Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease: Structure of a Viral Deubiquitinating Enzyme von Ratia, Kiira, Saikatendu, Kumar Singh, Santarsiero, Bernard D., Barretto, Naina, Baker, Susan C., Stevens, Raymond C., Mesecar, Andrew D.

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Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2 von Eggler, Aimee L, Gay, Kelly A, Mesecar, Andrew D

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A new model for protein stereospecificity von MESECAR, A. D, KOSHLAND, D. E

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Orbital Steering in the Catalytic Power of Enzymes: Small Structural Changes with Large Catalytic Consequences von Mesecar, Andrew D., Stoddard, Barry L., Koshland, Daniel E.

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The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating Activity von BARRETTO, Naina, JUKNELIENE, Dalia, RATIA, Kiira, ZHONGBIN CHEN, MESECAR, Andrew D, BAKER, Susan C

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Structure-Based and Random Mutagenesis Approaches Increase the Organophosphate-Degrading Activity of a Phosphotriesterase Homologue from Deinococcus radiodurans von Hawwa, Renda, Larsen, Sonia D., Ratia, Kiira, Mesecar, Andrew D.

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Structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase in complex with the feedback inhibitor CoA reveals only one active-site conformation von Wubben, T., Mesecar, A. D.

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The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds von Báez-Santos, Yahira M., St. John, Sarah E., Mesecar, Andrew D.

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Indole Chloropyridinyl Ester-Derived SARS-CoV‑2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure–Activity Relationship, and X‑ray Structural Studies von Ghosh, Arun K, Raghavaiah, Jakka, Shahabi, Dana, Yadav, Monika, Anson, Brandon J, Lendy, Emma K, Hattori, Shin-ichiro, Higashi-Kuwata, Nobuyo, Mitsuya, Hiroaki, Mesecar, Andrew D

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Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery von Grum-Tokars, Valerie, Ratia, Kiira, Begaye, Adrian, Baker, Susan C., Mesecar, Andrew D.

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Pleiotropic mechanisms facilitated by resveratrol and its metabolites von Calamini, Barbara, Ratia, Kiira, Malkowski, Michael G, Cuendet, Muriel, Pezzuto, John M, Santarsiero, Bernard D, Mesecar, Andrew D

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Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics von Ghosh, Arun K., Brindisi, Margherita, Shahabi, Dana, Chapman, Mackenzie E., Mesecar, Andrew D.

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SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads von Ghosh, Arun K., Shahabi, Dana, Imhoff, Mackenzie E.C., Kovela, Satish, Sharma, Ashish, Hattori, Shin-ichiro, Higashi-Kuwata, Nobuyo, Mitsuya, Hiroaki, Mesecar, Andrew D.

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Kinetic and X-Ray Structural Evidence for Negative Cooperativity in Substrate Binding to Nicotinate Mononucleotide Adenylyltransferase (NMAT) from Bacillus anthracis von Sershon, Valerie C., Santarsiero, Bernard D., Mesecar, Andrew D.

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Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors von Ghosh, Arun K., Yadav, Monika, Iddum, Satyanarayana, Ghazi, Somayeh, Lendy, Emma K., Jayashankar, Uttara, Beechboard, Sydney N., Takamatsu, Yuki, Hattori, Shin-ichiro, Amano, Masayuki, Higashi-Kuwata, Nobuyo, Mitsuya, Hiroaki, Mesecar, Andrew D.

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Addendum: A new model for protein stereospecificity von Mesecar, A. D, Koshland, Jr, D. E

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Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors von Yen, Yu-Chen, Kammeyer, Annalissa M, Jensen, Katherine C, Tirlangi, Jagannadharao, Ghosh, Arun K, Mesecar, Andrew D

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Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins von Zhang, Heng, Li, Zhuang, Daczkowski, Courtney M., Gabel, Clinton, Mesecar, Andrew D., Chang, Leifu

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Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities von Mielech, Anna M., Chen, Yafang, Mesecar, Andrew D., Baker, Susan C.

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Modifying Specific Cysteines of the Electrophile-Sensing Human Keap1 Protein Is Insufficient to Disrupt Binding to the Nrf2 Domain Neh2 von Eggler, Aimee L., Liu, Guowen, Pezzuto, John M., van Breemen, Richard B., Mesecar, Andrew D., Kustu, Sydney

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