Update on drug development targeting parasite cysteine proteases von McKerrow, James H

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Protease inhibitors targeting coronavirus and filovirus entry von Zhou, Yanchen, Vedantham, Punitha, Lu, Kai, Agudelo, Juliet, Carrion, Ricardo, Nunneley, Jerritt W., Barnard, Dale, Pöhlmann, Stefan, McKerrow, James H., Renslo, Adam R., Simmons, Graham

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Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent von Capparelli, Edmund V, Bricker-Ford, Robin, Rogers, M John, McKerrow, James H, Reed, Sharon L

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The diverse roles of cysteine proteases in parasites and their suitability as drug targets von McKerrow, James H

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A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit von De Muylder, Geraldine, Ang, Kenny K H, Chen, Steven, Arkin, Michelle R, Engel, Juan C, McKerrow, James H

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A Reprofiled Drug, Auranofin, Is Effective against Metronidazole-Resistant Giardia lamblia von TEJMAN-YARDEN, Noa, MIYAMOTO, Yukiko, LEITSCH, David, SANTINI, Jennifer, DEBNATH, Anjan, GUT, Jiri, MCKERROW, James H, REED, Sharon L, ECKMANN, Lars

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First report on prevalence of SARS-CoV-2 infection among health-care workers in Nicaragua von Huete-Perez, Jorge A., Cabezas-Robelo, Cristiana, Paiz-Medina, Lucia, Hernandez-Alvarez, Carlos A., Quant-Duran, Carlos, McKerrow, James H.

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target von Debnath, Anjan, Parsonage, Derek, Andrade, Rosa M, He, Chen, Cobo, Eduardo R, Hirata, Ken, Chen, Steven, García-Rivera, Guillermina, Orozco, Esther, Martínez, Máximo B, Gunatilleke, Shamila S, Barrios, Amy M, Arkin, Michelle R, Poole, Leslie B, McKerrow, James H, Reed, Sharon L

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Determinants of disease phenotype in trypanosomatid parasites von McCall, Laura-Isobel, McKerrow, James H

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Proteases in parasitic diseases von McKerrow, James H, Caffrey, Conor, Kelly, Ben, Loke, P'ng, Sajid, Mohammed

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X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action von Parsonage, Derek, Sheng, Fang, Hirata, Ken, Debnath, Anjan, McKerrow, James H., Reed, Sharon L., Abagyan, Ruben, Poole, Leslie B., Podust, Larissa M.

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Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening von Abdulla, Maha-Hamadien, Ruelas, Debbie S, Wolff, Brian, Snedecor, June, Lim, Kee-Chong, Xu, Fengyun, Renslo, Adam R, Williams, Janice, McKerrow, James H, Caffrey, Conor R

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Location, Location, Location: Five Facts about Tissue Tropism and Pathogenesis von McCall, Laura-Isobel, Siqueira-Neto, Jair L, McKerrow, James H

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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design von Kerr, Iain D., Lee, Ji H., Farady, Christopher J., Marion, Rachael, Rickert, Mathias, Sajid, Mohammed, Pandey, Kailash C., Caffrey, Conor R., Legac, Jennifer, Hansell, Elizabeth, McKerrow, James H., Craik, Charles S., Rosenthal, Philip J., Brinen, Linda S.

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The Trypanosoma cruzi protease cruzain mediates immune evasion von Doyle, Patricia S, Zhou, Yuan M, Hsieh, Ivy, Greenbaum, Doron C, McKerrow, James H, Engel, Juan C

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CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM) von Debnath, Anjan, Calvet, Claudia M, Jennings, Gareth, Zhou, Wenxu, Aksenov, Alexander, Luth, Madeline R, Abagyan, Ruben, Nes, W David, McKerrow, James H, Podust, Larissa M

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Spatial metabolomics identifies localized chemical changes in heart tissue during chronic cardiac Chagas Disease von Dean, Danya A., Gautham, Gautham, Siqueira-Neto, Jair L., McKerrow, James H., Dorrestein, Pieter C., Mccall, Laura-Isobel

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In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri von Debnath, Anjan, Nelson, Andrew T, Silva-Olivares, Angélica, Shibayama, Mineko, Siegel, Dionicio, McKerrow, James H

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Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors von Fajtová, Pavla, Štefanić, Saša, Hradilek, Martin, Dvořák, Jan, Vondrášek, Jiří, Jílková, Adéla, Ulrychová, Lenka, McKerrow, James H, Caffrey, Conor R, Mareš, Michael, Horn, Martin

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Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole von Calvet, Claudia Magalhaes, Silva, Tatiana Araujo, Thomas, Diane, Suzuki, Brian, Hirata, Ken, Siqueira-Neto, Jair Lage, McKerrow, James H.

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