Comparing World Economic and Net Energy Metrics, Part 2: Total Economy Expenditure Perspective von King, Carey W, Maxwell, John P, Donovan, Alyssa

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Comparing World Economic and Net Energy Metrics, Part 1: Single Technology and Commodity Perspective von King, Carey W, Maxwell, John P, Donovan, Alyssa

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Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer von Simoneau, Antoine, Engel, Justin L, Bandi, Madhavi, Lazarides, Katherine, Liu, Shangtao, Meier, Samuel R, Choi, Ashley H, Zhang, Hongxiang, Shen, Binzhang, Martires, Lauren, Gotur, Deepali, Pham, Truc V, Li, Fang, Gu, Lina, Gong, Shanzhong, Zhang, Minjie, Wilker, Erik, Pan, Xuewen, Whittington, Douglas A, Throner, Scott, Maxwell, John P, Chen, Yingnan, Yu, Yi, Huang, Alan, Andersen, Jannik N, Feng, Tianshu

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The impact of a web-based prognostic calculator on prognostic confidence in outpatient palliative care von Hui, David, Maxwell, John P., de la Rosa, Allison, Jennings, Kristofer, Vidal, Marieberta, Reddy, Akhila, Azhar, Ahsan, Dev, Rony, Tanco, Kimberson, Heung, Yvonne, Delgado-Guay, Marvin, Zhukovsky, Donna, Arthur, Joseph, Reddy, Suresh, Yennu, Sriram, Ontai, Amy, Bruera, Eduardo

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Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers von Cottrell, Kevin M., Briggs, Kimberly J., Whittington, Douglas A., Jahic, Haris, Ali, Janid A., Davis, Charles B., Gong, Shanzhong, Gotur, Deepali, Gu, Lina, McCarren, Patrick, Tonini, Matthew R., Tsai, Alice, Wilker, Erik W., Yuan, Hongling, Zhang, Minjie, Zhang, Wenhai, Huang, Alan, Maxwell, John P.

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Immunonutrition and Colorectal Surgery von McClave, Stephen A, Martindale, Robert G, Maxwell, John P

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In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms von Lin, Chao, Lin, Kai, Luong, Yu-Ping, Rao, B Govinda, Wei, Yun-Yi, Brennan, Debra L, Fulghum, John R, Hsiao, Hsun-Mei, Ma, Sue, Maxwell, John P, Cottrell, Kevin M, Perni, Robert B, Gates, Cynthia A, Kwong, Ann D

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Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores von Henderson, James A., Bilimoria, Darius, Bubenik, Monica, Cadilhac, Caroline, Cottrell, Kevin M., Denis, Francois, Dietrich, Evelyne, Ewing, Nigel, Falardeau, Guy, Giroux, Simon, L’Heureux, Lucille, Liu, Bingcan, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Pereira, Oswy Z., Poisson, Carl, Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Vaillancourt, Louis, Wang, Jian, Xu, Jinwang, Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.

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Benzimidazole-containing HCV NS5A inhibitors: Effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency von Henderson, James A., Bilimoria, Darius, Bubenik, Monica, Cadilhac, Caroline, Cottrell, Kevin M., Dietrich, Evelyne, Denis, Francois, Ewing, Nigel, Falardeau, Guy, Giroux, Simon, Grey, Ronald, L’Heureux, Lucille, Liu, Bingcan, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Pereira, Oswy Z., Poisson, Carl, Govinda Rao, B., Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Vaillancourt, Louis, Wang, Jian, Yannopoulos, Constantin G., Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.

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Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: Non-symmetric inhibitors with potent activity against genotype 1a and 1b von Giroux, Simon, Bilimoria, Darius, Cadilhac, Caroline, Cottrell, Kevin M., Denis, Francois, Dietrich, Evelyne, Ewing, Nigel, Henderson, James A., L’Heureux, Lucille, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Xu, Jinwang, Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.

