Binding Site Characterization and Resistance to a Class of Non-nucleoside Inhibitors of the Hepatitis C Virus NS5B Polymerase von Kukolj, George, McGibbon, Graham A., McKercher, Ginette, Marquis, Martin, Lefèbvre, Sylvain, Thauvette, Louise, Gauthier, Jean, Goulet, Sylvie, Poupart, Marc-André, Beaulieu, Pierre L.

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Non-Nucleoside Benzimidazole-Based Allosteric Inhibitors of the Hepatitis C Virus NS5B Polymerase:  Inhibition of Subgenomic Hepatitis C Virus RNA Replicons in Huh-7 Cells von Beaulieu, Pierre L, Bousquet, Yves, Gauthier, Jean, Gillard, James, Marquis, Martin, McKercher, Ginette, Pellerin, Charles, Valois, Serge, Kukolj, George

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A Simple Variable Number of Tandem Repeat-Based Genotyping Strategy for the Detection of Handling Errors and Validation of Sample Identity in Biobanks von Pellerin, Charles, McKercher, Ginette, Aprikian, Armen G, Saad, Fred, Lacombe, Louis, Carmel, Michel, Chevalier, Simone

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Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds von Beaulieu, Pierre L., Gillard, James, Bykowski, Darren, Brochu, Christian, Dansereau, Nathalie, Duceppe, Jean-Simon, Haché, Bruno, Jakalian, Araz, Lagacé, Lisette, LaPlante, Steven, McKercher, Ginette, Moreau, Elaine, Perreault, Stéphane, Stammers, Timothy, Thauvette, Louise, Warrington, Jeff, Kukolj, George

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The Immune Landscape of Cancer von Bortone, Dante S., Eddy, James A., Liu, Yuexin, Weinstein, John N., Holt, Robert A., Zenklusen, Jean C., Cho, Juok, Reynolds, Sheila, Liu, Wenbin, Ryan, Michael, Chakravarty, Debyani, Schultz, Nikolaus, Stuart, Joshua M., Wilkerson, Matthew D., Balasundaram, Miruna, Carlsen, Rebecca, Chuah, Eric, Holt, Robert, Lee, Darlene, Ha, Gavin, Schumacher, Steven E., Cope, Leslie, Balu, Saianand, Shi, Yan, Hinoue, Toshinori, Glenn, Robert, Miller, Christopher A., Curley, Erin, Mallery, David, Morris, Scott, Longatto-Filho, Adhemar, Reis, Rui M., Scapulatempo-Neto, Cristovam, Singh, Rosy, Le, Xuan, Thorp, Richard, Setdikova, Galiya, Shabunin, Alexey, Barrett, Wendi, Ostrom, Quinn T., Karlan, Beth Y., Hu, Hai, Latour, Mathieu, Lacombe, Louis, Su, Tao, Signoretti, Sabina, Marks, Jeffrey, Olson, Jeffrey J., Sica, Gabriel, Stoop, Hans, Pollo, Bianca, Aymerich, Marta, Stepa, Serghei, Moser, Catherine, Roberts, Lewis, Czerniak, Bogdan, Lazar, Alexander J., Jakrot, Valerie, Scolyer, Richard, Thompson, John, Wilmott, James, Reuter, Victor, Tien, Nguyen Viet, Park, Joong-Won, Pinto, Peter A., Moncrieff, Marc, Botnariuc, Natalia, Pirtac, Maria, Parfitt, Jeremy, Bifulco, Carlo, Antenucci, Anna, Grazi, Gianluca, Marino, Mirella, Chevalier, Simone, McKercher, Ginette, Naska, Theresa, Borgia, Jeffrey A., Pool, Mark, Junker, Kerstin, Moiseenko, Fedor, Hilty, Joe, Pilarski, Robert, Porten, Sima, Asa, Sylvia L., Schadendorf, Dirk, Disaia, Philip, Kelley, Robin K., Sifri, Suzanne, Mannelli, Massimo, Knutson, Tina, Sigmund, Rita, Postier, Russel, Walker, Joan, Feldman, Michael, Luketich, James, Rozek, Laura, Fong, Kwun M., Hooke, Jeffrey A., Govindan, Ramaswamy, Aredes, Natália D.

