Exploratory Analysis for a Targeted Patient Population Responsive to the Metabotropic Glutamate 2/3 Receptor Agonist Pomaglumetad Methionil in Schizophrenia von Kinon, Bruce J, Millen, Brian A, Zhang, Lu, McKinzie, David L

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LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders von Rorick-Kehn, Linda M., Witkin, Jeffrey M., Statnick, Michael A., Eberle, Elizabeth L., McKinzie, Jamie H., Kahl, Steven D., Forster, Beth M., Wong, Conrad J., Li, Xia, Crile, Robert S., Shaw, David B., Sahr, Allison E., Adams, Benjamin L., Quimby, Steven J., Diaz, Nuria, Jimenez, Alma, Pedregal, Concepcion, Mitch, Charles H., Knopp, Kelly L., Anderson, Wesley H., Cramer, Jeffrey W., McKinzie, David L.

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Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for Schizophrenia von Shekhar, Anantha, Potter, William Z., Lightfoot, Jeffrey, Lienemann, John, Dubé, Sanjay, Mallinckrodt, Craig, Bymaster, Frank P., McKinzie, David L., Felder, Christian C.

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Bassoon contributes to tau-seed propagation and neurotoxicity von Martinez, Pablo, Patel, Henika, You, Yanwen, Jury, Nur, Perkins, Abigail, Lee-Gosselin, Audrey, Taylor, Xavier, You, Yingjian, Viana Di Prisco, Gonzalo, Huang, Xiaoqing, Dutta, Sayan, Wijeratne, Aruna B., Redding-Ochoa, Javier, Shahid, Syed Salman, Codocedo, Juan F., Min, Sehong, Landreth, Gary E., Mosley, Amber L., Wu, Yu-Chien, McKinzie, David L., Rochet, Jean-Christophe, Zhang, Jie, Atwood, Brady K., Troncoso, Juan, Lasagna-Reeves, Cristian A.

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Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophrenia von Fell, Matthew J., McKinzie, David L., Monn, James A., Svensson, Kjell A.

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The M1/M4 preferring muscarinic agonist xanomeline modulates functional connectivity and NMDAR antagonist-induced changes in the mouse brain von Montani, Caterina, Canella, Carola, Schwarz, Adam J, Li, Jennifer, Gilmour, Gary, Galbusera, Alberto, Wafford, Keith, Gutierrez-Barragan, Daniel, McCarthy, Andrew, Shaw, David, Knitowski, Karen, McKinzie, David, Gozzi, Alessandro, Felder, Christian

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Molecular Mechanisms of Action and In Vivo Validation of an M4 Muscarinic Acetylcholine Receptor Allosteric Modulator with Potential Antipsychotic Properties von Leach, Katie, Loiacono, Richard E, Felder, Christian C, McKinzie, David L, Mogg, Adrian, Shaw, David B, Sexton, Patrick M, Christopoulos, Arthur

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Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats von Cowen, Stephen L., Phelps, Caroline E., Navratilova, Edita, McKinzie, David L., Okun, Alec, Husain, Omar, Gleason, Scott D., Witkin, Jeffrey M., Porreca, Frank

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Hedonic and motivational responses to food reward are unchanged in rats with neuropathic pain von Okun, Alec, McKinzie, David L., Witkin, Jeffrey M., Remeniuk, Bethany, Husein, Omar, Gleason, Scott D., Oyarzo, Janice, Navratilova, Edita, McElroy, Brian, Cowen, Stephen, Kennedy, Jeffrey D., Porreca, Frank

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Diverse Psychotomimetics Act through a Common Signaling Pathway von Svenningsson, Per, Tzavara, Eleni T., Carruthers, Robert, Rachleff, Ilan, Wattler, Sigrid, Nehls, Michael, McKinzie, David L., Fienberg, Allen A., Nomikos, George G., Greengard, Paul

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Synthesis and Pharmacological Characterization of C4‑(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)‑2-Amino-4-(1H‑1,... von Monn, James A, Prieto, Lourdes, Taboada, Lorena, Hao, Junliang, Reinhard, Matthew R, Henry, Steven S, Beadle, Christopher D, Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Getman, Brian G, Catlow, John T, Swanson, Steven, Johnson, Bryan G, Shaw, David B, McKinzie, David L

