Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade von Bulawa, Christine E, Connelly, Stephen, DeVit, Michael, Wang, Lan, Weigel, Charlotte, Fleming, James A, Packman, Jeff, Powers, Evan T, Wiseman, R. Luke, Foss, Theodore R, Wilson, Ian A, Kelly, Jeffery W, Labaudinière, Richard

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Dolaflexin: A Novel Antibody-Drug Conjugate Platform Featuring High Drug Loading and a Controlled Bystander Effect von Yurkovetskiy, Aleksandr, Bodyak, Natalya D., Yin, Mao, Thomas, Joshua D., Clardy, Susan M., Conlon, Patrick R., Stevenson, Cheri A., Uttard, Alex, Qin, LiuLiang, Gumerov, Dmitry R., Ter-Ovanesyan, Elena, Bu, Charlie, Johnson, Alex J., Gurijala, Venu R., McGillicuddy, Dennis, DeVit, Michael J., Poling, Laura L., Protopopova, Marina, Xu, Ling, Zhang, Qingxiu, Park, Peter U., Bergstrom, Donald A., Lowinger, Timothy B.

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The Dolaflexin-based Antibody-Drug Conjugate XMT-1536 Targets the Solid Tumor Lineage Antigen SLC34A2/NaPi2b von Bodyak, Natalya D., Mosher, Rebecca, Yurkovetskiy, Aleksandr, Yin, Mao, Bu, Charlie, Conlon, Patrick R., Demady, Damon R., DeVit, Michael J., Gumerov, Dmitry R., Gurijala, Venu R., Lee, Winnie, McGillicuddy, Dennis, Park, Peter U., Poling, Laura L., Protopova, Marina, Qin, LiuLiang, Stevenson, Cheri A., Ter-Ovanesyan, Elena, Uttard, Alex, Xiao, Dongmei, Xu, Jian, Xu, Ling, Bergstrom, Donald A., Lowinger, Timothy B.

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Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein von Willingham, Stephen, Outeiro, Tiago Fleming, DeVit, Michael J., Lindquist, Susan L., Muchowski, Paul J.

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Abstract 596: Optimization of lead antibody selection for XMT-1522, a novel, highly potent HER2-targeted antibody-drug conjugate (ADC) von Bodyak, Natasha, Yurkovetskiy, Alex, Gumerov, Dmitry R., Xiao, Dongmei, Thomas, Joshua D. Thomas D., Poling, Laura L., Qin, LiuLiang, Yin, Mao, DeVit, Michael J., Park, Peter U., Lee, Winnie, Prinz, Bianka, Bergstrom, Donald A., Lowinger, Timothy B.

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The nuclear exportin Msn5 is required for nuclear export of the Mig1 glucose repressor of Saccharomyces cerevisiae von DeVit, Michael J., Johnston, Mark

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Genetic immunization is a simple method for eliciting an immune response von Tang, De-chu, DeVit, Michael, Johnston, Stephen A

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Characterization of three related glucose repressors and genes they regulate in Saccharomyces cerevisiae von Lutfiyya, L.L. (Washington University School of Medicine, St. Louis, MO.), Iyer, V.R, DeRisi, J, DeVit, M.J, Brown, P.O, Johnston, M

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Systematic exploration of essential yeast gene function with temperature-sensitive mutants von Andrews, Brenda, Boone, Charles, Li, Zhijian, Vizeacoumar, Franco J, Bahr, Sondra, Li, Jingjing, Warringer, Jonas, Vizeacoumar, Frederick S, Min, Renqiang, VanderSluis, Benjamin, Bellay, Jeremy, DeVit, Michael, Fleming, James A, Stephens, Andrew, Haase, Julian, Lin, Zhen-Yuan, Baryshnikova, Anastasia, Lu, Hong, Yan, Zhun, Jin, Ke, Barker, Sarah, Datti, Alessandro, Giaever, Guri, Nislow, Corey, Bulawa, Chris, Myers, Chad L, Costanzo, Michael, Gingras, Anne-Claude, Zhang, Zhaolei, Blomberg, Anders, Bloom, Kerry