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Driver Fusions and Their Implications in the Development and Treatment of Human Cancers von Foltz, Steven M., Yu, Lihua, Ferguson, Martin L., Liu, Jia, Heiman, David I., Lawrence, Michael S., Saksena, Gordon, Dhankani, Varsha, Hegde, Apurva M., Li, Jun, Liu, Wenbin, Nissan, Moriah G., Sander, Chris, Wong, Christopher K., Ally, Adrian, Kasaian, Katayoon, Moore, Richard A., Cherniack, Andrew D., Meyerson, Matthew, Baylin, Stephen, Bootwalla, Moiz S., Hoadley, Katherine A., Mose, Lisle E., Hale, Walker, Morton, Donna, Santibanez, Jireh, Wheeler, David A., Fulton, Robert S., Wilson, Richard K., Penny, Robert, Gerken, Mark, Leraas, Kristen M., Huntsman, David, Duffy, Elizabeth R., Berkowitz, Ross, Malykh, Andrei, Iacocca, Mary, Roman-Roman, Sergio, Stern, Marc-Henri, Lipp, Eric, Sharp, Alexis, Delman, Keith, Owonikoko, Taofeek, Gillis, Ad, Korpershoek, Esther, Looijenga, Leendert, DiMeco, Francesco, Chen, Chu, Stoehr, Robert, Bubley, Glenn, Campo, Elias, Martignetti, John A., Breggia, Anne, Kocher, Jean-Pierre, Petersen, Gloria, Smyrk, Thomas, Ajani, Jaffer A., Esmaeli, Bita, Logothetis, Christopher, Rice, David, Sood, Anil, Kefford, Richard, Al-Ahmadie, Hikmat, Miller, Judy, Schiffman, Mark, Wentzensen, Nicolas, Caraman, Irina, Clipca, Adrian, Doruc, Serghei, Stancul, Irina, Albert, Monique, Arnaout, Angel, Bartlett, John, Engel, Jay, Urba, Walter, Marino, Mirella, Barnett, Gene, Farver, Carol, Abdel-Rahman, Mohamed H., Cebulla, Colleen M., Kumar, Bahavna, Rai, Karan, Lechan, Ronald, Graefen, Markus, Simon, Ronald, Tennstedt, Pierre, Glenn, Pat, Simko, Jeffry, Steele, Ruth, Campos, Benito, Rosenthal, Howard G., Adebamowo, Sally N., Giordano, Thomas, Moore, Kathleen, Moxley, Katherine, Shipman, Cassaundra, Wolf, Gregory, Ley, Timothy, Van Tine, Brian, Shmulevich, Ilya

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Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context von Chen, Ting-Wen, Singh, Vivek P., Caesar-Johnson, Samantha J., Hutter, Carolyn M., Sun, Qiang, Wu, Ye, Gehlenborg, Nils, Zhang, Hailei, Broom, Bradley M., Ling, Shiyun, Rao, Arvind, Kundra, Ritika, Dhalla, Noreen, Robertson, A. Gordon, Wong, Tina, Kucherlapati, Raju S., Fan, Cheng, Perou, Charles M., Roach, Jeffrey, Simons, Janae V., Fan, Huihui, Shen, Hui, Dinh, Huyen, Doddapaneni, HarshaVardhan, Lee, Sandra, Hess, Julian, Appelbaum, Elizabeth L., Ding, Li, Fulton, Lucinda A., Shelton, Troy, Sherman, Mark, Zmuda, Erik, Corcoran, Niall, de Carvalho, Ana C., Vidal, Daniel O., Hermes, Beth, Paklina, Oxana, Shabunin, Alexey, Eckman, John, Rabeno, Brenda, Bergeron, Alain, Staugaitis, Susan M., Desjardins, Laurence, Sastre, Xavier, Bigner, Darell, McCall, Shannon, McLendon, Roger, Behera, Madhusmita, Brat, Daniel J., Force, Seth, Eijckenboom, Wil, van Kessel, Kim E., Zwarthoff, Ellen C., Wullich, Bernd, Murawa, Dawid, Phu, Bui Duc, Tang, Yufang, Colman, Howard, Bell, Debra, Flotte, Thomas, Ho, Thai, Zhang, Lizhi, Gonzalez, Ana Maria Angulo, Bondaruk, Jolanta, Gershenwald, Jeffrey, Hersey, Peter, Quinn, Michael, Stretch, Jonathan, Synott, Maria, Wilmott, James, Mirsaidi, Cyrus, Nair, Praveen, Vocke, Cathy D., Goparaju, Chandra, Cernat, Mircea, Timmers, Henri, Schilero, Cathy, Manikhas, George, Alvaro, Domenico, Dhanasekaran, Renumathy, Duell, Rebecca, Mandt, Randy, Nguyen, Phuong, Wakely, Paul, Huland, Hartwig, Carroll, Peter R., Chan, June M., Fehrenbach, Ashley, Galbraith, Joseph, Knudson, Michael, Saad, Fred, Zuna, Rosemary, Feldman, Michael, Creaney, Jenette, Kendall, Sara, Bradford, Carol, Haddad, Andrea, DiPersio, John, Rubin, Mark A., Sood, Anil K.

