Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening von Ye, Dong, Harder, Anna, Fang, Zhizhou, Weinheimer, Manuel, Laplanche, Loic, Mezler, Mario

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Conquering the beyond Rule of Five Space with an Optimized High-Throughput Caco-2 Assay to Close Gaps in Absorption Prediction von Muschong, Patricia, Awwad, Khader, Price, Edward, Mezler, Mario, Weinheimer, Manuel

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Collecting antibodies and large molecule biomarkers in mouse interstitial brain fluid: a comparison of microdialysis and cerebral open flow microperfusion von Le Prieult, Florie, Barini, Erica, Laplanche, Loic, Schlegel, Kerstin, Mezler, Mario

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Novel Developments to Enable Treatment of CNS Diseases with Targeted Drug Delivery von Meyer, Axel H, Feldsien, Thomas M, Mezler, Mario, Untucht, Christopher, Venugopalan, Ramakrishna, Lefebvre, Didier R

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Challenges in Permeability Assessment for Oral Drug Product Development von Koziolek, Mirko, Augustijns, Patrick, Berger, Constantin, Cristofoletti, Rodrigo, Dahlgren, David, Keemink, Janneke, Matsson, Pär, McCartney, Fiona, Metzger, Marco, Mezler, Mario, Niessen, Janis, Polli, James E, Vertzoni, Maria, Weitschies, Werner, Dressman, Jennifer

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Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media von Ye, Dong, López Mármol, Álvaro, Lenz, Verena, Muschong, Patricia, Wilhelm-Alkubaisi, Anita, Weinheimer, Manuel, Koziolek, Mirko, Sauer, Kerstin A, Laplanche, Loic, Mezler, Mario

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Effects of a positive allosteric modulator of group II metabotropic glutamate receptors, LY487379, on cognitive flexibility and impulsive-like responding in rats von Nikiforuk, Agnieszka, Popik, Piotr, Drescher, Karla U, van Gaalen, Marcel, Relo, Ana-Lucia, Mezler, Mario, Marek, Gerard, Schoemaker, Hans, Gross, Gerhard, Bespalov, Anton

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Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model von Dallas, Shannon, Salphati, Laurent, Gomez-Zepeda, David, Wanek, Thomas, Chen, Liangfu, Chu, Xiaoyan, Kunta, Jeevan, Mezler, Mario, Menet, Marie-Claude, Chasseigneaux, Stephanie, Declèves, Xavier, Langer, Oliver, Pierre, Esaie, DiLoreto, Karen, Hoft, Carolin, Laplanche, Loic, Pang, Jodie, Pereira, Tony, Andonian, Clara, Simic, Damir, Rode, Anja, Yabut, Jocelyn, Zhang, Xiaolin, Scheer, Nico

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Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins von Salphati, Laurent, Chu, Xiaoyan, Chen, Liangfu, Prasad, Bhagwat, Dallas, Shannon, Evers, Raymond, Mamaril-Fishman, Donna, Geier, Ethan G, Kehler, Jonathan, Kunta, Jeevan, Mezler, Mario, Laplanche, Loic, Pang, Jodie, Rode, Anja, Soars, Matthew G, Unadkat, Jashvant D, van Waterschoot, Robert A B, Yabut, Jocelyn, Schinkel, Alfred H, Scheer, Nico

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Awake rat pharmacological magnetic resonance imaging as a translational pharmacodynamic biomarker: metabotropic glutamate 2/3 agonist modulation of ketamine-induced blood oxygenati... von Chin, Chih-Liang, Upadhyay, Jaymin, Marek, Gerard J, Baker, Scott J, Zhang, Min, Mezler, Mario, Fox, Gerard B, Day, Mark

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Inhibitors of GlyT1 Affect Glycine Transport via Discrete Binding Sites von Mezler, Mario, Hornberger, Wilfried, Mueller, Reinhold, Schmidt, Martin, Amberg, Martin Schmidt Willi, Amberg, Willi, Braje, Wilfried, Ochse, Michael, Schoemaker, Hans, Behl, Berthold

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Cloning and functional expression of GABAB receptors from Drosophila von Mezler, Mario, Müller, Thomas, Raming, Klaus

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Behavioral characterization of the mGlu group II/III receptor antagonist, LY-341495, in animal models of anxiety and depression von Bespalov, Anton Y., van Gaalen, Marcel M., Sukhotina, Irina A., Wicke, Karsten, Mezler, Mario, Schoemaker, Hans, Gross, Gerhard

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Improvement of Workflows and Assay Reproducibility by The Introduction of “Assay-Ready” Culturing of MDCK Cells for Transport Studies von Muschong, Patricia, Jin, Liang, Schejbal, Jan, Mezler, Mario, Weinheimer, Manuel

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Correction: Improvement of Workfows and Assay Reproducibility by The Introduction of “Assay-Ready” Culturing of MDCK Cells for Transport Studie von Muschong, Patricia, Jin, Liang, Schejbal, Jan, Mezler, Mario, Weinheimer, Manuel

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Depletion of microglia with CSF1R inhibitor prevents tau aggregation in the mouse model Thy1P301S von Lombardo, Sylvia, Stanek, Agathe, Wuest, Carolin, Reich, Thomas, Secker, Philipp, Sefrin, Julian, Biber, Knut, Mezler, Mario, Klein, Corinna

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PBPK model for antibody disposition in mouse brain: validation using large-pore microdialysis data von Wu, Shengjia, Le Prieult, Florie, Phipps, Colin J., Mezler, Mario, Shah, Dhaval K.

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Tau in the brain interstitial fluid is fragmented and seeding–competent von Barini, Erica, Plotzky, Gudrun, Mordashova, Yulia, Hoppe, Jonas, Rodriguez-Correa, Esther, Julier, Sonja, LePrieult, Florie, Mairhofer, Ina, Mezler, Mario, Biesinger, Sandra, Cik, Miroslav, Meinhardt, Marcus W., Ercan-Herbst, Ebru, Ehrnhoefer, Dagmar E., Striebinger, Andreas, Bodie, Karen, Klein, Corinna, Gasparini, Laura, Schlegel, Kerstin

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Analysis of the bile acid composition in a fibroblast growth factor 19-expressing liver-humanized mouse model and its use for CYP3A4-mediated drug-drug interaction studies von Mezler, Mario, Jones, Robert S, Sangaraju, Dewakar, Goldman, Devorah C, Hoffmann, Matthew, Heikkinen, Aki T, Mannila, Janne, Chang, Jae H, Foquet, Lander, Pusalkar, Sandeepraj, Clothe, Paresh P, Scheer, Nico

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The two faces of the pharmacological interaction of mGlu2 and 5-HT2A – Relevance of receptor heterocomplexes and interaction through functional brain pathways von Delille, Hannah K., Mezler, Mario, Marek, Gerard J.

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