The Discovery of N‑[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]‑N′‑propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor Ant... von Bolli, Martin H, Boss, Christoph, Binkert, Christoph, Buchmann, Stephan, Bur, Daniel, Hess, Patrick, Iglarz, Marc, Meyer, Solange, Rein, Josiane, Rey, Markus, Treiber, Alexander, Clozel, Martine, Fischli, Walter, Weller, Thomas

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Starving the Malaria Parasite: Inhibitors Active against the Aspartic Proteases Plasmepsins I, II, and IV von Hof, Fraser, Schütz, Andri, Fäh, Christoph, Meyer, Solange, Bur, Daniel, Liu, Jun, Goldberg, Daniel E., Diederich, François

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X-ray Structure of Plasmepsin II Complexed with a Potent Achiral Inhibitor von Prade, Lars, Jones, Andrew F., Boss, Christoph, Richard-Bildstein, Sylvia, Meyer, Solange, Binkert, Christoph, Bur, Daniel

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Exploring the Flap Pocket of the Antimalarial Target Plasmepsin II: The "55 % Rule" Applied to Enzymes von Zürcher, Martina, Gottschalk, Thomas, Meyer, Solange, Bur, Daniel, Diederich, François

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Achiral, Cheap, and Potent Inhibitors of Plasmepsins I, II, and IV von Boss, Christoph, Corminboeuf, Olivier, Grisostomi, Corinna, Meyer, Solange, Jones, Andrew F., Prade, Lars, Binkert, Christoph, Fischli, Walter, Weller, Thomas, Bur, Daniel

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Fragment‐based screening targeting an open form of the SARS‐CoV‐2 main protease binding pocket von Huang, Chia-Ying, Metz, Alexander, Lange, Roland, Artico, Nadia, Potot, Céline, Hazemann, Julien, Müller, Manon, Dos Santos, Marina, Chambovey, Alain, Ritz, Daniel, Eris, Deniz, Meyer, Solange, Bourquin, Geoffroy, Sharpe, May, Mac Sweeney, Aengus

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Identification of a New Chemical Class of Antimalarials von Brunner, Ralf, Aissaoui, Hamed, Boss, Christoph, Bozdech, Zbynek, Brun, Reto, Corminboeuf, Olivier, Delahaye, Stephane, Fischli, Christoph, Heidmann, Bibia, Kaiser, Marcel, Kamber, Jolanda, Meyer, Solange, Papastogiannidis, Petros, Siegrist, Romain, Voss, Till, Welford, Richard, Wittlin, Sergio, Binkert, Christoph

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Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold von Ciana, Claire-Lise, Siegrist, Romain, Aissaoui, Hamed, Marx, Léo, Racine, Sophie, Meyer, Solange, Binkert, Christoph, de Kanter, Ruben, Fischli, Christoph, Wittlin, Sergio, Boss, Christoph

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Novel S1P(1) receptor agonists--part 2: from bicyclo[3.1.0]hexane-fused thiophenes to isobutyl substituted thiophenes von Bolli, Martin H, Velker, Jörg, Müller, Claus, Mathys, Boris, Birker, Magdalena, Bravo, Roberto, Bur, Daniel, de Kanter, Ruben, Hess, Patrick, Kohl, Christopher, Lehmann, David, Meyer, Solange, Nayler, Oliver, Rey, Markus, Scherz, Michael, Steiner, Beat

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Novel S1P1 Receptor Agonists - Part 2: From Bicyclo[3.1.0]hexane-Fused Thiophenes to Isobutyl Substituted Thiophenes von Bolli, Martin H, Velker, Jörg, Müller, Claus, Mathys, Boris, Birker, Magdalena, Bravo, Roberto, Bur, Daniel, de Kanter, Ruben, Hess, Patrick, Kohl, Christopher, Lehmann, David, Meyer, Solange, Nayler, Oliver, Rey, Markus, Scherz, Michael, Steiner, Beat

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Potent Inhibitors of Malarial Aspartic Proteases, the Plasmepsins, by Hydroformylation of Substituted 7-Azanorbornenes von Aureggi, Valentina, Ehmke, Veronika, Wieland, Joerg, Schweizer, W. Bernd, Bernet, Bruno, Bur, Daniel, Meyer, Solange, Rottmann, Matthias, Freymond, Céline, Brun, Reto, Breit, Bernhard, Diederich, François

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Enantiomerically Pure and Highly Substituted Alicyclic α,α-Difluoro Ketones: Potential Inhibitors for Malarial Aspartic Proteases, the Plasmepsins von Fäh, Christoph, Mathys, Roland, Hardegger, Leo A., Meyer, Solange, Bur, Daniel, Diederich, François