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Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S‑2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metab... von Monn, James A, Prieto, Lourdes, Taboada, Lorena, Pedregal, Concepcion, Hao, Junliang, Reinhard, Matt R, Henry, Steven S, Goldsmith, Paul J, Beadle, Christopher D, Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Xiang, Chuanxi, Catlow, John T, Swanson, Steven, Sanger, Helen, Broad, Lisa M, Johnson, Michael P, Knopp, Kelly L, Simmons, Rosa M. A, Johnson, Bryan G, Shaw, David B, McKinzie, David L

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Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor von McKinzie, David L, Winneroski, Leonard L, Green, Steven J, Hembre, Erik J, Erickson, Jon A, Willis, Brian A, Monk, Scott A, Aluise, Christopher D, Baker, Thomas K, Lopez, Jose E, Hendle, Jörg, Beck, James P, Brier, Richard A, Boggs, Leonard N, Borders, Anthony R, Cocke, Patrick J, Garcia-Losada, Pablo, Lowe, Stephen L, Mathes, Brian M, May, Patrick C, Porter, Warren J, Stout, Stephanie L, Timm, David E, Watson, Brian M, Yang, Zhixiang, Mergott, Dustin J

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Synthesis and Pharmacological Characterization of C4 β -Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-meth... von Monn, James A, Henry, Steven S, Massey, Steven M, Clawson, David K, Chen, Qi, Diseroad, Benjamin A, Bhardwaj, Rajni M, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xu-Shan, Carter, Joan H, Getman, Brian G, Adragni, Kofi, Broad, Lisa M, Sanger, Helene E, Ursu, Daniel, Catlow, John T, Swanson, Steven, Johnson, Bryan G, Shaw, David B, McKinzie, David L, Hao, Junliang

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In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders von RORICK-KEHN, Linda M, JOHNSON, Bryan G, SCHOEPP, Darryle D, KNITOWSKI, Karen M, SALHOFF, Craig R, WITKIN, Jeffrey M, PERRY, Kenneth W, GRIFFEY, Kelly I, TIZZANO, Joseph P, MONN, James A, MCKINZIE, David L

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Reduction of dendritic spines and elevation of GABAergic signaling in the brains of mice treated with an estrogen receptor β ligand von Tan, Xin-jie, Dai, Yu-bing, Wu, Wan-fu, Kim, Hyun-Jin, Barros, Rodrigo P. A, Richardson, Timothy I, Yaden, Benjamin C, Warner, Margaret, McKinzie, David L, Krishnan, Venkatesh, Gustafsson, Jan-Åke

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Sucla2 Knock‐Out in Skeletal Muscle Yields Mouse Model of Mitochondrial Myopathy With Muscle Type–Specific Phenotypes von Lancaster, Makayla S., Hafen, Paul, Law, Andrew S., Matias, Catalina, Meyer, Timothy, Fischer, Kathryn, Miller, Marcus, Hao, Chunhai, Gillespie, Patrick, McKinzie, David, Brault, Jeffrey J., Graham, Brett H.

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Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s) von Johnson, Michael P, Barda, David, Britton, Thomas C, Emkey, Renee, Hornback, William J, Jagdmann, G Erik, McKinzie, David L, Nisenbaum, Eric S, Tizzano, Joseph P, Schoepp, Darryle D

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Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human von Rorick-Kehn, Linda M, Witcher, Jennifer W, Lowe, Stephen L, Gonzales, Celedon R, Weller, Mary Ann, Bell, Robert L, Hart, John C, Need, Anne B, McKinzie, Jamie H, Statnick, Michael A, Suico, Jeffrey G, McKinzie, David L, Tauscher-Wisniewski, Sitra, Mitch, Charles H, Stoltz, Randall R, Wong, Conrad J

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Discovery of Aminobenzyloxyarylamides as κ Opioid Receptor Selective Antagonists: Application to Preclinical Development of a κ Opioid Receptor Antagonist Receptor Occupancy Tracer... von Mitch, Charles H, Quimby, Steven J, Diaz, Nuria, Pedregal, Concepcion, de la Torre, Marta G, Jimenez, Alma, Shi, Qing, Canada, Emily J, Kahl, Steven D, Statnick, Michael A, McKinzie, David L, Benesh, Dana R, Rash, Karen S, Barth, Vanessa N

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