An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme von Ceccarelli, Derek F., Tang, Xiaojing, Pelletier, Benoit, Orlicky, Stephen, Xie, Weilin, Plantevin, Veronique, Neculai, Dante, Chou, Yang-Chieh, Ogunjimi, Abiodun, Al-Hakim, Abdallah, Varelas, Xaralabos, Koszela, Joanna, Wasney, Gregory A., Vedadi, Masoud, Dhe-Paganon, Sirano, Cox, Sarah, Xu, Shuichan, Lopez-Girona, Antonia, Mercurio, Frank, Wrana, Jeff, Durocher, Daniel, Meloche, Sylvain, Webb, David R., Tyers, Mike, Sicheri, Frank

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Protacs: Chimeric Molecules That Target Proteins to the Skp1-Cullin-F Box Complex for Ubiquitination and Degradation von Sakamoto, K M, Kim, K B, Kumagai, A, Mercurio, F, Crews, C M, Deshaies, R J

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Suprafacial Orientation of the SCFCdc4 Dimer Accommodates Multiple Geometries for Substrate Ubiquitination von Tang, Xiaojing, Orlicky, Stephen, Lin, Zhenyuan, Willems, Andrew, Neculai, Dante, Ceccarelli, Derek, Mercurio, Frank, Shilton, Brian H., Sicheri, Frank, Tyers, Mike

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Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy von Chen, Qing, Xie, Weilin, Kuhn, Deborah J., Voorhees, Peter M., Lopez-Girona, Antonia, Mendy, Derek, Corral, Laura G., Krenitsky, Veronique Plantevin, Xu, Weiming, Moutouh-de Parseval, Laure, Webb, David R., Mercurio, Frank, Nakayama, Keiichi I., Nakayama, Keiko, Orlowski, Robert Z.

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Genotoxic Stress Targets Human Chk1 for Degradation by the Ubiquitin-Proteasome Pathway von Zhang, You-Wei, Otterness, Diane M., Chiang, Gary G., Xie, Weilin, Liu, Yun-Cai, Mercurio, Frank, Abraham, Robert T.

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Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases von Xu, Yibing, Li, Jianwu, Ferguson, Gregory D., Mercurio, Frank, Khambatta, Gody, Morrison, Lisa, Lopez-Girona, Antonia, Corral, Laura G., Webb, David R., Bennett, Brydon L., Xie, Weilin

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NF-κB and the link between inflammation and cancer von DiDonato, Joseph A., Mercurio, Frank, Karin, Michael

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Activation of NF-κB is Required for Hypertrophic Growth of Primary Rat Neonatal Ventricular Cardiomyocytes von Purcell, Nicole H., Tang, Guilin, Yu, Chenfei, Mercurio, Frank, DiDonato, Joseph A., Lin, Anning

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Enhanced NF-κB Activation and Cellular Function in Macrophages Lacking IκB Kinase 1 (IKK1) von Li, Quitang, Lu, Qingxian, Bottero, Virginie, Estepa, Gabriela, Morrison, Lisa, Mercurio, Frank, Verma, Inder M.

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IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex von Mercurio, Frank, Murray, Brion W., Shevchenko, Andrej, Bennett, Brydon L., Young, David B., Li, Jian Wu, Pascual, Gabriel, Motiwala, Aparna, Zhu, Hengyi, Mann, Matthias, Manning, Anthony M.

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Role of IKK1 and IKK2 in Lipopolysaccharide Signaling in Human Monocytic Cells von O'Connell, Maria A., Bennett, Brydon L., Mercurio, Frank, Manning, Anthony M., Mackman, Nigel

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Role of the IκB Kinase Complex in Oncogenic Ras- and Raf-Mediated Transformation of Rat Liver Epithelial Cells von Arsura, Marcello, Mercurio, Frank, Oliver, Aundrea L., Thorgeirsson, Snorri S., Sonenshein, Gail E.

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Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models von Minzel, Waleed, Venkatachalam, Avanthika, Fink, Avner, Hung, Eric, Brachya, Guy, Burstain, Ido, Shaham, Maya, Rivlin, Amitai, Omer, Itay, Zinger, Adar, Elias, Shlomo, Winter, Eitan, Erdman, Paul E., Sullivan, Robert W., Fung, Leah, Mercurio, Frank, Li, Dansu, Vacca, Joseph, Kaushansky, Nathali, Shlush, Liran, Oren, Moshe, Levine, Ross, Pikarsky, Eli, Snir-Alkalay, Irit, Ben-Neriah, Yinon

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Substrate Recognition and Ubiquitination of SCFSkp2/Cks1 Ubiquitin-Protein Isopeptide Ligase von Xu, Shuichan, Abbasian, Mahan, Patel, Palka, Jensen-Pergakes, Kristen, Lombardo, Christian R., Cathers, Brian E., Xie, Weilin, Mercurio, Frank, Pagano, Michele, Giegel, David, Cox, Sarah

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BTX-1188, a first-in-class dual degrader of GSPT1 and IKZF1/3, for treatment of acute myeloid leukemia (AML) and solid tumors von Chourasia, Aparajita Hoskote, Majeski, Hannah, Pasis, Angela, Erdman, Paul, Oke, Ashwini, Hecht, David, Lonergan, David, Mercurio, Frank, Chan, Kyle, Thai, Dung Luong, Fung, Leah

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Suprafacial Orientation of the SCF[superscript Cdc4] Dimer Accommodates Multiple Geometries for Substrate Ubiquitination von Tang, Xiaojing, Orlicky, Stephen, Lin, Zhenyuan, Willems, Andrew, Neculai, Dante, Ceccarelli, Derek, Mercurio, Frank, Shilton, Brian H., Sicheri, Frank, Tyers, Mike

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Abstract 1963: Targeting hematological malignancies with two functionally and mechanistically distinct classes of cereblon mediated protein homeostatic modulators von Chourasia, Aparajita Hoskote, Fung, Leah, Pasis, Angela, McElwee, Brooke, Schoolmeesters, Angela, Richard, Normand, Lam, Imelda, Torres, Eduardo, Erdman, Paul, Sullivan, Robert, Hecht, David, Chan, Kyle W., Mercurio, Frank, Stirling, David I.

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NF-κB as a primary regulator of the stress response von Mercurio, Frank, Manning, Anthony M

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Multiple signals converging on NF-κB von Mercurio, Frank, Manning, Anthony M

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Targeting AML: The Development of Two Functionally and Mechanistically Distinct Classes of Cereblon-Mediated Protein Homeostatic Modulators von Chourasia, Aparajita Hoskote, Fung, Leah, McElwee, Brooke, Richard, Normand, Lam, Imelda, Torres, Eduardo, Erdman, Paul, Sullivan, Robert, Hecht, David, Chan, Kyle WH, Mercurio, Frank, Stirling, David I

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