Urokinase Plasminogen Activator Receptor Choreographs Multiple Ligand Interactions: Implications for Tumor Progression and Therapy von MAZAR, Andrew P

Volltext

Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion von Kenny, Hilary A, Chiang, Chun-Yi, White, Erin A, Schryver, Elizabeth M, Habis, Mohammed, Romero, Iris L, Ladanyi, Andras, Penicka, Carla V, George, Joshy, Matlin, Karl, Montag, Anthony, Wroblewski, Kristen, Yamada, S Diane, Mazar, Andrew P, Bowtell, David, Lengyel, Ernst

Volltext

Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response von Ding, Li, Madamsetty, Vijay S, Kiers, Spencer, Alekhina, Olga, Ugolkov, Andrey, Dube, John, Zhang, Yu, Zhang, Jin-San, Wang, Enfeng, Dutta, Shamit K, Schmitt, Daniel M, Giles, Francis J, Kozikowski, Alan P, Mazar, Andrew P, Mukhopadhyay, Debabrata, Billadeau, Daniel D

Volltext

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation von Calvert, Andrea E., Chalastanis, Alexandra, Wu, Yongfei, Hurley, Lisa A., Kouri, Fotini M., Bi, Yingtao, Kachman, Maureen, May, Jasmine L., Bartom, Elizabeth, Hua, Youjia, Mishra, Rama K., Schiltz, Gary E., Dubrovskyi, Oleksii, Mazar, Andrew P., Peter, Marcus E., Zheng, Hongwu, James, C. David, Burant, Charles F., Chandel, Navdeep S., Davuluri, Ramana V., Horbinski, Craig, Stegh, Alexander H.

Volltext

Arsenoplatin‑1 Is a Dual Pharmacophore Anticancer Agent von Miodragović, Đenana, Merlino, Antonello, Swindell, Elden P, Bogachkov, Abraham, Ahn, Richard W, Abuhadba, Sara, Ferraro, Giarita, Marzo, Tiziano, Mazar, Andrew P, Messori, Luigi, O’Halloran, Thomas V

Volltext

9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the effects of anticancer therapeutics in bladder cancer von Kuroki, Hiroo, Anraku, Tsutomu, Kazama, Akira, Bilim, Vladimir, Tasaki, Masayuki, Schmitt, Daniel, Mazar, Andrew P., Giles, Francis J, Ugolkov, Andrey, Tomita, Yoshihiko

Volltext

Biodistribution and in vivo toxicity of aptamer-loaded gold nanostars von Dam, Duncan Hieu M, Culver, Kayla S.B, Kandela, Irawati, PhD, Lee, Raymond C, Chandra, Kavita, Lee, Hyojin, PhD, Mantis, Christine, Ugolkov, Andrey, PhD, Mazar, Andrew P., PhD, Odom, Teri W., PhD

Volltext

α5β1 Integrin Signaling Mediates Oxidized Low-Density Lipoprotein–Induced Inflammation and Early Atherosclerosis von Yurdagul, Arif, Green, Jonette, Albert, Patrick, McInnis, Marshall C, Mazar, Andrew P, Orr, A Wayne

Volltext

Melanoma Cells Block PEDF Production in Fibroblasts to Induce the Tumor-Promoting Phenotype of Cancer-Associated Fibroblasts von Nwani, Nkechiyere G, Deguiz, Maria L, Jimenez, Benilde, Vinokour, Elena, Dubrovskyi, Oleksii, Ugolkov, Andrey, Mazar, Andrew P, Volpert, Olga V

Volltext

Nano-encapsulation of arsenic trioxide enhances efficacy against murine lymphoma model while minimizing its impact on ovarian reserve in vitro and in vivo von Ahn, Richard W, Barrett, Susan L, Raja, Meera R, Jozefik, Jennifer K, Spaho, Lidia, Chen, Haimei, Bally, Marcel B, Mazar, Andrew P, Avram, Michael J, Winter, Jane N, Gordon, Leo I, Shea, Lonnie D, O'Halloran, Thomas V, Woodruff, Teresa K

Volltext

Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation von Bell, Jonathan B, Eckerdt, Frank, Dhruv, Harshil D, Finlay, Darren, Peng, Sen, Kim, Seungchan, Kroczynska, Barbara, Beauchamp, Elspeth M, Alley, Kristen, Clymer, Jessica, Goldman, Stewart, Cheng, Shi-Yuan, James, C David, Nakano, Ichiro, Horbinski, Craig, Mazar, Andrew P, Vuori, Kristiina, Kumthekar, Priya, Raizer, Jeffrey, Berens, Michael E, Platanias, Leonidas C

Volltext

uPAR antibody (huATN-658) and Zometa reduce breast cancer growth and skeletal lesions von Mahmood, Niaz, Arakelian, Ani, Khan, Haseeb Ahmed, Tanvir, Imrana, Mazar, Andrew P, Rabbani, Shafaat A

Volltext

Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM) von Xu, Xiang, Cai, Yuan, Wei, Ying, Donate, Fernando, Juarez, Jose, Parry, Graham, Chen, Liqing, Meehan, Edward J, Ahn, Richard W, Ugolkov, Andrey, Dubrovskyi, Oleksii, O'Halloran, Thomas V, Huang, Mingdong, Mazar, Andrew P

Volltext

Combination Treatment with the GSK-3 Inhibitor 9-ING-41 and CCNU Cures Orthotopic Chemoresistant Glioblastoma in Patient-Derived Xenograft Models von Ugolkov, Andrey, Qiang, Wenan, Bondarenko, Gennadiy, Procissi, Daniel, Gaisina, Irina, James, C. David, Chandler, James, Kozikowski, Alan, Gunosewoyo, Hendra, O'Halloran, Thomas, Raizer, Jeffrey, Mazar, Andrew P.

Volltext

Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity von Portelli, Michael A, Bhaker, Sangita, Pang, Vincent, Bates, David O, Johnson, Simon R, Mazar, Andrew P, Shaw, Dominick, Brightling, Christopher, Sayers, Ian

Volltext

An Anti-Urokinase Plasminogen Activator Receptor Antibody (ATN-658) Blocks Prostate Cancer Invasion, Migration, Growth, and Experimental Skeletal Metastasis In Vitro and In Vivo von Rabbani, Shafaat A., Ateeq, Bushra, Arakelian, Ani, Valentino, Maria Luisa, Shaw, David E., Dauffenbach, Lisa M., Kerfoot, Christopher A., Mazar, Andrew P.

Volltext

Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes von Huang, Mingdong, Huai, Qing, Zhou, Aiwu, Lin, Lin, Mazar, Andrew P, Parry, Graham C, Callahan, Jennifer, Shaw, David E, Furie, Bruce, Furie, Barbara C

Volltext

A non–RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo von Khalili, Parisa, Arakelian, Ani, Chen, Gaoping, Plunkett, Marian L, Beck, Ivy, Parry, Graham C, Doñate, Fernando, Shaw, David E, Mazar, Andrew P, Rabbani, Shafaat A

Volltext

Copper Binding by Tetrathiomolybdate Attenuates Angiogenesis and Tumor Cell Proliferation through the Inhibition of Superoxide Dismutase 1 von Jose C. Juarez, Oscar Betancourt, Jr, Steven R. Pirie-Shepherd, Xiaojun Guan, Melissa L. Price, David E. Shaw, Andrew P. Mazar, Fernando Doñate

Volltext

Targeting SOD1 reduces experimental non–small-cell lung cancer von Glasauer, Andrea, Sena, Laura A, Diebold, Lauren P, Mazar, Andrew P, Chandel, Navdeep S

Volltext