Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation von Didonato, Joseph, Mercurio, Frank, Rosette, Caridad, Wu-Li, Jian, Suyang, Helena, Ghosh, Sankar, Karin, Michael

Volltext

NF-κB and the link between inflammation and cancer von DiDonato, Joseph A., Mercurio, Frank, Karin, Michael

Volltext

An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme von Ceccarelli, Derek F., Tang, Xiaojing, Pelletier, Benoit, Orlicky, Stephen, Xie, Weilin, Plantevin, Veronique, Neculai, Dante, Chou, Yang-Chieh, Ogunjimi, Abiodun, Al-Hakim, Abdallah, Varelas, Xaralabos, Koszela, Joanna, Wasney, Gregory A., Vedadi, Masoud, Dhe-Paganon, Sirano, Cox, Sarah, Xu, Shuichan, Lopez-Girona, Antonia, Mercurio, Frank, Wrana, Jeff, Durocher, Daniel, Meloche, Sylvain, Webb, David R., Tyers, Mike, Sicheri, Frank

Volltext

Suprafacial Orientation of the SCF[superscript Cdc4] Dimer Accommodates Multiple Geometries for Substrate Ubiquitination von Tang, Xiaojing, Orlicky, Stephen, Lin, Zhenyuan, Willems, Andrew, Neculai, Dante, Ceccarelli, Derek, Mercurio, Frank, Shilton, Brian H., Sicheri, Frank, Tyers, Mike

Volltext

Suprafacial Orientation of the SCFCdc4 Dimer Accommodates Multiple Geometries for Substrate Ubiquitination von Tang, Xiaojing, Orlicky, Stephen, Lin, Zhenyuan, Willems, Andrew, Neculai, Dante, Ceccarelli, Derek, Mercurio, Frank, Shilton, Brian H., Sicheri, Frank, Tyers, Mike

Volltext

Protacs: Chimeric Molecules That Target Proteins to the Skp1-Cullin-F Box Complex for Ubiquitination and Degradation von Sakamoto, K M, Kim, K B, Kumagai, A, Mercurio, F, Crews, C M, Deshaies, R J

Volltext

Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy von Chen, Qing, Xie, Weilin, Kuhn, Deborah J., Voorhees, Peter M., Lopez-Girona, Antonia, Mendy, Derek, Corral, Laura G., Krenitsky, Veronique Plantevin, Xu, Weiming, Moutouh-de Parseval, Laure, Webb, David R., Mercurio, Frank, Nakayama, Keiichi I., Nakayama, Keiko, Orlowski, Robert Z.

Volltext

Genotoxic Stress Targets Human Chk1 for Degradation by the Ubiquitin-Proteasome Pathway von Zhang, You-Wei, Otterness, Diane M., Chiang, Gary G., Xie, Weilin, Liu, Yun-Cai, Mercurio, Frank, Abraham, Robert T.

Volltext

Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B von DiDonato, Joseph A., Mercurio, Frank, Karin, Michael

Volltext

Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases von Xu, Yibing, Li, Jianwu, Ferguson, Gregory D., Mercurio, Frank, Khambatta, Gody, Morrison, Lisa, Lopez-Girona, Antonia, Corral, Laura G., Webb, David R., Bennett, Brydon L., Xie, Weilin

Volltext

Activation of NF-κB is Required for Hypertrophic Growth of Primary Rat Neonatal Ventricular Cardiomyocytes von Purcell, Nicole H., Tang, Guilin, Yu, Chenfei, Mercurio, Frank, DiDonato, Joseph A., Lin, Anning

Volltext

Enhanced NF-κB Activation and Cellular Function in Macrophages Lacking IκB Kinase 1 (IKK1) von Li, Quitang, Lu, Qingxian, Bottero, Virginie, Estepa, Gabriela, Morrison, Lisa, Mercurio, Frank, Verma, Inder M.

Volltext

BTX-1188, a first-in-class dual degrader of GSPT1 and IKZF1/3, for treatment of acute myeloid leukemia (AML) and solid tumors von Chourasia, Aparajita Hoskote, Majeski, Hannah, Pasis, Angela, Erdman, Paul, Oke, Ashwini, Hecht, David, Lonergan, David, Mercurio, Frank, Chan, Kyle, Thai, Dung Luong, Fung, Leah

Volltext

IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex von Mercurio, Frank, Murray, Brion W., Shevchenko, Andrej, Bennett, Brydon L., Young, David B., Li, Jian Wu, Pascual, Gabriel, Motiwala, Aparna, Zhu, Hengyi, Mann, Matthias, Manning, Anthony M.

Volltext

Abstract 1963: Targeting hematological malignancies with two functionally and mechanistically distinct classes of cereblon mediated protein homeostatic modulators von Chourasia, Aparajita Hoskote, Fung, Leah, Pasis, Angela, McElwee, Brooke, Schoolmeesters, Angela, Richard, Normand, Lam, Imelda, Torres, Eduardo, Erdman, Paul, Sullivan, Robert, Hecht, David, Chan, Kyle W., Mercurio, Frank, Stirling, David I.

Volltext

Bioavailable Dual-Protein Degraders of CK1α and Transcriptional Kinase CDK9 As Potential Therapeutics for Hematological Malignancies von Fung, Leah, Chourasia, Aparajita Hoskote, Torres, Eduardo, Lam, Imelda, Erdman, Paul, Hecht, David, Sullivan, Robert, McElwee, Brooke, Richard, Normand, Venkatachalam, Avanthika, Snir-Alkalay, Irit, Chan, Kyle WH, Mercurio, Frank, Ben-Neriah, Yinon, Stirling, David I

Volltext

Targeting AML: The Development of Two Functionally and Mechanistically Distinct Classes of Cereblon-Mediated Protein Homeostatic Modulators von Chourasia, Aparajita Hoskote, Fung, Leah, McElwee, Brooke, Richard, Normand, Lam, Imelda, Torres, Eduardo, Erdman, Paul, Sullivan, Robert, Hecht, David, Chan, Kyle WH, Mercurio, Frank, Stirling, David I

Volltext

Role of IKK1 and IKK2 in Lipopolysaccharide Signaling in Human Monocytic Cells von O'Connell, Maria A., Bennett, Brydon L., Mercurio, Frank, Manning, Anthony M., Mackman, Nigel

Volltext

Role of the IκB Kinase Complex in Oncogenic Ras- and Raf-Mediated Transformation of Rat Liver Epithelial Cells von Arsura, Marcello, Mercurio, Frank, Oliver, Aundrea L., Thorgeirsson, Snorri S., Sonenshein, Gail E.

Volltext

NF-κB as a primary regulator of the stress response von Mercurio, Frank, Manning, Anthony M

Volltext