Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme‑1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation von Mandal, Mihirbaran, Zhu, Zhaoning, Cumming, Jared N, Liu, Xiaoxiang, Strickland, Corey, Mazzola, Robert D, Caldwell, John P, Leach, Prescott, Grzelak, Michael, Hyde, Lynn, Zhang, Qi, Terracina, Giuseppe, Zhang, Lili, Chen, Xia, Kuvelkar, Reshma, Kennedy, Matthew E, Favreau, Leonard, Cox, Kathleen, Orth, Peter, Buevich, Alexei, Voigt, Johannes, Wang, Hongwu, Kazakevich, Irina, McKittrick, Brian A, Greenlee, William, Parker, Eric M, Stamford, Andrew W

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Biased ligand modulation of seven transmembrane receptors (7TMRs): functional implications for drug discovery von Correll, Craig C, McKittrick, Brian A

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Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor von Cumming, Jared N., Smith, Elizabeth M., Wang, Lingyan, Misiaszek, Jeffrey, Durkin, James, Pan, Jianping, Iserloh, Ulrich, Wu, Yusheng, Zhu, Zhaoning, Strickland, Corey, Voigt, Johannes, Chen, Xia, Kennedy, Matthew E., Kuvelkar, Reshma, Hyde, Lynn A., Cox, Kathleen, Favreau, Leonard, Czarniecki, Michael F., Greenlee, William J., McKittrick, Brian A., Parker, Eric M., Stamford, Andrew W.

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Discovery of Cyclic Acylguanidines as Highly Potent and Selective β-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part IInhibitor Design and Validation von Zhu, Zhaoning, Sun, Zhong-Yue, Ye, Yuanzan, Voigt, Johannes, Strickland, Corey, Smith, Elizabeth M, Cumming, Jared, Wang, Lingyan, Wong, Jesse, Wang, Yu-Sen, Wyss, Daniel F, Chen, Xia, Kuvelkar, Reshma, Kennedy, Matthew E, Favreau, Leonard, Parker, Eric, McKittrick, Brian A, Stamford, Andrew, Czarniecki, Michael, Greenlee, William, Hunter, John C

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Structure-Based Design of an Iminoheterocyclic β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates von Mandal, Mihirbaran, Wu, Yusheng, Misiaszek, Jeffrey, Li, Guoqing, Buevich, Alexei, Caldwell, John P, Liu, Xiaoxiang, Mazzola, Robert D, Orth, Peter, Strickland, Corey, Voigt, Johannes, Wang, Hongwu, Zhu, Zhaoning, Chen, Xia, Grzelak, Michael, Hyde, Lynn A, Kuvelkar, Reshma, Leach, Prescott T, Terracina, Giuseppe, Zhang, Lili, Zhang, Qi, Michener, Maria S, Smith, Brad, Cox, Kathleen, Grotz, Diane, Favreau, Leonard, Mitra, Kaushik, Kazakevich, Irina, McKittrick, Brian A, Greenlee, William, Kennedy, Matthew E, Parker, Eric M, Cumming, Jared N, Stamford, Andrew W

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Biased Ligand Modulation of Seven Transmembrane Receptors (7TMRs): Functional Implications for Drug Discovery: Miniperspective von Correll, Craig C, McKittrick, Brian A

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Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM... von Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H, Kennedy, Matthew E, Beyer, Brian M, Senior, Mary M, Smith, Elizabeth M, Nechuta, Terry L, Madison, Vincent S, Czarniecki, Michael, McKittrick, Brian A, Stamford, Andrew W, Parker, Eric M, Hunter, John C, Greenlee, William J, Wyss, Daniel F

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Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction von Stamford, Andrew W, Scott, Jack D, Li, Sarah W, Babu, Suresh, Tadesse, Dawit, Hunter, Rachael, Wu, Yusheng, Misiaszek, Jeffrey, Cumming, Jared N, Gilbert, Eric J, Huang, Chunli, McKittrick, Brian A, Hong, Liwu, Guo, Tao, Zhu, Zhaoning, Strickland, Corey, Orth, Peter, Voigt, Johannes H, Kennedy, Matthew E, Chen, Xia, Kuvelkar, Reshma, Hodgson, Robert, Hyde, Lynn A, Cox, Kathleen, Favreau, Leonard, Parker, Eric M, Greenlee, William J

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Stereoselective synthesis of C-6 hydroxy tricyclic sulfone as a γ-secretase inhibitor von Su, Jing, Tang, Haiqun, McKittrick, Brian A.

