Good Manufacturing Practice Production of Self-Complementary Serotype 8 Adeno-Associated Viral Vector for a Hemophilia B Clinical Trial von ALLAY, James A, SLEEP, Susan, NATHWANI, Amit C, GRAY, John T, LONG, Scott, TILLMAN, David M, CLARK, Rob, CARNEY, Gael, FAGONE, Paolo, MCINTOSH, Jenny H, NIENHUIS, Arthur W, DAVIDOFF, Andrew M

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Purification of recombinant adeno-associated virus type 8 vectors by ion exchange chromatography generates clinical grade vector stock von Davidoff, Andrew M., Ng, Catherine Y.C., Sleep, Susan, Gray, John, Azam, Selina, Zhao, Yuan, McIntosh, Jenny H., Karimipoor, Morteza, Nathwani, Amit C.

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AAV-Mediated Expression of a Single-Chain FVIII Mimetic Antibody Efficiently Corrects Bleeding in Haemophilia a Mice von Muczynski, Vincent, Bun, Eric, Tanner, Lewis, McIntosh, Jenny H., Christophe, Olivier D., Nathwani, Amit C.

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Long-Term Persistence of Antibodies to Adeno-Associated Viral Vectors Following Gene Therapy with scAAV8-LP1-Fixco von McIntosh, Jenny H., Mohamed, Saira, Ireland, Lydia, Morton, Christopher L, Reiss, Ulrike M., Chowdary, Pratima, Tuddenham, Edward G. D., Davidoff, Andrew M., Nathwani, Amit C.

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GO-8: Stable Expression of Factor VIII over 5 Years Following Adeno-Associated Gene Transfer in Subjects with Hemophilia a Using a Novel Human Factor VIII Variant von Chowdary, Pratima, Reiss, Ulrike M., Tuddenham, Edward G. D., Batty, Paul, McIntosh, Jenny H., Radulescu, Vlad Calin, Chang, Eugenia, Laffan, Michael A., Riddell, Anne, Calvert, Joanna C. M., Pie, Arnulfo, Peralta, Rita, Dissanayake, Upuli Pabakumari, Kamel, Kirollos, Sreedhar, Bharath Ram, Zhou, Junfang, Kang, Guolian, Olufadi, Yunus, Meagher, Michael M, Morton, Christopher L, Evans, Alison J., Davidoff, Andrew M., Nathwani, Amit C.

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Stable Therapeutic Transgenic FIX Levels for More Than 10 Years in Subjects with Severe Hemophilia B Who Received scAAV2/8-LP1-Hfixco Adeno-Associated Virus Gene Therapy von Reiss, Ulrike M., Davidoff, Andrew M., Tuddenham, Edward G. D., Chowdary, Pratima, McIntosh, Jenny H., Riddell, Anne, Pie, Arnulfo, Batty, Paul, Calvert, Joanna C. M., Mangles, Sarah, Mahlangu, Johnny, Haley, Kristina M., Recht, Michael, Shen, Yu-Min, Halka, Kathleen G., Zhou, Junfang, Kang, Guolian, Okhomina, Victoria, Morton, Christopher L, Nathwani, Amit C.

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Assessing the Potential of Perinatal Gene Transfer Using Congenital Factor VII Deficiency as a Model System von Binny, Christopher J, McIntosh, Jenny H, Tuddenham, Edward, Waddington, Simon, Buckley, Suzanne, Thrasher, Adrian, Gray, John T., Nathwani, Amit, Tarantal, Alice F, Davidoff, Andrew

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Adeno-Associated Viral Vector Mediated Gene Transfer for Hemophilia B von Nathwani, Amit C, Tuddenham, Edward GD, Rangarajan, Savita, Rosales, Cecilia, McIntosh, Jenny H, Linch, David C, Chowdary, Pratima, Griffioen, Anja, Riddell, Anne, Pie, Jun, Harrington, Chris, O'Beirne, James, Smith, Keith, Pasi, John, Glader, Bertil, Rustagi, Pradip, Ng, Catherine, Kay, Mark, Zhou, Junfang, Spence, Yunyu, Morton, Christopher, Allay, James, Coleman, John, Sleep, Susan, Cunningham, John M, Basner-Tschakarjan, Etiena, Mingozzi, Federico, High, Katherine A., Gray, John T., Reiss, Ulrike M., Nienhuis, Arthur W., Davidoff, Andrew

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490. Successful Readministration of AAV8 Following Administration of Nondepleting CD4 Antibody at the Time of Vector Administration von McIntosh, JennyH, Cochrane, Melanie, Prizzey, Arnold, Waldmann, Herman, Davidoff, Andrew M., Nathwani, Amit C.

