Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial von Brightling, Christopher E, Prof, Chanez, Pascal, Prof, Leigh, Richard, MBChB, O'Byrne, Paul M, Prof, Korn, Stephanie, PhD, She, Dewei, PhD, May, Richard D, PhD, Streicher, Katie, PhD, Ranade, Koustubh, PhD, Piper, Edward, Dr

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A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma von PIPER, Edward, BRIGHTLING, Christopher, MOLFINO, Nestor A, NIVEN, Robert, OH, Chad, FAGGIONI, Raffaella, POON, Kwai, DEWEI SHE, KELL, Chris, MAY, Richard D, GEBA, Gregory P

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Biological clustering supports both “Dutch” and “British” hypotheses of asthma and chronic obstructive pulmonary disease von Ghebre, Michael A., MSc, Bafadhel, Mona, PhD, Desai, Dhananjay, MBBS, Cohen, Suzanne E., PhD, Newbold, Paul, PhD, Rapley, Laura, PhD, Woods, Jo, PhD, Rugman, Paul, PhD, Pavord, Ian D., MD, Newby, Chris, PhD, Burton, Paul R., MD, May, Richard D., PhD, Brightling, Chris E., PhD

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Moving toward endotypes in atopic dermatitis: Identification of patient clusters based on serum biomarker analysis von Thijs, Judith L., MD, Strickland, Ian, PhD, Bruijnzeel-Koomen, Carla A.F.M., MD, PhD, Nierkens, Stefan, PhD, Giovannone, Barbara, PhD, Csomor, Eszter, PhD, Sellman, Bret R., PhD, Mustelin, Tomas, MD, PhD, Sleeman, Matthew A., PhD, de Bruin-Weller, Marjolein S., MD, PhD, Herath, Athula, PhD, Drylewicz, Julia, PhD, May, Richard D., PhD, Hijnen, DirkJan, MD, PhD

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IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells von Camelo, Ana, Rosignoli, Guglielmo, Ohne, Yoichiro, Stewart, Ross A., Overed-Sayer, Catherine, Sleeman, Matthew A., May, Richard D.

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Severe exacerbations in moderate-to-severe asthmatics are associated with increased pro-inflammatory and type 1 mediators in sputum and serum von Ghebre, Michael A, Pang, Pee Hwee, Desai, Dhananjay, Hargadon, Beverley, Newby, Chris, Woods, Joanne, Rapley, Laura, Cohen, Suzanne E, Herath, Athula, Gaillard, Erol A, May, Richard D, Brightling, Chris E

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Strategies targeting the IL-4/IL-13 axes in disease von May, Richard D., Fung, Michael

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A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma von Cohen, E Suzanne, Dobson, Claire L, Käck, Helena, Wang, Bing, Sims, Dorothy A, Lloyd, Christopher O, England, Elizabeth, Rees, D Gareth, Guo, Hongwei, Karagiannis, Sophia N, O'Brien, Siobhan, Persdotter, Sofia, Ekdahl, Helena, Butler, Robin, Keyes, Feenagh, Oakley, Sarah, Carlsson, Mats, Briend, Emmanuel, Wilkinson, Trevor, Anderson, Ian K, Monk, Phillip D, von Wachenfeldt, Karin, Eriksson, Per-Olof F, Gould, Hannah J, Vaughan, Tristan J, May, Richard D

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Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles von Ghebre, Michael A., Pang, Pee Hwee, Diver, Sarah, Desai, Dhananjay, Bafadhel, Mona, Haldar, Koirobi, Kebadze, Tatiana, Cohen, Suzanne, Newbold, Paul, Rapley, Laura, Woods, Joanne, Rugman, Paul, Pavord, Ian D., Johnston, Sebastian L., Barer, Michael, May, Richard D., Brightling, Christopher E.