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Identification of 2-aminooxazole amides as acyl-CoA: Diacylglycerol acyltransferase 1 (DGAT1) inhibitors through scaffold hopping strategy von Kim, Hyunjin M., Smith, Michelle D., Kim, Jae-Hun, Caplen, Mary Ann, Chan, Tin Yau, McKittrick, Brian A., Cook, John A., van Heek, Margaret, Lachowicz, Jean

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Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitors von McKittrick, Brian A., Caldwell, John P., Bara, Thomas, Boykow, George, Chintala, Madhu, Clader, John, Czarniecki, Michael, Courneya, Brandy, Duffy, Ruth, Fleming, Linda, Giessert, Rachel, Greenlee, William J., Heap, Charles, Hong, Liwu, Huang, Ying, Iserloh, Ulrich, Josien, Hubert, Khan, Tanweer, Korfmacher, Walter, Liang, Xian, Mazzola, Robert, Mitra, Soumya, Moore, Kristina, Orth, Peter, Rajagopalan, Murali, Roy, Sudipta, Sakwa, Samuel, Strickland, Corey, Vaccaro, Henry, Voigt, Johannes, Wang, Hongwu, Wong, Jesse, Zhang, Rumin, Zych, Andrew

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Synthesis and SAR study of tricyclic sulfones as γ-secretase inhibitors: C-6 and C-8 positions von Su, Jing, Tang, Haiqun, McKittrick, Brian A., Xu, Ruo, Clader, John W., Greenlee, William J., Hyde, Lynn, Zhang, Lili

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SAR studies of C2 ethers of 2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-triones as nicotinic acid receptor (NAR) agonist von Huang, Xianhai, Su, Jing, Rao, Ashwin U., Tang, Haiqun, Zhou, Wei, Zhu, Xiaohong, Chen, Xiao, Liu, Zhidan, Huang, Ying, Degrado, Sylvia, Xiao, Dong, Qin, Jun, Aslanian, Robert, McKittrick, Brian A., Greenfeder, Scott, Heek, Margaret van, Chintala, Madhu, Palani, Anandan

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T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones—optimization, design and synthesis von Smith, Elizabeth M., Sorota, Steve, Kim, Hyunjin M., McKittrick, Brian A., Nechuta, Terry L., Bennett, Chad, Knutson, Chad, Burnett, Duane A., Kieselgof, Jane, Tan, Zheng, Rindgen, Diane, Bridal, Terry, Zhou, Xiaoping, Jia, Yu-Ping, Dong, Zoe, Mullins, Debbie, Zhang, Xiaoping, Priestley, Tony, Correll, Craig C., Tulshian, Deen, Czarniecki, Michael, Greenlee, William J.

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Modification of the clozapine structure by parallel synthesis von Su, Jing, Tang, Haiqun, McKittrick, Brian A., Burnett, Duane A., Zhang, Hongtao, Smith-Torhan, April, Fawzi, Ahmad, Lachowicz, Jean

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Tetrahydroquinoline sulfonamides as vasopressin 1b receptor anatgonists von Scott, Jack D., Miller, Michael W., Li, Sarah W., Lin, Sue-Ing, Vaccaro, Henry A., Hong, Liwu, Mullins, Deborra E., Guzzi, Mario, Weinstein, Jay, Hodgson, Robert A., Varty, Geoffrey B., Stamford, Andrew W., Chan, Tin-Yau, McKittrick, Brian A., Greenlee, William J., Priestley, Tony, Parker, Eric M.

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Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists von Qiang, Li, Sasikumar, T K, Burnett, Duane A, Su, Jing, Tang, Haiqun, Ye, Yuanzan, Mazzola, Jr, Robert D, Zhu, Zhaoning, McKittrick, Brian A, Greenlee, William J, Fawzi, Ahmad, Smith, Michelle, Zhang, Hongtao, Lachowicz, Jean E

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Spiro-piperidine azetidinones as potent TRPV1 antagonists von Xiao, Dong, Palani, Anandan, Aslanian, Robert, McKittrick, Brian A., McPhail, Andrew T., Correll, Craig C., Phelps, P. Tara, Anthes, John C., Rindgen, Diane

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2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors von Pissarnitski, Dmitri A., Asberom, Theodros, Bara, Thomas A., Buevich, Alex V., Clader, John W., Greenlee, William J., Guzik, Henry S., Josien, Hubert B., Li, Wei, McEwan, Michael, McKittrick, Brian A., Nechuta, Terry L., Parker, Eric M., Sinning, Lisa, Smith, Elizabeth M., Song, Lixin, Vaccaro, Henry A., Voigt, Johannes H., Zhang, Lili, Zhang, Qi, Zhao, Zhiqiang

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Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis von Su, Jing, McKittrick, Brian A., Tang, Haiqun, Czarniecki, Michael, Greenlee, William J., Hawes, Brian E., O’Neill, Kim

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