Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma von Chapuy, Bjoern, McKeown, Michael R., Lin, Charles Y., Monti, Stefano, Roemer, Margaretha G.M., Qi, Jun, Rahl, Peter B., Sun, Heather H., Yeda, Kelly T., Doench, John G., Reichert, Elaine, Kung, Andrew L., Rodig, Scott J., Young, Richard A., Shipp, Margaret A., Bradner, James E.

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Small-Molecule Inhibition of BRDT for Male Contraception von Matzuk, Martin M., McKeown, Michael R., Filippakopoulos, Panagis, Li, Qinglei, Ma, Lang, Agno, Julio E., Lemieux, Madeleine E., Picaud, Sarah, Yu, Richard N., Qi, Jun, Knapp, Stefan, Bradner, James E.

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BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc von Delmore, Jake E., Issa, Ghayas C., Lemieux, Madeleine E., Rahl, Peter B., Shi, Junwei, Jacobs, Hannah M., Kastritis, Efstathios, Gilpatrick, Timothy, Paranal, Ronald M., Qi, Jun, Chesi, Marta, Schinzel, Anna C., McKeown, Michael R., Heffernan, Timothy P., Vakoc, Christopher R., Bergsagel, P. Leif, Ghobrial, Irene M., Richardson, Paul G., Young, Richard A., Hahn, William C., Anderson, Kenneth C., Kung, Andrew L., Bradner, James E., Mitsiades, Constantine S.

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Improving the photostability of bright monomeric orange and red fluorescent proteins von Shaner, Nathan C, Lin, Michael Z, McKeown, Michael R, Steinbach, Paul A, Hazelwood, Kristin L, Davidson, Michael W, Tsien, Roger Y

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Antitumor synergy with SY-1425, a selective RARα agonist, and hypomethylating agents in retinoic acid receptor pathway activated models of acute myeloid leukemia von McKeown, Michael R, Johannessen, Liv, Lee, Emily, Fiore, Christopher, di Tomaso, Emmanuelle

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Therapeutic strategies to inhibit MYC von McKeown, Michael R, Bradner, James E

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Improving FRET dynamic range with bright green and red fluorescent proteins von Lam, Amy J, St-Pierre, François, Gong, Yiyang, Marshall, Jesse D, Cranfill, Paula J, Baird, Michelle A, McKeown, Michael R, Wiedenmann, Jörg, Davidson, Michael W, Schnitzer, Mark J, Tsien, Roger Y, Lin, Michael Z

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Selective inhibition of BET bromodomains von Filippakopoulos, Panagis, Qi, Jun, Picaud, Sarah, Shen, Yao, Smith, William B., Fedorov, Oleg, Morse, Elizabeth M., Keates, Tracey, Hickman, Tyler T., Felletar, Ildiko, Philpott, Martin, Munro, Shonagh, McKeown, Michael R., Wang, Yuchuan, Christie, Amanda L., West, Nathan, Cameron, Michael J., Schwartz, Brian, Heightman, Tom D., La Thangue, Nicholas, French, Christopher A., Wiest, Olaf, Kung, Andrew L., Knapp, Stefan, Bradner, James E.

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Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist von McKeown, Michael R, Corces, M Ryan, Eaton, Matthew L, Fiore, Chris, Lee, Emily, Lopez, Jeremy T, Chen, Mei Wei, Smith, Darren, Chan, Steven M, Koenig, Julie L, Austgen, Kathryn, Guenther, Matthew G, Orlando, David A, Lovén, Jakob, Fritz, Christian C, Majeti, Ravindra

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Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers von Freeman, David B., Hopkins, Tamara D., Mikochik, Peter J., Vacca, Joseph P., Gao, Hua, Naylor-Olsen, Adel, Rudra, Sonali, Li, Huixu, Pop, Marius S., Villagomez, Rosa A., Lee, Christina, Li, Heng, Zhou, Minyun, Saffran, Douglas C., Rioux, Nathalie, Hood, Tressa R., Day, Melinda A. L., McKeown, Michael R., Lin, Charles Y., Bischofberger, Norbert, Trotter, B. Wesley