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Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant von McIntosh, Jenny, Lenting, Peter J., Rosales, Cecilia, Lee, Doyoung, Rabbanian, Samira, Raj, Deepak, Patel, Nishil, Tuddenham, Edward G.D., Christophe, Olivier D., McVey, John H., Waddington, Simon, Nienhuis, Arthur W., Gray, John T., Fagone, Paolo, Mingozzi, Federico, Zhou, Shang-Zhen, High, Katherine A., Cancio, Maria, Ng, Catherine Y.C., Zhou, Junfang, Morton, Christopher L., Davidoff, Andrew M., Nathwani, Amit C.

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Codon optimization of human factor VIII cDNAs leads to high-level expression von Ward, Natalie J., Buckley, Suzanne M.K., Waddington, Simon N., VandenDriessche, Thierry, Chuah, Marinee K.L., Nathwani, Amit C., McIntosh, Jenny, Tuddenham, Edward G.D., Kinnon, Christine, Thrasher, Adrian J., McVey, John H.

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Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV-mediated gene transfer with a non-depleting CD4 antibody and cyclosporine von McIntosh, J H, Cochrane, M, Cobbold, S, Waldmann, H, Nathwani, S A, Davidoff, A M, Nathwani, A C

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Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging von McCartney, Daniel L, Min, Josine L, Richmond, Rebecca C, Lu, Ake T, Sobczyk, Maria K, Davies, Gail, Broer, Linda, Guo, Xiuqing, Jeong, Ayoung, Jung, Jeesun, Kasela, Silva, Katrinli, Seyma, Kuo, Pei-Lun, Matias-Garcia, Pamela R, Mishra, Pashupati P, Nygaard, Marianne, Palviainen, Teemu, Patki, Amit, Raffield, Laura M, Ratliff, Scott M, Richardson, Tom G, Robinson, Oliver, Soerensen, Mette, Sun, Dianjianyi, Tsai, Pei-Chien, van der Zee, Matthijs D, Walker, Rosie M, Wang, Xiaochuan, Wang, Yunzhang, Xia, Rui, Xu, Zongli, Yao, Jie, Zhao, Wei, Correa, Adolfo, Boerwinkle, Eric, Dugué, Pierre-Antoine, Durda, Peter, Elliott, Hannah R, Gieger, Christian, de Geus, Eco J C, Harris, Sarah E, Hemani, Gibran, Imboden, Medea, Kähönen, Mika, Kardia, Sharon L R, Kresovich, Jacob K, Li, Shengxu, Lunetta, Kathryn L, Mangino, Massimo, Mason, Dan, McIntosh, Andrew M, Mengel-From, Jonas, Moore, Ann Zenobia, Murabito, Joanne M, Ollikainen, Miina, Pankow, James S, Pedersen, Nancy L, Peters, Annette, Polidoro, Silvia, Porteous, David J, Raitakari, Olli, Rich, Stephen S, Sandler, Dale P, Sillanpää, Elina, Smith, Alicia K, Southey, Melissa C, Strauch, Konstantin, Tiwari, Hemant, Tanaka, Toshiko, Tillin, Therese, Uitterlinden, Andre G, Van Den Berg, David J, van Dongen, Jenny, Wilson, James G, Wright, John, Yet, Idil, Arnett, Donna, Bandinelli, Stefania, Bell, Jordana T, Binder, Alexandra M, Boomsma, Dorret I, Chen, Wei, Christensen, Kaare, Conneely, Karen N, Elliott, Paul, Ferrucci, Luigi, Fornage, Myriam, Hägg, Sara, Hayward, Caroline, Irvin, Marguerite, Kaprio, Jaakko, Lawlor, Deborah A, Lehtimäki, Terho, Lohoff, Falk W, Milani, Lili, Milne, Roger L, Probst-Hensch, Nicole, Reiner, Alex P, Ritz, Beate, Rotter, Jerome I

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Digital pathology for reporting histopathology samples, including cancer screening samples – definitive evidence from a multisite study von Azam, Ayesha S, Tsang, Yee‐Wah, Thirlwall, Jenny, Kimani, Peter K, Sah, Shatrughan, Gopalakrishnan, Kishore, Boyd, Clinton, Loughrey, Maurice B, Kelly, Paul J, Boyle, David P, Salto‐Tellez, Manuel, Clark, David, Ellis, Ian O, Ilyas, Mohammad, Rakha, Emad, Bickers, Adam, Roberts, Ian S D, Soares, Maria F, Neil, Desley A H, Takyi, Abi, Raveendran, Sinthuri, Hero, Emily, Evans, Harriet, Osman, Rania, Fatima, Khunsha, Hughes, Rhian W, McIntosh, Stuart A, Moran, Gordon W, Ortiz‐Fernandez‐Sordo, Jacobo, Rajpoot, Nasir M, Storey, Ben, Ahmed, Imtiaz, Dunn, Janet A, Hiller, Louise, Snead, David R J

