Reflections on the mechanism of the Barton-McCombie Deoxygenation and on its consequences von McCombie, Stuart W., Quiclet-Sire, Béatrice, Zard, Samir Z.

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Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. IV. Discovery of 1-[(4,6-Dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-{2-methoxy-1(R)-4-(trifluoromethyl)phenyl}ethyl-3(S)-methyl-1... von Tagat, Jayaram R, McCombie, Stuart W, Nazareno, Dennis, Labroli, Marc A, Xiao, Yushi, Steensma, Ruo W, Strizki, Julie M, Baroudy, Bahige M, Cox, Kathleen, Lachowicz, Jean, Varty, Geoffrey, Watkins, Robert

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HIV-1 Escape from a Small Molecule, CCR5-Specific Entry Inhibitor Does Not Involve CXCR4 Use von Trkola, Alexandra, Kuhmann, Shawn E., Strizki, Julie M., Maxwell, Elizabeth, Ketas, Tom, Morgan, Tom, Pugach, Pavel, Xu, Serena, Wojcik, Lisa, Tagat, Jayaram, Palani, Anandan, Shapiro, Sherry, Clader, John W., McCombie, Stuart, Reyes, Gregory R., Baroudy, Bahige M., Moore, John P.

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Interaction of small molecule inhibitors of HIV-1 entry with CCR5 von Seibert, Christoph, Ying, Weiwen, Gavrilov, Svetlana, Tsamis, Fotini, Kuhmann, Shawn E., Palani, Anandan, Tagat, Jayaram R., Clader, John W., McCombie, Stuart W., Baroudy, Bahige M., Smith, Steven O., Dragic, Tatjana, Moore, John P., Sakmar, Thomas P.

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Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry von Tsamis, Fotini, Gavrilov, Svetlana, Kajumo, Francis, Seibert, Christoph, Kuhmann, Shawn, Ketas, Tom, Trkola, Alexandra, Palani, Anadan, Clader, John W, Tagat, Jayaram R, McCombie, Stuart, Baroudy, Bahige, Moore, John P, Sakmar, Thomas P, Dragic, Tatjana

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Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. II. Discovery of 1-[(2,4-Dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoro- methyl)phenyl]ethyl]-... von Tagat, Jayaram R, Steensma, Ruo W, McCombie, Stuart W, Nazareno, Dennis V, Lin, Sue-Ing, Neustadt, Bernard R, Cox, Kathleen, Xu, Serena, Wojcik, Lisa, Murray, Michael G, Vantuno, Nicole, Baroudy, Bahige M, Strizki, Julie M

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Piperazine-Based CCR5 antagonists as HIV-1 inhibitors. I: 2( S)-methyl piperazine as a key pharmacophore element von Tagat, Jayaram R., McCombie, Stuart W., Steensma, Ruo W., Lin, Sue-Ing, Nazareno, Dennis V., Baroudy, Bahige, Vantuno, Nicole, Xu, Serena, Liu, Jia

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Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors von Gilbert, Eric J., Zhou, Guowei, Wong, Michael K.C., Tong, Ling, Shankar, Bandarpalle B., Huang, Chunli, Kelly, Joseph, Lavey, Brian J., McCombie, Stuart W., Chen, Lei, Rizvi, Razia, Dong, Youhao, Shu, Youheng, Kozlowski, Joseph A., Shih, Neng-Yang, Hipkin, R. William, Gonsiorek, Waldemar, Malikzay, Asra, Lunn, Charles A., Favreau, Len, Lundell, Daniel J.

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Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: synthesis, antiviral and pharmacokinetic profiles of symmetrical heteroaryl carboxamides von McCombie, Stuart W., Tagat, Jayaram R., Vice, Susan F., Lin, Sue-Ing, Steensma, Ruo, Palani, Anandan, Neustadt, Bernard R., Baroudy, Bahige M., Strizki, Julie M., Endres, Michael, Cox, Kathleen, Dan, Niya, Chou, Chuan-Chu

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One-pot, three-component synthesis of arylidenesuccinates and related compounds von McCombie, Stuart W, Luchaco, Courtney A

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Optimization of triaryl bis-sulfones as cannabinoid-2 receptor ligands von Lavey, Brian J., Kozlowski, Joseph A., Shankar, Bandarpalle B., Spitler, James M., Zhou, Guowei, Yang, De-Yi, Shu, Youheng, Wong, Michael K.C., Wong, Shing-Chun, Shih, Neng-Yang, Wu, Jie, McCombie, Stuart W., Rizvi, Razia, Wolin, Ronald L., Lunn, Charles A.

