TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells von Woznicki, Jerzy A., Saini, Nisha, Flood, Peter, Rajaram, Subhasree, Lee, Ciaran M., Stamou, Panagiota, Skowyra, Agnieszka, Bustamante-Garrido, Milan, Regazzoni, Karine, Crawford, Nyree, McDade, Simon S., Longley, Daniel B., Aza-Blanc, Pedro, Shanahan, Fergus, Zulquernain, Syed A., McCarthy, Jane, Melgar, Silvia, McRae, Bradford L., Nally, Ken

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Near infrared readouts offer sensitive and rapid assessments of intestinal permeability and disease severity in inflammatory bowel disease models von Zhang, Liang, Wallace, Craig D., Erickson, Jamie E., Nelson, Christine M., Gaudette, Stephanie M., Pohl, Calvin S., Karsen, Samuel D., Simler, Gricelda H., Peng, Ruoqi, Stedman, Christopher A., Laroux, F. Stephen, Wurbel, Marc A., Kamath, Rajesh V., McRae, Bradford L., Schwartz Sterman, Annette J., Mitra, Soumya

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CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches von Argiriadi, Maria A, Benatuil, Lorenzo, Dubrovska, Ievgeniia, Egan, David A, Gao, Lei, Greischar, Amy, Hardman, Jennifer, Harlan, John, Iyer, Ramesh B, Judge, Russell A, Lake, Marc, Perron, Denise C, Sadhukhan, Ramkrishna, Sielaff, Bernhard, Sousa, Silvino, Wang, Rui, McRae, Bradford L

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Treatment with a CD40 Antagonist Antibody Reverses Severe Proteinuria and Loss of Saliva Production and Restores Glomerular Morphology in Murine Systemic Lupus Erythematosus von Perper, Stuart J, Westmoreland, Susan V, Karman, Jozsef, Twomey, Rachel, Seagal, Jane, Wang, Rui, McRae, Bradford L, Clarke, Stephen H

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Type I IFNs Inhibit Human Dendritic Cell IL-12 Production and Th1 Cell Development von McRae, Bradford L, Semnani, Roshanak Tolouei, Hayes, Mark P, van Seventer, Gijs A

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DNA sensor-associated type I interferon signaling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids von Flood, Peter, Fanning, Aine, Woznicki, Jerzy A, Crowley, Tadhg, Christopher, Andrea, Vaccaro, Alessandra, Houston, Aileen, McSweeney, Sheila, Ross, Sarah, Hogan, Aileen, Brint, Elizabeth, Skowyra, Agnieszka, Bustamante, Milan, Ambrose, Monica, Moloney, Gerard, MacSharry, John, Hammarström, Marie-Louise, Hurley, Margot, Fitzgibbons, Christine, Quigley, Eamonn M M, Shanahan, Fergus, Zulquernain, Syed A, McCarthy, Jane, Dodson, G Steven, Dabbagh, Karim, McRae, Bradford L, Melgar, Silvia, Nally, Ken

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Distinct spatiotemporal pattern of CNS lesions revealed by USPIO-enhanced MRI in MOG-induced EAE rats implicates the involvement of spino-olivocerebellar pathways von Chin, Chih-Liang, Pai, Madhavi, Bousquet, Peter F, Schwartz, Annette J, O'Connor, Elizabeth M, Nelson, Christine M, Hradil, Vincent P, Cox, Bryan F, McRae, Bradford L, Fox, Gerard B

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Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease von Zhu, Qifan, Korenfeld, Daniel, Suarez-Fueyo, Abel, Graham, Sean, Jin, Liang, Punit, Shivesh, Duffy, Rachael, Puri, Munish, Caruso, Andrew, Hu, Chenqi, Tian, Yu, McRae, Bradford L., Kamath, Raj, Phillips, Lucy, Schwartz-Sterman, Annette J., Westmoreland, Susan, Cao, Xiaohong, Levesque, Marc C., Bi, Yingtao, Paez-Cortez, Jesus, Goenka, Radhika

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Anti–Tumor Necrosis Factor With a Glyco-Engineered Fc-Region Has Increased Efficacy in Mice With Colitis von Bloemendaal, Felicia M., Levin, Alon D., Wildenberg, Manon E., Koelink, Pim J., McRae, Bradford L., Salfeld, Jochen, Lum, Jenifer, van der Neut Kolfschoten, Marijn, Claassens, Jill W., Visser, Remco, Bentlage, Arthur, D’Haens, Geert R.A.M., Verbeek, J. Sjef, Vidarsson, Gestur, van den Brink, Gijs R.

