Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications von Henning, Nathaniel J, Manford, Andrew G, Spradlin, Jessica N, Brittain, Scott M, Zhang, Erika, McKenna, Jeffrey M, Tallarico, John A, Schirle, Markus, Rape, Michael, Nomura, Daniel K

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Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC von Boike, Lydia, Cioffi, Alexander G., Majewski, Felix C., Co, Jennifer, Henning, Nathaniel J., Jones, Michael D., Liu, Gang, McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Nomura, Daniel K.

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The development and mechanistic investigation of a palladium-catalyzed 1,3-arylfluorination of chromenes von Thornbury, Richard T, Saini, Vaneet, Fernandes, Talita de A, Santiago, Celine B, Talbot, Eric P A, Sigman, Matthew S, McKenna, Jeffrey M, Toste, F Dean

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Gold-Catalyzed Redox Synthesis of Imidazo[1,2-a]pyridines using Pyridine N-Oxide and Alkynes von Talbot, Eric P. A., Richardson, Melodie, McKenna, Jeffrey M., Toste, F. Dean

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Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB von King, Elizabeth A., Cho, Yoojin, Hsu, Nathan S., Dovala, Dustin, McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Nomura, Daniel K.

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Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function von Luo, Mai, Spradlin, Jessica N., Boike, Lydia, Tong, Bingqi, Brittain, Scott M., McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Maimone, Thomas J., Nomura, Daniel K.

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Chiral Diaryliodonium Phosphate Enables Light Driven Diastereoselective α‑C(sp3)–H Acetalization von Ye, Baihua, Zhao, Jie, Zhao, Ke, McKenna, Jeffrey M, Toste, F. Dean

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Manumycin polyketides act as molecular glues between UBR7 and P53 von Isobe, Yosuke, Okumura, Mikiko, McGregor, Lynn M., Brittain, Scott M., Jones, Michael D., Liang, Xiaoyou, White, Ross, Forrester, William, McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Maimone, Thomas J., Nomura, Daniel K.

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Correction to “Rational Chemical Design of Molecular Glue Degraders” von Toriki, Ethan S., Papatzimas, James W., Nishikawa, Kaila, Dovala, Dustin, Frank, Andreas O., Hesse, Matthew J., Dankova, Daniela, Song, Jae-Geun, Bruce-Smythe, Megan, Struble, Heidi, Garcia, Francisco J., Brittain, Scott M., Kile, Andrew C., McGregor, Lynn M., McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Nomura, Daniel K.

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Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity von Sivick, Kelsey E., Desbien, Anthony L., Glickman, Laura Hix, Reiner, Gabrielle L., Corrales, Leticia, Surh, Natalie H., Hudson, Thomas E., Vu, Uyen T., Francica, Brian J., Banda, Tamara, Katibah, George E., Kanne, David B., Leong, Justin J., Metchette, Ken, Bruml, Jacob R., Ndubaku, Chudi O., McKenna, Jeffrey M., Feng, Yan, Zheng, Lianxing, Bender, Steven L., Cho, Charles Y., Leong, Meredith L., van Elsas, Andrea, Dubensky, Thomas W., McWhirter, Sarah M.

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Targeted Protein Degradation through E2 Recruitment von Forte, Nafsika, Dovala, Dustin, Hesse, Matthew J., McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Nomura, Daniel K.

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Amine Protection/α-Activation with the tert-Butoxythiocarbonyl Group: Application to Azetidine Lithiation–Electrophilic Substitution von Hodgson, David M, Mortimer, Claire L, McKenna, Jeffrey M

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Correction to “Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications” von Henning, Nathaniel J., Manford, Andrew G., Spradlin, Jessica N., Brittain, Scott M., Zhang, Erika, McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Rape, Michael, Nomura, Daniel K.

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Photo-Brook rearrangement of acyl silanes as a strategy for photoaffinity probe design von Page, Annika C. S, Scholz, Spencer O, Keenan, Katherine N, Spradlin, Jessica N, Belcher, Bridget P, Brittain, Scott M, Tallarico, John A, McKenna, Jeffrey M, Schirle, Markus, Nomura, Daniel K, Toste, F. Dean

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Ophiobolin A Covalently Targets Mitochondrial Complex IV Leading to Metabolic Collapse in Cancer Cells von Gowans, Flor A., Thach, Danny Q., Zhu, Zhouyang, Wang, Yangzhi, Altamirano Poblano, Belen E., Dovala, Dustin, Tallarico, John A., McKenna, Jeffrey M., Schirle, Markus, Maimone, Thomas J., Nomura, Daniel K.

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Discovery of Potent Pyrazoline‐Based Covalent SARS‐CoV‐2 Main Protease Inhibitors von Moon, Patrick, Zammit, Charlotte M., Shao, Qian, Dovala, Dustin, Boike, Lydia, Henning, Nathaniel J., Knapp, Mark, Spradlin, Jessica N., Ward, Carl C., Wolleb, Helene, Fuller, Daniel, Blake, Gabrielle, Murphy, Jason P., Wang, Feng, Lu, Yipin, Moquin, Stephanie A., Tandeske, Laura, Hesse, Matthew J., McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Toste, F. Dean, Nomura, Daniel K.

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Abstract 1445: STING activation in the tumor microenvironment with a synthetic human STING-activating cyclic dinucleotide leads to potent anti-tumor immunity von Glickman, Laura Hix, Kanne, David B., Kasibhatla, Shailaja, Li, Jie, Pferdekamper, AnneMarie Culazzo, Gauthier, Kelsey Sivick, Deng, Weiwen, Desbien, Anthony L., Katibah, George E., Leong, Justin J., Sung, Leonard, Metchette, Ken, Ndubaku, Chudi, Zheng, Lianxing, Cho, Charles, Feng, Yan, McKenna, Jeffrey M., Tallarico, John A., Bender, Steven L., Dubensky, Thomas W., McWhirter, Sarah M.

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Covalency-enabled Drug Discovery is Redefining Druggability: Medicinal Chemistry and Chemical Biology Highlights von McKenna, Jeffrey M., Proctor, Rupert S. J.

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Development, Synthesis, and in silico Investigations of Novel Acyclic Allyl Fluoride Derivatives von Chauhan, Nishita, Singh, Harjinder, Singh, Kamal Nain, McKenna, Jeffrey M., Saini, Vaneet

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An Algorithm-Directed Two-Component Library Synthesized Via Solid-Phase Methodology Yielding Potent and Orally Bioavailable p38 MAP Kinase Inhibitors von McKenna, Jeffrey M, Halley, Frank, Souness, John E, McLay, Iain M, Pickett, Stephen D, Collis, Alan J, Page, Kenneth, Ahmed, Imtiaz

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