The Immune System Bridges the Gut Microbiota with Systemic Energy Homeostasis: Focus on TLRs, Mucosal Barrier, and SCFAs von Spiljar, Martina, Merkler, Doron, Trajkovski, Mirko

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High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease von Mrdjen, Dunja, Pavlovic, Anto, Hartmann, Felix J., Schreiner, Bettina, Utz, Sebastian G., Leung, Brian P., Lelios, Iva, Heppner, Frank L., Kipnis, Jonathan, Merkler, Doron, Greter, Melanie, Becher, Burkhard

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Resident-Memory T Cells in Tissue-Restricted Immune Responses: For Better or Worse? von Steinbach, Karin, Vincenti, Ilena, Merkler, Doron

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PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions von Ercolano, Giuseppe, Gomez-Cadena, Alejandra, Dumauthioz, Nina, Vanoni, Giulia, Kreutzfeldt, Mario, Wyss, Tania, Michalik, Liliane, Loyon, Romain, Ianaro, Angela, Ho, Ping-Chih, Borg, Christophe, Kopf, Manfred, Merkler, Doron, Krebs, Philippe, Romero, Pedro, Trabanelli, Sara, Jandus, Camilla

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Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements von Fabbiano, Salvatore, Suárez-Zamorano, Nicolas, Chevalier, Claire, Lazarević, Vladimir, Kieser, Silas, Rigo, Dorothée, Leo, Stefano, Veyrat-Durebex, Christelle, Gaïa, Nadia, Maresca, Marcello, Merkler, Doron, Gomez de Agüero, Mercedes, Macpherson, Andrew, Schrenzel, Jacques, Trajkovski, Mirko

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Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity von Fecher, Caroline, Trovò, Laura, Müller, Stephan A., Snaidero, Nicolas, Wettmarshausen, Jennifer, Heink, Sylvia, Ortiz, Oskar, Wagner, Ingrid, Kühn, Ralf, Hartmann, Jana, Karl, Rosa Maria, Konnerth, Arthur, Korn, Thomas, Wurst, Wolfgang, Merkler, Doron, Lichtenthaler, Stefan F., Perocchi, Fabiana, Misgeld, Thomas

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Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner von Datta, Moumita, Staszewski, Ori, Raschi, Elena, Frosch, Maximilian, Hagemeyer, Nora, Tay, Tuan Leng, Blank, Thomas, Kreutzfeldt, Mario, Merkler, Doron, Ziegler-Waldkirch, Stephanie, Matthias, Patrick, Meyer-Luehmann, Melanie, Prinz, Marco

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High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease von Mrdjen, Dunja, Pavlovic, Anto, Hartmann, Felix J., Schreiner, Bettina, Utz, Sebastian G., Leung, Brian P., Lelios, Iva, Heppner, Frank L., Kipnis, Jonathan, Merkler, Doron, Greter, Melanie, Becher, Burkhard

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Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis von Jürgens, Tanja, Jafari, Mehrnoosh, Kreutzfeldt, Mario, Bahn, Erik, Brück, Wolfgang, Kerschensteiner, Martin, Merkler, Doron

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Persistence of self-reactive CD8+ T cells in the CNS requires TOX-dependent chromatin remodeling von Page, Nicolas, Lemeille, Sylvain, Vincenti, Ilena, Klimek, Bogna, Mariotte, Alexandre, Wagner, Ingrid, Di Liberto, Giovanni, Kaye, Jonathan, Merkler, Doron

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Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue von Snaidero, Nicolas, Möbius, Wiebke, Czopka, Tim, Hekking, Liesbeth H.P., Mathisen, Cliff, Verkleij, Dick, Goebbels, Sandra, Edgar, Julia, Merkler, Doron, Lyons, David A., Nave, Klaus-Armin, Simons, Mikael

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CD8+ T cells induce cachexia during chronic viral infection von Baazim, Hatoon, Schweiger, Martina, Moschinger, Michael, Xu, Haifeng, Scherer, Thomas, Popa, Alexandra, Gallage, Suchira, Ali, Adnan, Khamina, Kseniya, Kosack, Lindsay, Vilagos, Bojan, Smyth, Mark, Lercher, Alexander, Friske, Joachim, Merkler, Doron, Aderem, Alan, Helbich, Thomas H., Heikenwälder, Mathias, Lang, Philipp A., Zechner, Rudolf, Bergthaler, Andreas

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Fundamental mechanistic insights from rare but paradigmatic neuroimmunological diseases von Wiendl, Heinz, Gross, Catharina C., Bauer, Jan, Merkler, Doron, Prat, Alexandre, Liblau, Roland

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Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients von Migliorini, Denis, Dutoit, Valérie, Allard, Mathilde, Grandjean Hallez, Nicole, Marinari, Eliana, Widmer, Valérie, Philippin, Géraldine, Corlazzoli, Francesca, Gustave, Robin, Kreutzfeldt, Mario, Blazek, Nathalie, Wasem, Joëlle, Hottinger, Andreas, Koka, Avinash, Momjian, Shahan, Lobrinus, Alexander, Merkler, Doron, Vargas, Maria-Isabel, Walker, Paul R, Patrikidou, Anna, Dietrich, Pierre-Yves

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Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming during thermal adaptation von Hadadi, Noushin, Spiljar, Martina, Steinbach, Karin, Çolakoğlu, Melis, Chevalier, Claire, Salinas, Gabriela, Merkler, Doron, Trajkovski, Mirko

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Infection of type I interferon receptor-deficient mice with various old world arenaviruses: a model for studying virulence and host species barriers von Rieger, Toni, Merkler, Doron, Günther, Stephan

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IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling von Peters, Anneli, Fowler, Kevin D, Chalmin, Fanny, Merkler, Doron, Kuchroo, Vijay K, Pot, Caroline

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Bassoon proteinopathy drives neurodegeneration in multiple sclerosis von Schattling, Benjamin, Engler, Jan Broder, Volkmann, Constantin, Rothammer, Nicola, Woo, Marcel S., Petersen, Meike, Winkler, Iris, Kaufmann, Max, Rosenkranz, Sina C., Fejtova, Anna, Thomas, Ulrich, Bose, Aparajita, Bauer, Simone, Träger, Simone, Miller, Katharine K., Brück, Wolfgang, Duncan, Kent E., Salinas, Gabriela, Soba, Peter, Gundelfinger, Eckart D., Merkler, Doron, Friese, Manuel A.

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USP18 lack in microglia causes destructive interferonopathy of the mouse brain von Goldmann, Tobias, Zeller, Nicolas, Raasch, Jenni, Kierdorf, Katrin, Frenzel, Kathrin, Ketscher, Lars, Basters, Anja, Staszewski, Ori, Brendecke, Stefanie M, Spiess, Alena, Tay, Tuan Leng, Kreutz, Clemens, Timmer, Jens, Mancini, Grazia MS, Blank, Thomas, Fritz, Günter, Biber, Knut, Lang, Roland, Malo, Danielle, Merkler, Doron, Heikenwälder, Mathias, Knobeloch, Klaus-Peter, Prinz, Marco

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Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown von Aydin, Sidar, Pareja, Javier, Schallenberg, Vivianne M., Klopstein, Armelle, Gruber, Thomas, Page, Nicolas, Bouillet, Elisa, Blanchard, Nicolas, Liblau, Roland, Körbelin, Jakob, Schwaninger, Markus, Johnson, Aaron J., Schenk, Mirjam, Deutsch, Urban, Merkler, Doron, Engelhardt, Britta

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