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Anti-Inflammatory Effects of FTY720 Do Not Prevent Neuronal Cell Loss in a Rat Model of Optic Neuritis von Rau, Christian R, Hein, Katharina, Sättler, Muriel B, Kretzschmar, Benedikt, Hillgruber, Carina, McRae, Bradford L, Diem, Ricarda, Bähr, Mathias

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Fc Receptor-mediated Effector Function Contributes to the Therapeutic Response of Anti-TNF Monoclonal Antibodies in a Mouse Model of Inflammatory Bowel Disease von McRae, Bradford L., Levin, Alon D., Wildenberg, Manon E., Koelink, Pim J., Bousquet, Peter, Mikaelian, Igor, Sterman, Annette Schwartz, Bryant, Shaughn, D’Haens, Geert, Kamath, Rajesh, Salfeld, Jochen, van den Brink, Gijs R

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631 - BCL2 Regulates Differentiation of Intestinal Fibroblasts von Weder, Bruce, Mamie, Céline, Rogler, Gerhard, Clarke, Stephen, McRae, Bradford L., Ruiz-Castro, Pedro A., Hausmann, Martin

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Suppression of CD4 + T cell activation by a novel inhibitor of Src family kinases von McRae, Bradford L., Wallace, Craig, Dixon, Kathleen Fitzgerald, Roux, Alyson, Mohan, Sukumari, Jia, Yong, Presky, David H., Tracey, Daniel E., Hirst, Gavin C.

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Induction of active and adoptive relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein von McRae, Bradford L., Kennedy, Mary K., Tan, Lit-Jen, Dal Canto, Mauro C., Picha, Kathleen S., Miller, Stephen D.

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158 – Leveraging Human Intestinal Organoids to Advance Il-22-Based Therapies for Ulcerative Colitis von Patnaude, Lori, Mayo, Martha, Mario, Regina, Wilson, Sarah, Peso, Paul, Knight, Heather, Legendre, Kristen, Karsen, Sam, Yang, Yingli, Melim, Terry, Creamer, Kelly, Pivorunas, Valerie L., Westmoreland, Susan, Dunstan, Robert, Sterman, Annette Schwartz, Slavin, Anthony, Kamath, Rajesh, McRae, Bradford L., Terrillon, Sonia

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Su2050 – Near Infrared (NIR) Fluorescence Readouts of Intestinal Permeability and Disease Severity in Murine IBD Models von Mitra, Soumya, Zhang, Liang, Wallace, Craig, Erickson, Jamie, Nelson, Christine, Gaudette, Stephanie, Karsen, Sam, Stedman, Christopher, Laroux, Stephen, Simler, Gricelda, Peng, Ruoqi, Wurbel, Marc-Andre, Kamath, Rajesh, McRae, Bradford L., Slavin, Anthony, Sterman, Annette Schwartz

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Tu1736 - Biomarkers for IL-22 Based Therapies von Pivorunas, Valerie L., Patnaude, Lori, Bousquet, Peter, Lynch, Grace, Hart, Michelle, Wallace, Craig, Wong, Laura, Creamer, Kelly, Tian, Yu, Cui, Baoliang, Cuff, Carolyn, Sterman, Annette Schwartz, McRae, Bradford L.

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Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis von McRae, B L, Vanderlugt, C L, Dal Canto, M C, Miller, S D

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Degenerate antigen recognition by CD4 + effector T cells in experimental autoimmune encephalomyelitis von McRae, Bradford L, Karandikar, Nitin J, Miller, Stephen D

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Interferon-α and -β inhibit the in vitro differentiation of immunocompetent human dendritic cells from CD14+ precursors von MCRAE, B. L, NAGAI, T, SEMNANI, R. T, VAN SEVENTER, J. M, VAN SEVENTER, G. A

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