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Long term evaluation of optimized Gleason grading in a large cohort of men with prostate cancer in Canada von Wissing, Michel, Brimo, Fadi, McKercher, Ginette, Scarlata, Eleonora, Saad, Fred, Carmel, Michel, Lacombe, Louis, Têtu, Bernard, Ekindi-Ndongo, Nadia, Latour, Mathieu, Trudel, Dominique, Chevalier, Simone, Aprikian, Armen

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Optimization of the 2014 Gleason grade grouping in a Canadian cohort of patients with localized prostate cancer von Wissing, Michel, Brimo, Fadi, Chevalier, Simone, Scarlata, Eleonora, McKercher, Ginette, O'Flaherty, Ana, Aprikian, Saro, Thibodeau, Valérie, Saad, Fred, Carmel, Michel, Lacombe, Louis, Têtu, Bernard, Ekindi‐Ndongo, Nadia, Latour, Mathieu, Trudel, Dominique, Aprikian, Armen

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The relationship between body-mass index, physical activity, and pathologic and clinical outcomes after radical prostatectomy for prostate cancer von Wissing, Michel, Chevalier, Simone, McKercher, Ginette, Laprise, Claudie, Aprikian, Saro, O’Flaherty, Ana, Scarlata, Eleonora, Saad, Fred, Carmel, Michel, Lacombe, Louis, Brimo, Fadi, Latour, Mathieu, Ekindi-Ndongo, Nadia, Têtu, Bernard, Aprikian, Armen

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The Immune Landscape of Cancer von Bortone, Dante S., Eddy, James A., Liu, Yuexin, Weinstein, John N., Holt, Robert A., Zenklusen, Jean C., Cho, Juok, Reynolds, Sheila, Liu, Wenbin, Ryan, Michael, Chakravarty, Debyani, Schultz, Nikolaus, Stuart, Joshua M., Wilkerson, Matthew D., Balasundaram, Miruna, Carlsen, Rebecca, Chuah, Eric, Holt, Robert, Lee, Darlene, Ha, Gavin, Schumacher, Steven E., Cope, Leslie, Balu, Saianand, Shi, Yan, Hinoue, Toshinori, Glenn, Robert, Miller, Christopher A., Curley, Erin, Mallery, David, Morris, Scott, Longatto-Filho, Adhemar, Reis, Rui M., Scapulatempo-Neto, Cristovam, Singh, Rosy, Le, Xuan, Thorp, Richard, Setdikova, Galiya, Shabunin, Alexey, Barrett, Wendi, Ostrom, Quinn T., Karlan, Beth Y., Hu, Hai, Latour, Mathieu, Lacombe, Louis, Su, Tao, Signoretti, Sabina, Marks, Jeffrey, Olson, Jeffrey J., Sica, Gabriel, Stoop, Hans, Pollo, Bianca, Aymerich, Marta, Stepa, Serghei, Moser, Catherine, Roberts, Lewis, Czerniak, Bogdan, Lazar, Alexander J., Jakrot, Valerie, Scolyer, Richard, Thompson, John, Wilmott, James, Reuter, Victor, Tien, Nguyen Viet, Park, Joong-Won, Pinto, Peter A., Moncrieff, Marc, Botnariuc, Natalia, Pirtac, Maria, Parfitt, Jeremy, Bifulco, Carlo, Antenucci, Anna, Grazi, Gianluca, Marino, Mirella, Chevalier, Simone, McKercher, Ginette, Naska, Theresa, Borgia, Jeffrey A., Pool, Mark, Junker, Kerstin, Moiseenko, Fedor, Hilty, Joe, Pilarski, Robert, Porten, Sima, Asa, Sylvia L., Schadendorf, Dirk, Disaia, Philip, Kelley, Robin K., Sifri, Suzanne, Mannelli, Massimo, Knutson, Tina, Sigmund, Rita, Postier, Russel, Walker, Joan, Feldman, Michael, Luketich, James, Rozek, Laura, Fong, Kwun M., Hooke, Jeffrey A., Govindan, Ramaswamy, Aredes, Natália D.

