Transforming Academic Drug Discovery von Meinke, Peter T.

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On-demand male contraception via acute inhibition of soluble adenylyl cyclase von Balbach, Melanie, Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Ritagliati, Carla, Myers, Robert W., Huggins, David J., Steegborn, Clemens, Miranda, Ileana C., Meinke, Peter T., Buck, Jochen, Levin, Lonny R.

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PPARs: therapeutic targets for metabolic disease von Berger, Joel P., Akiyama, Taro E., Meinke, Peter T.

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LINC’ing form and function at the nuclear envelope von Meinke, Peter, Schirmer, Eric C.

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Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization von Balbach, Melanie, Ghanem, Lubna, Rossetti, Thomas, Kaur, Navpreet, Ritagliati, Carla, Ferreira, Jacob, Krapf, Dario, Puga Molina, Lis C, Santi, Celia Maria, Hansen, Jan Niklas, Wachten, Dagmar, Fushimi, Makoto, Meinke, Peter T, Buck, Jochen, Levin, Lonny R

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Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression von Lama, Lodoe, Adura, Carolina, Xie, Wei, Tomita, Daisuke, Kamei, Taku, Kuryavyi, Vitaly, Gogakos, Tasos, Steinberg, Joshua I., Miller, Michael, Ramos-Espiritu, Lavoisier, Asano, Yasutomi, Hashizume, Shogo, Aida, Jumpei, Imaeda, Toshihiro, Okamoto, Rei, Jennings, Andy J., Michino, Mayako, Kuroita, Takanobu, Stamford, Andrew, Gao, Pu, Meinke, Peter, Glickman, J. Fraser, Patel, Dinshaw J., Tuschl, Thomas

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Indazole to 2‐Cyanoindole Scaffold Progression for Mycobacterial Lipoamide Dehydrogenase Inhibitors Achieves Extended Target Residence Time and Improved Antibacterial Activity von Sun, Shan, Ginn, John, Kochanczyk, Tomasz, Arango, Nancy, Jiang, Xiuju, Huggins, David J., Bean, James, Michino, Mayako, Baxt, Leigh, Liverton, Nigel, Meinke, Peter T., Bryk, Ruslana

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Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration von Balbach, Melanie, Fushimi, Makoto, Huggins, David J, Steegborn, Clemens, Meinke, Peter T, Levin, Lonny R, Buck, Jochen

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Myotonic Dystrophy-A Progeroid Disease? von Meinke, Peter, Hintze, Stefan, Limmer, Sarah, Schoser, Benedikt

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Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization von Meinke, Peter, Mattioli, Elisabetta, Haque, Farhana, Antoku, Susumu, Columbaro, Marta, Straatman, Kees R, Worman, Howard J, Gundersen, Gregg G, Lattanzi, Giovanna, Wehnert, Manfred, Shackleton, Sue

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Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates von Miller, Michael, Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Balbach, Melanie, Kaur, Navpreet, Levin, Lonny R., Buck, Jochen, Kehr, Maria, Coquille, Sandrine, van den Heuvel, Joop, Steegborn, Clemens, Fushimi, Makoto, Finkin-Groner, Efrat, Myers, Robert W., Kargman, Stacia, Liverton, Nigel J., Huggins, David J., Meinke, Peter T.

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Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential von Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Buck, Hannes, Steegborn, Clemens, Myers, Robert W, Meinke, Peter T, Levin, Lonny R, Buck, Jochen

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Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells von Mullarky, Edouard, Xu, Jiayi, Robin, Anita D., Huggins, David J., Jennings, Andy, Noguchi, Naoyoshi, Olland, Andrea, Lakshminarasimhan, Damodharan, Miller, Michael, Tomita, Daisuke, Michino, Mayako, Su, Taojunfeng, Zhang, Guoan, Stamford, Andrew W., Meinke, Peter T., Kargman, Stacia, Cantley, Lewis C.

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Degeneration of muscle spindles in a murine model of Pompe disease von Watkins, Bridgette, Schultheiß, Jürgen, Rafuna, Andi, Hintze, Stefan, Meinke, Peter, Schoser, Benedikt, Kröger, Stephan

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Discovery of MK-8742: An HCV NS5A Inhibitor with Broad Genotype Activity von Coburn, Craig A., Meinke, Peter T., Chang, Wei, Fandozzi, Christine M., Graham, Donald J., Hu, Bin, Huang, Qian, Kargman, Stacia, Kozlowski, Joseph, Liu, Rong, McCauley, John A., Nomeir, Amin A., Soll, Richard M., Vacca, Joseph P., Wang, Dahai, Wu, Hao, Zhong, Bin, Olsen, David B., Ludmerer, Steven W.

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Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation von Sun, Shan, Fushimi, Makoto, Rossetti, Thomas, Kaur, Navpreet, Ferreira, Jacob, Miller, Michael, Quast, Jonathan, van den Heuvel, Joop, Steegborn, Clemens, Levin, Lonny R., Buck, Jochen, Myers, Robert W., Kargman, Stacia, Liverton, Nigel, Meinke, Peter T., Huggins, David J.

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Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia von Liu, Yiman, Li, Qinglan, Alikarami, Fatemeh, Barrett, Declan R, Mahdavi, Leila, Li, Hangpeng, Tang, Sylvia, Khan, Tanweer A, Michino, Mayako, Hill, Connor, Song, Lele, Yang, Lu, Li, Yuanyuan, Pokharel, Sheela Pangeni, Stamford, Andrew W, Liverton, Nigel, Renzetti, Louis M, Taylor, Simon, Watt, Gillian F, Ladduwahetty, Tammy, Kargman, Stacia, Meinke, Peter T, Foley, Michael A, Shi, Junwei, Li, Haitao, Carroll, Martin, Chen, Chun-Wei, Gardini, Alessandro, Maillard, Ivan, Huggins, David J, Bernt, Kathrin M, Wan, Liling

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Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors von Zhang, Hao, Ginn, John, Zhan, Wenhu, Liu, Yi J., Leung, Annie, Toita, Akinori, Okamoto, Rei, Wong, Tzu-Tshin, Imaeda, Toshihiro, Hara, Ryoma, Yukawa, Takafumi, Michino, Mayako, Vendome, Jeremie, Beuming, Thijs, Sato, Kenjiro, Aso, Kazuyoshi, Meinke, Peter T., Nathan, Carl F., Kirkman, Laura A., Lin, Gang

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Addition to “Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation” von Sun, Shan, Fushimi, Makoto, Rossetti, Thomas, Kaur, Navpreet, Ferreira, Jacob, Miller, Michael, Quast, Jonathan, van den Heuvel, Joop, Steegborn, Clemens, Levin, Lonny R., Buck, Jochen, Myers, Robert W., Kargman, Stacia, Liverton, Nigel, Meinke, Peter T., Huggins, David J.

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Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential von Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Buck, Hannes, Steegborn, Clemens, Myers, Robert W, Meinke, Peter T, Levin, Lonny R, Buck, Jochen

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