Review of high-content screening applications in toxicology von Li, Shuaizhang, Xia, Menghang

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Application of In Vitro Metabolism Activation in High-Throughput Screening von Ooka, Masato, Lynch, Caitlin, Xia, Menghang

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Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction von Li, Zhong, Brecher, Matthew, Deng, Yong-Qiang, Zhang, Jing, Sakamuru, Srilatha, Liu, Binbin, Huang, Ruili, Koetzner, Cheri A, Allen, Christina A, Jones, Susan A, Chen, Haiying, Zhang, Na-Na, Tian, Min, Gao, Fengshan, Lin, Qishan, Banavali, Nilesh, Zhou, Jia, Boles, Nathan, Xia, Menghang, Kramer, Laura D, Qin, Cheng-Feng, Li, Hongmin

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Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen von Xu, Miao, Lee, Emily M, Wen, Zhexing, Cheng, Yichen, Huang, Wei-Kai, Qian, Xuyu, TCW, Julia, Kouznetsova, Jennifer, Ogden, Sarah C, Hammack, Christy, Jacob, Fadi, Nguyen, Ha Nam, Itkin, Misha, Hanna, Catherine, Shinn, Paul, Allen, Chase, Michael, Samuel G, Simeonov, Anton, Huang, Wenwei, Christian, Kimberly M, Goate, Alison, Brennand, Kristen J, Huang, Ruili, Xia, Menghang, Ming, Guo-li, Zheng, Wei, Song, Hongjun, Tang, Hengli

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Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics von Zhu, Hu, Chen, Catherine Z., Sakamuru, Srilatha, Zhao, Jinghua, Ngan, Deborah K., Simeonov, Anton, Hall, Mathew D., Xia, Menghang, Zheng, Wei, Huang, Ruili

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Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization von Huang, Ruili, Xia, Menghang, Sakamuru, Srilatha, Zhao, Jinghua, Shahane, Sampada A., Attene-Ramos, Matias, Zhao, Tongan, Austin, Christopher P., Simeonov, Anton

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The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform von Shukla, Sunita J., Huang, Ruili, Austin, Christopher P., Xia, Menghang

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Human Cell Toxicogenomic Analysis Linking Reactive Oxygen Species to the Toxicity of Monohaloacetic Acid Drinking Water Disinfection Byproducts von Pals, Justin, Attene-Ramos, Matias S, Xia, Menghang, Wagner, Elizabeth D, Plewa, Michael J

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Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors von Singh, Anju, Venkannagari, Sreedhar, Oh, Kyu H, Zhang, Ya-Qin, Rohde, Jason M, Liu, Li, Nimmagadda, Sridhar, Sudini, Kuladeep, Brimacombe, Kyle R, Gajghate, Sachin, Ma, Jinfang, Wang, Amy, Xu, Xin, Shahane, Sampada A, Xia, Menghang, Woo, Juhyung, Mensah, George A, Wang, Zhibin, Ferrer, Marc, Gabrielson, Edward, Li, Zhuyin, Rastinejad, Fraydoon, Shen, Min, Boxer, Matthew B, Biswal, Shyam

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Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using Antioxidant Response Element Reporter Gene Assay Models and Big Data von Kim, Marlene Thai, Huang, Ruili, Sedykh, Alexander, Wang, Wenyi, Xia, Menghang, Zhu, Hao

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The Tox21 robotic platform for the assessment of environmental chemicals – from vision to reality von Attene-Ramos, Matias S., Miller, Nicole, Huang, Ruili, Michael, Sam, Itkin, Misha, Kavlock, Robert J., Austin, Christopher P., Shinn, Paul, Simeonov, Anton, Tice, Raymond R., Xia, Menghang

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Use of Tox21 Screening Data to Evaluate the COVID-19 Drug Candidates for Their Potential Toxic Effects and Related Pathways von Sakamuru, Srilatha, Huang, Ruili, Xia, Menghang

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Biological activity-based modeling identifies antiviral leads against SARS-CoV-2 von Huang, Ruili, Xu, Miao, Zhu, Hu, Chen, Catherine Z., Zhu, Wei, Lee, Emily M., He, Shihua, Zhang, Li, Zhao, Jinghua, Shamim, Khalida, Bougie, Danielle, Huang, Wenwei, Xia, Menghang, Hall, Mathew D., Lo, Donald, Simeonov, Anton, Austin, Christopher P., Qiu, Xiangguo, Tang, Hengli, Zheng, Wei

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Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library von Lynch, Caitlin, Sakamuru, Srilatha, Huang, Ruili, Niebler, Jake, Ferguson, Stephen S., Xia, Menghang

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Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation von Kim, Nam-Shik, Wen, Zhexing, Liu, Jing, Zhou, Ying, Guo, Ziyuan, Xu, Chongchong, Lin, Yu-Ting, Yoon, Ki-Jun, Park, Junhyun, Cho, Michelle, Kim, Minji, Wang, Xinyuan, Yu, Huimei, Sakamuru, Srilatha, Christian, Kimberly M., Hsu, Kuei-sen, Xia, Menghang, Li, Weidong, Ross, Christopher A., Margolis, Russell L., Lu, Xin-Yun, Song, Hongjun, Ming, Guo-li

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Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library von Paul-Friedman, Katie, Martin, Matt, Crofton, Kevin M, Hsu, Chia-Wen, Sakamuru, Srilatha, Zhao, Jinghua, Xia, Menghang, Huang, Ruili, Stavreva, Diana A, Soni, Vikas, Varticovski, Lyuba, Raziuddin, Razi, Hager, Gordon L, Houck, Keith A

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High-Throughput Screening Assays in Toxicology

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High-Throughput Screening to Predict Chemical-Assay Interference von Borrel, Alexandre, Huang, Ruili, Sakamuru, Srilatha, Xia, Menghang, Simeonov, Anton, Mansouri, Kamel, Houck, Keith A., Judson, Richard S., Kleinstreuer, Nicole C.

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Bisphenol A affects androgen receptor function via multiple mechanisms von Teng, Christina, Goodwin, Bonnie, Shockley, Keith, Xia, Menghang, Huang, Ruili, Norris, John, Merrick, B. Alex, Jetten, Anton M., Austin, Christopher P., Tice, Raymond R.

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5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary von Khare, Tarang, Pai, Shraddha, Koncevicius, Karolis, Pal, Mrinal, Kriukiene, Edita, Liutkeviciute, Zita, Irimia, Manuel, Jia, Peixin, Ptak, Carolyn, Xia, Menghang, Tice, Raymond, Tochigi, Mamoru, Moréra, Solange, Nazarians, Anaies, Belsham, Denise, Wong, Albert H C, Blencowe, Benjamin J, Wang, Sun Chong, Kapranov, Philipp, Kustra, Rafal, Labrie, Viviane, Klimasauskas, Saulius, Petronis, Arturas

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