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Elevated Sputum Interleukin-5 and Submucosal Eosinophilia in Obese Individuals with Severe Asthma von DESAI, Dhananjay, NEWBY, Christopher, HERATH, Athula, ANDERSON, Ian K, BRADDING, Peter, GREEN, Ruth, KULKARNI, Nita, PAVORD, Ian, MARSHALL, Richard P, SOUSA, Ana R, MAY, Richard D, WARDLAW, Andrew J, SYMON, Fiona A, BRIGHTLING, Chris E, HALDAR, Pranabashis, SHAH, Sachil, GUPTA, Sumit, BAFADHEL, Mona, SINGAPURI, Amisha, SIDDIQUI, Salman, WOODS, Joanne

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Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction von England, Elizabeth, Rees, D. Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T. Y., Chaillan Huntington, Catherine E., Houslay, Kirsty F., Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B., Rapley, Laura, Sims, Dorothy A., Hollins, Claire, Hinchy, Elizabeth C., Strain, Martin D., Kemp, Benjamin P., Corkill, Dominic J., May, Richard D., Vousden, Katherine A., Butler, Robin J., Mustelin, Tomas, Vaughan, Tristan J., Lowe, David C., Colley, Caroline, Cohen, E. Suzanne

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Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation von Cohen, E. Suzanne, Scott, Ian C., Majithiya, Jayesh B., Rapley, Laura, Kemp, Benjamin P., England, Elizabeth, Rees, D. Gareth, Overed-Sayer, Catherine L., Woods, Joanne, Bond, Nicholas J., Veyssier, Christel Séguy, Embrey, Kevin J., Sims, Dorothy A., Snaith, Michael R., Vousden, Katherine A., Strain, Martin D., Chan, Denice T. Y., Carmen, Sara, Huntington, Catherine E., Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E., Vaughan, Tristan J., Butler, Robin, Lowe, David C., Higazi, Daniel R., Corkill, Dominic J., May, Richard D., Sleeman, Matthew A., Mustelin, Tomas

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Sputum microbiomic clustering in asthma and chronic obstructive pulmonary disease reveals a Haemophilus‐predominant subgroup von Diver, Sarah, Richardson, Matt, Haldar, Koirobi, Ghebre, Michael A., Ramsheh, Mohammadali Y., Bafadhel, Mona, Desai, Dhananjay, Cohen, Emma Suzanne, Newbold, Paul, Rapley, Laura, Rugman, Paul, Pavord, Ian D., May, Richard D., Barer, Michael, Brightling, Christopher.E.

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Serum biomarker profiles suggest that atopic dermatitis is a systemic disease von Thijs, Judith L., Strickland, Ian, Bruijnzeel-Koomen, Carla A.F.M., Nierkens, Stefan, Giovannone, Barbara, Knol, Edward F., Csomor, Eszter, Sellman, Bret R., Mustelin, Tomas, Sleeman, Matthew A., de Bruin-Weller, Marjolein S., Herath, Athula, Drylewicz, Julia, May, Richard D., Hijnen, DirkJan

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Immunohistochemical Characterization of the IL-13:IL-4 Receptor α Axis in the Skin of Adult Patients with Moderate to Severe Atopic Dermatitis and Healthy Controls von Miranda, Elena, Roberts, Jennifer, Novick, Steven, Lapointe, Jean-Martin, Bruijnzeel-Koomen, Carla, Thijs, JudithL, Sleeman, Matthew A., May, Richard D., Hijnen, DirkJan, Strickland, Ian

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A Predictive Model of Human Myelotoxicity Using Five Camptothecin Derivatives and the In vitro Colony-Forming Unit Granulocyte/Macrophage Assay von MASUBUCHI, Noriko, MAY, Richard D, ATSUMI, Ryo

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Sputum biomarkers during acute severe asthma attacks in children—a case‐control study von Ramphul, Manisha, Welsh, Kathryn G., May, Richard D., Ghebre, Michael A., Rapley, Laura, Cohen, Emma Suzanne, Herath, Athula, Monteiro, William, Rousseau, Karine, Thornton, David J., Brightling, Christopher E., Gaillard, Erol A.

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EASI p-EASI: Utilizing a combination of serum biomarkers offers an objective measurement tool for disease severity in atopic dermatitis patients von Thijs, Judith L., Drylewicz, Julia, Fiechter, Renée, Strickland, Ian, Sleeman, Matthew A., Herath, Athula, May, Richard D., Bruijnzeel-Koomen, Catharina A.F.M., Knol, Edward F., Giovannone, Barbara, de Bruin-Weller, Marjolein S., Nierkens, Stefan, Hijnen, Dirk Jan

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Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponins von Marciani, Dante J., Pathak, Ashish K., Reynolds, Robert C., Seitz, Lainne, May, Richard D.

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Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100 von Marciani, Dante J, Reynolds, Robert C, Pathak, Ashish K, Finley-Woodman, Kyra, May, Richard D

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