Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus von Lam, Angela M, Espiritu, Christine, Bansal, Shalini, Micolochick Steuer, Holly M, Niu, Congrong, Zennou, Veronique, Keilman, Meg, Zhu, Yuao, Lan, Shuiyun, Otto, Michael J, Furman, Phillip A

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Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977 von Murakami, Eisuke, Tolstykh, Tatiana, Bao, Haiying, Niu, Congrong, Steuer, Holly M. Micolochick, Bao, Donghui, Chang, Wonsuk, Espiritu, Christine, Bansal, Shalini, Lam, Angela M., Otto, Michael J., Sofia, Michael J., Furman, Phillip A.

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Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA von MOSLEY, Ralph T, EDWARDS, Thomas E, MURAKAMI, Eisuke, LAM, Angela M, GRICE, Rena L, JINFA DU, SOFIA, Michael J, FURMAN, Philip A, OTTO, Michael J

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PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication von LAM, Angela M, MURAKAMI, Eisuke, MORREY, John D, SMEE, Donald F, FRICK, David N, HECK, Julie A, PEIYUAN WANG, NAGARATHNAM, Dhanapalan, ROSS, Bruce S, SOFIA, Michael J, OTTO, Michael J, FURMAN, Phillip A, ESPIRITU, Christine, MICOLOCHICK STEUER, Holly M, NIU, Congrong, KEILMAN, Meg, HAIYING BAO, ZENNOU, Veronique, BOURNE, Nigel, JULANDER, Justin G

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The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Po... von Murakami, Eisuke, Niu, Congrong, Bao, Haiying, Micolochick Steuer, Holly M, Whitaker, Tony, Nachman, Tammy, Sofia, Michael A, Wang, Peiyuan, Otto, Michael J, Furman, Phillip A

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Design, Synthesis, and Antiviral Activity of 2‘-Deoxy-2‘-fluoro-2‘-C-methylcytidine, a Potent Inhibitor of Hepatitis C Virus Replication von Clark, Jeremy L, Hollecker, Laurent, Mason, J. Christian, Stuyver, Lieven J, Tharnish, Phillip M, Lostia, Stefania, McBrayer, Tamara R, Schinazi, Raymond F, Watanabe, Kyoichi A, Otto, Michael J, Furman, Phillip A, Stec, Wojciech J, Patterson, Steven E, Pankiewicz, Krzysztof W

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Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA von LAM, Angela M, ESPIRITU, Christine, BANSAL, Shalini, MICOLOCHICK STEUER, Holly M, ZENNOU, Veronique, OTTO, Michael J, FURMAN, Phillip A

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Cytostatic 6-Arylpurine Nucleosides. 6. † SAR in Anti-HCV and Cytostatic Activity of Extended Series of 6-Hetarylpurine Ribonucleosides von Hocek, Michal, Nauš, Petr, Pohl, Radek, Votruba, Ivan, Furman, Phillip A, Tharnish, Phillip M, Otto, Michael J

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Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance von Lam, Angela M, Edwards, Thomas E, Mosley, Ralph T, Murakami, Eisuke, Bansal, Shalini, Lugo, Christopher, Bao, Haiying, Otto, Michael J, Sofia, Michael J, Furman, Phillip A

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Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus von Sofia, Michael J, Bao, Donghui, Chang, Wonsuk, Du, Jinfa, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Reddy, P. Ganapati, Ross, Bruce S, Wang, Peiyuan, Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine, Keilman, Meg, Lam, Angela M, Steuer, Holly M. Micolochick, Niu, Congrong, Otto, Michael J, Furman, Phillip A

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Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine von LAM, Angela M, ESPIRITU, Christine, VESELENAK, Ronald L, GANAPATI REDDY, P, CHANG, Wonsuk, JINFA DU, NAGARATHNAM, Dhanapalan, SOFIA, Michael J, OTTO, Michael J, FURMAN, Phillip A, MURAKAMI, Eisuke, ZENNOU, Veronique, BANSAL, Shalini, MICOLOCHICK STEUER, Holly M, CONGRONG NIU, KEILMAN, Meg, HAIYING BAO, BOURNE, Nigel

