Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients von de Sousa E Melo, Felipe, Colak, Selcuk, Buikhuisen, Joyce, Koster, Jan, Cameron, Kate, de Jong, Joan H., Tuynman, Jurriaan B., Prasetyanti, Pramudita R., Fessler, Evelyn, van den Bergh, Saskia P., Rodermond, Hans, Dekker, Evelien, van der Loos, Chris M., Pals, Steven T., van de Vijver, Marc J., Versteeg, Rogier, Richel, Dick J., Vermeulen, Louis, Medema, Jan Paul

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Microenvironmental regulation of stem cells in intestinal homeostasis and cancer von Medema, Jan Paul, Vermeulen, Louis

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ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy von Wielenga, Mattheus C.B., Colak, Selcuk, Heijmans, Jarom, van Lidth de Jeude, Jooske F., Rodermond, Hans M., Paton, James C., Paton, Adrienne W., Vermeulen, Louis, Medema, Jan Paul, van den Brink, Gijs R.

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The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis von Asif, Paris Jabeen, Longobardi, Ciro, Hahne, Michael, Medema, Jan Paul

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Oncogenic K-Ras Turns Death Receptors Into Metastasis-Promoting Receptors in Human and Mouse Colorectal Cancer Cells von Hoogwater, Frederik J.H, Nijkamp, Maarten W, Smakman, Niels, Steller, Ernst J.A, Emmink, Benjamin L, Westendorp, B. Florien, Raats, Danielle A.E, Sprick, Martin R, Schaefer, Uta, Van Houdt, Winan J, De Bruijn, Menno T, Schackmann, Ron C.J, Derksen, Patrick W.B, Medema, Jan–Paul, Walczak, Henning, Borel Rinkes, Inne H.M, Kranenburg, Onno

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Colon Cancer Stem Cells: Promise of Targeted Therapy von Todaro, Matilde, Francipane, Maria Giovanna, Medema, Jan Paul, Stassi, Giorgio

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Colorectal cancer heterogeneity and targeted therapy: a case for molecular disease subtypes von Linnekamp, Janneke F, Wang, Xin, Medema, Jan Paul, Vermeulen, Louis

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Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF von Fessler, Evelyn, Borovski, Tijana, Medema, Jan Paul

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Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis von Jackstadt, Rene, van Hooff, Sander R., Leach, Joshua D., Cortes-Lavaud, Xabier, Lohuis, Jeroen O., Ridgway, Rachel A., Wouters, Valérie M., Roper, Jatin, Kendall, Timothy J., Roxburgh, Campbell S., Horgan, Paul G., Nixon, Colin, Nourse, Craig, Gunzer, Matthias, Clark, William, Hedley, Ann, Yilmaz, Omer H., Rashid, Mamunur, Bailey, Peter, Biankin, Andrew V., Campbell, Andrew D., Adams, David J., Barry, Simon T., Steele, Colin W., Medema, Jan Paul, Sansom, Owen J.

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The developing cancer stem-cell model: clinical challenges and opportunities von Vermeulen, Louis, Dr, de Sousa e Melo, Felipe, MSc, Richel, Dick J, Prof, Medema, Jan Paul, Prof

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Cancer heterogeneity-a multifaceted view von Melo, Felipe De Sousa E, Vermeulen, Louis, Fessler, Evelyn, Medema, Jan Paul

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Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival von Reijmers, Rogier M., Groen, Richard W.J., Kuil, Annemieke, Weijer, Kees, Kimberley, Fiona C., Medema, Jan Paul, van Kuppevelt, Toin H., Li, Jin-Ping, Spaargaren, Marcel, Pals, Steven T.

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Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells von Kemper, Kristel, Prasetyanti, Pramudita R., De Lau, Wim, Rodermond, Hans, Clevers, Hans, Medema, Jan Paul

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Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions von De Sousa E Melo, Felipe, Wang, Xin, Jansen, Marnix, Fessler, Evelyn, Trinh, Anne, de Rooij, Laura P M H, de Jong, Joan H, de Boer, Onno J, van Leersum, Ronald, Bijlsma, Maarten F, Rodermond, Hans, van der Heijden, Maartje, van Noesel, Carel J M, Tuynman, Jurriaan B, Dekker, Evelien, Markowetz, Florian, Medema, Jan Paul, Vermeulen, Louis

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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment von Merz, Christian, Medema, Jan Paul, Rodermond, Hans, Borovski, Tijana, Sprick, Martin R, Richel, Dick J, de Jong, Joan H, Todaro, Matilde, Cameron, Kate, De Sousa E Melo, Felipe, van der Heijden, Maartje, Vermeulen, Louis, Tuynman, Jurriaan B, Kemper, Kristel, Stassi, Giorgio

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Lipid Droplets: A New Player in Colorectal Cancer Stem Cells Unveiled by Spectroscopic Imaging von Tirinato, Luca, Liberale, Carlo, Di Franco, Simone, Candeloro, Patrizio, Benfante, Antonina, La Rocca, Rosanna, Potze, Lisette, Marotta, Roberto, Ruffilli, Roberta, Rajamanickam, Vijayakumar P., Malerba, Mario, De Angelis, Francesco, Falqui, Andrea, Carbone, Ennio, Todaro, Matilde, Medema, Jan Paul, Stassi, Giorgio, Di Fabrizio, Enzo

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Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma von Ebbing, Eva A., van der Zalm, Amber P., Steins, Anne, Creemers, Aafke, Hermsen, Simone, Rentenaar, Rosa, Klein, Michelle, Waasdorp, Cynthia, Hooijer, Gerrit K. J., Meijer, Sybren L., Krishnadath, Kausilia K., Punt, Cornelis J. A., van Berge Henegouwen, Mark I., Gisbertz, Suzanne S., van Delden, Otto M., Hulshof, Maarten C. C. M., Medema, Jan Paul, van Laarhoven, Hanneke W. M., Bijlsma, Maarten F.

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Cancer stem cells: The challenges ahead von Medema, Jan Paul

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Think About the Environment: Cellular Reprogramming by the Extracellular Matrix von Huels, David J., Medema, Jan Paul

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Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity von Smit, Wouter Laurentius, Spaan, Claudia Nanette, de Boer, Ruben Johannes, Ramesh, Prashanthi, Garcia, Tânia Martins, Meijer, Bartolomeus Joannes, Vermeulen, Jacqueline Ludovicus Maria, Lezzerini, Marco, MacInnes, Alyson Winfried, Koster, Jan, Medema, Jan Paul, van den Brink, Gijs Robert, Muncan, Vanesa, Heijmans, Jarom

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