Allosteric MAPKAPK2 inhibitors improve plaque stability in advanced atherosclerosis von Ozcan, Lale, Kasikara, Canan, Yurdagul, Jr, Arif, Kuriakose, George, Hubbard, Brian, Serrano-Wu, Michael H, Tabas, Ira

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Identification of Hepatitis C Virus NS5A Inhibitors von LEMM, Julie A, O'BOYLE, Donald, ROMINE, Jeffrey L, MEANWELL, Nicholas A, MIN GAO, MENGPING LIU, NOWER, Peter T, COLONNO, Richard, DESHPANDE, Milind S, SNYDER, Lawrence B, MARTIN, Scott W, LAURENT, Denis R. St, SERRANO-WU, Michael H

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High-Throughput Melanin-Binding Affinity and In Silico Methods to Aid in the Prediction of Drug Exposure in Ocular Tissue von Reilly, John, Williams, Sarah L., Forster, Cornelia J., Kansara, Viral, End, Peter, Serrano-Wu, Michael H.

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A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1 von Clifton, Matthew C, Dranow, David M, Leed, Alison, Fulroth, Ben, Fairman, James W, Abendroth, Jan, Atkins, Kateri A, Wallace, Ellen, Fan, Dazhong, Xu, Guoping, Ni, Z J, Daniels, Doug, Van Drie, John, Wei, Guo, Burgin, Alex B, Golub, Todd R, Hubbard, Brian K, Serrano-Wu, Michael H

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Large-scale chemical–genetics yields new M. tuberculosis inhibitor classes von Johnson, Eachan O., LaVerriere, Emily, Office, Emma, Stanley, Mary, Meyer, Elisabeth, Kawate, Tomohiko, Gomez, James E., Audette, Rebecca E., Bandyopadhyay, Nirmalya, Betancourt, Natalia, Delano, Kayla, Da Silva, Israel, Davis, Joshua, Gallo, Christina, Gardner, Michelle, Golas, Aaron J., Guinn, Kristine M., Kennedy, Sofia, Korn, Rebecca, McConnell, Jennifer A., Moss, Caitlin E., Murphy, Kenan C., Nietupski, Raymond M., Papavinasasundaram, Kadamba G., Pinkham, Jessica T., Pino, Paula A., Proulx, Megan K., Ruecker, Nadine, Song, Naomi, Thompson, Matthew, Trujillo, Carolina, Wakabayashi, Shoko, Wallach, Joshua B., Watson, Christopher, Ioerger, Thomas R., Lander, Eric S., Hubbard, Brian K., Serrano-Wu, Michael H., Ehrt, Sabine, Fitzgerald, Michael, Rubin, Eric J., Sassetti, Christopher M., Schnappinger, Dirk, Hung, Deborah T.

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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect von Meanwell, Nicholas A, Gao, Min, Nettles, Richard E, Belema, Makonen, Snyder, Lawrence B, Nguyen, Van N, Fridell, Robert A, Serrano-Wu, Michael H, Langley, David R, Sun, Jin-Hua, O’Boyle II, Donald R, Lemm, Julie A, Wang, Chunfu, Knipe, Jay O, Chien, Caly, Colonno, Richard J, Grasela, Dennis M, Hamann, Lawrence G

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Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes von Romine, Jeffrey L, St. Laurent, Denis R, Leet, John E, Martin, Scott W, Serrano-Wu, Michael H, Yang, Fukang, Gao, Min, O’Boyle, Donald R, Lemm, Julie A, Sun, Jin-Hua, Nower, Peter T, Huang, Xiaohua (Stella), Deshpande, Milind S, Meanwell, Nicholas A, Snyder, Lawrence B

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Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane von Klobucar, Kristina, Côté, Jean-Philippe, French, Shawn, Borrillo, Louis, Guo, Amelia Bing Ya, Serrano-Wu, Michael H, Lee, Katie K, Hubbard, Brian, Johnson, Jarrod W, Gaulin, Jeffrey L, Magolan, Jakob, Hung, Deborah T, Brown, Eric D

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Discovery of Potent Hepatitis C Virus NS5A Inhibitors with Dimeric Structures von Lemm, Julie A, Leet, John E, O'Boyle, 2nd, Donald R, Romine, Jeffrey L, Huang, Xiaohua Stella, Schroeder, Daniel R, Alberts, Jeffrey, Cantone, Joseph L, Sun, Jin-Hua, Nower, Peter T, Martin, Scott W, Serrano-Wu, Michael H, Meanwell, Nicholas A, Snyder, Lawrence B, Gao, Min

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Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1) von Fang, Chao, D’Souza, Brendan, Thompson, Christopher F, Clifton, Matthew C, Fairman, James W, Fulroth, Ben, Leed, Alison, McCarren, Patrick, Wang, Lili, Wang, Yikai, Feau, Clementine, Kaushik, Virendar K, Palmer, Michelle, Wei, Guo, Golub, Todd R, Hubbard, Brian K, Serrano-Wu, Michael H

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Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity von Ozcan, Lale, Xu, Xiaoming, Deng, Shi-Xian, Ghorpade, Devram S, Thomas, Tiffany, Cremers, Serge, Hubbard, Brian, Serrano-Wu, Michael H, Gaestel, Matthias, Landry, Donald W, Tabas, Ira

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Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors von Fang, Chao, Lee, Katie K., Nietupski, Raymond, Bates, Robert H., Fernandez-Menendez, Raquel, Lopez-Roman, Eva Maria, Guijarro-Lopez, Laura, Yin, Yunxing, Peng, Zuozhong, Gomez, James E., Fisher, Stewart, Barros-Aguirre, David, Hubbard, Brian K., Serrano-Wu, Michael H., Hung, Deborah T.