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The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists von Ting, Pauline C., Lee, Joe F., Wu, Jie, Umland, Shelby P., Aslanian, Robert, Cao, Jianhua, Dong, Youhao, Garlisi, Charles G., Gilbert, Eric J., Huang, Ying, Jakway, James, Kelly, Joseph, Liu, Zhidan, McCombie, Stuart, Shah, Himanshu, Tian, Fang, Wan, Yuntao, Shih, Neng-Yang

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Synthesis of Mono- and Difluoronaphthoic Acids von Tagat, Jayaram R, McCombie, Stuart W, Nazareno, Dennis V, Boyle, Craig D, Kozlowski, Joseph A, Chackalamannil, Samuel, Josien, Hubert, Wang, Yuguang, Zhou, Guowei

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Concise Formation of 4-Benzyl Piperidines and Related Derivatives Using a Suzuki Protocol von Vice, Susan, Bara, Tom, Bauer, Annette, Evans, C. Anderson, Ford, Jennifer, Josien, Hubert, McCombie, Stuart, Miller, Michael, Nazareno, Dennis, Palani, Anandan, Tagat, Jay

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A novel method for the synthesis of aryl sulfones von Steensma, Ruo W, Galabi, Sharen, Tagat, Jayaram R, McCombie, Stuart W

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Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity von CLADER, John W, BILLARD, William, LIU, Charles, MCCOMBIE, Stuart W, VICE, Susan, GOWEI ZHOU, GREENLEE, William J, BINCH, Herbert III, CHEN, Lian-Yong, CROSBY, Gordon JR, DUFFY, Ruth A, FORD, Jennifer, KOZLOWSKI, Joseph A, LACHOWICZ, Jean E, SHENGJIAN LI

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Substituted 2-(R)-methyl piperazines as muscarinic M2 selective ligands von KOZLOWSKI, Joseph A, GUOWEI ZHOU, BILLARD, William, BINCH, Herbert III, LACHOWICZ, Jean E, TAGAT, Jayaram R, LIN, Sue-Ing, MCCOMBIE, Stuart W, RUPERTO, Vilma B, DUFFY, Ruth A, MCQUADE, Robert A, CROSBY, Gordon JR, TAYLOR, Lisa A

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SCH-C (SCH 351125), An Orally Bioavailable, Small Molecule Antagonist of the Chemokine Receptor CCR5, is a Potent Inhibitor of HIV-1 Infection in vitro and in vivo von Strizki, Julie M., Xu, Serena, Wagner, Nicole E., Wojcik, Lisa, Liu, Jia, Hou, Yan, Endres, Michael, Palani, Anandan, Shapiro, Sherry, Clader, John W., Greenlee, William J., Tagat, Jayaram R., McCombie, Stuart, Cox, Kathleen, Fawzi, Ahmad B., Chou, Chuan-Chu, Pugliese-Sivo, Catherine, Davies, Liza, Moreno, Mary E., Ho, David D., Trkola, Alexandra, Stoddart, Cheryl A., Moore, John P., Reyes, Gregory R., Baroudy, Bahige M.

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Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M2 muscarinic receptor antagonists via benzamide modification von BOYLE, Craig D, VICE, Susan F, COFFIN, Vicki L, COX, Kathleen A, GROTZ, Diane E, DUFFY, Ruth A, RUPERTO, Vilma, LACHOWICZ, Jean E, CAMPION, Jennifer, CHACKALAMANNIL, Samuel, LANKIN, Claire M, MCCOMBIE, Stuart W, BILLARD, William, BINCH, Herbert III, CROSBY, Gordon, WILLIAMS, Mary-Cohen

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Synthesis and structure-activity relationships of M2-selective muscarinic receptor ligands in the 1-[4-(4-arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family von MCCOMBIE, Stuart W, LIN, Sue-Ing, RUPERTO, Vilma B, DUFFY, Ruth A, LACHOWICZ, Jean E, TAGAT, Jayaram R, NAZARENO, Dennis, VICE, Susan, FORD, Jennifer, ASBEROM, Theodros, LEONE, Daria, KOZLOWSKI, Joseph A, GUOWEI ZHOU

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