A Biodegradable Nanoparticle Platform for the Induction of Antigen-Specific Immune Tolerance for Treatment of Autoimmune Disease von Hunter, Zoe, McCarthy, Derrick P, Yap, Woon Teck, Harp, Christopher T, Getts, Daniel R, Shea, Lonnie D, Miller, Stephen D

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Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice von Carrero, Javier A., McCarthy, Derrick P., Ferris, Stephen T., Wan, Xiaoxiao, Hu, Hao, Zinselmeyer, Bernd H., Vomund, Anthony N., Unanue, Emil R.

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Oligodendrocyte death results in immune-mediated CNS demyelination von Traka, Maria, Podojil, Joseph R, McCarthy, Derrick P, Miller, Stephen D, Popko, Brian

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Exploiting apoptosis for therapeutic tolerance induction von Getts, Daniel R, McCarthy, Derrick P, Miller, Stephen D

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Mouse Models of Multiple Sclerosis: Experimental Autoimmune Encephalomyelitis and Theiler’s Virus-Induced Demyelinating Disease von McCarthy, Derrick P., Richards, Maureen H., Miller, Stephen D.

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Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis von Getts, Daniel R, Martin, Aaron J, McCarthy, Derrick P, Terry, Rachael L, Hunter, Zoe N, Yap, Woon Teck, Getts, Meghann Teague, Pleiss, Michael, Luo, Xunrong, King, Nicholas JC, Shea, Lonnie D, Miller, Stephen D

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Antigen-specific immune therapy (CNP-106) for treatment of generalised myasthenia gravis: rationale and design of first-in-human randomised controlled trial von G Brew, Samantha, Frey, Molly, P McCarthy, Derrick, Elhofy, Adam, Nowak, Richard J

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An antigen-encapsulating nanoparticle platform for TH1/17 immune tolerance therapy von McCarthy, Derrick P., Yap, Jonathan Woon-Teck, Harp, Christopher T., Song, W. Kelsey, Chen, Jeane, Pearson, Ryan M., Miller, Stephen D., Shea, Lonnie D.

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Tolerance induction using nanoparticles bearing HY peptides in bone marrow transplantation von Hlavaty, Kelan A, McCarthy, Derrick P, Saito, Eiji, Yap, Woon Teck, Miller, Stephen D, Shea, Lonnie D

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ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms von Luo, Xunrong, Pothoven, Kathryn L, McCarthy, Derrick, DeGutes, Mathew, Martin, Aaron, Getts, Daniel R, Xia, Guliang, He, Jie, Zhang, Xiaomin, Kaufman, Dixon B, Miller, Stephen D

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Have we overestimated the benefit of human(ized) antibodies? von Getts, Daniel R., Getts, Meghann T., McCarthy, Derrick P., Chastain, Emily ML, Miller, Stephen D.

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Targeted immunomodulation using antigen-conjugated nanoparticles von McCarthy, Derrick P., Hunter, Zoe N., Chackerian, Bryce, Shea, Lonnie D., Miller, Stephen D.

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Intravenous immune-modifying nanoparticles as a therapy for spinal cord injury in mice von Jeong, Su Ji, Cooper, John G., Ifergan, Igal, McGuire, Tammy L., Xu, Dan, Hunter, Zoe, Sharma, Sripadh, McCarthy, Derrick, Miller, Stephen D., Kessler, John A.

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173 Expression of a membrane-tethered IL-15/IL-15 receptor fusion protein enhances the persistence of MSLN-targeted TRuC-T cells von Fleury, Michelle, McCarthy, Derrick, Horton, Holly, Anderson, Courtney, Watt, Amy, Zieba, Adam, Webb, Lindsay, Ding, Jian, Tighe, Robert, Hofmeister, Robert, Gutierrez, Dario

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Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis von Getts, Daniel R, Martin, Aaron J, Mccarthy, Derrick P, Terry, Rachael L, Hunter, Zoe N, Yap, Woon Teck, Getts, Meghann Teague, Pleiss, Michael, Luo, Xunrong, King, Nicholas J C, Shea, Lonnie D, Miller, Stephen D

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Antigen-specific nanoparticle tolerance reduced inflammation at the target tissue and increased target protein expression in recombinant adeno-associated virus (AAV)-mediated gene... von Podojil, Joseph, Xu, Dan, Chiang, Ming-Yi, Kakade, Sandeep, McCarthy, Derrick, Elhofy, Adam, Miller, Stephen

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Preclinical studies to determine myelin peptide-specific nanoparticle tolerance mechanisms and clinical translation von Podojil, Joseph, Cogswell, Andrew, Chiang, Ming-Yi, Xu, Dan, Ifergan, Igal, Kakade, Sandeep, McCarthy, Derrick, Elhofy, Adam, Miller, Stephen

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Functional enhancement of mesothelin-targeted TRuC-T cells by a PD1-CD28 chimeric switch receptor von McCarthy, Derrick, Lofgren, Michael, Watt, Amy, Horton, Holly, Kieffer-Kwon, Philippe, Ding, Jian, Kobold, Sebastian, Baeuerle, Patrick A., Hofmeister, Robert, Gutierrez, Dario A., Tighe, Robert

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Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells von Getts, Daniel R, Turley, Danielle M, Smith, Cassandra E, Harp, Christopher T, McCarthy, Derrick, Feeney, Emma M, Getts, Meghann Teague, Martin, Aaron J, Luo, Xunrong, Terry, Rachael L, King, Nicholas J C, Miller, Stephen D

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Abstract 1528: Discovery and preclinical characterization of fratricide-resistant TRuC T-cells targeting CD70 von Ding, Jian, Watt, Amy, Liu, Erica, Adam, Zieba, McCarthy, Derrick, Gierut, Jessica, Schrand, Brett, Lofgren, Michael, Lajoie, Jason, Kenanova, Vania, Kiefer-Kwon, Philippe, Horton, Holly, Gutierrez, Dario A., Hofmeister, Robert, Tighe, Robert

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