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Evaluation of expanded 2-aminobenzothiazole library as inhibitors of a model histidine kinase and virulence suppressors in Pseudomonas aeruginosa von Fihn, Conrad A., Lembke, Hannah K., Gaulin, Jeffrey, Bouchard, Patricia, Villarreal, Alex R., Penningroth, Mitchell R., Crone, Kathryn K., Vogt, Grace A., Gilbertsen, Adam J., Ayotte, Yann, Coutinho de Oliveira, Luciana, Serrano-Wu, Michael H., Drouin, Nathalie, Hung, Deborah T., Hunter, Ryan C., Carlson, Erin E.

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Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Tr... von Nakajima, Katsumasa, Chatelain, Ricardo, Clairmont, Kevin B, Commerford, Renee, Coppola, Gary M, Daniels, Thomas, Forster, Cornelia J, Gilmore, Thomas A, Gong, Yongjin, Jain, Monish, Kanter, Aaron, Kwak, Youngshin, Li, Jingzhou, Meyers, Charles D, Neubert, Alan D, Szklennik, Paul, Tedesco, Vivienne, Thompson, James, Truong, David, Yang, Qing, Hubbard, Brian K, Serrano-Wu, Michael H

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Preclinical Development of Pentamidine Analogs Identifies a Potent and Nontoxic Antibiotic Adjuvant von MacNair, Craig R, Farha, Maya A, Serrano-Wu, Michael H, Lee, Katie K, Hubbard, Brian, Côté, Jean-Philippe, Carfrae, Lindsey A, Tu, Megan M, Gaulin, Jeffrey L, Hunt, Diana K, Hung, Deborah T, Brown, Eric D

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Discovery of diamide compounds as diacylglycerol acyltransferase 1 (DGAT1) inhibitors von Nakajima, Katsumasa, April, Myriam, Brewer, Jason T., Daniels, Thomas, Forster, Cornelia J., Gilmore, Thomas A., Jain, Monish, Kanter, Aaron, Kwak, Youngshin, Li, Jingzhou, McQuire, Les, Serrano-Wu, Michael H., Streeper, Ryan, Szklennik, Paul, Thompson, James, Wang, Bing

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HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies von Lopez, Omar D, Nguyen, Van N, St. Laurent, Denis R, Belema, Makonen, Serrano-Wu, Michael H, Goodrich, Jason T, Yang, Fukang, Qiu, Yuping, Ripka, Amy S, Nower, Peter T, Valera, Lourdes, Liu, Mengping, O’Boyle, Donald R., II, Sun, Jin-Hua, Fridell, Robert A, Lemm, Julie A, Gao, Min, Good, Andrew C, Meanwell, Nicholas A, Snyder, Lawrence B

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HCV NS5A replication complex inhibitors. Part 2: Investigation of stilbene prolinamides von St. Laurent, Denis R., Belema, Makonen, Gao, Min, Goodrich, Jason, Kakarla, Ramesh, Knipe, Jay O., Lemm, Julie A., Liu, Mengping, Lopez, Omar D., Nguyen, Van N., Nower, Peter T., O’Boyle, Donald, Qiu, Yuping, Romine, Jeffrey L., Serrano-Wu, Michael H., Sun, Jin-Hua, Valera, Lourdes, Yang, Fukang, Yang, Xuejie, Meanwell, Nicholas A., Snyder, Lawrence B.

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HCV NS5A Replication Complex Inhibitors. Part 4. Optimization for Genotype 1a Replicon Inhibitory Activity von St. Laurent, Denis R., Serrano-Wu, Michael H., Belema, Makonen, Ding, Min, Fang, Hua, Gao, Min, Goodrich, Jason T., Krause, Rudolph G., Lemm, Julie A., Liu, Mengping, Lopez, Omar D., Nguyen, Van N., Nower, Peter T., O’Boyle, Donald R., Pearce, Bradley C., Romine, Jeffrey L., Valera, Lourdes, Sun, Jin-Hua, Wang, Ying-Kai, Yang, Fukang, Yang, Xuejie, Meanwell, Nicholas A., Snyder, Lawrence B.

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Intestinally Targeted Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors Robustly Suppress Postprandial Triglycerides von Serrano-Wu, Michael H, Coppola, Gary M, Gong, Yongjin, Neubert, Alan D, Chatelain, Ricardo, Clairmont, Kevin B, Commerford, Renee, Cosker, Theresa, Daniels, Thomas, Hou, Ying, Jain, Monish, Juedes, Marlene, Li, Lisha, Mullarkey, Tara, Rocheford, Erik, Sung, Moo Je, Tyler, Andrew, Yang, Qing, Yoon, Taeyoung, Hubbard, Brian K

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