HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers von Mendillo, Marc L., Santagata, Sandro, Koeva, Martina, Bell, George W., Hu, Rong, Tamimi, Rulla M., Fraenkel, Ernest, Ince, Tan A., Whitesell, Luke, Lindquist, Susan

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The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy von Scherz-Shouval, Ruth, Santagata, Sandro, Mendillo, Marc L., Sholl, Lynette M., Ben-Aharon, Irit, Beck, Andrew H., Dias-Santagata, Dora, Koeva, Martina, Stemmer, Salomon M., Whitesell, Luke, Lindquist, Susan

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Luminidependens (LD) is an Arabidopsis protein with prion behavior von Chakrabortee, Sohini, Kayatekin, Can, Newby, Greg A., Mendillo, Marc L., Lancaster, Alex, Lindquist, Susan

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A Genome-wide siRNA Screen Identifies Proteasome Addiction as a Vulnerability of Basal-like Triple-Negative Breast Cancer Cells von Petrocca, Fabio, Altschuler, Gabriel, Tan, Shen Mynn, Mendillo, Marc L., Yan, Haoheng, Jerry, D. Joseph, Kung, Andrew L., Hide, Winston, Ince, Tan A., Lieberman, Judy

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Addicted to proteostasis: How KRAS-driven cancers acquire resistance to clinical KRAS inhibitors von Klein, Austin T., Mendillo, Marc L.

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HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models von Whitesell, Luke, Santagata, Sandro, Mendillo, Marc L., Lin, Nancy U., Proia, David A., Lindquist, Susan

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Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E) von Park, Joonhee, Yang, Jingyi, Wenzel, Alexander T., Ramachandran, Akshaya, Lee, Wung J., Daniels, Jay C., Kim, Juhyun, Martinez-Escala, Estela, Amankulor, Nduka, Pro, Barbara, Guitart, Joan, Mendillo, Marc L., Savas, Jeffrey N., Boggon, Titus J., Choi, Jaehyuk

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The heat shock factor code: Specifying a diversity of transcriptional regulatory programs broadly promoting stress resilience von Alasady, Milad J, Mendillo, Marc L

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Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State von Santagata, Sandro, Mendillo, Marc L., Tang, Yun-chi, Subramanian, Aravind, Perley, Casey C., Roche, Stéphane P., Wong, Bang, Narayan, Rajiv, Kwon, Hyoungtae, Koeva, Martina, Amon, Angelika, Golub, Todd R., Porco, John A., Whitesell, Luke, Lindquist, Susan

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High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer von Santagata, Sandro, Hu, Rong, Lin, Nancy U, Mendillo, Marc L, Collins, Laura C, Hankinson, Susan E, Schnitt, Stuart J, Whitesell, Luke, Tamimi, Rulla M, Lindquist, Susan, Ince, Tan A

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Octopamine metabolically reprograms astrocytes to confer neuroprotection against α-synuclein von Shum, Andrew, Zaichick, Sofia, McElroy, Gregory S, D'Alessandro, Karis, Alasady, Milad J, Novakovic, Michaela, Peng, Wesley, Grebenik, Ekaterina A, Chung, Daayun, Flanagan, Margaret E, Smith, Roger, Morales, Alejandro, Stumpf, Laetitia, McGrath, Kaitlyn, Krainc, Dimitri, Mendillo, Marc L, Prakriya, Murali, Chandel, Navdeep S, Caraveo, Gabriela

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A network of core and subtype-specific gene expression programs in myositis von Amici, David R., Pinal-Fernandez, Iago, Christopher-Stine, Lisa, Mammen, Andrew L., Mendillo, Marc L.

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The HAPSTR2 retrogene buffers stress signaling and resilience in mammals von Amici, David R., Cingoz, Harun, Alasady, Milad J., Alhayek, Sammy, Phoumyvong, Claire M., Sahni, Nidhi, Yi, S. Stephen, Mendillo, Marc L.

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Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway von Smith, Catherine E, Mendillo, Marc L, Bowen, Nikki, Hombauer, Hans, Campbell, Christopher S, Desai, Arshad, Putnam, Christopher D, Kolodner, Richard D

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The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis von Ali, Eunus S., Lipońska, Anna, O’Hara, Brendan P., Amici, David R., Torno, Michael D., Gao, Peng, Asara, John M., Yap, Mee-Ngan F., Mendillo, Marc L., Ben-Sahra, Issam

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An HSF1-JMJD6-HSP feedback circuit promotes cell adaptation to proteotoxic stress von Alasady, Milad J, Koeva, Martina, Takagishi, Seesha R, Segal, Dmitri, Amici, David R, Smith, Roger S, Ansel, Daniel J, Lindquist, Susan, Whitesell, Luke, Bartom, Elizabeth T, Taipale, Mikko, Mendillo, Marc L

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Quantitative and multiplexed chemical-genetic phenotyping in mammalian cells with QMAP-Seq von Brockway, Sonia, Wang, Geng, Jackson, Jasen M., Amici, David R., Takagishi, Seesha R., Clutter, Matthew R., Bartom, Elizabeth T., Mendillo, Marc L.

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The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection von Filone, Claire Marie, Caballero, Ignacio S, Dower, Ken, Mendillo, Marc L, Cowley, Glenn S, Santagata, Sandro, Rozelle, Daniel K, Yen, Judy, Rubins, Kathleen H, Hacohen, Nir, Root, David E, Hensley, Lisa E, Connor, John

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Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer von Kunder, Ratika, Velyunskiy, Michelle, Dunne, Sara F., Cho, Byoung-Kyu, Kanojia, Deepak, Begg, Lauren, Orriols, Adrienne M., Fleming-Trujillo, Erica, Vadlamani, Pranathi, Vialichka, Alesia, Bolin, Rosemary, Perrino, Jessica N., Roth, Diane, Clutter, Matthew R., Zielinski-Mozny, Nicolette A., Goo, Young Ah, Cristofanilli, Massimo, Mendillo, Marc L., Vassilopoulos, Athanassios, Horiuchi, Dai

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C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways von Amici, David R, Ansel, Daniel J, Metz, Kyle A, Smith, Roger S, Phoumyvong, Claire M, Gayatri, Sitaram, Chamera, Tomasz, Edwards, Stacey L, O'Hara, Brendan P, Srivastava, Shashank, Brockway, Sonia, Takagishi, Seesha R, Cho, Byoung-Kyu, Goo, Young Ah, Kelleher, Neil L, Ben-Sahra, Issam, Foltz, Daniel R, Li, Jian, Mendillo, Marc L

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