THE ROLE OF DUE DILIGENCE IN INTERNATIONAL LAW von McDonald, Neil

Volltext

Control of atypical PKCι membrane dissociation by tyrosine phosphorylation within a PB1-C1 interdomain interface von Cobbaut, Mathias, McDonald, Neil Q., Parker, Peter J.

Volltext

Into the fold: advances in understanding aPKC membrane dynamics von Cobbaut, Mathias, Parker, Peter J, McDonald, Neil Q

Volltext

RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability von Diring, Jessica, Mouilleron, Stephane, McDonald, Neil Q., Treisman, Richard

Volltext

Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application von Yan, Wei, Lakkaniga, Naga Rajiv, Carlomagno, Francesca, Santoro, Massimo, McDonald, Neil Q, Lv, Fengping, Gunaganti, Naresh, Frett, Brendan, Li, Hong-yu

Volltext

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins von Riou, Philippe, Kjær, Svend, Garg, Ritu, Purkiss, Andrew, George, Roger, Cain, Robert J., Bineva, Ganka, Reymond, Nicolas, McColl, Brad, Thompson, Andrew J., O’Reilly, Nicola, McDonald, Neil Q., Parker, Peter J., Ridley, Anne J.

Volltext

A secondary RET mutation in the activation loop conferring resistance to vandetanib von Nakaoku, Takashi, Kohno, Takashi, Araki, Mitsugu, Niho, Seiji, Chauhan, Rakhee, Knowles, Phillip P., Tsuchihara, Katsuya, Matsumoto, Shingo, Shimada, Yoko, Mimaki, Sachiyo, Ishii, Genichiro, Ichikawa, Hitoshi, Nagatoishi, Satoru, Tsumoto, Kouhei, Okuno, Yasushi, Yoh, Kiyotaka, McDonald, Neil Q., Goto, Koichi

Volltext

Oncogenic RET Kinase Domain Mutations Perturb the Autophosphorylation Trajectory by Enhancing Substrate Presentation In trans von Plaza-Menacho, Iván, Barnouin, Karin, Goodman, Kerry, Martínez-Torres, Rubén J., Borg, Annabel, Murray-Rust, Judith, Mouilleron, Stephane, Knowles, Phillip, McDonald, Neil Q.

Volltext

Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology von Moccia, Marialuisa, Frett, Brendan, Zhang, Lingtian, Lakkaniga, Naga Rajiv, Briggs, David C, Chauhan, Rakhee, Brescia, Annalisa, Federico, Giorgia, Yan, Wei, Santoro, Massimo, McDonald, Neil Q, Li, Hong-yu, Carlomagno, Francesca

Volltext

aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization von Soriano, Erika V., Ivanova, Marina E., Fletcher, Georgina, Riou, Philippe, Knowles, Philip P., Barnouin, Karin, Purkiss, Andrew, Kostelecky, Brenda, Saiu, Peter, Linch, Mark, Elbediwy, Ahmed, Kjær, Svend, O’Reilly, Nicola, Snijders, Ambrosius P., Parker, Peter J., Thompson, Barry J., McDonald, Neil Q.

Volltext

Structural and functional relationships of the XPF/MUS81 family of proteins von Ciccia, Alberto, McDonald, Neil, West, Stephen C

Volltext

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing von Adams, Sarah E., Purkiss, Andrew G., Knowles, Phillip P., Nans, Andrea, Briggs, David C., Borg, Annabel, Earl, Christopher P., Goodman, Kerry M., Nawrotek, Agata, Borg, Aaron J., McIntosh, Pauline B., Houghton, Francesca M., Kjær, Svend, McDonald, Neil Q.

Volltext

Equivocal, explicit and emergent actions of PKC isoforms in cancer von Parker, Peter J., Brown, Sophie J., Calleja, Veronique, Chakravarty, Probir, Cobbaut, Mathias, Linch, Mark, Marshall, Jacqueline J. T., Martini, Silvia, McDonald, Neil Q., Soliman, Tanya, Watson, Lisa

Volltext

Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation von Jones, Morgan, Beuron, Fabienne, Borg, Aaron, Nans, Andrea, Earl, Christopher P., Briggs, David C., Snijders, Ambrosius P., Bowles, Maureen, Morris, Edward P., Linch, Mark, McDonald, Neil Q.

Volltext

A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division von Martini, Silvia, Davis, Khalil, Faraway, Rupert, Elze, Lisa, Lockwood, Nicola, Jones, Andrew, Xie, Xiao, McDonald, Neil Q., Mann, David J., Armstrong, Alan, Ule, Jernej, Parker, Peter J.

Volltext

Optimized PAR-2 RING dimerization mediates cooperative and selective membrane binding for robust cell polarity von Bland, Tom, Hirani, Nisha, Briggs, David C, Rossetto, Riccardo, Ng, KangBo, Taylor, Ian A, McDonald, Neil Q, Zwicker, David, Goehring, Nathan W

Volltext

Study of an FBXO7 patient mutation reveals Fbxo7 and PI31 co-regulate proteasomes and mitochondria von Al Rawi, Sara, Simpson, Lorna, Agnarsdóttir, Guðrún, McDonald, Neil Q, Chernuha, Veronika, Elpeleg, Orly, Zeviani, Massimo, Barker, Roger A, Spiegel, Ronen, Laman, Heike

Volltext

A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease von Conduit, Sarah E., Pearce, Wayne, Bhamra, Amandeep, Bilanges, Benoit, Bozal-Basterra, Laura, Foukas, Lazaros C., Cobbaut, Mathias, Castillo, Sandra D., Danesh, Mohammad Amin, Adil, Mahreen, Carracedo, Arkaitz, Graupera, Mariona, McDonald, Neil Q., Parker, Peter J., Cutillas, Pedro R., Surinova, Silvia, Vanhaesebroeck, Bart

Volltext

Oligonucleotide-Recognizing Topoisomerase Inhibitors (OTIs): Precision Gene Editors for Neurodegenerative Diseases? von Bax, Ben D., Sutormin, Dmitry, McDonald, Neil Q., Burley, Glenn A., Shelkovnikova, Tatyana

Volltext

Competitive Inhibition of aPKC by Par-3/Bazooka and Other Substrates von Thompson, Barry J., McDonald, Neil Q.

Volltext