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Abstract 48: Non-clinical pharmacokinetics of XMT-1522, a HER2 targeting auristatin-based antibody drug conjugate von Yurkovetskiy, Alex, Gumerov, Dmitry, Ter-Ovanesyan, Elena, Conlon, Patrick, Devit, Michael, Bu, Charlie, Bodyak, Natalya, Lowinger, Timothy, Bergstrom, Donald

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Abstract 641: Trastuzumab-dolaflexin, a highly potent Fleximer-based antibody-drug conjugate, demonstrates a favorable therapeutic index in exploratory toxicology studies in multip... von Bodyak, Natalya, Yurkovetskiy, Alex, Park, Peter U., Gumerov, Dmitry R., DeVit, Michael, Yin, Mao, Thomas, Joshua D., Qin, LiuLiang, Lowinger, Timothy B., Bergstrom, Donald A.

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Abstract 1194: Discovery and preclinical development of a highly potent NaPi2b-targeted antibody-drug conjugate (ADC) with significant activity in patient-derived non-small cell lu... von Bodyak, Natalya, Yurkovetskiy, Alex, Yin, Mao, Gumerov, Dmitry, Bollu, Reddy, Conlon, Patrick, Gurijala, Venu R., McGillicuddy, Dennis, Stevenson, Cheri, Ter-Ovanesyan, Elena, Park, Peter U., Poling, Laura, Lee, Winnie, DeVit, Michael, Xiao, Dongmei, Qin, LiuLiang, Lowinger, Timothy B., Bergstrom, Donald A.

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Abstract LB-231: A novel, highly potent HER2-targeted antibody-drug conjugate (ADC) for the treatment of low HER2-expressing tumors and combination with trastuzumab-based regimens... von Bergstrom, Donald A., Bodyak, Natalya, Yurkovetskiy, Alex, Park, Peter U., DeVit, Michael, Yin, Mao, Poling, Laura, Thomas, Joshua D., Gumerov, Dmitry, Xiao, Dongmei, Ter-Ovanesyan, Elena, Qin, LiuLiang, Uttard, Alex, Johnson, Alex, Lowinger, Timothy B.

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Regulated nuclear translocation of the Mig1 glucose repressor von De Vit, M J, Waddle, J A, Johnston, M

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Abstract 4331: Advantages of polyacetal polymer-based antibody drug conjugates employing cysteine bioconjugation von Yurkovetskiy, Alex, Bodyak, Natalya, Yin, Mao, Thomas, Joshua, Conlon, Patrick, Stevenson, Cheri, Uttard, Alex, Qin, Liu, Gumerov, Dmitry, Ter-Ovaneysan, Elena, DeVit, Michael, Lowinger, Timothy B.

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Abstract 2645: Advantages of polyacetal polymer-based ADCs: Application to low expression targets von Yurkovetskiy, Alex, Bodyak, Natalya, Yin, Mao, Thomas, Joshua D., Conlon, Patrick, Stevenson, Cheri A., Uttard, Alex, Qin, LiuLiang, Gumerov, Dmitry R., Ter-Ovaneysan, Elena, Gurijala, Venu R., McGillicuddy, Dennis, Glynn, Roberta E., DeVit, Michael, Poling, Laura L., Park, Peter U., Lowinger, Timothy B.

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Abstract C238: Polyacetal polymer-based anti-HER2 antibody-drug conjugate employing cysteine bioconjugation through thioether linkage allows a high drug loading of dolastatin-deriv... von Thomas, Joshua, Yurkovetskiy, Alex, Bodyak, Natalya, Yin, Mao, Conlon, Patrick, Stevenson, Cheri, Uttard, Alex, Qin, Liu, Gumerov, Dmitry, Ter-Ovaneysan, Elena, DeVit, Michael, Poling, Laura L., Park, Peter U., Lowinger, Timothy B.

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Introduction of Foreign Genes into Tissues of Living Mice by DNA-Coated Microprojectiles von Williams, R. Sanders, Johnston, Stephen A., Riedy, Mark, DeVit, Michael J., McElligott, Sandra G., Sanford, John C.

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Forcing interactions as a genetic screen to identify proteins that exert a defined activity von Devit, Michael, Cullen, Paul J, Branson, Margaret, Sprague, Jr, George F, Fields, Stanley

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New genetic strategies for protein discovery based on whole-genome sequences von DeVit, Michael J., Powers, Trey

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