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Molecular Dynamics Simulations and Structure-Based Rational Design Lead to Allosteric HCV NS5B Polymerase Thumb Pocket 2 Inhibitor with Picomolar Cellular Replicon Potency von Hucke, Oliver, Coulombe, René, Bonneau, Pierre, Bertrand-Laperle, Mégan, Brochu, Christian, Gillard, James, Joly, Marc-André, Landry, Serge, Lepage, Olivier, Llinàs-Brunet, Montse, Pesant, Marc, Poirier, Martin, Poirier, Maude, McKercher, Ginette, Marquis, Martin, Kukolj, George, Beaulieu, Pierre L., Stammers, Timothy A.

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Discovery of BI 207524, an Indole Diamide NS5B Thumb Pocket 1 Inhibitor with Improved Potency for the Potential Treatment of Chronic Hepatitis C Virus Infection von Beaulieu, Pierre L, Anderson, Paul C, Bethell, Richard, Bös, Michael, Bousquet, Yves, Brochu, Christian, Cordingley, Michael G, Fazal, Gulrez, Garneau, Michel, Gillard, James R, Kawai, Stephen, Marquis, Martin, McKercher, Ginette, Poupart, Marc-André, Stammers, Timothy, Thavonekham, Bounkham, Wernic, Dominik, Duan, Jianmin, Kukolj, George

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Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate von McKercher, Ginette, Beaulieu, Pierre L., Lamarre, Daniel, LaPlante, Steven, Lefebvre, Sylvain, Pellerin, Charles, Thauvette, Louise, Kukolj, George

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Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives von Beaulieu, Pierre L, Bös, Michael, Bousquet, Yves, Fazal, Gulrez, Gauthier, Jean, Gillard, James, Goulet, Sylvie, LaPlante, Steven, Poupart, Marc-André, Lefebvre, Sylvain, McKercher, Ginette, Pellerin, Charles, Austel, Volkhard, Kukolj, George

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Benzimidazole Thumb Pocket I finger-loop inhibitors of HCV NS5B polymerase: Improved drug-like properties through C-2 SAR in three sub-series von Beaulieu, Pierre L., Dansereau, Nathalie, Duan, Jianmin, Garneau, Michel, Gillard, James, McKercher, Ginette, LaPlante, Steven, Lagacée, Lisette, Thauvette, Louise, Kukolj, George

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Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency von BEAULIEU, Pierre L, BÖS, Michael, VALOIS, Serge, KUKOLJ, George, BOUSQUET, Yves, DEROY, Patrick, FAZAL, Gulrez, GAUTHIER, Jean, GILLARD, James, GOULET, Sylvie, MCKERCHER, Ginette, POUPART, Marc-André

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N-Acetamideindolecarboxylic acid allosteric ‘finger-loop’ inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies von Beaulieu, Pierre L., Jolicoeur, Eric, Gillard, James, Brochu, Christian, Coulombe, René, Dansereau, Nathalie, Duan, Jianmin, Garneau, Michel, Jakalian, Araz, Kühn, Peter, Lagacé, Lisette, LaPlante, Steven, McKercher, Ginette, Perrault, Stéphane, Poirier, Martin, Poupart, Marc-André, Stammers, Timothy, Thauvette, Louise, Thavonekham, Bounkham, Kukolj, George

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Internal initiation sites of de novo RNA synthesis within the hepatitis C virus polypyrimidine tract von Pellerin, Charles, Lefebvre, Sylvain, Little, Michael J, McKercher, Ginette, Lamarre, Daniel, Kukolj, George

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A method for identifying a potential inhibitor of the binding between a HCV NS5B RNA-dependent RNA polymerase and an appropriate primer-template von KUKOLJ, GEORGE, MCKERCHER, GINETTE

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