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DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan von van Dongen, Jenny, Hagenbeek, Fiona A., Suderman, Matthew, Roetman, Peter J., Sugden, Karen, Chiocchetti, Andreas G., Ismail, Khadeeja, Mulder, Rosa H., Hafferty, Jonathan D., Adams, Mark J., Walker, Rosie M., Morris, Stewart W., Lahti, Jari, Küpers, Leanne K., Escaramis, Georgia, Alemany, Silvia, Jan Bonder, Marc, Meijer, Mandy, Ip, Hill F., Jansen, Rick, Baselmans, Bart M. L., Parmar, Priyanka, Lowry, Estelle, Streit, Fabian, Sirignano, Lea, Send, Tabea S., Frank, Josef, Jylhävä, Juulia, Wang, Yunzhang, Mishra, Pashupati Prasad, Colins, Olivier F., Corcoran, David L., Poulton, Richie, Mill, Jonathan, Hannon, Eilis, Arseneault, Louise, Korhonen, Tellervo, Vuoksimaa, Eero, Felix, Janine F., Bakermans-Kranenburg, Marian J., Campbell, Archie, Czamara, Darina, Binder, Elisabeth, Corpeleijn, Eva, Gonzalez, Juan R., Grazuleviciene, Regina, Gutzkow, Kristine B., Evandt, Jorunn, Vafeiadi, Marina, Klein, Marieke, van der Meer, Dennis, Ligthart, Lannie, Kluft, Cornelis, Davies, Gareth E., Hakulinen, Christian, Keltikangas-Järvinen, Liisa, Franke, Barbara, Freitag, Christine M., Konrad, Kerstin, Hervas, Amaia, Fernández-Rivas, Aranzazu, Vetro, Agnes, Raitakari, Olli, Lehtimäki, Terho, Vermeiren, Robert, Strandberg, Timo, Räikkönen, Katri, Snieder, Harold, Witt, Stephanie H., Deuschle, Michael, Pedersen, Nancy L., Hägg, Sara, Sunyer, Jordi, Franke, Lude, Kaprio, Jaakko, Ollikainen, Miina, Moffitt, Terrie E., Tiemeier, Henning, van IJzendoorn, Marinus H., Relton, Caroline, Vrijheid, Martine, Sebert, Sylvain, Jarvelin, Marjo-Riitta, Caspi, Avshalom, Evans, Kathryn L., McIntosh, Andrew M., Bartels, Meike, Boomsma, Dorret I.

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Distinct alterations in probabilistic reversal learning across at-risk mental state, first episode psychosis and persistent schizophrenia von Griffin, J. D., Diederen, K. M. J., Haarsma, J., Jarratt Barnham, I. C., Cook, B. R. H., Fernandez-Egea, E., Williamson, S., van Sprang, E. D., Gaillard, R., Vinckier, F., Goodyer, I. M., Murray, G. K., Fletcher, P. C.

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A Novel Lysine to Arginine Substitution at Position 301 Enhances Activity of Factor IX von Verhoef, Daniel, Foley, Jonathan H., Goodale, Andrew, Macrae, Emma, McIntosh, Jenny, Corbau, Romuald, Gomez, Keith, Riddell, Anne, Nathwani, Amit C

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Beef Production in the Southwestern United States: Strategies Toward Sustainability von Spiegal, Sheri, Cibils, Andres F., Bestelmeyer, Brandon T., Steiner, Jean L., Estell, Richard E., Archer, David W., Auvermann, Brent W., Bestelmeyer, Stephanie V., Boucheron, Laura E., Cao, Huiping, Cox, Andrew R., Devlin, Daniel, Duff, Glenn C., Ehlers, Kristy K., Elias, Emile H., Gifford, Craig A., Gonzalez, Alfredo L., Holland, John P., Jennings, Jenny S., Marshall, Ann M., McCracken, David I., McIntosh, Matthew M., Miller, Rhonda, Musumba, Mark, Paulin, Robert, Place, Sara E., Redd, Matthew, Rotz, C. Alan, Tolle, Cindy, Waterhouse, Anthony

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The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19) von Shi, Jianguo, McIntosh, Richard S, Adame-Gallegos, Jaime, Dehal, Prabhjyot K, van Egmond, Marjolein, van de Winkel, Jan, Draper, Simon J, Forbes, Emily K, Corran, Patrick H, Holder, Anthony A, Woof, Jenny M, Pleass, Richard J

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Liver-Directed AAV Gene Therapy for Gaucher Disease von Miranda, Carlos J, Canavese, Miriam, Chisari, Elisa, Pandya, Jalpa, Cocita, Clement, Portillo, Maria, McIntosh, Jenny, Kia, Azadeh, Foley, Jonathan H., Dane, Allison, Jeyakumar, Jey M, Sheridan, Rose, Corbau, Romuald, Nathwani, Amit C.

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