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Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action von Boss, Christoph, Aissaoui, Hamed, Amaral, Nathalie, Bauer, Aude, Bazire, Stephanie, Binkert, Christoph, Brun, Reto, Bürki, Cédric, Ciana, Claire-Lise, Corminboeuf, Olivier, Delahaye, Stephane, Dollinger, Claire, Fischli, Christoph, Fischli, Walter, Flock, Alexandre, Frantz, Marie-Céline, Girault, Malory, Grisostomi, Corinna, Friedli, Astrid, Heidmann, Bibia, Hinder, Claire, Jacob, Gael, Le Bihan, Amelie, Malrieu, Sophie, Mamzed, Saskia, Merot, Aurelien, Meyer, Solange, Peixoto, Sabrina, Petit, Nolwenn, Siegrist, Romain, Trollux, Julien, Weller, Thomas, Wittlin, Sergio

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New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic alpha,alpha-difluoroketone hydrates von Fäh, Christoph, Hardegger, Leo A, Baitsch, Lukas, Schweizer, W Bernd, Meyer, Solange, Bur, Daniel, Diederich, François

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Novel S1P1 Receptor Agonists – Part 1: From Pyrazoles to Thiophenes von Bolli, Martin H, Müller, Claus, Mathys, Boris, Abele, Stefan, Birker, Magdalena, Bravo, Roberto, Bur, Daniel, Hess, Patrick, Kohl, Christopher, Lehmann, David, Nayler, Oliver, Rey, Markus, Meyer, Solange, Scherz, Michael, Schmidt, Gunther, Steiner, Beat, Treiber, Alexander, Velker, Jörg, Weller, Thomas

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Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling von Le Bihan, Amélie, de Kanter, Ruben, Angulo-Barturen, Iñigo, Binkert, Christoph, Boss, Christoph, Brun, Reto, Brunner, Ralf, Buchmann, Stephan, Burrows, Jeremy, Dechering, Koen J, Delves, Michael, Ewerling, Sonja, Ferrer, Santiago, Fischli, Christoph, Gamo-Benito, Francisco Javier, Gnädig, Nina F, Heidmann, Bibia, Jiménez-Díaz, María Belén, Leroy, Didier, Martínez, Maria Santos, Meyer, Solange, Moehrle, Joerg J, Ng, Caroline L, Noviyanti, Rintis, Ruecker, Andrea, Sanz, Laura María, Sauerwein, Robert W, Scheurer, Christian, Schleiferboeck, Sarah, Sinden, Robert, Snyder, Christopher, Straimer, Judith, Wirjanata, Grennady, Marfurt, Jutta, Price, Ric N, Weller, Thomas, Fischli, Walter, Fidock, David A, Clozel, Martine, Wittlin, Sergio

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Novel S1P 1 Receptor Agonists - Part 2: From Bicyclo[3.1.0]hexane-Fused Thiophenes to Isobutyl Substituted Thiophenes von Bolli, Martin H., Velker, Jörg, Müller, Claus, Mathys, Boris, Birker, Magdalena, Bravo, Roberto, Bur, Daniel, de Kanter, Ruben, Hess, Patrick, Kohl, Christopher, Lehmann, David, Meyer, Solange, Nayler, Oliver, Rey, Markus, Scherz, Michael, Steiner, Beat

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Novel S1P 1 Receptor Agonists – Part 1: From Pyrazoles to Thiophenes von Bolli, Martin H., Müller, Claus, Mathys, Boris, Abele, Stefan, Birker, Magdalena, Bravo, Roberto, Bur, Daniel, Hess, Patrick, Kohl, Christopher, Lehmann, David, Nayler, Oliver, Rey, Markus, Meyer, Solange, Scherz, Michael, Schmidt, Gunther, Steiner, Beat, Treiber, Alexander, Velker, Jörg, Weller, Thomas

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Inhibitors of Plasmepsin II – Potential Antimalarial Agents von Boss, Christoph, Brun, Reto, Fischli, Walter, Binkert, Christoph, Meyer, Solange, Prade, Lars, Harris, Luke, Coppex, Lionel, Grisostomi, Corinna, Corminboeuf, Olivier, Bourgeois, Jean-Marc, Furnari, Rocco, Richard-Bildstein, Sylvia, Weller, Thomas

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Back Cover: Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action (ChemMedChem 18/2016) von Boss, Christoph, Aissaoui, Hamed, Amaral, Nathalie, Bauer, Aude, Bazire, Stephanie, Binkert, Christoph, Brun, Reto, Bürki, Cédric, Ciana, Claire-Lise, Corminboeuf, Olivier, Delahaye, Stephane, Dollinger, Claire, Fischli, Christoph, Fischli, Walter, Flock, Alexandre, Frantz, Marie-Céline, Girault, Malory, Grisostomi, Corinna, Friedli, Astrid, Heidmann, Bibia, Hinder, Claire, Jacob, Gael, Le Bihan, Amelie, Malrieu, Sophie, Mamzed, Saskia, Merot, Aurelien, Meyer, Solange, Peixoto, Sabrina, Petit, Nolwenn, Siegrist, Romain, Trollux, Julien, Weller, Thomas, Wittlin, Sergio

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