Lavallee, Genevieve, Levesque, Jean-Francois, Li, Lianhai, Mamane, Yael, Mancini, Joseph, Morin, Nicolas, Mulrooney, Erin, Robichaud, Joel, Therien, Michel, Tranmer, Geoffrey, Wang, Zhaoyin, Wu, Jin, Black, WCameron

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