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Mechanism of Activation of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase von MURAKAMI, Eisuke, HAIYING BAO, FURMAN, Phillip A, RAMESH, Mangala, MCBRAYER, Tamara R, WHITAKER, Tony, MICOLOCHICK STEUER, Holly M, SCHINAZI, Raymond F, STUYVER, Lieven J, OBIKHOD, Aleksandr, OTTO, Michael J

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Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture von STUYVER, Lieven J, WHITAKER, Tony, RACHAKONDA, Suguna, WATANABE, Kyoichi A, OTTO, Michael J, SCHINAZI, Raymond F, MCBRAYER, Tamara R, HERNANDEZ-SANTIAGO, Brenda I, LOSTIA, Stefania, THARNISH, Phillip M, RAMESH, Mangala, CHU, Chung K, JORDAN, Robert, JUNXING SHI

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Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938 von CONGRONG NIU, TOLSTYKH, Tatiana, ZHANG, Hai-Ren, WOOLLY, Joseph, WANG, Li-Quan, CHAO, Piyun B, RAY, Adrian S, OTTO, Michael J, SOFIA, Michael J, FURMAN, Phillip A, MURAKAMI, Eisuke, HAIYING BAO, PARK, Yeojin, BABUSIS, Darius, LAM, Angela M, BANSAL, Shalini, JINFA DU, CHANG, Wonsuk, GANAPATI REDDY, P

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Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection von Chang, Wonsuk, Bao, Donghui, Chun, Byoung-Kwon, Naduthambi, Devan, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Reddy, P. Ganapati, Ross, Bruce S, Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine L, Keilman, Meg, Lam, Angela M, Niu, Congrong, Steuer, Holly Micolochick, Furman, Phillip A, Otto, Michael J, Sofia, Michael J

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Antiviral Activities and Cellular Toxicities of Modified 2′,3′-Dideoxy-2′,3′-Didehydrocytidine Analogues von STUYVER, Lieven J, LOSTIA, Stefania, CHU, Chung K, OTTO, Michael J, SCHINAZI, Raymond F, ADAMS, Marjorie, MATHEW, Judy S, PAI, Balakrishna S, GRIER, Jason, THARNISH, Phillip M, YONGSEOK CHOI, YOUHOON CHONG, HYUNAH CHOO

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Synthesis and antiviral activity of 2′-deoxy-2′-fluoro-2′-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication von Clark, Jeremy L., Mason, J. Christian, Hollecker, Laurent, Stuyver, Lieven J., Tharnish, Phillip M., McBrayer, Tamara R., Otto, Michael J., Furman, Phillip A., Schinazi, Raymond F., Watanabe, Kyoichi A.

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Synthesis and anti-HCV activity of 3′,4′-oxetane nucleosides von Chang, Wonsuk, Du, Jinfa, Rachakonda, Suguna, Ross, Bruce S., Convers-Reignier, Serge, Yau, Wei T., Pons, Jean-Francois, Murakami, Eisuke, Bao, Haiying, Steuer, Holly Micolochick, Furman, Phillip A., Otto, Michael J., Sofia, Michael J.

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Inhibition of the Subgenomic Hepatitis C Virus Replicon in Huh-7 Cells by 2′-Deoxy-2′-Fluorocytidine von Stuyver, Lieven J, McBrayer, Tamara R, Whitaker, Tony, Tharnish, Phillip M, Ramesh, Mangala, Lostia, Stefania, Cartee, Leanne, Shi, Junxing, Hobbs, Ann, Schinazi, Raymond F, Watanabe, Kyoichi A, Otto, Michael J

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Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics von Chang, Wonsuk, Mosley, Ralph T., Bansal, Shalini, Keilman, Meg, Lam, Angela M., Furman, Phillip A., Otto, Michael J., Sofia, Michael J.

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