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Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-Symmetric inhibitors with diyne and biphenyl linkers von Giroux, Simon, Bilimoria, Darius, Cadilhac, Caroline, Cottrell, Kevin M., Denis, Francois, Dietrich, Evelyne, Ewing, Nigel, Henderson, James A., L’Heureux, Lucille, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Xu, Jinwang, Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.

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Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors von Giroux, Simon, Xu, Jinwang, Reddy, T. Jagadeeswar, Morris, Mark, Cottrell, Kevin M, Cadilhac, Caroline, Henderson, James A, Nicolas, Oliver, Bilimoria, Darius, Denis, Francois, Mani, Nagraj, Ewing, Nigel, Shawgo, Rebecca, L’Heureux, Lucille, Selliah, Subajini, Chan, Laval, Chauret, Nathalie, Berlioz-Seux, Francoise, Namchuk, Mark N, Grillot, Anne-Laure, Bennani, Youssef L, Das, Sanjoy K, Maxwell, John P

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Mild, Fast, and Stereoselective Epoxide Opening by Ketone Enolate Anions. Application to Synthesis of the Norlignan Curculigine von Posner, Gary H, Maxwell, John P, Kahraman, Mehmet

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Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants von Perni, Robert B, Farmer, Luc J, Cottrell, Kevin M, Court, John J, Courtney, Lawrence F, Deininger, David D, Gates, Cynthia A, Harbeson, Scott L, Kim, Joseph L, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C, Tung, Roger D, Van Drie, John H, Wilson, Keith, Thomson, John A

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Inhibitors of hepatitis C virus NS3·4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics von Perni, Robert B., Chandorkar, Gurudatt, Cottrell, Kevin M., Gates, Cynthia A., Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P., Murcko, Mark A., Pitlik, Janos, Rao, Govinda, Schairer, Wayne C., Drie, John Van, Wei, Yunyi

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Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics von Perni, Robert B, Chandorkar, Gurudatt, Cottrell, Kevin M, Gates, Cynthia A, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, Govinda, Schairer, Wayne C, Van Drie, John, Wei, Yunyi

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Abstract P214: MTAPnull-selective PRMT5 inhibitors drive regressions in MTAP -deleted xenograft models across histologies von Briggs, Kimberly J., Cottrell, Kevin M., Tonini, Matthew R., Wilker, Erik, Gu, Lina, Davis, Charles B., Whittington, Doug, Gotur, Deepali, Jahic, Haris, Goldstein, Matthew J., Huang, Alan, Maxwell, John P.

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The impact of a web-based prognostic intervention on physicians’ prognostic confidence von Hui, David, De La Rosa, Allison, Shelal, Zeena, Maxwell, John P, Hosain, Monawar, De La Cruz, Maxine Grace Jaucian, Vidal, Marieberta, Reddy, Akhila Sunkepally, Azhar, Ahsan, Dev, Rony, Tanco, Kimberson Cochien, Wong, Angelique, Heung, Yvonne, Delgado Guay, Marvin, Zhukovsky, Donna S., Arthur, Joseph Anthony, Reddy, Suresh, Yennu, Sriram, Bruera, Eduardo

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Abstract B018: MTA-cooperative PRMT5 inhibitors selectively modulate RNA splicing in MTAP-deleted cancer cells across histologies von Tonini, Matthew R, Meier, Samuel R, Liu, Shangtao, Cottrell, Kevin M, Maxwell, John P, Andersen, Jannik N, Huang, Alan, Cimmino, Luisa, Briggs, Kimberly J

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Abstract 3452: TNG908, a brain-penetrant MTA-cooperative PRMT5 inhibitor, is efficacious in preclinical glioblastoma models von Zhang, Minjie, Tsai, Alice, Cottrell, Kevin M., Haines, Brian B., Wilker, Erik, DiBenedetto, Heather, Weitzman, Ron, Huang, Alan, Davis, Charles B., Maxwell, John P., Briggs, Kimberly J.

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