Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets von Bedford, Lynn, Lowe, James, Dick, Lawrence R., Mayer, R. John, Brownell, James E.

Volltext

Assembly, structure, and function of the 26S proteasome von Bedford, Lynn, Paine, Simon, Sheppard, Paul W, Mayer, R. John, Roelofs, Jeroen

Volltext

Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway von Kageyama, Shun, Sou, Yu-shin, Uemura, Takefumi, Kametaka, Satoshi, Saito, Tetsuya, Ishimura, Ryosuke, Kouno, Tsuguka, Bedford, Lynn, Mayer, R. John, Lee, Myung-Shik, Yamamoto, Masayuki, Waguri, Satoshi, Tanaka, Keiji, Komatsu, Masaaki

Volltext

Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies von Bedford, Lynn, Hay, David, Devoy, Anny, Paine, Simon, Powe, Des G, Seth, Rashmi, Gray, Trevor, Topham, Ian, Fone, Kevin, Rezvani, Nooshin, Mee, Maureen, Soane, Tim, Layfield, Robert, Sheppard, Paul W, Ebendal, Ted, Usoskin, Dmitry, Lowe, James, Mayer, R. John

Volltext

Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway von Ugun-Klusek, Aslihan, Tatham, Michael H, Elkharaz, Jamal, Constantin-Teodosiu, Dumitru, Lawler, Karen, Mohamed, Hala, Paine, Simon M L, Anderson, Glen, John Mayer, R, Lowe, James, Ellen Billett, E, Bedford, Lynn

Volltext

The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53 von Higashitsuji, Hiroaki, Higashitsuji, Hisako, Itoh, Katsuhiko, Sakurai, Toshiharu, Nagao, Toshikazu, Sumitomo, Haruhiko, Masuda, Tomoko, Dawson, Simon, Shimada, Yutaka, Mayer, R. John, Fujita, Jun

Volltext

The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction von Pan, Bo, Li, Jie, Parajuli, Nirmal, Tian, Zongwen, Wu, Penglong, Lewno, Megan T., Zou, Jianqiu, Wang, Wenjuan, Bedford, Lynn, Mayer, R. John, Fang, Jing, Liu, Jinbao, Cui, Taixing, Su, Huabo, Wang, Xuejun

Volltext

Pale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of α-synuclein von Paine, Simon M L, Anderson, Glenn, Bedford, Karen, Lawler, Karen, Mayer, R John, Lowe, James, Bedford, Lynn

Volltext

Gankyrin Is an Ankyrin-repeat Oncoprotein That Interacts with CDK4 Kinase and the S6 ATPase of the 26 S Proteasome von Dawson, Simon, Apcher, Sebastien, Mee, Maureen, Mayer, R. John, Higashitsuji, Hiroaki, Baker, Rohan, Uhle, Stefan, Dubiel, Wolfgang, Fujita, Jun

Volltext

Ubiquitin and ubiquitin-like proteins as multifunctional signals von Welchman, Rebecca L., Gordon, Colin, Mayer, R. John

Volltext

Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas von Higashitsuji, Hiroaki, Itoh, Katsuhiko, Nagao, Toshikazu, Dawson, Simon, Nonoguchi, Kohsuke, Kido, Tsuneo, Mayer, R. John, Arii, Shigeki, Fujita, Jun

Volltext

The Oncoprotein Gankyrin Negatively Regulates Both p53 and RB by Enhancing Proteasomal Degradation von Higashitsuji, Hiroaki, Liu, Yu, Mayer, R. John, Fujita, Jun

Volltext

Heterozygosity for the proteasomal Psmc1 ATPase is insufficient to cause neuropathology in mouse brain, but causes cell cycle defects in mouse embryonic fibroblasts von Rezvani, Nooshin, Elkharaz, Jamal, Lawler, Karen, Mee, Maureen, Mayer, R. John, Bedford, Lynn

Volltext

MAGE-A4 Interacts with the Liver Oncoprotein Gankyrin and Suppresses Its Tumorigenic Activity von Nagao, Toshikazu, Higashitsuji, Hiroaki, Nonoguchi, Kohsuke, Sakurai, Toshiharu, Dawson, Simon, Mayer, R John, Itoh, Katsuhiko, Fujita, Jun

Volltext

The Crystal Structure of Gankyrin, an Oncoprotein Found in Complexes with Cyclin-dependent Kinase 4, a 19 S Proteasomal ATPase Regulator, and the Tumor Suppressors Rb and p53 von Krzywda, Szymon, Brzozowski, Andrzej M., Higashitsuji, Hiroaki, Fujita, Jun, Welchman, Rebecca, Dawson, Simon, Mayer, R.John, Wilkinson, Anthony J.

Volltext

The meteoric rise of regulated intracellular proteolysis von John Mayer, R.

Volltext

The UPS and autophagy in chronic neurodegenerative disease: Six of one and half a dozen of the other-Or not? von Bedford, Lynn, Paine, Simon, Rezvani, Nooshin, Mee, Maureen, Lowe, James, Mayer, R. John

Volltext

Subcellular distribution of the TSC2 gene product tuberin in human airway smooth muscle cells is driven by multiple localization sequences and is cell-cycle dependent von Clements, Debbie, Mayer, R. John, Johnson, Simon R

Volltext

The ubiquitin protein catabolic disorders von Layfield, Robert, Alban, Andrew, Mayer, R. John, Lowe, James

Volltext

Gankyrin: a new oncoprotein and regulator of pRb and p53 von Dawson, Simon, Higashitsuji, Hiroaki, Wilkinson, Anthony J., Fujita, Jun, Mayer, R. John

Volltext