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Biased Multicomponent Reactions to Develop Novel Bromodomain Inhibitors von McKeown, Michael R, Shaw, Daniel L, Fu, Harry, Liu, Shuai, Xu, Xiang, Marineau, Jason J, Huang, Yibo, Zhang, Xiaofeng, Buckley, Dennis L, Kadam, Asha, Zhang, Zijuan, Blacklow, Stephen C, Qi, Jun, Zhang, Wei, Bradner, James E

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Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains von Wang, Jinhua, Erazo, Tatiana, Ferguson, Fleur M, Buckley, Dennis L, Gomez, Nestor, Muñoz-Guardiola, Pau, Diéguez-Martínez, Nora, Deng, Xianming, Hao, Mingfeng, Massefski, Walter, Fedorov, Oleg, Offei-Addo, Nana Kwaku, Park, Paul M, Dai, Lingling, DiBona, Amy, Becht, Kelly, Kim, Nam Doo, McKeown, Michael R, Roberts, Justin M, Zhang, Jinwei, Sim, Taebo, Alessi, Dario R, Bradner, James E, Lizcano, Jose M, Blacklow, Stephen C, Qi, Jun, Xu, Xiang, Gray, Nathanael S

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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma von Chapuy, Bjoern, McKeown, Michael R., Lin, Charles Y., Monti, Stefano, Roemer, Margaretha G.M., Qi, Jun, Rahl, Peter B., Sun, Heather H., Yeda, Kelly T., Doench, John G., Reichert, Elaine, Kung, Andrew L., Rodig, Scott J., Young, Richard A., Shipp, Margaret A., Bradner, James E.

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The Combination of Lanraplenib, a Selective SYK Inhibitor, and Gilteritinib, a FLT3 Inhibitor, Targets Aberrant Proliferation and Differentiation Blockade in Acute Myeloid Leukemia von Carvajal, Luis A., McKeown, Michael R., Hood, Tressa, Guo, Linlin, Lin, Charles Y., DiMartino, Jorge F.

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The Novel Profiling Relative Inhibition Simultaneously in Mixtures (PRISM) Platform Identifies Synergistic Activity of Lanraplenib and Ruxolitinib in Hematological Malignancies von Pandey, Akanksha, Carvajal, Luis A., Boghossian, Andrew S, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Hood, Tressa, Guo, Linlin, Hopkins, Tamara D, Obholzer, Nikolaus, McKeown, Michael R., DiMartino, Jorge F., Lin, Charles Y.

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Abstract 3085: SY-1425 (tamibarotene), a selective RARα agonist, shows synergistic anti-tumor activity with hypomethylating agents in a biomarker selected subset of AML von McKeown, Michael R., Lee, Emily, Fiore, Chris, Eaton, Matthew L., Fritz, Christian C., Olson, Eric

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Autofluorescent Proteins with Excitation in the Optical Window for Intravital Imaging in Mammals von Lin, Michael Z., McKeown, Michael R., Ng, Ho-Leung, Aguilera, Todd A., Shaner, Nathan C., Campbell, Robert E., Adams, Stephen R., Gross, Larry A., Ma, Wendy, Alber, Tom, Tsien, Roger Y.

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Clinical Pharmacodynamic Markers and Combinations with SY1425 (tamibarotene) in a Genomically-Defined Subset of Non-APL AML von McKeown, Michael R, Fiore, Christopher, Lee, Emily, Eaton, Matthew L, Fritz, Christian C.

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SY1425 (tamibarotene) Induces Profound Transcriptional Changes in AML Tumors with High Retinoic Acid Receptor Alpha von Fiore, Christopher, McKeown, Michael R, Lee, Emily, Eaton, Matthew L, Fritz, Christian C.

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OA-32 p300 Catalytic Inhibition Selectively Disrupts IRF4 Oncogenic Programs Impacting Multiple Myeloma Cell Growth and Survival von McKeown, Michael R., Giorgetti, Giulia, Lenoir, Walter F., Kobylarz, Marek, Hopkins, Tamara, Glore, Wayne, Shum, Michelle G., Martín, Elena Maroto, Wen, Kenneth, Farrukh, Hizra, Mori, Kameron R., Gao, Hua, Carvajal, Luis A., Obholzer, Nikolaus, Trotter, Benjamin, Dinsmore, Christopher, Munshi, Nikhil, Rahl, Peter, Lin, Charles, Fulciniti, Mariateresa

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